Annals of Neurology, ISSN 0364-5134, 02/2019, Volume 85, Issue 2, pp. 259 - 271
Objective To use digital histology in a large autopsy cohort of Lewy body disorder (LBD) patients with dementia to test the hypotheses that co‐occurring...
UNIVERSITY-OF-PENNSYLVANIA | NATIONAL INSTITUTE | ALZHEIMERS-DISEASE | IMAGE-ANALYSIS | BODIES | ALPHA-SYNUCLEIN | CLINICAL DIAGNOSTIC-CRITERIA | BRAIN PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | PARKINSONS-DISEASE DEMENTIA | NEUROPATHOLOGIC ASSESSMENT | Parkinson's disease | Cognitive ability | Synuclein | Heterogeneity | Histopathology | Autopsy | Cortex (frontal) | Dementia disorders | Amyloid | Alzheimer's disease | Movement disorders | Cortex (temporal) | Temporal lobe | Autopsies | Neurodegenerative diseases | Cortex | Histology | Patients | Putamen | Lewy bodies | Pathology | Cortex (entorhinal) | Tau protein | Correlation analysis | Cognitive tasks | Dementia
UNIVERSITY-OF-PENNSYLVANIA | NATIONAL INSTITUTE | ALZHEIMERS-DISEASE | IMAGE-ANALYSIS | BODIES | ALPHA-SYNUCLEIN | CLINICAL DIAGNOSTIC-CRITERIA | BRAIN PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | PARKINSONS-DISEASE DEMENTIA | NEUROPATHOLOGIC ASSESSMENT | Parkinson's disease | Cognitive ability | Synuclein | Heterogeneity | Histopathology | Autopsy | Cortex (frontal) | Dementia disorders | Amyloid | Alzheimer's disease | Movement disorders | Cortex (temporal) | Temporal lobe | Autopsies | Neurodegenerative diseases | Cortex | Histology | Patients | Putamen | Lewy bodies | Pathology | Cortex (entorhinal) | Tau protein | Correlation analysis | Cognitive tasks | Dementia
Journal Article
Neurology, ISSN 0028-3878, 01/2013, Volume 80, Issue 2, pp. 176 - 180
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0175674
Objectives To assess the neurobiological substrate of initial cognitive decline in Parkinson's disease (PD) to inform patient management, clinical trial...
INITIATIVE PPMI | DEMENTIA | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | INCIDENT | DISORDER | POLYMORPHISM | DIAGNOSTIC-CRITERIA | PLANNING ABILITY | LEWY BODIES | DECLINE | Brain-Derived Neurotrophic Factor - genetics | Dopamine Plasma Membrane Transport Proteins - metabolism | Parkinson Disease - complications | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | tau Proteins - cerebrospinal fluid | Cognitive Dysfunction - cerebrospinal fluid | Catechol O-Methyltransferase - genetics | Diffusion Tensor Imaging | Magnetic Resonance Imaging | Cognitive Dysfunction - epidemiology | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Adult | Cognitive Dysfunction - genetics | Female | Aged | Polymorphism, Single Nucleotide | Biomarkers - cerebrospinal fluid | Cognitive Dysfunction - diagnostic imaging | Complications and side effects | Care and treatment | Parkinson's disease | Development and progression | Cognition disorders | Biological markers | Identification and classification | Brain | Cognitive ability | Nervous system | Cerebrospinal fluid | Risk factors | Eye | Design | Computed tomography | Education | Aging | Alzheimer's disease | Public health | Movement disorders | Deoxyribonucleic acid--DNA | Apolipoprotein E4 | Emotional behavior | Temporal lobe | Neurodegenerative diseases | Catechol | Cortex (visual) | Single photon emission computed tomography | Substrates | Neurology | Pathology | Thinning | Experimental design | Biomarkers | β-Amyloid | Dementia | Neuroimaging | Haplotypes | Mental disorders | Laboratories | Parkinsons disease | Visual perception | Atrophy | Dementia disorders | Dopamine | Review boards | Health risks | Pharmacology | Dentistry | Medicine | Brain research | Sleep | Brain-derived neurotrophic factor | Magnetic resonance imaging | Parietal lobe | Alzheimers disease | Psychiatry | Polymorphism | Deoxyribonucleic acid | DNA
