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Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2008, Volume 104, Issue 4, pp. 1116 - 1131
Electrophilic compounds are a newly recognized class of redox‐active neuroprotective compounds with electron deficient, electrophilic carbon centers that react... 
neurite outgrowth‐promoting prostaglandin 11 | Keap1 | alkylation | cysteine thiol | Nrf2 | carnosic acid | S-alkylation | Cysteine thiol | Carnosic acid | Neurite outgrowth-promoting prostaglandin 11 | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CEREBRAL-ISCHEMIA | NEUROSCIENCES | TERT-BUTYLHYDROQUINONE | NERVE GROWTH-FACTOR | CELL-DEATH | GLUTAMATE TOXICITY | CORTICAL-NEURONS | CYCLOPENTENONE PROSTAGLANDINS | neurite outgrowth-promoting prostaglandin 11 | TRANSCRIPTION FACTOR | METHYL-D-ASPARTATE | Plant Extracts - chemistry | Plant Extracts - pharmacology | Cercopithecus aethiops | Catechols - chemistry | Male | PC12 Cells | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Cattle | Catechols - pharmacology | Cysteine - metabolism | Neurons - metabolism | Neurons - drug effects | Kelch-Like ECH-Associated Protein 1 | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Cells, Cultured | Diterpenes, Abietane - chemistry | Intracellular Signaling Peptides and Proteins | Rats | Rats, Sprague-Dawley | Diterpenes, Abietane - pharmacology | Animals | Proteins - metabolism | Signal Transduction - drug effects | Rosmarinus | NF-E2-Related Factor 2 - metabolism | Alkylation - drug effects | Signal Transduction - physiology | Mice | COS Cells | Neurons | Cysteine | Herbs | Neurosciences | Biochemistry | Oxidation | Chemical compounds | Index Medicus
Journal Article
Annals of Nutrition and Metabolism, ISSN 0250-6807, 10/2008, Volume 53, Issue 1, pp. 58 - 58
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2011, Volume 26, Issue 11, pp. 2682 - 2694
The aging process correlates with the accumulation of cellular and tissue damage caused by oxidative stress. Although previous studies have suggested that... 
Low‐turnover osteoporosis | Bone fragility | Copper/zinc superoxide dismutase (CuZn‐SOD OR | Senescent collagen cross‐links | Reactive oxygen species (ROS) | SOD1 | Senescent collagen cross-links | Low-turnover osteoporosis | Copper/zinc superoxide dismutase (CuZn-SOD OR SOD1) | OSTEOBLAST | ANTIOXIDANTS | INCREASES | ACCELERATION | SKELETAL-MUSCLE | MINERAL DENSITY | REACTIVE OXYGEN SPECIES (ROS) | BONE FRAGILITY | DISMUTASE | ENDOCRINOLOGY & METABOLISM | COPPER/ZINC SUPEROXIDE DISMUTASE (CuZn-SOD OR SOD1) | ELEVATED OXIDATIVE STRESS | MICE | LOW-TURNOVER OSTEOPOROSIS | SENESCENT COLLAGEN CROSS-LINKS | EXPRESSION | Bone and Bones - pathology | RANK Ligand - metabolism | Cell Count | Aging - drug effects | Cytoplasm - metabolism | Bone and Bones - drug effects | Osteoporosis - metabolism | Bone and Bones - metabolism | Oxidation-Reduction - drug effects | Superoxides - metabolism | Osteoporosis - physiopathology | Superoxide Dismutase - metabolism | Cell Survival - drug effects | Bone Resorption - physiopathology | Osteoclasts - pathology | Osteoblasts - drug effects | Osteogenesis - drug effects | Ascorbic Acid - administration & dosage | Superoxide Dismutase - deficiency | Bone Resorption - complications | Macrophage Colony-Stimulating Factor - metabolism | Aging - pathology | Cross-Linking Reagents - metabolism | Collagen - metabolism | Osteoblasts - pathology | Bone and Bones - physiopathology | Organ Size - drug effects | Phenotype | Animals | Osteoporosis - pathology | Signal Transduction - drug effects | Osteoporosis - complications | Ascorbic Acid - pharmacology | Bone Resorption - pathology | Mice | Cytoplasm - drug effects | Osteoclasts - drug effects | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 15585 - 10
The oxygen consumption rate (OCR) and cytochrome c oxidase (CcO) activity of respiratory complex IV (CIV) in brain mitochondria significantly decline in... 
