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1. Full Text DNA Ligases: Progress and Prospects
by Stewart Shuman
Journal of Biological Chemistry, ISSN 0021-9258, 06/2009, Volume 284, Issue 26, pp. 17365 - 17369
DNA ligases seal 5′-PO 4 and 3′-OH polynucleotide ends via three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA... 
MYCOBACTERIUM-TUBERCULOSIS | REPAIR | ADENYLATE | RNA LIGASE-1 | MECHANISM | SPECIFICITY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGATION | NICKED DNA | IDENTIFICATION | DNA Ligases - genetics | Humans | DNA Ligases - chemistry | DNA Ligases - metabolism | Enzymes | polynucleotides | DNA | Substrate specificity | genomics | Nucleotides | Phylogeny | nucleic acids | Crystal structure | Minireview
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2. Full Text Jerard Hurwitz (1928–2019)
by Shuman, Stewart and Marians, Kenneth
Molecular Cell, ISSN 1097-2765, 03/2019, Volume 73, Issue 6, pp. 1085 - 1086
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3. Full Text RNA capping: Progress and prospects
by Shuman, Stewart
RNA, ISSN 1355-8382, 04/2015, Volume 21, Issue 4, pp. 735 - 737
The 5' m super(7)GpppN cap, co-discovered by Shatkin, Furuichi, and Moss in 1975, is the signature feature of eukaryal cellular and viral messenger RNA that... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | RNA Caps | RNA, Messenger - genetics | Personal Reflections
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4. Characterization of Runella slithyformis HD-Pnk, a Bifunctional DNA/RNA End-Healing Enzyme Composed of an N-Terminal 2',3'-Phosphoesterase HD Domain and a C-Terminal 5'-OH Polynucleotide Kinase Domain
by Annum Munir and Stewart Shuman
Journal of Bacteriology, ISSN 0021-9193, 02/2017, Volume 199, Issue 3, p. E00739
  5'- and 3'-end-healing reactions are key steps in nucleic acid break repair in which 5'-OH ends are phosphorylated by a polynucleotide kinase (Pnk) and... 
Enzymes | Phosphorylation | Polypeptides | RNA-protein interactions | Gram-negative bacteria | Kinases | Adenosine triphosphatase
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5. Full Text Crystal structure and biochemical characterization of a Mycobacterium smegmatis AAA-Type nucleoside triphosphatase phosphohydrolase (Msm0858)
by Unciuleac, Mihaela-Carmen and Smith, Paul C and Shumana, Stewart and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of Bacteriology, ISSN 0021-9193, 05/2016, Volume 198, Issue 10, pp. 1521 - 1533
AAA proteins (ATPases associated with various cellular activities) use the energy of ATP hydrolysis to drive conformational changes in diverse macromolecular... 
Catalytic Domain | Mycobacterium smegmatis - chemistry | Protein Structure, Secondary | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | Crystallography, X-Ray | Nucleoside-Triphosphatase - genetics | Nuclear Proteins - chemistry | DNA Mutational Analysis | Adenosine Triphosphate - metabolism | Protein Structure, Quaternary | Adenosine Triphosphatases - chemistry | Mutation | Mycobacterium smegmatis - enzymology | Nucleoside-Triphosphatase - chemistry | Mycobacterium | Bacterial proteins | Mycobacteria | Crystals | Physiological aspects | Research | Structure
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6. Full Text Kinetic mechanism and fidelity of nick sealing byEscherichia coliNAD+-dependent DNA ligase (LigA)
by Chauleau, Mathieu and Shuman, Stewart
Nucleic Acids Research, ISSN 0305-1048, 03/2016, Volume 44, Issue 5, pp. 2298 - 2309
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7. Kinetic mechanism and fidelity of nick sealing by Escherichia coli NAD super(+)-dependent DNA ligase (LigA)
by Chauleau, Mathieu and Shuman, Stewart
Nucleic Acids Research, ISSN 0305-1048, 03/2016, Volume 44, Issue 5, pp. 2298 - 2309
Escherichia coli DNA ligase (EcoLigA) repairs 3'-OH/5'-PO sub(4) nicks in duplex DNA via reaction of LigA with NAD super(+) to form a covalent LigA-(lysyl-N... 
