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1. Full Text Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade
by Kwon, Jeongho and Han, Eunhye and Bui, Chi‐Bao and Shin, Woochul and Lee, Junho and Lee, Sejeong and Choi, Young‐Bong and Lee, Ann‐Hwee and Lee, Kyong‐Hoon and Park, Chankyu and Obin, Martin S and Park, Sung Kyu and Seo, Yun Jeong and Oh, Goo Taeg and Lee, Han‐Woong and Shin, Jaekyoon
EMBO reports, ISSN 1469-221X, 02/2012, Volume 13, Issue 2, pp. 150 - 156
Sqstm1/p62 functions in the non‐canonical activation of nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2). However, its physiological relevance is not... 
nrf2 | p62 | mammalian longevity | mitochondria | nqo1 | LIFE-SPAN | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | DROSOPHILA | CELL BIOLOGY | INACTIVATION | TRANSCRIPTION FACTOR NRF2 | RESISTANCE | MICE | Oxidation-Reduction | Signal Transduction | Sequestosome-1 Protein | Heat-Shock Proteins - metabolism | Male | Mitochondria - metabolism | Autophagy | Heat-Shock Proteins - deficiency | Animals | Adaptor Proteins, Signal Transducing - deficiency | NF-E2-Related Factor 2 - metabolism | Mammals - physiology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Cytoskeletal Proteins - metabolism | Female | Mice | Adaptor Proteins, Signal Transducing - metabolism | Kelch-Like ECH-Associated Protein 1 | Longevity - physiology | Genotype & phenotype | Mitochondria | Life expectancy | Rodents | Aging | Molecular biology | Gene expression | Scientific Reports
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2. Full Text ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress
by Lee, Huikyong and Lee, Huikyong and Ahn, Hye-Hyun and Ahn, Hye-Hyun and Lee, WonJae and Lee, WonJae and Oh, Yumin and Oh, Yumin and Choi, Hyunwoo and Choi, Hyunwoo and Shim, Sang Mi and Shim, Sang Mi and Shin, Jaekyoon and Shin, Jaekyoon and Jung, Yong-Keun and Jung, Yong-Keun
Molecular Neurobiology, ISSN 0893-7648, 12/2016, Volume 53, Issue 10, pp. 6620 - 6634
Huntington’s disease (HD) is a devastating neurodegenerative disorder, which is caused by the expression and aggregation of polyQ-expanded mutant huntingtin... 
Aggregation | Neurology | Neurosciences | Biomedicine | Neurobiology | ENC1 | ER stress | p62/SQSTM1 | Huntington’s disease | Autophagy | Cell Biology | PHOSPHORYLATION | NEURONAL CELL-DEATH | ENDOPLASMIC-RETICULUM STRESS | Huntington's disease | SELECTIVE AUTOPHAGY | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | NRP/B | NUCLEAR-MATRIX PROTEIN | INHIBITION | NRF2 | PATHWAY | Protein Aggregates | Neurons - pathology | Phosphorylation | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Proteolysis | Protein Binding - drug effects | HEK293 Cells | Mutant Proteins - toxicity | Microfilament Proteins - metabolism | Neurons - metabolism | Sequestosome-1 Protein - metabolism | Protein-Serine-Threonine Kinases - metabolism | Endoribonucleases - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Neuropeptides - metabolism | Neurotoxins - toxicity | Nuclear Proteins - metabolism | Animals | Huntingtin Protein - toxicity | Endoplasmic Reticulum Stress | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Enzymes | Medical colleges | Nervous system diseases | Detergents, Synthetic | Stress (Physiology) | Cells | Huntingtons disease | Pathogenesis | Stress
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3. Full Text Sasa Quelpaertensis Nakai Induced Antidepressant-Like Effect in Ovariectomized Rats
by Shaif, NA and Cho, D and Jang, D and Kim, HM and Chung, JO and Kim, S and Seo, DB and Kim, KR and Shin, J and Shim, I
BIOMED RESEARCH INTERNATIONAL, ISSN 2314-6133, 07/2019, Volume 2019, pp. 5815604 - 11
Background. Sasa quelpaertensis Nakai extract (SQE) or dwarf bamboo has been extensively investigated for its antioxidant and anti-inflammatory effects;... 
