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1. Full Text Childhood Obesity and Adulthood Cardiovascular Disease : Quantifying the Lifetime Cumulative Burden of Cardiovascular Risk Factors
by Litwin, Sheldon E
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2014, Volume 64, Issue 15, pp. 1588 - 1590
risk factors | hypertension | body mass index | childhood obesity | cardiovascular disease | MORTALITY | cardiovascular disease | risk factors | IMPACT | CARDIAC & CARDIOVASCULAR SYSTEMS | MORBIDITY | BODY-MASS | BLOOD-PRESSURE | Risk Assessment - methods | Ventricular Function, Left | Humans | Female | Male | Adiposity - physiology | Blood Pressure - physiology | Hypertrophy, Left Ventricular - physiopathology | Ventricular Remodeling - physiology | Forecasting
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2. Full Text Redefining Reverse Remodeling: Can Echocardiography Refine Our Ability to Assess Response to Heart Failure Treatments?
by Waring, Ashley A and Litwin, Sheldon E
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2016, Volume 68, Issue 12, pp. 1277 - 1280
  Demonstrating improvements in clinical outcomes after CRT, particularly in long-term survival, requires large numbers of patients and a long duration of... 
ventricular remodeling | left ventricular function | cardiac resynchronization therapy | mitral valve insufficiency | MORTALITY | SURVIVAL | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | VOLUMES | REPRODUCIBILITY | LEFT-VENTRICULAR DYSFUNCTION | CLINICAL-IMPLICATIONS | IMPROVEMENT | ATRIAL FUNCTION | Heart Failure | Ventricular Remodeling | Echocardiography | Humans | Geometry | Studies | Heart failure | Heart attacks | Pulmonary arteries | Medical prognosis | Mortality | Physiology | Clinical outcomes
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3. Full Text Which Measures of Obesity Best Predict Cardiovascular Risk?
by Litwin, Sheldon E., MD, FACC
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2008, Volume 52, Issue 8, pp. 616 - 619
Cardiovascular | Internal Medicine | coronary artery disease | adiposity | body mass index | mortality | population studies | visceral fat | obesity | UNITED-STATES | WAIST-HIP RATIO | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | FOLLOW-UP | FAT DISTRIBUTION | ABDOMINAL OBESITY | PROSPECTIVE COHORT | BODY-MASS INDEX | CORONARY-HEART-DISEASE | ADIPOSE-TISSUE | Body Mass Index | Cardiovascular Diseases - physiopathology | Risk Assessment | Humans | Obesity - epidemiology | Risk Factors | Cardiovascular Diseases - epidemiology | Obesity - physiopathology | Abdominal Fat - physiopathology | Waist-Hip Ratio
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4. Full Text Cardiac “Morphomics”
by Litwin, Sheldon E., MD
JACC: Cardiovascular Imaging, ISSN 1936-878X, 2015, Volume 8, Issue 9, pp. 1016 - 1018
Cardiovascular
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5. Full Text Mechanisms of Exercise Intolerance: Insights from Tissue Doppler Imaging
by Skaluba, Stanislaw J and Litwin, Sheldon E
Circulation, ISSN 0009-7322, 03/2004, Volume 109, Issue 8, pp. 972 - 977
Background - A decreased ratio of early to late diastolic mitral inflow velocities ( E/ A < 1.0) reflects slowing of left ventricular ( LV) relaxation. This... 
Heart failure | Exercise | Diastole | Imaging | Echocardiography, Doppler | VENTRICULAR DIASTOLIC FUNCTION | heart failure | FILLING PRESSURES | CARDIAC & CARDIOVASCULAR SYSTEMS | DETERMINANTS | HEART-FAILURE | exercise | SYSTOLIC FUNCTION | imaging | HYPERTROPHIC CARDIOMYOPATHY | NORMAL EJECTION FRACTION | TASK-FORCE | echocardiography, Doppler | PERIPHERAL VASCULAR DISEASE | ECHOCARDIOGRAPHIC ASSESSMENT | DYSFUNCTION | HEMATOLOGY | diastole | Myocardial Contraction | Humans | Middle Aged | Male | Obesity - physiopathology | Echocardiography, Stress | Hypertension - physiopathology | Mitral Valve - physiopathology | Ventricular Dysfunction, Left - diagnostic imaging | Exercise Test | Aging - physiology | Coronary Artery Disease - physiopathology | Exercise Tolerance | Adult | Female | Aged | Hypertrophy, Left Ventricular - physiopathology
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6. Full Text Cardiac “Morphomics”: Do We Need to Measure LV Mass and Geometry in Everyone?