CHAIN | CYTOCHROME-C-OXIDASE | BC COMPLEX | SUPERCOMPLEXES | MULTIDISCIPLINARY SCIENCES | NEURODEGENERATION | ALPHA-SYNUCLEIN | FISSION | COENZYME-Q | PARKINSONS-DISEASE | Cytochrome | Mitochondria | Actin | Cytochrome-c oxidase | Polymerization | Oxygen consumption | Mitochondrial DNA | Monomers | Cytochalasin B
Journal Article
Japanese Journal of Geriatrics, ISSN 0300-9173, 03/2012, Volume 49, Issue 1, pp. 36 - 39
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2008, Volume 107, Issue 6, pp. 1730 - 1740
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta.... 
neurotoxicity | p38 mitogen‐activated protein kinase | Parkinson’s disease | 6‐hydroxydopamine | reactive oxygen species | astaxanthin | 6-hydroxydopamine | Neurotoxicity | Reactive oxygen species | Parkinson's disease | p38 mitogen-activated protein kinase | Astaxanthin | KAPPA-B ACTIVATION | SIGNALING PATHWAYS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | GREEN TEA POLYPHENOLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | NEUROSCIENCES | NERVE GROWTH-FACTOR | DISTINCT MECHANISMS | DOPAMINE INDUCES APOPTOSIS | PARKINSONS-DISEASE | Enzyme-Linked Immunosorbent Assay - methods | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Cytochromes c - metabolism | Humans | Caspase 3 - metabolism | Enzyme Activation - drug effects | Membrane Potential, Mitochondrial - drug effects | Adrenergic Agents - pharmacology | Dose-Response Relationship, Drug | Annexin A5 - metabolism | Neuroprotective Agents - pharmacology | Oxidopamine - pharmacology | Cell Line, Tumor | Xanthophylls - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | DNA Fragmentation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neuroblastoma - pathology | Antioxidants | Analysis | Membrane potentials | Neuroblastoma | Universities and colleges | Protein kinases | Apoptosis | Neurology | Biochemistry | Parkinsons disease | Index Medicus
Journal Article
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, ISSN 0300-9173, 2012, Volume 49, Issue 1, pp. 36 - 39
Journal Article
Scientific Reports, ISSN 2045-2322, 06/2015, Volume 5, Issue 1, pp. 11722 - 11722
Mechanical stress and aging are major risk factors of cartilage degeneration. Human studies have previously reported that oxidative damage increased, while... 
VITAMIN-C | SKIN ATROPHY | APOPTOSIS | INTRAARTICULAR HYALURONIC-ACID | ARTICULAR-CARTILAGE | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | MICE | KNEE OSTEOARTHRITIS | ASCORBIC-ACID | PROGRESSION | Superoxide Dismutase - genetics | Gene Expression - drug effects | Humans | Stress, Mechanical | Mitochondria - ultrastructure | Chondrocytes - drug effects | Cartilage Diseases - genetics | Cartilage, Articular - metabolism | Superoxides - metabolism | Paraquat - pharmacology | Chondrocytes - metabolism | Superoxide Dismutase - metabolism | Ascorbic Acid - analogs & derivatives | Mice, Inbred C57BL | Cells, Cultured | Ascorbic Acid - administration & dosage | Mice, Transgenic | Herbicides - pharmacology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Microscopy, Electron | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Cartilage, Articular - pathology | Animals | Cartilage Diseases - prevention & control | Chondrocytes - ultrastructure | Antioxidants - administration & dosage | Ascorbic Acid - pharmacology | Injections, Intra-Articular | Weight-Bearing | Cartilage, Articular - drug effects | Cartilage Diseases - metabolism | Cartilage | Mitochondria | Mechanical loading | Chondrocytes | Superoxide dismutase | Degeneration | Oxidation | Superoxide | Osteoarthritis | Risk factors | Cartilage diseases | Index Medicus
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2015, Volume 5, Issue 1, pp. 9148 - 9148
Journal Article