X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (14) 14
humans (10) 10
ligands (10) 10
animals (9) 9
binding sites (7) 7
chemistry, medicinal (7) 7
cho cells (7) 7
cricetulus (7) 7
receptors, dopamine d2 - metabolism (7) 7
functional selectivity (6) 6
isoquinolines - chemistry (5) 5
isoquinolines - pharmacology (5) 5
protein binding (5) 5
protein conformation (5) 5
structure-activity relationship (5) 5
antagonist (4) 4
article (4) 4
biochemistry & molecular biology (4) 4
g protein-coupled receptor (4) 4
indoles - chemistry (4) 4
indoles - pharmacology (4) 4
muscarinic acetylcholine-receptor (4) 4
pharmacology (4) 4
protein-coupled receptors (4) 4
receptors, g-protein-coupled - metabolism (4) 4
allosteric regulation (3) 3
discovery (3) 3
drug discovery (3) 3
force-field (3) 3
hydrogen bonding (3) 3
models, molecular (3) 3
molecular docking simulation (3) 3
pharmacology & pharmacy (3) 3
receptors, dopamine d2 - chemistry (3) 3
receptors, g-protein-coupled - chemistry (3) 3
agonist (2) 2
allosteric modulation (2) 2
beta adrenergic-receptor (2) 2
bias (2) 2
biased agonism (2) 2
binding-site (2) 2
bitopic ligands (2) 2
bivalent ligands (2) 2
chemistry, organic (2) 2
chemistry, pharmaceutical - methods (2) 2
congener (2) 2
crystal structure (2) 2
crystallography, x-ray (2) 2
crystals (2) 2
d3 receptor (2) 2
design (2) 2
dopamine (2) 2
dopamine agents - pharmacology (2) 2
dopamine d2 receptor antagonists - chemistry (2) 2
dopamine d2 receptor antagonists - pharmacology (2) 2
dopamine d2 receptors (2) 2
dopamine receptor (2) 2
dopamine-d-2 receptor (2) 2
drug design (2) 2
g protein-coupled receptors (2) 2
isoquinolines - chemical synthesis (2) 2
kinetics (2) 2
kw 6002 (2) 2
ligand (2) 2
mitogen-activated protein kinase 1 - metabolism (2) 2
mitogen-activated protein kinase 3 - metabolism (2) 2
molecular dynamics simulations (2) 2
molecular structure (2) 2
multidisciplinary sciences (2) 2
mutagenesis (2) 2
mutation (2) 2
parkinson's disease (2) 2
parkinsons-disease (2) 2
protein structure, tertiary (2) 2
protein-coupled receptor (2) 2
radioligand assay (2) 2
rats (2) 2
receptors, dopamine d2 - agonists (2) 2
receptors, dopamine d2 - drug effects (2) 2
signal transduction (2) 2
stereoisomerism (2) 2
structure (2) 2
zm 241385 (2) 2
1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives (1) 1
2nd (1) 1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (1) 1
7-transmembrane receptors (1) 1
a adenosine receptor (1) 1
activation (1) 1
adenosine a (1) 1
adenosine a antagonist (1) 1
adenosine a receptor (1) 1
adenosine a receptors (1) 1
adenosine a2 receptor antagonists - chemical synthesis (1) 1
adenosine a2 receptor antagonists - chemistry (1) 1
adenosine a2 receptor antagonists - metabolism (1) 1
adenosine a2a antagonist (1) 1
agent-development (1) 1
allosteric properties (1) 1
allosteric regulation - drug effects (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Chemistry – A European Journal, ISSN 0947-6539, 02/2018, Volume 24, Issue 8, pp. 1922 - 1930
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 12
Sodium ions (Na+) allosterically modulate the binding of orthosteric agonists and antagonists to many class A G protein-coupled receptors, including the... 
Allosteric properties | G protein-coupled receptors | Dopamine | Sodium | Indole | Computer applications | Tetrahydroisoquinoline | Antagonists | Drug development | Dopamine D2 receptors | Binding sites
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2017, Volume 60, Issue 11, pp. 4693 - 4713
By means of a formal structural hybridization of the antipsychotic drug aripiprazole and the heterocyclic catecholamine surrogates present in the... 
BETA-ADRENOCEPTOR AGONIST | QT PROLONGATION | DOPAMINE-D-2 RECEPTOR | CHEMISTRY, MEDICINAL | DOPA-INDUCED DYSKINESIA | RECEPTOR PARTIAL AGONISTS | FUNCTIONAL SELECTIVITY | G-PROTEIN | BINDING | DISCOVERY | PARKINSONS-DISEASE
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3427 - 3433
Growing evidence has suggested a role in targeting the adenosine A receptor for the treatment of Parkinson’s disease. The literature compounds KW 6002 ( ) and... 
ZM 241385 | Congener | KW 6002 | Parkinson’s disease | Adenosine A2A antagonist | Parkinson's disease | antagonist | Adenosine A
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2018, Volume 148, pp. 315 - 328
SB269652 is a negative allosteric modulator of the dopamine D receptor (D R) yet possesses structural similarity to ligands with a competitive mode of... 
G protein-coupled receptor | Bitopic ligands | Molecular dynamics simulations | Mutagenesis | Allosteric modulation | Dopamine receptor | Index Medicus | molecular dynamics simulations | bitopic ligands | mutagenesis | dopamine receptor | allosteric modulation
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 11/2014, Volume 34, Issue 6, pp. 1286 - 1330
Journal Article