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1. Full Text Patient-derived xenografts undergo mouse-specific tumor evolution
by Ben-David, Uri and Ha, Gavin and Tseng, Yuen-Yi and Greenwald, Noah F and Oh, Coyin and Shih, Juliann and McFarland, James M and Wong, Bang and Boehm, Jesse S and Beroukhim, Rameen and Golub, Todd R
Nature genetics, ISSN 1061-4036, 11/2017, Volume 49, Issue 11, pp. 1567 - 1575
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Species Specificity | DNA, Neoplasm - metabolism | Heterografts - drug effects | Humans | Selection, Genetic | Heterografts - metabolism | Aneuploidy | Neoplasms - classification | Clonal Evolution - genetics | DNA Copy Number Variations | Neoplasms - drug therapy | Animals | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Clone Cells | Mice | DNA, Neoplasm - genetics | Tumor Cells, Cultured | Neoplasms - pathology | Heterografts - pathology | Disease Models, Animal | Drugs | Medical research | Propagation | Copy number | Positive selection | Genomes | Breast cancer | Gene expression | Studies | Chemotherapy | Stem cells | Xenografts | Evolution | Chromosomes | Deoxyribonucleic acid--DNA | Tumors | Cancer | Index Medicus
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2. Full Text Next-generation characterization of the Cancer Cell Line Encyclopedia
by Ghandi, Mahmoud and Huang, Franklin W and Jané-Valbuena, Judit and Kryukov, Gregory V and Lo, Christopher C and McDonald, E. Robert and Barretina, Jordi and Gelfand, Ellen T and Bielski, Craig M and Li, Haoxin and Hu, Kevin and Andreev-Drakhlin, Alexander Y and Kim, Jaegil and Hess, Julian M and Haas, Brian J and Aguet, François and Weir, Barbara A and Rothberg, Michael V and Paolella, Brenton R and Lawrence, Michael S and Akbani, Rehan and Lu, Yiling and Tiv, Hong L and Gokhale, Prafulla C and de Weck, Antoine and Mansour, Ali Amin and Oh, Coyin and Shih, Juliann and Hadi, Kevin and Rosen, Yanay and Bistline, Jonathan and Venkatesan, Kavitha and Reddy, Anupama and Sonkin, Dmitriy and Liu, Manway and Lehar, Joseph and Korn, Joshua M and Porter, Dale A and Jones, Michael D and Golji, Javad and Caponigro, Giordano and Taylor, Jordan E and Dunning, Caitlin M and Creech, Amanda L and Warren, Allison C and McFarland, James M and Zamanighomi, Mahdi and Kauffmann, Audrey and Stransky, Nicolas and Imielinski, Marcin and Maruvka, Yosef E and Cherniack, Andrew D and Tsherniak, Aviad and Vazquez, Francisca and Jaffe, Jacob D and Lane, Andrew A and Weinstock, David M and Johannessen, Cory M and Morrissey, Michael P and Stegmeier, Frank and Schlegel, Robert and Hahn, William C and Getz, Gad and Mills, Gordon B and Boehm, Jesse S and Golub, Todd R and Garraway, Levi A and Sellers, William R
Nature (London), ISSN 0028-0836, 2019, Volume 569, Issue 7757, pp. 503 - 508
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | Humans | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Biomarkers, Tumor | Gene Editing | DNA Methylation | RNA Splicing | Ethnic Groups - genetics | Neoplasms - genetics | Cell Line, Tumor | Protein Array Analysis | Antineoplastic Agents - pharmacology | MicroRNAs - genetics | Histones - metabolism | Neoplasms - pathology | Technology application | Research | Oncology, Experimental | Methods | Cancer | Cell culture | Biotechnology | Genomics | Encyclopedias | Genomes | Proteins | DNA methylation | miRNA | Signatures | Bioinformatics | Deoxyribonucleic acid--DNA | CRISPR | Medical research | Phenotypes | Splicing | Tumor cell lines | Ribonucleic acid--RNA | Gene expression | Generalized linear models | Genetic variance | Protein arrays | MicroRNAs | Biomarkers | Mutation | Methylation | Acceleration | Histone H3 | Index Medicus
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3. Full Text De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies
