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1. Full Text Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
by Dastani, Zari and Hivert, Marie-France and Timpson, Nicholas and Perry, John R. B and Yuan, Xin and Scott, Robert A and Henneman, Peter and Heid, Iris M and Kizer, Jorge R and Lyytikäinen, Leo-Pekka and Fuchsberger, Christian and Tanaka, Toshiko and Morris, Anew P and Small, Kerrin and Isaacs, Aaron and Beekman, Marian and Coassin, Stefan and Lohman, Kurt and Qi, Lu and Kanoni, Stavroula and Pankow, James S and Uh, Hae-Won and Wu, Ying and Bidulescu, Aurelian and Rasmussen-Torvik, Laura J and Greenwood, Celia M. T and Ladouceur, Martin and Grimsby, Jonna and Manning, Alisa K and Liu, Ching-Ti and Kooner, Jaspal and Mooser, Vincent E and Vollenweider, Peter and Kapur, Karen A and Chambers, John and Wareham, Nicholas J and Langenberg, Claudia and Frants, Rune and Willems-Vandijk, Ko and Oostra, Ben A and Willems, Sara M and Lamina, Claudia and Winkler, Thomas W and Psaty, Bruce M and Tracy, Russell P and Brody, Jennifer and Chen, Ida and Viikari, Jorma and Kähönen, Mika and Pramstaller, Peter P and Evans, David M and St Pourcain, Beate and Sattar, Naveed and Wood, Anew R and Bandinelli, Stefania and Carlson, Olga D and Egan, Josephine M and Böhringer, Stefan and van Heemst, Diana and Kedenko, Lyudmyla and Kristiansson, Kati and Nuotio, Marja-Liisa and Loo, Britt-Marie and Harris, Tamara and Garcia, Melissa and Kanaya, Alka and Haun, Margot and Klopp, Norman and Wichmann, H.-Erich and Deloukas, Panos and Katsareli, Efi and Couper, David J and Duncan, Bruce B and Kloppenburg, Margreet and Adair, Linda S and Borja, Judith B and Wilson, James G and Musani, Solomon and Guo, Xiuqing and Johnson, Toby and Semple, Robert and Teslovich, Tanya M and Allison, Matthew A and Redline, Susan and Buxbaum, Sarah G and Mohlke, Karen L and Meulenbelt, Ingrid and Ballantyne, Christie M and Dedoussis, George V and Hu, Frank B and Liu, Yongmei and Paulweber, Bernhard and Spector, Timothy D and Slagboom, P. Eline and Ferrucci, Luigi and Jula, Antti and Perola, Markus and Raitakari, Olli and Florez, Jose C and Salomaa, Veikko and ... and GLGC Investigators and DIAGRAM Consortium and MAGIC Consortium and MuTHER Consortium and Global B Pgen Consortium and MAGIC investigators and Procardis Consortium and DIAGRAM+ Consortium and GLGC Consortium and GIANT Consortium
PLoS genetics, ISSN 1553-7390, 2012, Volume 8, Issue 3, pp. e1002607 - e1002607
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes... 
POPULATION | GENETIC-BASIS | VARIANTS | INSULIN-RESISTANCE | LIPID CONCENTRATIONS | GENETICS & HEREDITY | RISK | RECEPTOR | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Glucose Tolerance Test | Diabetes Mellitus, Type 2 - genetics | Humans | African Americans | European Continental Ancestry Group | Male | Cholesterol, HDL - genetics | Adiponectin - blood | Asian Continental Ancestry Group | Metabolic Networks and Pathways | Adiponectin - genetics | Insulin Resistance - genetics | Female | Polymorphism, Single Nucleotide | Waist-Hip Ratio | Type 2 diabetes | Physiological aspects | Development and progression | Genetic aspects | Research | Metabolism | Health aspects | Blood proteins | Meta-analysis | Medical research | Cardiovascular disease | Drug therapy | Insulin | Metabolic disorders | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
