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Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 62, Issue 4, pp. 1701 - 1714
Two decades have passed since the rule of five ushered in the concept of "drug-like" properties. Attempts to quantify, correlate, and categorize molecules... 
DESIGN | CHEMISTRY, MEDICINAL | IN-VIVO | SIZE | CANDIDATES | ATTRITION | DESCRIPTORS | TRENDS | DISCOVERY | LIGAND EFFICIENCY METRICS | MOLECULAR-PROPERTIES
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1701 - 1714
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2013, Volume 23, Issue 21, pp. 5980 - 5991
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2013, Volume 23, Issue 21, pp. 5992 - 6000
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2014, Volume 5, Issue 1, pp. 2 - 5
To increase the probability of success in drug discovery, the concept of drug-like properties was introduced. Efficiency metrics that normalize potency against... 
efficiency metrics | drug-likeness | Ligand efficiency (LE) | fragment-based drug design | lipophilic efficiency (LipE) | decision making | OPTIMIZATIONS | CHEMISTRY, MEDICINAL | EFFICIENCY
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | BASIC BIOLOGICAL SCIENCES
Journal Article
by Ghinda, Diana and Chen, Suzan and Bedaiwy, Mahmoud and Jabri, Hussam and Alshardan, Mohammad and Taccone, Michael S and Lai, Carolyn and Rabski, Jessica and Tsai, Eve and Dedek, Annemarie and Xu, Jian and Tsai, Eve and Lombroso, Paul and Hildebrand, Mike and Mothe, Andrea and Tator, Charles H and Siladi, Andrew and Nally, Jaqueline and Stirling, David and Keller, Anastasia and Buckley, Christian and Shum-Siu, Alice and Magnuson, David and Rosenbaum, Benjamin P and Kelly, Michael L and Ahuja, Christopher and Ahuja, Christopher and Nori, Satoshi and Khazaei, Mohamad and Ahlfors, Jan-Eric and Liu, Yang and Wang, Jian and Fuehrmann, Tobias and Pakulska, Malgosia and Hettiaratchi, Marian H and Poon, Peter and Shoichet, Molly S and Fehlings, Michael G and Fehlings, Michael G and Fehlings, Michael G and Hazrati, Lili-Naz and Cherian, Leela and Nilewski, Lizanne and Tour, James M and Kent, Thomas A and Robertson, Claudia S and Wilde, Elisabeth and Newsome, Mary and Scheibel, Randall and Troyanskaya, Maya and Velez, Carmen and Wade, Benjamin and Drennon, Ann Marie and York, Gerald and Bigler, Erin and Abildskov, Tracy and Taylor, Brian and Jaramillo, Carlos and Eapen, Blessen and Belanger, Heather and Morey, Rajendra and Haswell, Courtney and Levin, Harvey and Hinds, Sidney and Walker, William and Walker, William and Kochunov, Peter and Jahanshad, Neda and Thompson, Paul and Tate, David and Statz, Jonathan and Goodrich, Jessica and Goforth, Cdr Carl and Tschiffely, Anna E and Arena, John D and Smith, Douglas H and Wolf, John A and Johnson, Victoria E and Rhodes, James and Friess, Stuart and Lee, Taylor and Lycke, Roy J and Jang, Ikbeom and Vike, Nicole L and Nauman, Eric A and Talavage, Thomas M and Rispoli, Joseph V and Alonso-Escalante, Jose and Fulton, William and Sodhi, Chhinder and Hackam, David J and Nasr, Isam W and Hubbard, W B and Joseph, Binoy and Spry, Malinda L and Vekaria, Hemendra J and Saatman, Kathryn and Sullivan, Patrick G and Sullivan, Patrick G and Vascak, Michal and ...
Journal of Neurotrauma, ISSN 0897-7151, 08/2018, Volume 35, Issue 16, pp. A-1 - A-285
[...]the vast majority of basic science pain research ends at target identification and validation in rodent models of chronic pain without confirmation in... 
Abstracts | Neurosciences | Keywords | Traumatic brain injury | Cytokines | Central nervous system | Inflammation | Gene expression | Trauma | Studies | Brain research | Hospitals | Pain | Rodents | Stem cells | DNA methylation | Biomarkers | Spinal cord injuries | Growth factors | Research centers | Proteins
Journal Article
Nanomedicine, ISSN 1743-5889, 11/2013, Volume 8, Issue 11, pp. 1853 - 1864
Metallofullerenes have incited research endeavors across many disciplines owing to their wide range of properties obtainable by altering the metal component... 
Journal Article
The Journal of Physical Chemistry C, ISSN 1932-7447, 02/2011, Volume 115, Issue 6, pp. 2656 - 2664
This paper discusses the relationship between synthesis conditions, crystal morphology, and theoretical modeling of copper and nickel nanoparticles prepared by... 
C: Nanops and Nanostructures | COPPER NANOPARTICLES | MATERIALS SCIENCE, MULTIDISCIPLINARY | SIZE | METAL PARTICLES | HYDROLYSIS | CHEMISTRY, PHYSICAL | ELECTROCHEMICAL REDUCTION | NANOSCIENCE & NANOTECHNOLOGY | NICKEL NANOPARTICLES | ETHYLENE-GLYCOL | GROWTH | MAGNETIC-PROPERTIES | COBALT
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2007, Volume 129, Issue 9, pp. 2482 - 2487
Journal Article
1988, Handbooks in economics, ISBN 9780444703392, Volume bk. 9., 5 v.
Book
Journal of Sedimentary Research, ISSN 1527-1404, 10/2017, Volume 87, Issue 10, pp. 1075 - 1099
The three-dimensional reconstruction of meander-belt deposits from ancient strata provides insight into the formative processes of meander-bend evolution and... 
RAY-TRACING TECHNIQUES | CONCAVE-BANK BENCHES | CHANNEL MIGRATION | ATHABASCA OIL SANDS | GEOLOGY | POINT BARS | BRITISH-COLUMBIA | STEEPBANK RIVER AREA | FLUVIAL-ESTUARINE DEPOSITS | LARGE-AMPLITUDE MEANDERS | INCLINED HETEROLITHIC STRATIFICATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7773 - 7782
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. LB-023 - LB-023
Journal Article
Cancer Research, ISSN 0008-5472, 05/2016, Volume 76, Issue 10, pp. 2977 - 2989
Journal Article
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