INITIATIVE PPMI | DEMENTIA | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | INCIDENT | DISORDER | POLYMORPHISM | DIAGNOSTIC-CRITERIA | PLANNING ABILITY | LEWY BODIES | DECLINE | Brain-Derived Neurotrophic Factor - genetics | Dopamine Plasma Membrane Transport Proteins - metabolism | Parkinson Disease - complications | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | tau Proteins - cerebrospinal fluid | Cognitive Dysfunction - cerebrospinal fluid | Catechol O-Methyltransferase - genetics | Diffusion Tensor Imaging | Magnetic Resonance Imaging | Cognitive Dysfunction - epidemiology | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Adult | Cognitive Dysfunction - genetics | Female | Aged | Polymorphism, Single Nucleotide | Biomarkers - cerebrospinal fluid | Cognitive Dysfunction - diagnostic imaging | Complications and side effects | Care and treatment | Parkinson's disease | Development and progression | Cognition disorders | Biological markers | Identification and classification | Brain | Cognitive ability | Nervous system | Cerebrospinal fluid | Risk factors | Eye | Design | Computed tomography | Education | Aging | Alzheimer's disease | Public health | Movement disorders | Deoxyribonucleic acid--DNA | Apolipoprotein E4 | Emotional behavior | Temporal lobe | Neurodegenerative diseases | Catechol | Cortex (visual) | Single photon emission computed tomography | Substrates | Neurology | Pathology | Thinning | Experimental design | Biomarkers | β-Amyloid | Dementia | Neuroimaging | Haplotypes | Mental disorders | Laboratories | Parkinsons disease | Visual perception | Atrophy | Dementia disorders | Dopamine | Review boards | Health risks | Pharmacology | Dentistry | Medicine | Brain research | Sleep | Brain-derived neurotrophic factor | Magnetic resonance imaging | Parietal lobe | Alzheimers disease | Psychiatry | Polymorphism | Deoxyribonucleic acid | DNA
Journal Article
Movement Disorders, ISSN 0885-3185, 02/2014, Volume 29, Issue 2, pp. 164 - 165
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 5, pp. 514 - 524
Summary Recent findings question our present understanding of Parkinson's disease and suggest that new research criteria for the diagnosis of Parkinson's...
Neurology | NEURODEGENERATIVE DISEASE | OLFACTORY DYSFUNCTION | CLINICAL-DIAGNOSIS | LRRK2 G2019S MUTATION | TRANSCRANIAL SONOGRAPHY | LEWY BODY DISEASE | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | CLINICAL NEUROLOGY | SLEEP BEHAVIOR DISORDER | REM-SLEEP | Parkinson Disease - diagnosis | Parkinson Disease - pathology | Research | Humans
Neurology | NEURODEGENERATIVE DISEASE | OLFACTORY DYSFUNCTION | CLINICAL-DIAGNOSIS | LRRK2 G2019S MUTATION | TRANSCRANIAL SONOGRAPHY | LEWY BODY DISEASE | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | CLINICAL NEUROLOGY | SLEEP BEHAVIOR DISORDER | REM-SLEEP | Parkinson Disease - diagnosis | Parkinson Disease - pathology | Research | Humans
Journal Article
Parkinsonism and Related Disorders, ISSN 1353-8020, 03/2018, Volume 48, pp. 1 - 2
Journal Article
Movement Disorders, ISSN 0885-3185, 05/2018, Volume 33, Issue 5, pp. 771 - 782
ABSTRACT Objective: The objective of this study was to assess longitudinal change in clinical and dopamine transporter imaging outcomes in early, untreated PD....
