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article (6) 6
hiv-1 - genetics (6) 6
hiv (5) 5
index medicus (5) 5
rna, viral - genetics (5) 5
biochemistry & molecular biology (4) 4
dimerization (4) 4
genomes (4) 4
immunodeficiency-virus type-1 (4) 4
packaging (4) 4
rna (4) 4
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secondary structure (4) 4
genetic aspects (3) 3
genome, viral (3) 3
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human immunodeficiency virus--hiv (3) 3
multidisciplinary sciences (3) 3
ribonucleic acid--rna (3) 3
virus assembly (3) 3
5' untranslated regions (2) 2
7sl rna (2) 2
base sequence (2) 2
encapsidation (2) 2
humans (2) 2
molecular sequence data (2) 2
murine leukemia-virus (2) 2
mutation (2) 2
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protein binding (2) 2
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reverse transcription (2) 2
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structure (2) 2
translation (2) 2
viruses (2) 2
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5' region (1) 1
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70s rna (1) 1
analysis (1) 1
anti-hiv agents - pharmacology (1) 1
assembly in-vitro (1) 1
base pairing (1) 1
base pairs (1) 1
binding (1) 1
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biological sciences (1) 1
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determinants (1) 1
dimers (1) 1
diploid genome packaging (1) 1
dna mismatch repair - drug effects (1) 1
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1. Full Text Structure of the HIV-1 RNA packaging signal
by Keane, Sarah C and Heng, Xiao and Lu, Kun and Kharytonchyk, Siarhei and Ramakrishnan, Venkateswaran and Carter, Gregory and Barton, Shawn and Hosic, Azra and Florwick, Alyssa and Santos, Justin and Bolden, Nicholas C and McCowin, Sayo and Case, David A and Johnson, Bruce A and Salemi, Marco and Telesnitsky, Alice and Summers, Michael F
Science, ISSN 0036-8075, 05/2015, Volume 348, Issue 6237, pp. 917 - 921
The 5' leader of the HIV-1 genome contains conserved elements that direct selective packaging of the unspliced, dimeric viral RNA into assembling particles. By... 
GENOMES | DONOR | MULTIDISCIPLINARY SCIENCES | PSI | IMMUNODEFICIENCY-VIRUS TYPE-1 | DIMERIZATION | NUCLEOCAPSID PROTEIN | BINDING | EFFICIENCY | REVEALS | REGION | Genetic aspects | Research | Nuclear magnetic resonance | HIV (Viruses) | Analysis | Protein binding | Proteins | Genomes | Nuclear magnetic resonance--NMR | Ribonucleic acid--RNA | Human immunodeficiency virus--HIV | Binding | Ribonucleic acids | Packaging | Human immunodeficiency virus | Translations
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2. Full Text NMR Detection of Structures in the HIV-1 5'-Leader RNA That Regulate Genome Packaging
by Kun Lu and Xiao Heng and Lianko Garyu and Sarah Monti and Eric L. Garcia and Siarhei Kharytonchyk and Bilguujin Dorjsuren and Gowry Kulandaivel and Simonne Jones and Atheeth Hiremath and Sai Sachin Divakaruni and Courtney LaCotti and Shawn Barton and Daniel Tummillo and Azra Hosic and Kedy Edme and Sara Albrecht and Alice Telesnitsky and Michael F. Summers
Science, ISSN 0036-8075, 10/2011, Volume 334, Issue 6053, pp. 242 - 245
The 5′-leader of the HIV-1 genome regulates multiple functions during viral replication via mechanisms that have yet to be established. We developed a nuclear... 