MEDICINE, RESEARCH & EXPERIMENTAL | DEPRESSION | PROTEIN-KINASE-C | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HIGH-FAT DIET | LOCUS-COERULEUS | DOPAMINE | SEROTONIN | STRESS | P-COUMARIC ACID | MENOPAUSAL TRANSITION | EXTRACT | Povidone | Brain | Antidepressants | Menopause | Tryptophan | Aprotinin | Protein kinases | Enzyme-linked immunosorbent assay | Immunohistochemistry | Temperature | Neurosciences | Protein kinase C | Antibodies | Immobilization | Hormones | Mental depression | Hypothalamus | Kinases | Density | Experiments | Proteins | Antioxidants | Locus coeruleus | Medical research | Cortex (prefrontal) | Dopamine | Serotonin | Ovariectomy | Body temperature | Hydroxylase | Inflammation | Stress | Tryptophan hydroxylase | Studies | Neurotransmitters | Womens health | Bamboo
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4. Full Text Triage of oxidation-prone proteins by Sqstm1/p62 within the mitochondria
by Lee, Minjung and Shin, Jaekyoon
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2011, Volume 413, Issue 1, pp. 122 - 127
► The mitochondrion contains its own protein quality control system. ► p62 localizes within the mitochondria and forms mega-dalton sized complexes. ► p62... 
Mitochondria | Oxidation | Electron transport | p62 | Chaperone | P62 | RESPIRATORY-CHAIN | MECHANISM | GLUTATHIONYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | AUTOPHAGY | INACTIVATION | TRANSCRIPTION FACTOR NRF2 | BIOPHYSICS | COMPLEX-II | DEGRADATION | STRESS | Adaptor Proteins, Signal Transducing - chemistry | Oxidation-Reduction | Sequestosome-1 Protein | Heat-Shock Proteins - metabolism | Mitochondria - metabolism | Brain - metabolism | Animals | Mice, Mutant Strains | Mitochondrial Proteins - metabolism | Mitochondrial Proteins - chemistry | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - chemistry | Proteins | Control systems | Mitochondrial DNA | OXIDATION | TIME-OF-FLIGHT METHOD | ENZYMES | IN VITRO | MITOCHONDRIA | QUALITY CONTROL | MASS SPECTROSCOPY | 60 APPLIED LIFE SCIENCES | BIOLOGICAL STRESS | DAMAGE
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5. Full Text Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
by Jung, Hye Seung and Chung, Kun Wook and Won Kim, Jeong and Kim, Jin and Kim, Kwang-Won and Kim, Ji-Won and Komatsu, Masaaki and Tanaka, Keiji and Nguyen, Yen Hoang and Kang, Tong Mook and Yoon, Kun-Ho and Jeong, Yeon Taek and Han, Myoung Sook and Lee, Myung-Shik and Lee, Moon-Kyu and Shin, Jaekyoon
Cell Metabolism, ISSN 1550-4131, 2008, Volume 8, Issue 4, pp. 318 - 324
Autophagy is a cellular degradation-recycling system for aggregated proteins and damaged organelles. Although dysregulated autophagy is implicated in various... 
PROTEINS | HUMDISEASE | DIABETES-MELLITUS | SURVIVAL | APOPTOSIS | GLUCOSE-HOMEOSTASIS | NOD MICE | RAT HEPATOCYTES | PATHWAY | ER STRESS | ENDOCRINOLOGY & METABOLISM | DEATH | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Ubiquitin - metabolism | Autophagy - physiology | Diabetes Mellitus, Type 2 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Insulin-Secreting Cells - ultrastructure | Autophagy-Related Protein 7 | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Diabetes Mellitus, Type 2 - physiopathology | Hyperglycemia - pathology | Glucose - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Insulin-Secreting Cells - pathology
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6. Full Text P62 and the sequestosome, a novel mechanism for protein metabolism
by Shin, Jaekyoon
Archives of Pharmacal Research, ISSN 0253-6269, 1998, Volume 21, Issue 6, pp. 629 - 633
In addition to selecting proteins for degradation by the 26S proteasome, ubiqitination appears to serve other regulatory functions, including for... 