gait disorder predominant | tremor dominant | Parkinson's disease | disease subtypes | postural instability | TRIALS | SCALE MDS-UPDRS | PPMI | SOCIETY-SPONSORED REVISION | CLINICAL NEUROLOGY | LEVODOPA | Medicine, Experimental | Medical research | Development and progression | Tremor | Dopamine | Neurodegenerative diseases | Parkinsons disease | Neostriatum | Dopamine transporter | Movement disorders | Dopamine receptors
gait disorder predominant | tremor dominant | Parkinson's disease | disease subtypes | postural instability | TRIALS | SCALE MDS-UPDRS | PPMI | SOCIETY-SPONSORED REVISION | CLINICAL NEUROLOGY | LEVODOPA | Medicine, Experimental | Medical research | Development and progression | Tremor | Dopamine | Neurodegenerative diseases | Parkinsons disease | Neostriatum | Dopamine transporter | Movement disorders | Dopamine receptors
Journal Article
Annals of Neurology, ISSN 0364-5134, 06/2011, Volume 69, Issue 6, pp. 986 - 996
Objective: To assess factors associated with impulse control disorders (ICDs) in Parkinson disease (PD) using a multicenter case–control design. Methods:...
DEPRESSION | SYMPTOMS | ALCOHOL | ANXIETY | NEUROSCIENCES | CLINICAL NEUROLOGY | Disability Evaluation | Disruptive, Impulse Control, and Conduct Disorders - drug therapy | Parkinson Disease - complications | Cross-Sectional Studies | Levodopa - therapeutic use | Humans | Middle Aged | Dopamine Agonists - therapeutic use | Disruptive, Impulse Control, and Conduct Disorders - etiology | Male | Parkinson Disease - drug therapy | Case-Control Studies | Antiparkinson Agents - therapeutic use | Neuropsychological Tests | Psychiatric Status Rating Scales | Analysis of Variance | Cognition Disorders - etiology | Female | Aged | Medical research | Impulsivity | Parkinsons disease
DEPRESSION | SYMPTOMS | ALCOHOL | ANXIETY | NEUROSCIENCES | CLINICAL NEUROLOGY | Disability Evaluation | Disruptive, Impulse Control, and Conduct Disorders - drug therapy | Parkinson Disease - complications | Cross-Sectional Studies | Levodopa - therapeutic use | Humans | Middle Aged | Dopamine Agonists - therapeutic use | Disruptive, Impulse Control, and Conduct Disorders - etiology | Male | Parkinson Disease - drug therapy | Case-Control Studies | Antiparkinson Agents - therapeutic use | Neuropsychological Tests | Psychiatric Status Rating Scales | Analysis of Variance | Cognition Disorders - etiology | Female | Aged | Medical research | Impulsivity | Parkinsons disease
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 02/2005, Volume 46, Issue 2, pp. 227 - 232
We studied the correlation of striatal dopamine transporter (DAT) imaging with anxiety and depression symptoms in Parkinson's disease (PD). Methods: Patients...
