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1. Full Text AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
by Li, Yu and Xu, Shanqin and Mihaylova, Maria M and Zheng, Bin and Hou, Xiuyun and Jiang, Bingbing and Park, Ogyi and Luo, Zhijun and Lefai, Etienne and Shyy, John Y.-J and Gao, Bin and Wierzbicki, Michel and Verbeuren, Tony J and Shaw, Reuben J and Cohen, Richard A and Zang, Mengwei
Cell metabolism, ISSN 1550-4131, 04/2011, Volume 13, Issue 4, pp. 376 - 388
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptors, LDL - genetics | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Atherosclerosis - drug therapy | Benzopyrans - therapeutic use | Metformin - therapeutic use | Humans | Insulin Resistance | Sterol Regulatory Element Binding Protein 2 - antagonists & inhibitors | Receptors, LDL - metabolism | Male | Fatty Liver - drug therapy | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Dietary Fats - pharmacology | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Transcription, Genetic | Mice | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Lipogenesis | Sterol Regulatory Element Binding Protein 1 - metabolism | Disease Models, Animal | Type 2 diabetes | Liver diseases | Low density lipoproteins | Alcoholism | Oncology, Experimental | Research | Glucose | Gene expression | Dextrose | Atherosclerosis | Polyphenols | Insulin resistance | Binding proteins | Cancer | Protein binding | Medical colleges | Insulin | Cells | Index Medicus | Life Sciences
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2. Full Text AMP-activated protein kinase phosphorylation of angiotensin-converting enzyme 2 in endothelium mitigates pulmonary hypertension
by Zhang, Jiao and Dong, Jianjie and Martin, Marcy and He, Ming and Gongol, Brendan and Marin, Traci L and Chen, Lili and Shi, Xinxing and Yin, Yanjun and Shang, Fenqing and Wu, Yan and Huang, Hsi-Yuan and Zhang, Jin and Zhang, Yu and Kang, Jian and Moya, Esteban A and Huang, Hsien-Da and Powell, Frank L and Chen, Zhen and Thistlethwaite, Patricia A and Yuan, Zu-Yi and John, Y.-J
American journal of respiratory and critical care medicine, ISSN 1073-449X, 08/2018, Volume 198, Issue 4, pp. 509 - 520
Vascular endothelium | Angiotensin-converting enzyme 2 | AMP-activated protein kinase | Pulmonary hypertension | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Zebrafish | Kinases | Vascular endothelial growth factor | Nitric oxide | Rodents | Index Medicus | Abridged Index Medicus | vascular endothelium | angiotensin-converting enzyme 2 | Original | pulmonary hypertension
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3. Full Text AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1
by Marin, Traci L and Gongol, Brendan and Zhang, Fan and Martin, Marcy and Johnson, David A and Xiao, Han and Wang, Yinsheng and Subramaniam, Shankar and Chien, Shu and Shyy, John Y.-J
Science signaling, ISSN 1945-0877, 01/2017, Volume 10, Issue 464, p. eaaf7478
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Uncoupling Protein 3 - genetics | Humans | Histone Acetyltransferases - genetics | Chromatin Assembly and Disassembly - genetics | Immunoblotting | Mitochondrial Proteins - genetics | DNA (Cytosine-5-)-Methyltransferase 1 - metabolism | DNA-Binding Proteins - metabolism | Organelle Biogenesis | Tandem Mass Spectrometry | DNA Methylation | DNA (Cytosine-5-)-Methyltransferase 1 - genetics | Mitochondrial Proteins - metabolism | Histone Acetyltransferases - metabolism | Retinoblastoma-Binding Protein 7 - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Promoter Regions, Genetic | Uncoupling Protein 3 - metabolism | Uncoupling Protein 2 - metabolism | Cells, Cultured | Nucleosomes - metabolism | Nucleosomes - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Uncoupling Protein 2 - genetics | Retinoblastoma-Binding Protein 7 - genetics | Protein Binding | Index Medicus
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4. Full Text Mechanosensitive microRNAs—role in endothelial responses to shear stress and redox state
by Marin, Traci and Gongol, Brendan and Chen, Zhen and Woo, Brian and Subramaniam, Shankar and Chien, Shu and Shyy, John Y.-J
Free radical biology & medicine, ISSN 0891-5849, 09/2013, Volume 64, pp. 61 - 68
Oxidative stress | Free radicals | MiR | Shear stress | Inflammation | KLF2 | Endothelium | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Endothelium, Vascular - cytology | Inflammation - pathology | Oxidation-Reduction | Oxidative Stress | Pulsatile Flow | Endothelial Cells - metabolism | Humans | Gene Expression Regulation | Stress, Mechanical | MicroRNAs - metabolism | Mechanotransduction, Cellular | Inflammation - metabolism | Endothelial Cells - cytology | Endothelium, Vascular - metabolism | Kruppel-Like Transcription Factors - metabolism | Inflammation - genetics | MicroRNAs - genetics | Kruppel-Like Transcription Factors - genetics | Endothelin | Algorithms | MicroRNA | Index Medicus | Shear Stress | miR
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5. Full Text miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease
by He, Ming and Chen, Zhen and Martin, Marcy and Zhang, Jin and Sangwung, Panjamaporn and Woo, Brian and Tremoulet, Adriana H and Shimizu, Chisato and Jain, Mukesh K and Burns, Jane C and Shyy, John Y.-J
Circulation research, ISSN 0009-7330, 01/2017, Volume 120, Issue 2, pp. 354 - 365