RNA | REPORTS | Chemical bases | Packaging | Dimers | Genomes | Gene expression regulation | Nuclear magnetic resonance | Dimerization | Genetic mutation | Monomers | SIGNAL | SITE | RECOMBINATION | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | 5' REGION | DIMERIZATION | SECONDARY STRUCTURE | GAG GENE | RETROVIRUSES | TRANSLATION | Genome, Viral | Protein Biosynthesis | Mutagenesis, Site-Directed | Codon, Initiator | HIV-1 - genetics | Virus Assembly | Human Immunodeficiency Virus Proteins - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | HIV-1 - physiology | RNA, Viral - chemistry | RNA, Viral - genetics | Base Pairing | Nucleocapsid Proteins - metabolism | 5' Untranslated Regions | Genes, gag | Nuclear Magnetic Resonance, Biomolecular | Protein Binding | Nucleic Acid Conformation | Binding Sites | Usage | Genetic research | Genetic aspects | Research | HIV (Viruses) | Structure | Methods | Proteins | Nuclear magnetic resonance--NMR | Ribonucleic acid--RNA | Human immunodeficiency virus--HIV
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3. Full Text Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
by Siarhei Kharytonchyk and Sarah Monti and Philip J. Smaldino and Verna Van and Nicholas C. Bolden and Joshua D. Brown and Emily Russo and Canessa Swanson and Alex Shuey and Alice Telesnitsky and Michael F. Summers
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2016, Volume 113, Issue 47, pp. 13378 - 13383
The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at the U3–R boundary that have been proposed to function as sites for... 
HIV-1 | RNA | Transcription | Structure | 5'-leader | RNA DIMERIZATION | VIRUS | transcription | MECHANISM | DETERMINANTS | MULTIDISCIPLINARY SCIENCES | INITIATION SITE | 5 '-leader | TRANSLATION | structure | MINIMAL REGION | NMR DETECTION | ENCAPSIDATION | SECONDARY STRUCTURE | Genome, Viral | Promoter Regions, Genetic | Guanosine - genetics | Polyribosomes - genetics | HIV-1 - genetics | Virus Assembly | Genetic Heterogeneity | HIV-1 - physiology | RNA, Viral - chemistry | RNA, Viral - genetics | Virus Replication | Transcription Initiation Site | Transcription, Genetic | Molecular Structure | Mutation | Biological Sciences | 5′-leader
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4. Full Text Analysis of the human immunodeficiency virus-1 RNA packageome
by Eckwahl, Matthew J and Arnion, Helene and Kharytonchyk, Siarhei and Zang, Trinity and Bieniasz, Paul D and Telesnitsky, Alice and Wolin, Sandra L
RNA, ISSN 1355-8382, 08/2016, Volume 22, Issue 8, pp. 1228 - 1238
All retroviruses package cellular RNAs into virions. Studies of murine leukemia virus (MLV) revealed that the major host cell RNAs encapsidated by this simple... 
Retrotransposons | Retrovirus | Noncoding RNA precursors | pre-tRNAs | Nuclear export | retrovirus | 7SL RNA | noncoding RNA precursors | SRP-RNA | REVERSE TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MURINE LEUKEMIA-VIRUS | retrotransposons | nuclear export | HIV-1 PARTICLES | ROUS-SARCOMA-VIRUS | GENE-EXPRESSION | ASSEMBLY IN-VITRO | 70S RNA | RETROVIRUS PARTICLES | Cell Line | RNA, Viral - genetics | HIV-1 - genetics | Humans
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5. Full Text Identification of a Minimal Region of the HIV-1 5′-Leader Required for RNA Dimerization, NC Binding, and Packaging
by Heng, Xiao and Kharytonchyk, Siarhei and Garcia, Eric L and Lu, Kun and Divakaruni, Sai Sachin and LaCotti, Courtney and Edme, Kedy and Telesnitsky, Alice and Summers, Michael F
Journal of Molecular Biology, ISSN 0022-2836, 03/2012, Volume 417, Issue 3, pp. 224 - 239
Assembly of human immunodeficiency virus type 1 (HIV-1) particles is initiated in the cytoplasm by the formation of a ribonucleoprotein complex comprising the... 