by Litwin, Sheldon E
JACC: Cardiovascular Imaging, ISSN 1936-878X, 09/2015, Volume 8, Issue 9, pp. 1016 - 1018
metabolic syndrome | cardiovascular disease | diabetes | left ventricular mass | echocardiography | REGRESSION | OBESITY | CARDIAC & CARDIOVASCULAR SYSTEMS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | LEFT-VENTRICULAR HYPERTROPHY | Diabetes Mellitus - epidemiology | Humans | Cardiovascular Diseases - epidemiology | Female | Male | Hypertrophy, Left Ventricular - epidemiology | Metabolic Syndrome - epidemiology
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7. Full Text To Clip or Not to Clip? Can We Predict Which Patients with Functional Mitral Regurgitation Will Benefit From Transcatheter Mitral Valve Repair?
by El Hajj, Stephanie and Litwin, Sheldon E
Journal of Cardiac Failure, ISSN 1071-9164, 03/2018, Volume 24, Issue 3, pp. 146 - 147
CARDIAC & CARDIOVASCULAR SYSTEMS | Mitral Valve Insufficiency - surgery | Humans | Cardiac Catheterization - methods | Heart Valve Prosthesis Implantation - methods | Mitral Valve - surgery | Treatment Outcome | Ventricular Function, Left - physiology | Mitral Valve Insufficiency - physiopathology
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8. Full Text Good Fat, Bad Fat: The Increasingly Complex Interplay of Adipose Tissue and the Cardiovascular System
by Litwin, Sheldon E
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2013, Volume 62, Issue 2, pp. 136 - 137
cardiovascular | bariatric | obesity | TRIAL | CARDIAC & CARDIOVASCULAR SYSTEMS | DISEASE | PERIVASCULAR FAT | WEIGHT | PATHOPHYSIOLOGY | Bariatric Surgery | Inflammation - pathology | Vasoconstriction - physiology | Arteries - physiology | Adipocytes - pathology | Humans
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9. Full Text Normal weight obesity: Is bigger really badder?
by Litwin, Sheldon E
Circulation: Cardiovascular Imaging, ISSN 1941-9651, 05/2012, Volume 5, Issue 3, pp. 286 - 288
Heart failure | Obesity | Editorials | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | RISK | ENDOTHELIAL FUNCTION | INSULIN SENSITIVITY | EXERCISE | HIGH-FAT MEAL | ADOLESCENTS | CARDIOVASCULAR-DISEASE | ECHOCARDIOGRAPHY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | obesity | CARDIAC GEOMETRY | Inflammation - complications | Abdominal Fat - pathology | Obesity - complications | Humans | Insulin Resistance | Ventricular Dysfunction, Left - etiology | Female | Male | Heart Ventricles - pathology
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10. Full Text Which Measures of Obesity Best Predict Cardiovascular Risk?Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology
by Litwin, Sheldon E
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2008, Volume 52, Issue 8, pp. 616 - 619
  According to the latter theory, visceral fat, via a variety of mechanisms, is proatherogenic, but subcutaneous and/or peripheral fat is not (17-25).... 
coronary artery disease | adiposity | body mass index | mortality | population studies | visceral fat | obesity | Studies | Obesity | Womens health | Mortality | Cholesterol
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11. Full Text Cardiac Remodeling in Obesity: Time for a New Paradigm
by Litwin, Sheldon E
JACC: Cardiovascular Imaging, ISSN 1936-878X, 03/2010, Volume 3, Issue 3, pp. 275 - 277
epidemiology | remodeling | left ventricular hypertrophy | myocardial contractility | cardiac magnetic resonance | obesity | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | WEIGHT-LOSS | FAILURE | HEART-DISEASE | LEFT-VENTRICULAR STRUCTURE | MASS | CARDIOVASCULAR-DISEASE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | GEOMETRY | Body Mass Index | Risk Assessment | Heart Diseases - physiopathology | Obesity - complications | Humans | Risk Factors | Obesity - physiopathology | Magnetic Resonance Imaging, Cine | Obesity - pathology | Stroke Volume | Heart Diseases - etiology | Ventricular Remodeling | Waist Circumference | Heart Ventricles - physiopathology | Waist-Hip Ratio | Heart Diseases - pathology | Heart Ventricles - pathology
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12. Full Text Cardiac Remodeling in Obesity
by E. Dale Abel and Sheldon E. Litwin and Gary Sweeney
Physiological Reviews, ISSN 0031-9333, 04/2008, Volume 88, Issue 2, pp. 389 - 419
The dramatic increase in the prevalence of obesity and its strong association with cardiovascular disease have resulted in unprecedented interest in... 