by Appenzeller, Silke and Balling, Rudi and Barisic, Nina and Baulac, Stéphanie and Caglayan, Hande and Craiu, Dana and De Jonghe, Peter and Depienne, Christel and Dimova, Petia and Djémié, Tania and Gormley, Padhraig and Guerrini, Renzo and Helbig, Ingo and Hjalgrim, Helle and Hoffman-Zacharska, Dorota and Jähn, Johanna and Klein, Karl Martin and Koeleman, Bobby and Komarek, Vladimir and Krause, Roland and Kuhlenbäumer, Gregor and Leguern, Eric and Lehesjoki, Anna-Elina and Lemke, Johannes R and Lerche, Holger and Linnankivi, Tarja and Marini, Carla and May, Patrick and Møller, Rikke S and Muhle, Hiltrud and Pal, Deb and Palotie, Aarno and Pendziwiat, Manuela and Robbiano, Angela and Roelens, Filip and Rosenow, Felix and Selmer, Kaja and Serratosa, Jose M and Sisodiya, Sanjay and Stephani, Ulrich and Sterbova, Katalin and Striano, Pasquale and Suls, Arvid and Talvik, Tiina and von Spiczak, Sarah and Weber, Yvonne and Weckhuysen, Sarah and Zara, Federico and Abou-Khalil, Bassel and Alldredge, Brian K and Andermann, Eva and Andermann, Frederick and Amron, Dina and Bautista, Jocelyn F and Berkovic, Samuel F and Bluvstein, Judith and Boro, Alex and Cascino, Gregory and Consalvo, Damian and Crumrine, Patricia and Devinsky, Orrin and Dlugos, Dennis and Epstein, Michael P and Fiol, Miguel and Fountain, Nathan B and French, Jacqueline and Friedman, Daniel and Geller, Eric B and Glauser, Tracy and Glynn, Simon and Haas, Kevin and Haut, Sheryl R and Hayward, Jean and Helmers, Sandra L and Joshi, Sucheta and Kanner, Andres and Kirsch, Heidi E and Knowlton, Robert C and Kossoff, Eric H and Kuperman, Rachel and Kuzniecky, Ruben and Lowenstein, Daniel H and McGuire, Shannon M and Motika, Paul V and Novotny, Edward J and Ottman, Ruth and Paolicchi, Juliann M and Parent, Jack and Park, Kristen and Poduri, Annapurna and Sadleir, Lynette and Scheffer, Ingrid E and Shellhaas, Renée A and Sherr, Elliott and Shih, Jerry J and Singh, Rani and Sirven, Joseph and Smith, Michael C and Sullivan, Joe and Thio, Liu Lin and ... and Epilepsy Phenome/Genome Project and Epi4K Consortium and EuroEPINOMICS-RES Consortium and Epilepsy Phenome Genome Project
American journal of human genetics, ISSN 0002-9297, 10/2014, Volume 95, Issue 4, pp. 360 - 370
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fatty Acid Synthase, Type I - genetics | Receptors, GABA-B - genetics | Synaptic Transmission - genetics | Humans | Male | Spasms, Infantile - genetics | Gene Regulatory Networks | Mutation - genetics | Dynamin I - genetics | Lennox Gastaut Syndrome - genetics | Protein Interaction Maps | Exome - genetics | Ryanodine Receptor Calcium Release Channel - genetics | Female | Infant, Newborn | Cohort Studies | Genetic research | Genetic aspects | Research | Gene mutations | Epilepsy | Proteins | Consortia | Genetic disorders | Mutation | Genomics | Index Medicus
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4. Full Text The genomic landscape of tuberous sclerosis complex
by Martin, Katie R and Zhou, Wanding and Bowman, Megan J and Shih, Juliann and Au, Kit Sing and Dittenhafer-Reed, Kristin E and Sisson, Kellie A and Koeman, Julie and Weisenberger, Daniel J and Cottingham, Sandra L and Deroos, Steven T and Devinsky, Orrin and Winn, Mary E and Cherniack, Andrew D and Shen, Hui and Northrup, Hope and Krueger, Darcy A and Mackeigan, Jeffrey P
Nature communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, pp. 15816 - 15816
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tumor Suppressor Proteins - metabolism | Genomics | Humans | Tuberous Sclerosis Complex 1 Protein - genetics | Tuberous Sclerosis Complex 2 Protein - genetics | Tuberous Sclerosis - genetics | Tuberous Sclerosis Complex 1 Protein - metabolism | Tuberous Sclerosis - metabolism | Tumor Suppressor Proteins - genetics | Carcinoma - genetics | Tuberous Sclerosis Complex 2 Protein - metabolism | Carcinoma - metabolism | Mutation | TOR protein | Brain | Tuberous Sclerosis Complex 2 | Carcinoma | Deactivation | Computational neuroscience | Brain tumors | Benign | Tuberous sclerosis | Inflammation | Inactivation | Tuberous Sclerosis Complex 1 | Heterogeneity | Aberration | Lesions | Signatures | Chromosome aberrations | Tumors | Index Medicus