Protein metabolism | Ubiqitination | P62 | Sequestosome | CHEMISTRY, MEDICINAL | protein metabolism | KINASE | P56(LCK) | MULTIUBIQUITIN CHAINS | SH2 DOMAIN | PHOSPHOTYROSINE-INDEPENDENT LIGAND | sequestosome | ubiqitination | BINDING PROTEINS | PROTEASOME | SEQUENCE | GROWTH | PHARMACOLOGY & PHARMACY | COMPONENT | Protein Kinases - metabolism | Humans | Adenosine Triphosphatases - metabolism | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Proto-Oncogene Proteins c-myc - metabolism | Proto-Oncogene Proteins c-myc - physiology | Animals | Cysteine Endopeptidases - metabolism | Proteins - metabolism | Protein Binding | Proto-Oncogene Proteins c-myc - genetics | Ubiquitins - metabolism
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7. Full Text SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages
by Kim, Min-Ji and Bae, Soo Han and Ryu, Jae-Chan and Kwon, Younghee and Oh, Ji-Hwan and Kwon, Jeongho and Moon, Jong-Seok and Kim, Kyubo and Miyawaki, Atsushi and Lee, Min Goo and Shin, Jaekyoon and Kim, Young Sam and Kim, Chang-Hoon and Ryter, Stefan W and Choi, Augustine M. K and Rhee, Sue Goo and Ryu, Ji-Hwan and Yoon, Joo-Heon
Autophagy, ISSN 1554-8627, 08/2016, Volume 12, Issue 8, pp. 1272 - 1291
Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which mitophagy... 
mitochondrial priming | mitophagy | autophagy | NLRP3 inflammasome | sepsis | SESN2 | REGULATE AUTOPHAGY | RETICULOCYTE MATURATION | PHOSPHORYLATION | INFLAMMASOME ACTIVATION | AUTOPHAGIC DEGRADATION | P62/SQSTM1 | MITOCHONDRIAL QUALITY-CONTROL | CELL BIOLOGY | PINK1/PARKIN-MEDIATED MITOPHAGY | SESTRIN2 | PROMOTES | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Humans | Caspase 1 - metabolism | Male | Monocytes - metabolism | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | Shock, Septic - metabolism | Interleukin-1beta - blood | Interleukin-18 - blood | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Inflammation | Mitochondria - metabolism | Mitochondrial Degradation | Macrophages - metabolism | Animals | Leukocytes, Mononuclear - cytology | Mice | Enzyme Activation | Lysine - chemistry | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism
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8. Full Text Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2
by Pham, Truc P.T and Kwon, Jeongho and Shin, Jaekyoon
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2011, Volume 413, Issue 2, pp. 376 - 382
► Berberine inhibits adipogenesis by down-regulating C/EBPα and PPARγ. ► Berberine up-regulates two different C/EBP inhibitors, CHOP and DEC2. ► CHOP was... 
Berberine | C/EBP inhibitors | Unfolded protein response | Adipogenesis | ACTIVATED PROTEIN-KINASE | MECHANISM | 3T3-L1 ADIPOCYTE DIFFERENTIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | SUPPRESSION | BIOPHYSICS | CHOP/GADD153 | GENE-TRANSCRIPTION | Berberine - pharmacology | Up-Regulation | Animals | Adipocytes - metabolism | Adipogenesis - drug effects | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | Male | Transcription Factors - biosynthesis | Mice | Adipocytes - drug effects | Transcription Factor CHOP - biosynthesis | 3T3-L1 Cells | Dexamethasone | Dimethyl sulfoxide
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9. Full Text Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe
by Bui, Chi-Bao and Shin, Jaekyoon
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2011, Volume 412, Issue 2, pp. 347 - 352
► Upon prolonged mitosis, cells undergo p53-dependent mitotic catastrophe. ► p62-deficient cells were resistant to mitotic catastrophe. ► p53 stabilization was... 
Mitotic catastrophe | Aneuploidy | Noq1 | Nrf2 | p62 | p53 | P62 | P53 | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | AUTOPHAGY | ANTIOXIDANT RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | DISRUPTION | BIOPHYSICS | GENE | DEGRADATION | POSTMITOTIC CHECKPOINT | SPINDLE-ASSEMBLY CHECKPOINT | Mitosis | Sequestosome-1 Protein | Tubulin Modulators - pharmacology | HCT116 Cells | Humans | Nocodazole - pharmacology | Tumor Suppressor Protein p53 - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | NAD(P)H Dehydrogenase (Quinone) - biosynthesis | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Kelch-Like ECH-Associated Protein 1 | Tumor proteins
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10. Full Text West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus
by Yang, Mi-Ran and Lee, Sung Ryul and Oh, Wonkyung and Lee, Eun-Woo and Yeh, Jung-Yong and Nah, Jin-Ju and Joo, Yi-Seok and Shin, Jaekyoon and Lee, Han-Woong and Pyo, Suhkneung and Song, Jaewhan
Cellular Microbiology, ISSN 1462-5814, 01/2008, Volume 10, Issue 1, pp. 165 - 176
Summary The capsid protein of the West Nile virus (WNV) functions as an apoptotic agonist via the induction of mitochondrial dysfunction and the activation of... 