OBSTRUCTIVE SLEEP-APNEA | PHYSIOLOGY | FATTY-ACID OXIDATION | ACTIVATED-RECEPTOR-GAMMA | SELECTIVE LEPTIN RESISTANCE | EPICARDIAL ADIPOSE-TISSUE | LEFT-VENTRICULAR MASS | CORONARY-HEART-DISEASE | TYPE-2 DIABETES-MELLITUS | INDUCED INSULIN-RESISTANCE | GLYCATION END-PRODUCTS | Heart - physiopathology | Animals | Humans | Myocardium - pathology | Obesity - physiopathology | Ventricular Remodeling - physiology | Adipokines - physiology | Disease Models, Animal | Obesity - pathology | Adipose tissues | Heart | Obesity | Analysis | Physiological aspects | Research | Cardiovascular diseases | Risk factors | Apoptosis
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13. Full Text Reply
by Theophilus Owan and Sheldon E Litwin
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2011, Volume 58, Issue 18, p. 1924
  At a time when there is an increasing push for quantification of cardiac chamber sizes, we strongly support the notion that body surface area should be... 
Burns
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14. Full Text Childhood Obesity and Adulthood Cardiovascular Disease
by Litwin, Sheldon E., MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2014, Volume 64, Issue 15, pp. 1588 - 1590
  Fatty streaks in the aorta and coronary arteries, precursors of atherosclerosis, begin to appear in childhood, and the presence of such fatty streaks in... 
Cardiovascular | Internal Medicine | cardiovascular disease | risk factors | hypertension | body mass index | childhood obesity | Hypertension | Geometry | Studies | Obesity | Body mass index | Weight control | Heart attacks | Cardiovascular disease | Age
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15. Full Text Health Benefits of Gastric Bypass Surgery After 6 Years
by Adams, Ted D and Davidson, Lance E and Litwin, Sheldon E and Kolotkin, Ronette L and LaMonte, Michael J and Pendleton, Robert C and Strong, Michael B and Vinik, Russell and Wanner, Nathan A and Hopkins, Paul N and Gress, Richard E and Walker, James M and Cloward, Tom V and Nuttall, R. Tom and Hammoud, Ahmad and Greenwood, Jessica L. J and Crosby, Ross D and McKinlay, Rodrick and Simper, Steven C and Smith, Sherman C and Hunt, Steven C
JAMA, ISSN 0098-7484, 09/2012, Volume 308, Issue 11, pp. 1122 - 1131
CONTEXT Extreme obesity is associated with health and cardiovascular disease risks. Although gastric bypass surgery induces rapid weight loss and ameliorates... 
UNITED-STATES | LIFE-STYLE INTERVENTION | MEDICINE, GENERAL & INTERNAL | OBESITY | MEDICAL THERAPY | MORBIDITY | BARIATRIC SURGERY | WEIGHT | ROUX-EN-Y | TYPE-2 DIABETES-MELLITUS | CARDIOVASCULAR RISK-FACTORS | Obesity - surgery | Gastric Bypass | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Male | Obesity - physiopathology | Risk | Diabetes Mellitus | Case-Control Studies | Young Adult | Weight Loss | Adolescent | Cardiovascular Diseases - epidemiology | Quality of Life | Adult | Female | Aged | Health Status | Overweight persons | Usage | Care and treatment | Control | Patient outcomes | Gastric bypass | Weight loss | Diabetes | Methods | Obesity | Cardiovascular disease | Weight control | Gastrointestinal surgery
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16. Full Text Reply
: 1
by Sheldon E Litwin
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2009, Volume 53, Issue 6, p. 527
  Given this problem, I tried to make a case in the editorial that for a majority of the population, particularly those in the age range where interventions... 