by Dupuis, Josée and Langenberg, Claudia and Prokopenko, Inga and Saxena, Richa and Soranzo, Nicole and Jackson, Anne and Wheeler, Eleanor and Glazer, Nicole and Bouatia-Naji, Nabila and Gloyn, Anna and Lindgren, Cecilia and Mägi, Reedik and Morris, Anew and Randall, Joshua and Johnson, Toby and Elliott, Paul and Rybin, Denis and Thorleifsson, Gudmar and Steinthorsdottir, Valgerdur and Henneman, Peter and Grallert, Harald and Dehghan, Abbas and JanHottenga, Jouke and Franklin, Christopher and Navarro, Pau and Song, Kijoung and Goel, Anuj and Perry, John and Egan, Josephine and Lajunen, Taina and Grarup, Niels and Sparsø, Thomas and Doney, Alex and Voight, Benjamin and Stringham, Heather and Li, Man and Kanoni, Stavroula and Shrader, Peter and Cavalcanti-Proença, Christine and Kumari, Meena and Qi, Lu and Timpson, Nicholas and Gieger, Christian and Zabena, Carina and Rocheleau, Ghislain and Ingelsson, Erik and An, Ping and O´Connell, J.R and Luan, J and McCarroll, Steven and Payne, Felicity and Roccasecca, R.M and Pattou, François and Sethupathy, Praveen and Ardlie, Kristin and Ariyurek, Yavuz and Balkau, Beverley and Barter, Phil and Beilby, John and Ben-Shlomo, Y and Benediktsson, Rafn and Bennett, Amanda and Bergmann, Sven and Bochud, Murielle and Boerwinkle, Eric and Bonnefond, Amélie and Bonnycastle, Lori and Borch-Johnsen, K and Böttcher, Yvonne and Brunner, Eric and Bumpstead, Suzannah and Charpentier, Guillaume and IdaChen, Yii and Chines, Peter and Clarke, R and McOin, Lachlan and Cooper, Matthew and Cornelis, Marilyn and Crawford, Gabe and Crisponi, Laura and Day, Ian and Geus, Eco and Delplanque, Jerome and Dina, Christian and Erdos, Michael and Fedson, Annette and Fischer-Rosinsky, Antje and Forouhi, Nita and Fox, Caroline and Frants, Rune and GraziaFranzosi, Maria and Galan, Pilar and Goodarzi, Mark and Graessler, Jürgen and Groves, Christopher and Grundy, Scott and Gwilliam, Rhian and Gyllensten, Ulf and Hadjadj, Samy and Hallmans, Göran and ... and DIAGRAM Consortium and Global BPgen Consortium and Anders Hamsten Procardis Consortiu and GIANT Consortium and MAGIC Investigators and Anders Hamsten on behalf of Procardis Consortium and MAGIC investigators and the MAGIC investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Näringsforskning and Umeå universitet and Medicin
Nature Genetics, ISSN 1061-4036, 02/2010, Volume 42, Issue 2, pp. 105 - 116
textabstractLevels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide... 
CIRCADIAN CLOCK | DISEASE RISK | TRIGLYCERIDE LEVELS | INSULIN-RESISTANCE | GENETICS & HEREDITY | BETA-CELL DYSFUNCTION | PLASMA-GLUCOSE | MODEL ASSESSMENT | FOLLOW-UP | GENOME-WIDE ASSOCIATION | ESSENTIAL COMPONENTS | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Reproducibility of Results | Quantitative Trait, Heritable | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Expression Regulation | Genetic Loci - genetics | Databases, Genetic | DNA Copy Number Variations - genetics | Fasting - blood | Adolescent | Alleles | Polymorphism, Single Nucleotide - genetics | Adult | Blood Glucose - genetics | Blood Glucose - metabolism | Child | Homeostasis - genetics | Quantitative Trait Loci - genetics | Type 2 diabetes | Homeostasis | Physiological aspects | Genetic aspects | Research | Insulin | Health aspects | Risk factors | Studies | Hyperglycemia | Diabetes | Sample size | Meta-analysis | Index Medicus | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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3. Full Text A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
by Palmer, N.D and McDonough, C.W and Hicks, P.J and Roh, B.H and Wing, M.R and Sandy An, S and Hester, J.M and Cooke, J.N and Bostrom, M.A and Rudock, M.E and Talbert, M.E and Lewis, J.P and Hottenga, J.J and Geus, de, E.J.C and Willemsen, G and Boomsma, D.I and Ferrara, A and Lu, L and Ziegler, J.T and Sale, M.M and Divers, J and Shriner, D and Adeyemo, A and Rotimi, C.N and Ng, M.C.Y and Langefeld, C.D and Freedman, B.I and Bowden, D.W and Posthuma, D and Penninx, B.W.J.H and Sladek, R and DIAGRAM Consortium and MAGIC Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Näringsforskning and Umeå universitet and Medicin
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 1, pp. e29202 - e29202
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this... 