P19(ARF) | PATHWAY | CYTOPLASMIC LOCALIZATION | STABILITY | MDM2 | DEGRADATION | MICROBIOLOGY | INFECTION | EXPRESSION | ASSOCIATION | TUMOR-SUPPRESSOR P53 | CELL BIOLOGY | Fibroblasts - virology | Cell Line | West Nile virus - physiology | Capsid Proteins - metabolism | Humans | Cell Nucleolus - chemistry | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cercopithecus aethiops | bcl-2-Associated X Protein - biosynthesis | Animals | Protein Binding | Mice | Proto-Oncogene Proteins c-mdm2 - metabolism | Apoptosis | West Nile fever | Tumor proteins
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11. Full Text SOCS-6 negatively regulates T cell activation through targeting p56 lck to proteasomal degradation
by Choi, Young Bong and Son, Myoungsun and Park, Mijin and Shin, Jaekyoon and Yun, Gdae
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 10, pp. 7271 - 7280
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12. Full Text The Transcriptional Corepressor, PELP1, Recruits HDAC2 and Masks Histones Using Two Separate Domains
by Young Bong Choi and Jin Kyoung Ko and Jaekyoon Shin
Journal of Biological Chemistry, ISSN 0021-9258, 12/2004, Volume 279, Issue 49, pp. 50930 - 50941
PELP1 (proline-, glutamic acid-, and leucine-rich protein 1) has been recognized as a coactivator of estrogen receptor (ER)-recruiting p300/CREB-binding... 
ACTIVATION | RETINOBLASTOMA PROTEIN | INTERACTING PROTEIN | CHROMATIN-STRUCTURE | REPRESSION | ACETYLATION | DEACETYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | STEROID-RECEPTOR COACTIVATOR-1 | ESTROGEN-RECEPTOR | Chromatin - metabolism | NIH 3T3 Cells | Receptors, Estrogen - metabolism | Cell Proliferation | Histones - chemistry | Humans | Immunoblotting | Cell Nucleus - metabolism | Transfection | Chromatin Immunoprecipitation | Time Factors | Gene Deletion | Transcription, Genetic | Genes, Reporter | Repressor Proteins - metabolism | Fibroblasts - metabolism | RNA - metabolism | Protein Structure, Tertiary | Cell Line | Promoter Regions, Genetic | Enzyme Inhibitors - pharmacology | Proto-Oncogene Proteins c-fos - metabolism | Glutathione Transferase - metabolism | Nucleosomes - metabolism | Histone Deacetylase 2 | Histone Deacetylases - metabolism | Plasmids - metabolism | Mice, Inbred C3H | Animals | Cell Line, Tumor | Protein Binding | Trans-Activators - metabolism | Mice | Models, Genetic | Transcription Factors | HeLa Cells | Histones - metabolism | Co-Repressor Proteins | COS Cells | DNA, Complementary - metabolism
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13. Full Text SOCS-6 Negatively Regulates T Cell Activation through Targeting p56lck to Proteasomal Degradation
by Young Bong Choi and Myoungsun Son and Mijin Park and Jaekyoon Shin and Yungdae Yun
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 10, pp. 7271 - 7280
The T cell-specific tyrosine kinase, p56 lck , plays crucial roles in T cell receptor (TCR)-mediated T cell activation. Here, we report that SOCS-6 ( s... 