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5. Full Text Genomic activation of PPARG reveals a candidate therapeutic axis in bladder cancer
by Goldstein, Jonathan T and Berger, Ashton C and Shih, Juliann and Duke, Fujiko F and Furst, Laura and Kwiatkowski, David J and Cherniack, Andrew D and Meyerson, Matthew and Strathdee, Craig A
Cancer research (Chicago, Ill.), ISSN 0008-5472, 2017, Volume 77, Issue 24, pp. 6987 - 6998
Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Molecular Targeted Therapy | Mutation - physiology | Animals | Urinary Bladder Neoplasms - genetics | Gene Amplification - physiology | Microarray Analysis | Urinary Bladder Neoplasms - therapy | CRISPR-Cas Systems | Cell Line, Tumor | Transcriptome - physiology | PPAR gamma - genetics | Cell proliferation | Bladder | Retinoid X receptor α | Pharmacology | Gene expression | Ablation | Bladder cancer | Gene amplification | Urinary bladder | Mutation | Peroxisome proliferator-activated receptors | Inhibition | Health risk assessment | Cancer | Index Medicus | Genitourinary cancers: bladder | PPARG | RXRA | Nuclear receptors: structure and function
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6. Full Text Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
by Farshidfar, Farshad and Zheng, Siyuan and Gingras, Marie-Claude and Newton, Yulia and Shih, Juliann and Robertson, A. Gordon and Hinoue, Toshinori and Hoadley, Katherine A and Gibb, Ewan A and Roszik, Jason and Covington, Kyle R and Wu, Chia-Chin and Shinbrot, Eve and Stransky, Nicolas and Hegde, Apurva and Yang, Ju Dong and Reznik, Ed and Sadeghi, Sara and Pedamallu, Chandra Sekhar and Ojesina, Akinyemi I and Hess, Julian M and Auman, J. Todd and Rhie, Suhn K and Bowlby, Reanne and Borad, Mitesh J and Akbani, Rehan and Allotey, Loretta K and Ally, Adrian and Alvaro, Domenico and Andersen, Jesper B and Appelbaum, Elizabeth L and Arora, Arshi and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Bardeesy, Nabeel and Bathe, Oliver F and Baylin, Stephen B and Beroukhim, Rameen and Berrios, Mario and Bodenheimer, Tom and Boice, Lori and Bootwalla, Moiz S and Borad, Mitesh J and Bowen, Jay and Bowlby, Reanne and Bragazzi, Maria Consiglia and Brooks, Denise and Cardinale, Vincenzo and Carlsen, Rebecca and Carpino, Guido and Carvalho, Andre L and Chaiteerakij, Roongruedee and Chandan, Vishal C and Cherniack, Andrew D and Chin, Lynda and Cho, Juok and Choe, Gina and Chuah, Eric and Chudamani, Sudha and Cibulskis, Carrie and Cordes, Matthew G and Covington, Kyle R and Crain, Daniel and Curley, Erin and De Rose, Agostino Maria and Defreitas, Timothy and Demchok, John A and Deshpande, Vikram and Dhalla, Noreen and Ding, Li and Evason, Kimberley and Farshidfar, Farshad and Felau, Ina and Ferguson, Martin L and Foo, Wai Chin and Franchitto, Antonio and Frazer, Scott and Fronick, Catrina C and Fulton, Lucinda A and Fulton, Robert S and Gabriel, Stacey B and Gardner, Johanna and Gastier-Foster, Julie M and Gaudio, Eugenio and Gehlenborg, Nils and Genovese, Giannicola and Gerken, Mark and Getz, Gad and Giama, Nasra H and Gibbs, Richard A and Gingras, Marie-Claude and Giuliante, Felice and Grazi, Gian Luca and Hayes, D. Neil and Hegde, Apurva M and Heiman, David I and Hess, Julian M and Hinoue, Toshinori and Hoadley, Katherine A and ... and The Cancer Genome Atlas Network and Canc Genome Atlas Network and Cancer Genome Atlas Network
Cell reports (Cambridge), ISSN 2211-1247, 03/2017, Volume 18, Issue 11, pp. 2780 - 2794