FASTING GLUCOSE | COMMON VARIANTS | TCF7L2 GENE | LARGE-SCALE ASSOCIATION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | LINKAGE ANALYSIS | STAGE RENAL-DISEASE | TISSUE FACTOR | HOMEODOMAIN PROTEIN | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | African Americans - genetics | Genotype | Male | Case-Control Studies | Diabetes Mellitus, Type 2 - ethnology | Validation Studies as Topic | Adult | Female | Aged | Polymorphism, Single Nucleotide | Cohort Studies | Type 2 diabetes | Chronic kidney failure | Analysis | Genes | Genomics | African Americans | Genetic aspects | Genomes | Haplotypes | End-stage renal disease | Physicians | Science | Biochemistry | Single-nucleotide polymorphism | Epidemiology | Population genetics | Consortia | Precision medicine | Atherosclerosis | Genetics | Diabetes mellitus (non-insulin dependent) | Lupus | Diabetes mellitus | Gene expression | Minority & ethnic groups | Disease control | Loci | Nephropathy | Genotyping | Insulin resistance | Replication | Diabetes | Kidney diseases | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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4. Full Text Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
by Strawbridge, Rona J and Dupuis, Josée and Prokopenko, Inga and Barker, Adam and Ahlqvist, Emma and Rybin, Denis and Petrie, John R and Travers, Mary E and Bouatia-Naji, Nabila and Dimas, Antigone S and Nica, Alexana and Wheeler, Eleanor and Chen, Han and Voight, Benjamin F and Taneera, Jalal and Kanoni, Stavroula and Peden, John F and Turrini, Fabiola and Gustafsson, Stefan and Zabena, Carina and Almgren, Peter and Barker, David J. P and Barnes, Daniel and Dennison, Elaine M and Eriksson, Johan G and Eriksson, Per and Eury, Elodie and Folkersen, Lasse and Fox, Caroline S and Frayling, Timothy M and Goel, Anuj and Gu, Harvest F and Horikoshi, Momoko and Isomaa, Bo and Jackson, Anne U and Jameson, Karen A and Kajantie, Eero and Kerr-Conte, Julie and Kuulasmaa, Teemu and Kuusisto, Johanna and Loos, Ruth J. F and Luan, Jian'an and Makrilakis, Konstantinos and Manning, Alisa K and Martínez-Larrad, María Teresa and Narisu, Narisu and Nastase Mannila, Maria and Ohrvik, John and Osmond, Clive and Pascoe, Laura and Payne, Felicity and Sayer, Avan A and Sennblad, Bengt and Silveira, Angela and Stancáková, Alena and Stirrups, Kathy and Swift, Amy J and Syvänen, Ann-Christine and Tuomi, Tiinamaija and van 't Hooft, Ferdinand M and Walker, Mark and Weedon, Michael N and Xie, Weijia and Zethelius, Björn and Ongen, Halit and Mälarstig, Anders and Hopewell, Jemma C and Saleheen, Danish and Chambers, John and Parish, Sarah and Danesh, John and Kooner, Jaspal and Ostenson, Claes-Göran and Lind, Lars and Cooper, Cyrus C and Serrano-Ríos, Manuel and Ferrannini, Ele and Forsen, Tom J and Clarke, Robert and Franzosi, Maria Grazia and Seedorf, Udo and Watkins, Hugh and Froguel, Philippe and Johnson, Paul and Deloukas, Panos and Collins, Francis S and Laakso, Markku and Dermitzakis, Emmanouil T and Boehnke, Michael and McCarthy, Mark I and Wareham, Nicholas J and Groop, Leif and Pattou, François and Gloyn, Anna L and Dedoussis, George V and Lyssenko, Valeriya and Meigs, James B and Barroso, Inês and Watanabe, Richard M and Ingelsson, Erik and ... and C4D Consortium and DIAGRAM Consortium and GIANT Consortium and CARDIoGRAM Consortium and MuTHER Consortium and the MuTHER Consortium and the CARDIoGRAM Consortium and the C4D Consortium and the DIAGRAM Consortium and the GIANT Consortium and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Diabetes, ISSN 0012-1797, 2011, Volume 60, Issue 10, pp. 2624 - 2634
Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose... 
