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Neurosurgery, ISSN 0148-396X, 04/2019, Volume 84, Issue 4, pp. 954 - 964
Abstract BACKGROUND Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent... 
Cerebral cavernous malformation (CCM) | SURGERY | PROPRANOLOL | PERMEABILITY | ANGIOGENESIS | Trial readiness | BRAIN-STEM | Symptomatic hemorrhage | Drug development | NATURAL-HISTORY | CLINICAL MANAGEMENT | CLINICAL NEUROLOGY | Cavernous angioma | STROKE | Biomarkers | VASCULAR MALFORMATIONS | QUALITY-OF-LIFE | MUTATIONS
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7597, pp. 122 - 126
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7654, pp. 305 - 310
Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an... 
BACTERIA | ANGIOGENESIS | INTERFACE | STABILITY | MULTIDISCIPLINARY SCIENCES | GENES | LIPOPOLYSACCHARIDE | RECEPTOR | HOST | LPS | INSIGHTS | Injections, Intravenous | Humans | Lipopolysaccharides - administration & dosage | Male | Hemangioma, Cavernous, Central Nervous System - immunology | Gram-Negative Bacteria - immunology | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Toll-Like Receptor 4 - deficiency | Female | Toll-Like Receptor 4 - antagonists & inhibitors | Disease Susceptibility | Hemangioma, Cavernous, Central Nervous System - microbiology | Signal Transduction | Endothelial Cells - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Immunity, Innate | Animals | Hemangioma, Cavernous, Central Nervous System - pathology | Germ-Free Life | Lipopolysaccharide Receptors - genetics | Anti-Bacterial Agents - pharmacology | Mice | Gastrointestinal Microbiome - immunology | Anti-Bacterial Agents - administration & dosage | Toll-like receptors | Physiological aspects | Health aspects | Hemangioma, Cavernous | Brain | Stroke | Gnotobiotics | Pathogenesis | Pharmacology | TLR4 protein | Gene expression | CD14 antigen | Endothelial cells | Proteins | Signal transduction | Signaling | Stimulants | Antibiotics | Bacteria | Gram-negative bacteria | Lung Kruppel-like factor | Brain diseases | Immune system | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2010, Volume 207, Issue 4, pp. 881 - 896
Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans... 
CELL PERMEABILITY | PATHOGENESIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | P38 MAPK ACTIVATION | ACUTE LUNG INJURY | VE-CADHERIN | CCM2 | IMMUNOLOGY | 2-HIT MECHANISM | BRAIN | ENDOTHELIAL BARRIER FUNCTION | RNA, Small Interfering - genetics | Humans | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | rhoA GTP-Binding Protein - metabolism | Animal Structures - blood supply | Mutation - physiology | Phosphorylation - genetics | rho-Associated Kinases - metabolism | Edema, Cardiac - pathology | Phosphorylation - drug effects | Endothelial Cells - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | Hemangioma, Cavernous, Central Nervous System - drug therapy | Edema, Cardiac - genetics | Hemangioma, Cavernous, Central Nervous System - pathology | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Mice | Myosin Light Chains - metabolism | Animal Structures - metabolism | Protein Binding - physiology | Capillary Permeability - physiology | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Hemangioma, Cavernous, Central Nervous System - metabolism | rho-Associated Kinases - antagonists & inhibitors | Brain Edema - genetics | Edema, Cardiac - drug therapy | Mice, Mutant Strains | Pulmonary Edema - pathology | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Proto-Oncogene Proteins - metabolism | Pulmonary Edema - genetics | Brain Edema - pathology | Mice, Inbred C57BL | Proto-Oncogene Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Protein Kinase Inhibitors - therapeutic use | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Signal Transduction - physiology | Brain Edema - drug therapy | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - drug effects
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 12/2000, Volume 279, Issue 6, pp. 1137 - 1145
Journal Article
Genetics in Medicine, ISSN 1098-3600, 03/2015, Volume 17, Issue 3, pp. 188 - 196
Purpose: The phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a... 
cerebral cavernous malformation | vascular malformations | CCM3 | Rho kinase | PDCD10 | MANAGEMENT | MECHANISM | GCKIII PROTEINS | RHO-KINASE | MODEL | NATURAL-HISTORY | LESION | STRATEGIES | VASCULAR INTEGRITY | GENETICS & HEREDITY | Human Umbilical Vein Endothelial Cells | Prospective Studies | Stress Fibers - drug effects | Humans | Middle Aged | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Child, Preschool | Infant | Intracellular Signaling Peptides and Proteins - metabolism | Hemangioma, Cavernous, Central Nervous System - genetics | rho-Associated Kinases - antagonists & inhibitors | Young Adult | rho-Associated Kinases - metabolism | Apoptosis Regulatory Proteins - genetics | Adult | Membrane Proteins - metabolism | Child | Intracellular Signaling Peptides and Proteins - genetics | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Keratin-1 - genetics | Membrane Proteins - genetics | Central Nervous System Neoplasms - genetics | Cells, Cultured | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Central Nervous System Neoplasms - pathology | Stress Fibers - metabolism | Animals | Hemangioma, Cavernous, Central Nervous System - enzymology | Hemangioma, Cavernous, Central Nervous System - pathology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Adolescent | Central Nervous System Neoplasms - enzymology | Mice | Mutation | Cerebral cavernous malformations
Journal Article
Journal Article
Journal Article
Journal of Magnetic Resonance Imaging, ISSN 1053-1807, 04/2018, Volume 47, Issue 4, pp. 1133 - 1138
Journal Article
Journal Article