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Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2018, Volume 61, Issue 15, pp. 6647 - 6657
IDH1 plays a critical role in a number of metabolic processes and serves as a key source of cytosolic NADPH under conditions of cellular stress. However, few... 
CHEMISTRY, MEDICINAL | MECHANISM | HISTIDINE | MUTANT IDH1 | GROWTH | CARBOXYLATION | MUTATIONS | REVEAL
Journal Article
Journal of medicinal chemistry, 02/2019
We previously described the discovery of GSK5852 (1), a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV), in which a N-benzyl boronic acid... 
Journal Article
Organic Letters, ISSN 1523-7060, 06/2005, Volume 7, Issue 12, pp. 2405 - 2408
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 12/2008, Volume 73, Issue 23, pp. 9511 - 9514
A synthetic route to bisanilino-1H-pyrrolo[2,3-d]pyrimidines has been discovered, wherein the C(6)-chloride reactivity is necessarily enhanced via reversible... 
CHEMISTRY, ORGANIC | POTENT | INHIBITOR | KINASE | Chemistry, Organic - methods | Models, Chemical | Drug Design | Amides - chemistry | Pyrroles - chemistry | Catalysis | Chlorides - chemistry | Carbon - chemistry | Pyrimidines - chemistry | Pyrimidines | Dichloropropane | Aniline | Chlorides | Ring-opening polymerization | Chemical properties | Research | Structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19681 - 19696
2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-L constitute a major effector arm of interferon (IFN)-mediated antiviral defense. OAS produces a unique... 
APOPTOSIS | INTERFERON | L PATHWAY | PROTEIN | REPLICATION | RNASE-L | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | MITOCHONDRIA | 2-5A SYSTEM | BINDING | Interferon-alpha - pharmacology | Small Molecule Libraries - pharmacology | Endoribonucleases - genetics | Exoribonucleases - genetics | Encephalomyocarditis virus - genetics | Humans | Exoribonucleases - chemistry | Crystallography, X-Ray | Encephalomyocarditis virus - metabolism | Structure-Activity Relationship | Oligoribonucleotides - metabolism | Escherichia coli - metabolism | Respiratory Syncytial Viruses - metabolism | Antiviral Agents - pharmacology | Poly I-C - pharmacology | Adenine Nucleotides - immunology | Signal Transduction | Exoribonucleases - immunology | Gene Expression Regulation | Exoribonucleases - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - chemistry | Small Molecule Libraries - chemical synthesis | Recombinant Proteins - genetics | Gene Knockout Techniques | Immunity, Innate | 2',5'-Oligoadenylate Synthetase - genetics | 2',5'-Oligoadenylate Synthetase - immunology | Recombinant Proteins - immunology | Adenine Nucleotides - metabolism | Escherichia coli - genetics | Respiratory Syncytial Viruses - genetics | Antiviral Agents - chemical synthesis | Rhinovirus - metabolism | HeLa Cells | Oligoribonucleotides - immunology | Rhinovirus - genetics | Endoribonucleases - immunology | protein structure | Molecular Bases of Disease | gene knockout | antiviral agent | innate immunity | interferon
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2019, Volume 62, Issue 7, pp. 3254 - 3267
We previously described the discovery of GSK5852 (1), a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV), in which an N-benzyl boronic... 
IN-VITRO | CHEMISTRY, MEDICINAL | BORTEZOMIB | HEPATITIS-C VIRUS | DISCOVERY | POLYMERASE INHIBITOR
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2009, Volume 8, Issue 10, pp. 2811 - 2820
Journal Article
Organic Letters, ISSN 1523-7060, 10/2008, Volume 10, Issue 19, pp. 4343 - 4346
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 07/2007, Volume 7, Issue 14, pp. 1423 - 1423
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2014, Volume 57, Issue 5, pp. 1902 - 1913
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2013, Volume 57, Issue 11, pp. 5216 - 5224
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2015, Volume 56, Issue 44, pp. 6077 - 6079
We have discovered a 3-bromo-7-phenoxypyrazolo[1,5-a]pyrimidine intermediate that allows for the direct sequential funtionalization of the 3-position and... 
Pyrazolo[1,5-a]pyrimidine | SNAr | Heterocycle | Phenoxide | Suzuki | CHEMISTRY, ORGANIC
Journal Article
Organic Letters, ISSN 1523-7060, 10/2004, Volume 6, Issue 21, pp. 3865 - 3868
An efficient synthesis of the C(11)−C(29) fragment 31 of amphidinolide F has been accomplished via a diastereoselective [3 + 2]-annulation reaction of... 
TETRAHYDROFURAN SYNTHESIS | SI-H | SILICON | CHEMISTRY, ORGANIC | ALDOL REACTIONS | PROTIODESILYLATION REACTIONS | ABSOLUTE STEREOCHEMISTRY | ALDEHYDES | BIOACTIVE MACROLIDES | CHIRAL METHYL KETONES | BETA-HYDROXYSILANES | Heterocyclic Compounds - chemistry | Macrolides | Heterocyclic Compounds - chemical synthesis
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2012, Volume 3, Issue 7, pp. 565 - 569
A series of imidazo­[1,2-a]­pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro... 
hepatitis C virus | replicon | imidazo[1,2-a]pyridines | NS4B | CHEMISTRY, MEDICINAL | VIRUS | HCV
Journal Article
ChemInform, ISSN 0931-7597, 10/2005, Volume 36, Issue 42, pp. no - no
For see ChemInform in Full Text. 
protonation | furan derivatives | protection, deprotection
Journal Article
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