Depression | Dopamine transporter | Anxiety | Parkinson's disease | TRODAT-1 | SYSTEM | FRONTAL-LOBE | BASAL GANGLIA | DISORDERS | MAJOR DEPRESSION | PUTAMEN NUCLEI | COMORBIDITY | anxiety | dopamine transporter | PRAMIPEXOLE | depression | PERSONALITY-TRAITS | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Membrane Glycoproteins - metabolism | Humans | Middle Aged | Male | Tropanes - pharmacokinetics | Statistics as Topic | Corpus Striatum - metabolism | Depression - etiology | Tissue Distribution | Depression - metabolism | Sensitivity and Specificity | Anxiety - diagnostic imaging | Anxiety - diagnosis | Female | Membrane Transport Proteins - metabolism | Parkinson Disease - metabolism | Anxiety - metabolism | Dopamine Plasma Membrane Transport Proteins | Severity of Illness Index | Parkinson Disease - complications | Reproducibility of Results | Parkinson Disease - diagnostic imaging | Radiopharmaceuticals - pharmacokinetics | Depression - diagnosis | Nerve Tissue Proteins - metabolism | Organotechnetium Compounds - pharmacokinetics | Radionuclide Imaging | Biomarkers | Depression - diagnostic imaging | Corpus Striatum - diagnostic imaging | Anxiety - etiology
Depression | Dopamine transporter | Anxiety | Parkinson's disease | TRODAT-1 | SYSTEM | FRONTAL-LOBE | BASAL GANGLIA | DISORDERS | MAJOR DEPRESSION | PUTAMEN NUCLEI | COMORBIDITY | anxiety | dopamine transporter | PRAMIPEXOLE | depression | PERSONALITY-TRAITS | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Membrane Glycoproteins - metabolism | Humans | Middle Aged | Male | Tropanes - pharmacokinetics | Statistics as Topic | Corpus Striatum - metabolism | Depression - etiology | Tissue Distribution | Depression - metabolism | Sensitivity and Specificity | Anxiety - diagnostic imaging | Anxiety - diagnosis | Female | Membrane Transport Proteins - metabolism | Parkinson Disease - metabolism | Anxiety - metabolism | Dopamine Plasma Membrane Transport Proteins | Severity of Illness Index | Parkinson Disease - complications | Reproducibility of Results | Parkinson Disease - diagnostic imaging | Radiopharmaceuticals - pharmacokinetics | Depression - diagnosis | Nerve Tissue Proteins - metabolism | Organotechnetium Compounds - pharmacokinetics | Radionuclide Imaging | Biomarkers | Depression - diagnostic imaging | Corpus Striatum - diagnostic imaging | Anxiety - etiology
Journal Article
NEUROLOGY, ISSN 0028-3878, 01/2013, Volume 80, Issue 2, pp. 176 - 180
Objective: To determine the frequency and correlates of impulse control and related behavior symptoms in patients with de novo, untreated Parkinson disease...
CONTROL DISORDERS | MOCA | DYSREGULATION | COGNITIVE IMPAIRMENT | PREVALENCE | BEHAVIORS | PROGRESSION | ONSET | CLINICAL NEUROLOGY | DOPAMINE AGONISTS | Parkinson Disease - complications | Gambling - psychology | Humans | Middle Aged | Disruptive, Impulse Control, and Conduct Disorders - etiology | Male | Risk | Disease Progression | Disruptive, Impulse Control, and Conduct Disorders - diagnosis | Neuropsychological Tests | Disruptive, Impulse Control, and Conduct Disorders - epidemiology | Psychiatric Status Rating Scales | Biomarkers | Parkinson Disease - diagnosis | Parkinson Disease - epidemiology | Female | Surveys and Questionnaires | Aged | Research Design | 165 | 199 | 205
CONTROL DISORDERS | MOCA | DYSREGULATION | COGNITIVE IMPAIRMENT | PREVALENCE | BEHAVIORS | PROGRESSION | ONSET | CLINICAL NEUROLOGY | DOPAMINE AGONISTS | Parkinson Disease - complications | Gambling - psychology | Humans | Middle Aged | Disruptive, Impulse Control, and Conduct Disorders - etiology | Male | Risk | Disease Progression | Disruptive, Impulse Control, and Conduct Disorders - diagnosis | Neuropsychological Tests | Disruptive, Impulse Control, and Conduct Disorders - epidemiology | Psychiatric Status Rating Scales | Biomarkers | Parkinson Disease - diagnosis | Parkinson Disease - epidemiology | Female | Surveys and Questionnaires | Aged | Research Design | 165 | 199 | 205
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177924
Parkinson disease patients develop clinically significant cognitive impairment at variable times over their disease course, which is often preceded by milder...