Obesity | Body mass index | Weight control | Middle age | Older people | Population | Age | Abdomen
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17. Full Text Noninvasive Assessment of Pulmonary Artery Pressures Moving Beyond Tricuspid Regurgitation Velocities
by Litwin, SE
CIRCULATION-CARDIOVASCULAR IMAGING, ISSN 1941-9651, 03/2010, Volume 3, Issue 2, pp. 132 - 133
pulmonary heart disease | systolic time intervals | CARDIAC & CARDIOVASCULAR SYSTEMS | echocardiography | Editorials | pulmonary imaging | hypertension | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DOPPLER-ECHOCARDIOGRAPHY | Animals | Tricuspid Valve Insufficiency - physiopathology | Humans | Sensitivity and Specificity | Echocardiography, Doppler | Hypertension, Pulmonary - diagnostic imaging | Hypertension, Pulmonary - physiopathology | Mice, Transgenic | Mice | Pulmonary Artery - physiopathology | Tricuspid Valve Insufficiency - diagnostic imaging | Disease Models, Animal
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18. Full Text Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3
by Heiko Bugger and Sihem Boudina and Xiao Xuan Hu and Joseph Tuinei and Vlad G. Zaha and Heather A. Theobald and Ui Jeong Yun and Alfred P. McQueen and Benjamin Wayment and Sheldon E. Litwin and E. Dale Abel
Diabetes, ISSN 0012-1797, 11/2008, Volume 57, Issue 11, pp. 2924 - 2932
Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling... 
ACTIVATED-RECEPTOR-ALPHA | MUTANT MICE | OBESITY | REDUCED CARDIAC EFFICIENCY | FATTY-ACID OXIDATION | UCP3 | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | SUBSTRATE METABOLISM | DILATED CARDIOMYOPATHY | HUMAN SKELETAL-MUSCLE | Mitochondria, Heart - ultrastructure | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Diabetes Mellitus, Type 1 - metabolism | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | RNA, Messenger - metabolism | Mitochondrial Proteins - metabolism | Myocardium - metabolism | Myocardium - ultrastructure | Echocardiography | Mice, Inbred C57BL | RNA, Messenger - genetics | Diabetes Mellitus, Type 1 - pathology | Oxygen Consumption | Diabetes Mellitus, Type 1 - genetics | Microscopy, Electron | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Insulin - metabolism | Animals | Ion Channels - metabolism | Mice | Uncoupling Protein 2 | Uncoupling Protein 3 | Complications and side effects | Genetic aspects | Type 1 diabetes | Heart diseases | Risk factors | Metabolism
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19. Full Text Should We Test for Diastolic Dysfunction? How and How Often?
by Litwin, Sheldon E and Zile, Michael R
JACC: Cardiovascular Imaging, ISSN 1936-878X, 01/2020, Volume 13, Issue 1, pp. 297 - 309
Symptoms of heart failure (HF) are due in large part to elevation of left and/or right ventricular filling pressures. Although abnormal diastolic function is... 
implantable pressure monitoring | natriuretic peptides | diastolic function | hemodynamics | echocardiography | CHRONIC HEART-FAILURE | CARDIAC & CARDIOVASCULAR SYSTEMS | BRAIN NATRIURETIC PEPTIDE | CARDIAC STRUCTURE | CLINICAL CHARACTERISTICS | PRESERVED EJECTION FRACTION | TISSUE DOPPLER-ECHOCARDIOGRAPHY | RIGHT ATRIAL PRESSURE | natriuretic peptides | INFERIOR VENA-CAVA | VENTRICULAR FILLING PRESSURES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PULMONARY-ARTERY PRESSURE
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20. Full Text The Growing Problem of Obesity and the Heart: The Plot “Thickens”
by Litwin, Sheldon E
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2006, Volume 47, Issue 3, pp. 617 - 619
FRAMINGHAM | WOMEN | BODY-MASS INDEX | CARDIAC & CARDIOVASCULAR SYSTEMS | FAILURE | Sleep Apnea, Obstructive - physiopathology | Obesity - complications | Humans | Middle Aged | Risk Factors | Heart Failure - physiopathology | Obesity - physiopathology | Sleep Apnea, Obstructive - complications | Stroke Volume | Ventricular Dysfunction, Right - etiology | Echocardiography, Doppler | Adult | Ventricular Dysfunction, Right - physiopathology | Heart Failure - etiology | Ventricular Dysfunction, Right - diagnostic imaging
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