RNA sequencing | lncRNAs | integrative genomics | whole exome | multi-omics | DNA methylation | IDH | ARID1A | cholangiocarcinoma | TCGA | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Chromatin - metabolism | Liver - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Bile Duct Neoplasms - enzymology | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Bile Duct Neoplasms - genetics | Genomics - methods | Nuclear Proteins - genetics | Cholangiocarcinoma - enzymology | Liver Neoplasms - genetics | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Isocitrate Dehydrogenase - genetics | Pancreatic Neoplasms - genetics | DNA Methylation - genetics | Mitochondria - metabolism | RNA, Long Noncoding - genetics | Transcription Factors - genetics | Mutation - genetics | Cholangiocarcinoma - genetics | Aged | RNA, Long Noncoding - metabolism | Index Medicus
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7. Full Text Integrated Molecular Characterization of Testicular Germ Cell Tumors
by Shen, Hui and Shih, Juliann and Hollern, Daniel P and Wang, Linghua and Bowlby, Reanne and Tickoo, Satish K and Thorsson, Vésteinn and Mungall, Andrew J and Newton, Yulia and Hegde, Apurva M and Armenia, Joshua and Sánchez-Vega, Francisco and Pluta, John and Pyle, Louise C and Mehra, Rohit and Reuter, Victor E and Godoy, Guilherme and Jones, Jeffrey and Shelley, Carl S and Feldman, Darren R and Vidal, Daniel O and Lessel, Davor and Kulis, Tomislav and Cárcano, Flavio M and Leraas, Kristen M and Lichtenberg, Tara M and Brooks, Denise and Cherniack, Andrew D and Cho, Juok and Heiman, David I and Kasaian, Katayoon and Liu, Minwei and Noble, Michael S and Xi, Liu and Zhang, Hailei and Zhou, Wanding and ZenKlusen, Jean C and Hutter, Carolyn M and Felau, Ina and Zhang, Jiashan and Schultz, Nikolaus and Getz, Gad and Meyerson, Matthew and Stuart, Joshua M and Wang, Linghua and Xi, Liu and Wheeler, David and Hughes, Daniel and Covington, Kyle and Jayaseelan, Joy C and Korchina, Viktoriya and Lewis, Lora and Hu, Jianhong and Doddapaneni, HarshaVardhan and Muzny, Donna and Gibbs, Richard and Hoadley, Katherine A and Hollern, Daniel and Vincent, Benjamin G and Chai, Shengjie and Smith, Christof C and Auman, J. Todd and Shi, Yan and Meng, Shaowu and Skelly, Tara and Tan, Donghui and Veluvolu, Umadevi and Mieczkowski, Piotr A and Jones, Corbin D and Wilkerson, Matthew D and Balu, Saianand and Bodenheimer, Tom and Hoyle, Alan P and Jefferys, Stuart R and Mose, Lisle E and Simons, Janae V and Soloway, Matthew G and Roach, Jeffrey and Parker, Joel S and Hayes, D. Neil and Perou, Charles M and Shih, Juliann and Cherniack, Andrew D and Meyerson, Matthew and Saksena, Gordon and Cibulskis, Carrie and Schumacher, Steven E and Beroukhim, Rameen and Gabriel, Stacey B and Bowlby, Reanne and Mungall, Andrew J and Brooks, Denise and Kasaian, Katayoon and Ally, Adrian and Balasundaram, Miruna and Carlsen, Rebecca and Cheung, Dorothy and Chuah, Eric and Dhalla, Noreen and Holt, Robert A and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell reports (Cambridge), ISSN 2211-1247, 06/2018, Volume 23, Issue 11, pp. 3392 - 3406
exome sequencing | miR-375 | KIT | DNA methylation | seminoma | nonseminoma | copy number | testicular germ cell tumors | The Cancer Genome Atlas | Life Sciences & Biomedicine | Science & Technology | Cell Biology | ras Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Testicular Neoplasms - metabolism | ras Proteins - metabolism | Male | MicroRNAs - metabolism | Neoplasms, Germ Cell and Embryonal - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Testicular Neoplasms - pathology | DNA Copy Number Variations | Seminoma - metabolism | DNA Methylation | Neoplasms, Germ Cell and Embryonal - classification | Proto-Oncogene Proteins c-kit - genetics | Neoplasms, Germ Cell and Embryonal - pathology | Seminoma - pathology | Testicular Neoplasms - classification | Index Medicus
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