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8. Deinococcus radiodurans HD-Pnk, a Nucleic Acid End-Healing Enzyme, Abets Resistance to Killing by Ionizing Radiation and Mitomycin C
by Brad J Schmier and Stewart Shuman
Journal of Bacteriology, ISSN 0021-9193, 09/2018, Volume 200, Issue 17
5′- and 3′-end healing are key steps in nucleic acid break repair in which 5′-OH and 3′-PO4 or 2′,3′-cyclic-PO4 ends are converted to 5′-PO4 and 3′-OH termini... 
Transition metals | Polynucleotide kinase | Poly(ADP-ribose) | Phosphoesterase | Genomes | Kinases | Phosphatase | ADP | Cobalt | p-Nitrophenylphosphate | Proteins | Pulsed-field gel electrophoresis | Ionizing radiation | Ribonucleotide reductase | Histidine | Ribose | Acid resistance | Electrophoresis | Mitomycin C | Magnesium | Copper | Deoxyribonucleic acid--DNA | Phosphodiesterase | Killing | Enzymes | Wound healing | Mitomycin | Gel electrophoresis | Maintenance | Ablation | Heavy metals | Domains | Acids | Poly(ADP-ribose) glycohydrolase | Healing | Mutation
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9. Full Text Sex Differences in the Prevalence of Post-Stroke Depression: A Systematic Review
by Poynter, Brittany, M.D and Shuman Hon, Mira, B.Sc and Diaz-Granados, Natalia, M.Sc and Kapral, Moira, M.D., FRCPC and Grace, Sherry L., Ph.D and Stewart, Donna E., M.D., FRCPC
Psychosomatics, ISSN 0033-3182, 2011, Volume 50, Issue 6, pp. 563 - 569
Background Depression after stroke occurs in 33% of individuals. It is grossly underdiagnosed and untreated. Objective The authors studied sex differences in... 
Internal Medicine | Psychiatry | ACUTE-PHASE | MOOD DISORDERS | PSYCHIATRY | POST STROKE DEPRESSION | FOLLOW-UP | 1ST YEAR | CARDIAC REHABILITATION | SYMPTOMS | QUALITY-OF-LIFE | ISCHEMIC-STROKE | GENERALIZED ANXIETY | PSYCHOLOGY | Prevalence | Stroke - psychology | Comorbidity | Humans | Depressive Disorder - diagnosis | Sex Distribution | Female | Male | Stroke - epidemiology | Depressive Disorder - epidemiology | Depressive Disorder - psychology
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10. Full Text Structure-Function Analysis of the Phosphoesterase Component of the Nucleic Acid End-Healing Enzyme Runella slithyformis HD-Pnk
by Munir, A and Shuman, S
JOURNAL OF BACTERIOLOGY, ISSN 0021-9193, 08/2019, Volume 201, Issue 16
Runella slithyforrnis HD-Pnk is the prototype of a family of dual 5' and 3' nucleic acid end-healing enzymes that phosphorylate 5'-OH termini and dephos-... 
HD domain | DOMAIN | COMPLEX | polynucleotide kinase | MECHANISM | CRYSTAL-STRUCTURE | MICROBIOLOGY | nucleic acid repair | TRANSFER-RNA LIGASE | 3 ' phosphatase | DEFINES | PHOSPHODIESTERASE | REVEALS | Polynucleotide kinase | Phosphohydrolase | Metals | Modules | Phosphoesterase | Amino acids | Homology | Kinases | Substrates | p-Nitrophenylphosphate | Mutagenesis | Healing | Coordination compounds | Deoxyribonucleic acid--DNA | Function analysis | Structure-function relationships
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11. Full Text Bacterial DNA repair by non-homologous end joining
by Shuman, Stewart and Glickman, Michael S
Nature Reviews Microbiology, ISSN 1740-1526, 11/2007, Volume 5, Issue 11, pp. 852 - 861
The capacity to rectify DNA double-strand breaks (DSBs) is crucial for the survival of all species. DSBs can be repaired either by homologous recombination... 
MYCOBACTERIUM-TUBERCULOSIS | SUBSTRATE-SPECIFICITY | STRAND BREAK REPAIR | LIGASE-D | PROTEIN | BACILLUS-SUBTILIS | CRYSTAL-STRUCTURE | PSEUDOMONAS-AERUGINOSA | MICROBIOLOGY | POLYMERASE COMPONENT | NICKED DNA | Bacterial Physiological Phenomena | Recombination, Genetic - physiology | DNA, Bacterial - metabolism | DNA Breaks, Double-Stranded | DNA Repair - physiology | Physiological aspects | Research | Ligases | DNA repair | DNA damage
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12. Biochemical Characterization of Mycobacterium smegmatis RnhC (MSMEG_4305), a Bifunctional Enzyme Composed of Autonomous N-Terminal Type I RNase H and C-Terminal Acid Phosphatase Domains
by Agata Jacewicz and Stewart Shuman
Journal of Bacteriology, ISSN 0021-9193, 08/2015, Volume 197, Issue 15, p. 2489
  Mycobacterium smegmatis encodes several DNA repair polymerases that are adept at incorporating ribonucleotides, which raises questions about how... 