ITC | nucleocapsid protein | retrovirus assembly | RNA structure | diploid genome packaging | VIRAL-RNA | REVERSE TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEM-LOOP | HUMAN-IMMUNODEFICIENCY-VIRUS | SARCIN RICIN LOOP | STRUCTURAL FEATURES | MOLONEY MURINE LEUKEMIA | SECONDARY STRUCTURE | GENOME DIMERIZATION | Gene Products, gag - genetics | Molecular Sequence Data | HIV Long Terminal Repeat | Poly A - genetics | HIV-1 - genetics | Gene Products, gag - metabolism | RNA, Viral - chemistry | RNA, Viral - genetics | 5' Untranslated Regions | Nucleocapsid - metabolism | Base Sequence | RNA, Viral - metabolism | Mutation | Dimerization | RNA | Ribonuclease | Chemical properties | polyproteins | Gag protein | Nucleocapsids | Ribonucleoproteins | Packaging | Genomes | Cytoplasm
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6. Full Text Influence of gag and RRE Sequences on HIV-1 RNA Packaging Signal Structure and Function
by Kharytonchyk, Siarhei and Brown, Joshua D and Stilger, Krista and Yasin, Saif and Iyer, Aishwarya S and Collins, John and Summers, Michael F and Telesnitsky, Alice
Journal of Molecular Biology, ISSN 0022-2836, 07/2018, Volume 430, Issue 14, pp. 2066 - 2079
The packaging signal (Ψ) and Rev-responsive element (RRE) enable unspliced HIV-1 RNAs' export from the nucleus and packaging into virions. For some... 
free energy calculation | RNA packaging | retrovirus | Mfold | RNA dimerization | RESPONSE ELEMENT | TAR HAIRPIN | NMR DETECTION | ENCAPSIDATION | 7SL RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | CELLULAR RNAS | DIMERIZATION | SECONDARY STRUCTURE | GENOMIC RNA | RNA | Packaging | HIV (Viruses) | Free energy calculation
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7. Full Text Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication
by Kharytonchyk, Siarhei and King, Steven R and Ndongmo, Clement B and Stilger, Krista L and An, Wenfeng and Telesnitsky, Alice
Journal of Molecular Biology, ISSN 0022-2836, 06/2016, Volume 428, Issue 11, pp. 2275 - 2288
A key contributor to HIV-1 genetic variation is reverse transcriptase errors. Some mutations result because reverse transcriptase (RT) lacks 3′ to 5′... 
forced copy-choice recombination | retroviral error mechanisms | RNA-POLYMERASE-II | 3'-AZIDO-3'-DEOXYTHYMIDINE AZT | BIOCHEMISTRY & MOLECULAR BIOLOGY | MURINE LEUKEMIA-VIRUS | VIRAL REPLICATION | PRIMER UNBLOCKING | VIVO MUTATION-RATE | IN-VIVO | IMMUNODEFICIENCY-VIRUS TYPE-1 | STRAND TRANSFER | RETROVIRAL MUTATION | Anti-HIV Agents - pharmacology | Virus Replication - drug effects | DNA Replication - drug effects | HIV-1 - drug effects | Virus Replication - genetics | Humans | DNA Mismatch Repair - drug effects | Nucleotides - genetics | Reverse Transcriptase Inhibitors - pharmacology | Templates, Genetic | DNA Primers - genetics | DNA Mismatch Repair - genetics | HIV-1 - genetics | Mutation - genetics | HIV Reverse Transcriptase - metabolism | Drug Resistance, Viral - genetics | Mutation - drug effects | DNA Replication - genetics | DNA, Viral - genetics | DNA polymerases | Enzymes | Reverse transcriptase inhibitors | Nucleotides | Sarcoma | HIV (Viruses) | Index Medicus | forced copy choice recombination | Retroviral error mechanisms
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8. Full Text Flexibility in nucleic acid binding is central to APOBEC3H antiviral activity
by Bohn, Jennifer A and DaSilva, Justin and Kharytonchyk, Siarhei and Mercedes, Maria and Vosters, Jennifer and Telesnitsky, Alice and Hatziioannou, Theodora and Smith, Janet L
Journal of Virology, ISSN 0022-538X, 10/2019
APOBEC3 proteins, A3F, A3G, and A3H, are host restriction factors that inhibit HIV-1 through DNA cytidine deaminase-dependent and -independent mechanisms and... 