EndoMT | Kawasaki disease | miR-483 | microRNA | atorvastatin | endothelial dysfunction | CTGF | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Gene Targeting - methods | Atorvastatin Calcium - administration & dosage | Epithelial-Mesenchymal Transition - physiology | Humans | Child, Preschool | Epithelial-Mesenchymal Transition - drug effects | Infant | Male | Connective Tissue Growth Factor - biosynthesis | Dose-Response Relationship, Drug | Human Umbilical Vein Endothelial Cells - physiology | Cattle | Female | Mucocutaneous Lymph Node Syndrome - blood | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Cells - metabolism | MicroRNAs - administration & dosage | Mucocutaneous Lymph Node Syndrome - therapy | Mice, Transgenic | MicroRNAs - biosynthesis | Mucocutaneous Lymph Node Syndrome - genetics | Animals | Connective Tissue Growth Factor - genetics | Mice | MicroRNAs - genetics | Endothelial Cells - drug effects | Index Medicus | Pediatrics | Nitric Oxide | Endothelium | Translational Studies | Fibrosis | Vascular Disease | Vascular Type
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6. Full Text MiR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4
by Chen, Hsin-Yi and Lin, Yu-Min and Chung, Hsiang-Ching and Lang, Yaw-Dong and Lin, Ching-Jung and Huang, John and Wang, Wei-Chi and Lin, Feng-Mao and Chen, Zhen and Huang, Hsien-Da and Shyy, John Y.-J and Liang, Jin-Tung and Chen, Ruey-Hwa
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2012, Volume 72, Issue 14, pp. 3631 - 3641
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Colorectal Neoplasms - mortality | Prognosis | Colorectal Neoplasms - genetics | Down-Regulation | Humans | Gene Expression Regulation, Neoplastic | Male | Apoptosis Regulatory Proteins - metabolism | Neoplasm Metastasis - genetics | Animals | Cell-Matrix Junctions - metabolism | Kruppel-Like Transcription Factors - metabolism | Mice, Nude | Cell Line, Tumor | Mice | MicroRNAs - physiology | Colorectal Neoplasms - pathology | Death-Associated Protein Kinases | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Cell Movement | Index Medicus
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7. Full Text Role of Integrins in Endothelial Mechanosensing of Shear Stress
by Shyy, John Y.-J and Chien, Shu
Circulation research, ISSN 0009-7330, 11/2002, Volume 91, Issue 9, pp. 769 - 775
Rho | Shear stress | Mechanotransduction | Endothelium | Integrins | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Integrins - physiology | Protein-Tyrosine Kinases - metabolism | Humans | Focal Adhesion Protein-Tyrosine Kinases | Stress, Mechanical | rhoA GTP-Binding Protein - metabolism | Cell Membrane - physiology | Mechanotransduction, Cellular - physiology | Focal Adhesion Kinase 1 | Endothelium, Vascular - physiology | Animals | Cytoskeleton - physiology | Extracellular Matrix Proteins - metabolism | Index Medicus | Space life sciences
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8. Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension
by Wang, Xiao-Jian and Lian, Tian-Yu and Jiang, Xin and Liu, Shao-Fei and Li, Su-Qi and Jiang, Rong and Wu, Wen-Hui and Ye, Jue and Cheng, Chun-Yan and Du, Yao and Xu, Xi-Qi and Wu, Yan and Peng, Fu-Hua and Sun, Kai and Mao, Yi-Min and Yu, Huan and Liang, Chen and Shyy, John Y.-J and Zhang, Shu-Yang and Zhang, Xue and Jing, Zhi-Cheng
The European respiratory journal, ISSN 0903-1936, 03/2019, Volume 53, Issue 3
Life Sciences & Biomedicine | Respiratory System | Science & Technology
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9. Full Text Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1
by Yuan, Hongwei and Shyy, John Y.-J and Martins-Green, Manuela
Journal of hepatology, ISSN 0168-8278, 2009, Volume 51, Issue 3, pp. 535 - 547
Gastroenterology and Hepatology | Transcription factors | Sidestream whole smoke | Fatty liver | Kinases | Non-alcoholic fatty liver diseases | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Other diseases. Semiology | Apolipoproteins B - metabolism | Fatty Liver - pathology | Adenylate Kinase - drug effects | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Liver - drug effects | Adenylate Kinase - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Disease Models, Animal | Adiponectin - pharmacology | Fatty Liver - metabolism | Sterol Regulatory Element Binding Protein 1 - drug effects | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Apolipoproteins B - genetics | Triglycerides - metabolism | Animals | Tobacco Smoke Pollution - adverse effects | Signal Transduction - drug effects | Lipogenesis - drug effects | Signal Transduction - physiology | Mice | Phosphates | Synthesis | Liver diseases | Developmental biology | Air pollution | Triglycerides | DNA binding proteins | Fatty acids | Protein kinases | Sugars | Monosaccharides | Smoking | Index Medicus
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10. Full Text Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis
by Chen, Zhen and Lai, Tsung-Ching and Jan, Yi-Hua and Lin, Feng-Mao and Wang, Wei-Chi and Xiao, Han and Wang, Yun-Ting and Sun, Wei and Cui, Xiaopei and Li, Ying-Shiuan and Fang, Tzan and Zhao, Hongwei and Padmanabhan, Chellappan and Sun, Ruobai and Wang, Danny Ling and Jin, Hailing and Chau, Gar-Yang and Huang, Hsien-Da and Hsiao, Michael and Shyy, John Y.-J
The Journal of clinical investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1057 - 1067
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neoplasm Transplantation | Carcinoma, Hepatocellular - mortality | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Transcriptional Activation | Male | MicroRNAs - metabolism | Vascular Endothelial Growth Factor A - metabolism | Liver Neoplasms - mortality | Mammary Neoplasms, Experimental - metabolism |