Enzymes | Bacteria | Biochemistry | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Bacteriology
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13. Full Text A phosphate-binding histidine of binuclear metallophosphodiesterase enzymes is a determinant of 2′,3′-cyclic nucleotide phosphodiesterase activity
by Keppetipola, Niroshika and Shuman, Stewart
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 45, pp. 30942 - 30949
Binuclear metallophosphoesterases are an enzyme superfamily defined by a shared fold and a conserved active site. Although many family members have been... 
2',3'-Cyclic-Nucleotide Phosphodiesterases - genetics | Escherichia coli - enzymology | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Histidine - genetics | Mutation, Missense | Substrate Specificity - genetics | Protein Folding | Hydrolysis | Cyclic AMP - chemistry | Metalloproteins - chemistry | Escherichia coli - genetics | Mycobacterium tuberculosis - enzymology | Metalloproteins - genetics | 2',3'-Cyclic-Nucleotide Phosphodiesterases - chemistry | Cyclic AMP - genetics | Histidine - chemistry | Amino Acid Substitution | Mycobacterium tuberculosis - genetics | Enzyme Catalysis and Regulation
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14. Full Text Obsessive-Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling
by Andrighetti, Heather and Semaka, Alicia and Stewart, S Evelyn and Shuman, Cheryl and Hayeems, Robin and Austin, Jehannine
Journal of Genetic Counseling, ISSN 1059-7700, 10/2016, Volume 25, Issue 5, pp. 912 - 922
Obsessive-compulsive disorder (OCD) has primarily pediatric onset and well-documented unique impacts on family functioning. Limited research has assessed the... 
Human Genetics | Psychiatric genetic counseling | Ethics | Public Health | Biomedicine | Gynecology | Parents | Clinical Psychology | Obsessive-compulsive disorder | Qualitative | Pediatric | Adaptation | Obsessive‐compulsive disorder | RELATIVES | SCHIZOPHRENIA | BIPOLAR DISORDER | ATTITUDES | CHILDREN | ADOLESCENTS | GENETICS & HEREDITY | FAMILY ACCOMMODATION | QUALITY-OF-LIFE | MENTAL-ILLNESS | HEALTH | Obsessive-Compulsive Disorder - psychology | Family Relations | Parents - psychology | Humans | Middle Aged | Adult | Female | Male | British Columbia | Disease Management | Genetic Counseling | Parenting | Children's hospitals | Development and progression | Psychiatric services | Child psychopathology | Mentally ill | Domestic relations | Genetic counseling | Analysis | Medical genetics | Strategic planning (Business) | Genetic research | Family | Obsessive compulsive disorder | Mental disorders | Causal attributions | Population genetics | Aetiology | Genetic family histories | Parents & parenting | Grounded theory | Etiology | Counselling services | Blame | Obsessive-Compulsive neuroses | Children | Genetic counselling | Mental illness | Qualitative research | Family functioning | Management development programmes | Vignettes | Stigmatization | Counselling | Sick children | Guilt | Meaning | adaptation | qualitative | obsessive-compulsive disorder | psychiatric genetic counseling | pediatric | parents
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15. RNA polymerase II CTD interactome with 3′ processing and termination factors in fission yeast and its impact on phosphate homeostasis
by Ana M Sanchez and Stewart Shuman and Beate Schwer
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 45, p. E10652
The carboxy-terminal domain (CTD) code encrypted within the Y1S2P3T4S5P6S7 heptad repeats of RNA polymerase II (Pol2) is deeply rooted in eukaryal biology. Key... 
Phosphates | Yeast | Transcription | Homeostasis | RNA polymerase | Gene expression | Termination factors | DNA-directed RNA polymerase | Fission | PHO1 gene | Polymerase | Ribonucleic acids | Derepression | Polyadenylation | Mutation | Viability | RNA polymerase II
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16. Distinct Contributions of Enzymic Functional Groups to the 2',3'-Cyclic Phosphodiesterase, 3'-Phosphate Guanylylation, and 3'-ppG/5'-OH Ligation Steps of the Escherichia coli RtcB Nucleic Acid Splicing Pathway
by William P Maughan and Stewart Shuman
Journal of Bacteriology, ISSN 0021-9193, 04/2016, Volume 198, Issue 8, p. 1294
  Escherichia coli RtcB is a founding member of a family of manganese-dependent RNA repair enzymes that join RNA 2',3'-cyclic phosphate (RNA>p) or RNA... 