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9. Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
by Siarhei Kharytonchyk and Sarah Monti and Philip J Smaldino and Verna Van and Nicholas C Bolden and Joshua D Brown and Emily Russo and Canessa Swanson and Alex Shuey and Alice Telesnitsky and Michael F Summers
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2016, Volume 113, Issue 47, p. 13378
  The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at the U3-R boundary that have been proposed to function as sites for... 
Mutagenesis | Human immunodeficiency virus--HIV | Genomes | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Cells
Journal Article
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10. Full Text Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
by Kharytonchyk, Siarhei and Monti, Sarah and Smaldino, Philip J and Van, Verna and Bolden, Nicholas C and Brown, Joshua D and Russo, Emily and Swanson, Canessa and Shuey, Alex and Telesnitsky, Alice and Summers, Michael F
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 11/2016, Volume 113, Issue 47, p. 13378
Genetic aspects | Genetic transcription | HIV (Viruses) | Health aspects
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11. Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
by Kharytonchyk, Siarhei and Monti, Sarah and Smaldino, Philip J and Van, Verna and Bolden, Nicholas C and Brown, Joshua D and Russo, Emily and Swanson, Canessa and Shuey, Alex and Telesnitsky, Alice and Summers, Michael F
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 11/2016, Volume 113, Issue 47, pp. 13378 - 13378
The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at the U3-R boundary that have been proposed to function as sites for... 
Journal Article
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12. NMR Detection of Structures in the HIV-1 5'-Leader RNA That Regulate Genome Packaging
by Lu, Kun and Heng, Xiao and Garyu, Lianko and Monti, Sarah and Garcia, Eric L and Kharytonchyk, Siarhei and Dorjsuren, Bilguujin and Kulandaivel, Gowry and Jones, Simonne and Hiremath, Atheeth and Divakaruni, Sai Sachin and LaCotti, Courtney and Barton, Shawn and Tummillo, Daniel and Hosic, Azra and Edme, Kedy and Albrecht, Sara and Telesnitsky, Alice and Summers, Michael F
Science (Washington), ISSN 0036-8075, 10/2011, Volume 334, Issue 6053, pp. 242 - 245
The 5'-leader of the HIV-1 genome regulates multiple functions during viral replication via mechanisms that have yet to be established. We developed a nuclear... 
Base pairs
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13. Full Text RNA structure. Structure of the HIV-1 RNA packaging signal
by Keane, Sarah C and Heng, Xiao and Lu, Kun and Kharytonchyk, Siarhei and Ramakrishnan, Venkateswaran and Carter, Gregory and Barton, Shawn and Hosic, Azra and Florwick, Alyssa and Santos, Justin and Bolden, Nicholas C and McCowin, Sayo and Case, David A and Johnson, Bruce A and Salemi, Marco and Telesnitsky, Alice and Summers, Michael F
Science (New York, N.Y.), 05/2015, Volume 348, Issue 6237, p. 917
The 5' leader of the HIV-1 genome contains conserved elements that direct selective packaging of the unspliced, dimeric viral RNA into assembling particles. By... 
Genome, Viral | Molecular Sequence Data | gag Gene Products, Human Immunodeficiency Virus - chemistry | Peptide Chain Initiation, Translational | HIV-1 - genetics | Virus Assembly | RNA Splicing | HIV-1 - physiology | RNA, Viral - chemistry | RNA, Viral - genetics | Guanosine - chemistry | HIV-1 - chemistry | Base Sequence | Nuclear Magnetic Resonance, Biomolecular | Nucleic Acid Conformation
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