POPULATION | TCF7L2 | GLUCOSE-HOMEOSTASIS | OBESITY | METAANALYSIS | ENDOCRINOLOGY & METABOLISM | SUSCEPTIBILITY LOCI | RISK | CORONARY HEART-DISEASE | INSULIN SENSITIVITY | BETA-CELL FUNCTION | Proinsulin - blood | Diabetes Mellitus, Type 2 - genetics | Humans | Genotype | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Genetic Variation | Diabetes Mellitus, Type 2 - blood | Fasting - blood | Polymorphism, Single Nucleotide - genetics | Adult | Female | Genome, Human | Type 2 diabetes | Genetic susceptibility | Genetic variation | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus | Genetics | Medical and Health Sciences | Medicin och hälsovetenskap
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5. Full Text Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
by Voight, Benjamin and Scott, Laura and Steinthorsdottir, Valgerdur and Morris, Anew and Dina, Christian and Welch, Ryan and Zeggini, Eleftheria and Huth, Cornelia and Aulchenko, Yurii and Thorleifsson, Gudmar and McCulloch, Laura and Ferreira, Teresa and Grallert, Harald and Amin, Najaf and Wu, Guanming and Willer, Cristen and Raychaudhuri, Soumya and McCarroll, Steven and Langenberg, Claudia and Hofmann, Oliver and Dupuis, Josée and Qi, Lu and Segrè, Ayellet and Hoek, Mandy and Navarro, Pau and Ardlie, Kristin and Balkau, Beverley and Benediktsson, Rafn and Bennett, Amanda and Blagieva, Roza and Boerwinkle, Eric and Bonnycastle, Lori and Boström, Kristina Bengtsson and Bravenboer, Bert and Bumpstead, Suzannah and Burtt, Noël and Charpentier, Guillaume and Chines, Peter and Cornelis, Marilyn and Couper, David and Crawford, Gabe and Doney, Alex and Elliott, Katherine and Erdos, Michael and Fox, Caroline and Franklin, Christopher and Ganser, Martha and Gieger, Christian and Grarup, Niels and Green, Todd and Griffin, Simon and Groves, Christopher and Guiducci, Candace and Hadjadj, Samy and Hassanali, Neelam and Herder, Christian and Isomaa, Bo and Jackson, Anne and Johnson, Paul and Jørgensen, Torben and Kao, Wen and Klopp, Norman and Kong, Augustine and Kraft, Peter and Kuusisto, Johanna and Lauritzen, Torsten and Li, Man and Lieverse, Aloysius and Lindgren, Cecilia and Lyssenko, Valeriya and Marre, Michel and Meitinger, Thomas and Midthjell, Kristian and Morken, Mario and Narisu, Narisu and Nilsson, Peter and Owen, Katharine and Payne, Felicity and Perry, John and Petersen, A.K and Platou, Carl and Proença, Christine and Prokopenko, Inga and Rathmann, Wolfgang and Rayner, Nigel William and Robertson, Neil and Rocheleau, Ghislain and Roden, Michael and Sampson, Michael and Saxena, Richa and Shields, Beverley and Shrader, Peter and Sigurdsson, Gunnar and Sparsø, Thomas and Strassburger, Klaus and Stringham, Heather and Sun, Qi and Swift, Amy and Thorand, Barbara and Tichet, Jean and ... and GIANT Consortium and MAGIC Investigators and MAGIC investigators and The GIANT Consortium and The MAGIC investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Nature Genetics, ISSN 1061-4036, 07/2010, Volume 42, Issue 7, pp. 579 - 589
textabstractBy combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following... 
C-REACTIVE PROTEIN | COMMON VARIANTS | FASTING PLASMA-GLUCOSE | CROHNS-DISEASE | INSULIN-RESISTANCE | HNF1-ALPHA GENE | GENETICS & HEREDITY | GENE-EXPRESSION | COMPLEX DISEASES | QT INTERVAL DURATION | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Meta-Analysis as Topic | KCNQ1 Potassium Channel - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Dosage | Gene Expression Profiling | Mitogen-Activated Protein Kinase Phosphatases - genetics | Genetic Heterogeneity | Genome, Human - genetics | Diabetes Mellitus, Type 2 - blood | Fasting - blood | Dual-Specificity Phosphatases - genetics | Polymorphism, Single Nucleotide | Blood Glucose - metabolism | Type 2 diabetes | Genetic aspects | Research | Genetic susceptibility | Risk factors | Medical research | Diabetes | Meta-analysis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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