Phosphates | Enzymes | E coli | Mutagenesis | Ribonucleic acid--RNA | Crystal structure
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17. Full Text Deciphering the RNA Polymerase II CTD Code in Fission Yeast
by Schwer, Beate and Shuman, Stewart
Molecular Cell, ISSN 1097-2765, 07/2011, Volume 43, Issue 2, pp. 311 - 318
The RNA polymerase II carboxy-terminal domain (CTD) consists of tandem Y S P T S P S repeats. Dynamic remodeling of the CTD, especially its... 
RECOGNITION | PHOSPHORYLATION | IICTD | BIOCHEMISTRY & MOLECULAR BIOLOGY | LENGTH | CARBOXYL-TERMINAL DOMAIN | CAPPING ENZYME | POMBE | CELL BIOLOGY | Protein Structure, Tertiary | Schizosaccharomyces - genetics | Amino Acid Sequence | Schizosaccharomyces - metabolism | Phosphorylation | Molecular Sequence Data | Serine - genetics | RNA Polymerase II - genetics | Schizosaccharomyces - enzymology | RNA Polymerase II - metabolism | Binding Sites | RNA Polymerase II - chemistry | Enzymes | Messenger RNA | mRNA capping enzymes | carboxyl-terminal domain | sexual differentiation | serine phosphorylation | CTD receptors
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18. Full Text Structure–function relations in the NTPase domain of the antiviral tRNA ribotoxin Escherichia coli PrrC
by Meineke, Birthe and Shuman, Stewart
Virology, ISSN 0042-6822, 2012, Volume 427, Issue 2, pp. 144 - 150
Abstract Breakage of tRNA by Escherichia coli anticodon nuclease PrrC ( Eco PrrC) underlies a host antiviral response to phage T4 infection. Expression of Eco... 
Infectious Disease | Anticodon nuclease | Antiviral defense | Structure-guided mutagenesis | Amino Acid Sequence | Promoter Regions, Genetic | Ribonucleases - genetics | Ribonucleases - chemistry | Models, Molecular | Molecular Sequence Data | Escherichia coli Proteins - metabolism | Nucleoside-Triphosphatase - genetics | Saccharomyces cerevisiae - drug effects | Protein Structure, Tertiary - genetics | Structure-Activity Relationship | Ribonucleases - metabolism | Escherichia coli - virology | Nucleoside-Triphosphatase - metabolism | Plasmids | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Protein Conformation | Mutation | Escherichia coli Proteins - chemistry | Gene Expression Regulation, Bacterial | Nucleoside-Triphosphatase - chemistry | Protein Structure, Tertiary - physiology | Antiviral agents | RNA | Analysis | Escherichia coli | Transfer RNA | Anticodons | Gene dosage | tRNA | Toxicity | Phages | Conservation | Amino acid sequence | Data processing | Boundaries | Phylogeny | Infection | Nuclease | ABC transporter | Index Medicus | BACTERIOPHAGES | MUTAGENESIS | ESCHERICHIA COLI | YEASTS | HAEMOPHILUS | TOXICITY | PROTEINS | 60 APPLIED LIFE SCIENCES | antiviral defense | structure-guided mutagenesis | anticodon nuclease
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19. Characterization of 3'-Phosphate RNA Ligase Paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus Highlights DNA and RNA 5'-Phosphate Capping Activity of RtcB3
by William P Maughan and Stewart Shuman
Journal of Bacteriology, ISSN 0021-9193, 11/2015, Volume 197, Issue 22, p. 3616
  Escherichia coli RtcB exemplifies a family of GTP-dependent RNA repair/splicing enzymes that join 3'-PO... ends to 5'-OH ends via stable... 
Phosphates | Enzymes | E coli | Gram-negative bacteria | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA
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20. Full Text Mycobacterium smegmatisLhr Is a DNA-dependent ATPase and a 3′-to-5′ DNA Translocase and Helicase That Prefers to Unwind 3′-Tailed RNA:DNA Hybrids
by Ordonez, Heather and Shuman, Stewart
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 20, pp. 14125 - 14134
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