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New England Journal of Medicine, ISSN 0028-4793, 12/2014, Volume 371, Issue 23, pp. 2237 - 2238
Journal Article
Cell metabolism, ISSN 1550-4131, 1/2018, Volume 27, Issue 1, pp. 22 - 41
NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic diacylglycerol activates PKC-ε, impairing insulin receptor activation and... 
Journal Article
Science, ISSN 0036-8075, 03/2015, Volume 347, Issue 6227, pp. 1253 - 1256
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1263 - 1269
Type 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE-PHOSPHORYLATION | METFORMIN | ACTIVATED PROTEIN-KINASE | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | INDUCED INSULIN-RESISTANCE | CELL BIOLOGY | SKELETAL-MUSCLE | HYPERGLYCEMIA | OBESE GENE | IN-VIVO | NIH 3T3 Cells | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Uncoupling Agents - pharmacology | Fatty Liver - pathology | Humans | Fatty Liver - complications | Hyperglycemia - complications | Male | Hyperglycemia - drug therapy | Mitochondria - ultrastructure | Uncoupling Agents - therapeutic use | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Niclosamide - administration & dosage | Fasting - blood | Niclosamide - chemistry | Niclosamide - pharmacology | Diet, High-Fat | Cell Respiration - drug effects | Hyperglycemia - pathology | Diabetes Mellitus, Experimental - complications | Disease Models, Animal | Mammals - metabolism | Liver - ultrastructure | Administration, Oral | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Mitochondria - metabolism | Mitochondria - drug effects | Uncoupling Agents - administration & dosage | Uncoupling Agents - chemistry | Fatty Liver - drug therapy | Hep G2 Cells | Animals | Hyperglycemia - blood | Diabetes Mellitus, Experimental - pathology | Mice | Glucose Clamp Technique | Blood Glucose - metabolism | Energy Metabolism - drug effects | Niclosamide - therapeutic use | Type 2 diabetes | Mitochondria | Research | Analysis | Hyperglycemia | Transgenic animals | Rodents | Lipids | Diabetes | Metabolism | Index Medicus
Journal Article
2010, Essays in Biochemistry, Volume 47, 16
Although it is well established that physical activity increases mitochondrial content in muscle, the molecular mechanisms underlying this process have only... 
ACTIVATED PROTEIN-KINASE | ENZYME-ACTIVITY | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | TYPE-2 DIABETIC PARENTS | PGC-1-ALPHA TRANSCRIPTION | OXIDATIVE-METABOLISM | HUMAN SKELETAL-MUSCLE | CALORIE RESTRICTION
Book Chapter
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 225
We examined whether starvation alters rates of hepatic mitochondrial oxidation in humans by applying a novel 13C Positional Isotopomer NMR Tracer Analysis... 
Alanine | Mitochondria | Starvation | Fasting | Nuclear magnetic resonance--NMR | Intravenous administration | Liver | Pyruvic acid | Oxidation | Glucose | Lactic acid | Pyruvate carboxylase
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 179 - 185
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2/2014, Volume 59, Issue 2, pp. 713 - 723
Non alcoholic fatty liver disease (NAFLD), hepatic insulin resistance and type 2 diabetes are all strongly associated and are all reaching epidemic... 
NAFLD | Hepatic | Insulin Resistance | PKCε | DAG | endocanabinoid | Lipid | ceramides
Journal Article
Journal Article
Science, ISSN 0036-8075, 3/2011, Volume 331, Issue 6024, pp. 1621 - 1624
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7506, pp. 542 - 546
Journal Article