Interleukin-2 - metabolism | Promoter Regions, Genetic | T-Lymphocytes - physiology | Receptors, Antigen, T-Cell - metabolism | Jurkat Cells | Lymphocyte Activation | Humans | Suppressor of Cytokine Signaling Proteins - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Immunological Synapses - metabolism | Interleukin-2 - genetics | Two-Hybrid System Techniques | Animals | T-Lymphocytes - cytology | Protein Binding | Mice | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Proteasome Endopeptidase Complex - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | Binding Sites | Receptors | Immunology | Signal Transduction | Cellular Response | T Cell Receptor | Protein | Tyrosine Kinase | Processing | Protein-Protein Interactions
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14. Full Text Induction of endoplasmic reticulum stress under endotoxin tolerance increases inflammatory responses and decreases Pseudomonas aeruginosa pneumonia
by Kim, Sena and Joe, Yeonsoo and Park, Se‐Ung and Jeong, Sun Oh and Kim, Jin‐Kyung and Park, Seong Hoon and Pae, Hyun‐Ock and Surh, Young‐Joon and Shin, Jaekyoon and Chung, Hun Taeg
Journal of Leukocyte Biology, ISSN 0741-5400, 11/2018, Volume 104, Issue 5, pp. 1003 - 1012
Endotoxin tolerance develops in the late phase of sepsis to protect cells from an early hyperinflammatory response. Nonetheless, because it induces an... 
ER stress | GSK‐3β | endotoxin tolerance | CLP | TUDCA | GSK-3β | CLEARANCE | LUNG | ACTIVATION | INFECTIONS | MACROPHAGES | GSK-3 | MECHANISMS | SEPSIS | IMMUNOLOGY | CELL BIOLOGY | IMMUNOSUPPRESSION | HEMATOLOGY | EXPRESSION | INNATE IMMUNITY
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15. Full Text p62 Negatively Regulates TLR4 Signaling via Functional Regulation of the TRAF6-ECSIT Complex
by Mi-Jeong Kim and Yoon Min and Jeongho Kwon and Juhee Son and Ji Seon Im and Jaekyoon Shin and Ki-Young Lee
Immune Network, ISSN 1598-2629, 2019, Volume 19, Issue 3, pp. 19 - 32
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16. Full Text Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation
by Hiruma, Yuko and Honjo, Tadashi and Jelinek, Diane F and Windle, Jolene J and Shin, Jaekyoon and Roodman, G. David and Kurihara, Noriyoshi
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 20, pp. 4894 - 4902
Adhesive interactions between multiple myeloma ( MM) cells and marrow stromal cells activate multiple signaling pathways including nuclear factor kappa B... 
PROGENITOR CELLS | ADHESION | IN-VITRO | BONE MICROENVIRONMENT | RECEPTOR ACTIVATOR | DRUG-RESISTANCE | PAGETS-DISEASE | STROMAL CELLS | HEMATOLOGY | HUMAN MULTIPLE-MYELOMA | KAPPA-B LIGAND | Cell Proliferation | Sequestosome-1 Protein | Stromal Cells - pathology | Humans | Middle Aged | Male | Bone Marrow - physiology | Heat-Shock Proteins - genetics | Bone Marrow - metabolism | Up-Regulation - physiology | Aged, 80 and over | Female | Osteoclasts - physiology | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Stromal Cells - metabolism | Cells, Cultured | Mice, Transgenic | Up-Regulation - genetics | Signal Transduction - genetics | Multiple Myeloma - metabolism | Osteoclasts - metabolism | Adaptor Proteins, Signal Transducing - physiology | Multiple Myeloma - pathology | Animals | Bone Marrow - pathology | Adaptor Proteins, Signal Transducing - genetics | Environment | Signal Transduction - physiology | Aged | Mice | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - physiology | Multiple Myeloma - genetics | Stromal Cells - cytology | Lymphoid Neoplasia
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17. Full Text p62 forms a ternary complex with PKCζ and PAR-4 and antagonizes PAR-4-induced PKCζ inhibition
by Chang, Suhwan and Kim, Jung Hoe and Shin, Jaekyoon
FEBS Letters, ISSN 0014-5793, 2002, Volume 510, Issue 1, pp. 57 - 61
It has been reported that prostate apoptosis response‐4 (PAR‐4) binds to and inhibits protein kinase Cζ (PKCζ) which phosphorylates IκB kinase β (IKKβ) for... 
Protein kinase Cζ | Prostate apoptosis response-4 | Ternary complex | p62 | Nuclear factor κB | Apoptosis | NFκB, nuclear factor κB | TNF, tumor necrosis factor | PKC, protein kinase C | TRAF, tumor necrosis factor receptor associated factor | PAR-4, prostate apoptosis response-4 | RIP, receptor interacting protein | IKKβ, IκB kinase β
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