APOLIPOPROTEIN-E EPSILON-4 | POSITRON-EMISSION-TOMOGRAPHY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | VOLUME EFFECT CORRECTION | IN-VIVO | A-BETA | ALPHA-SYNUCLEIN | DIAGNOSTIC-CRITERIA | FLORBETAPIR F 18 | PET | Parkinson Disease - pathology | Dementia - pathology | Humans | Middle Aged | Cognition Disorders - pathology | Cognition Disorders - metabolism | Male | Positron-Emission Tomography - methods | Alzheimer Disease - pathology | Brain - metabolism | Dementia - metabolism | Amyloid - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Cognition - physiology | Female | Plaque, Amyloid - metabolism | Aged | Parkinson Disease - metabolism | Ethylene Glycols - administration & dosage | Aniline Compounds - administration & dosage | Amyloidogenesis | Brain | Parkinson's disease | Gait | Memory | Cognitive ability | Disorders | Nervous system | Cognition | Rigidity | Epidemiology | Freezing | Proteins | Autopsy | Education | Tomography | Aging | Alzheimer's disease | Movement disorders | Quantitative analysis | Binding | Apolipoprotein E4 | Neurodegenerative diseases | Cortex | Regression analysis | Assessments | Apolipoproteins | Emissions | Studies | Pathology | Neurology | Radiology | β-Amyloid | Cognitive tasks | Dementia | Neuroimaging | Nuclear medicine | Neurosciences | Mental disorders | Laboratories | Physicians | Parkinsons disease | Risk | Population studies | Accumulation | Apolipoprotein E | Dementia disorders | Qualitative analysis | Deposition | Autopsies | Medical imaging | Health risks | Medicine | Brain research | Cognition & reasoning | Magnetic resonance imaging | Gene frequency | Alleles | Amyloidosis | In vivo methods and tests | Reliability | Positron emission tomography | Psychiatry
APOLIPOPROTEIN-E EPSILON-4 | POSITRON-EMISSION-TOMOGRAPHY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | VOLUME EFFECT CORRECTION | IN-VIVO | A-BETA | ALPHA-SYNUCLEIN | DIAGNOSTIC-CRITERIA | FLORBETAPIR F 18 | PET | Parkinson Disease - pathology | Dementia - pathology | Humans | Middle Aged | Cognition Disorders - pathology | Cognition Disorders - metabolism | Male | Positron-Emission Tomography - methods | Alzheimer Disease - pathology | Brain - metabolism | Dementia - metabolism | Amyloid - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Cognition - physiology | Female | Plaque, Amyloid - metabolism | Aged | Parkinson Disease - metabolism | Ethylene Glycols - administration & dosage | Aniline Compounds - administration & dosage | Amyloidogenesis | Brain | Parkinson's disease | Gait | Memory | Cognitive ability | Disorders | Nervous system | Cognition | Rigidity | Epidemiology | Freezing | Proteins | Autopsy | Education | Tomography | Aging | Alzheimer's disease | Movement disorders | Quantitative analysis | Binding | Apolipoprotein E4 | Neurodegenerative diseases | Cortex | Regression analysis | Assessments | Apolipoproteins | Emissions | Studies | Pathology | Neurology | Radiology | β-Amyloid | Cognitive tasks | Dementia | Neuroimaging | Nuclear medicine | Neurosciences | Mental disorders | Laboratories | Physicians | Parkinsons disease | Risk | Population studies | Accumulation | Apolipoprotein E | Dementia disorders | Qualitative analysis | Deposition | Autopsies | Medical imaging | Health risks | Medicine | Brain research | Cognition & reasoning | Magnetic resonance imaging | Gene frequency | Alleles | Amyloidosis | In vivo methods and tests | Reliability | Positron emission tomography | Psychiatry
Journal Article
JAMA Neurology, ISSN 2168-6149, 2013, Volume 70, Issue 10, pp. 1277 - 1287
Journal Article
Movement Disorders, ISSN 0885-3185, 04/2012, Volume 27, Issue 5, pp. 608 - 616
Parkinson's disease (PD) has a prodromal phase during which nonmotor clinical features as well as physiological abnormalities may be present. These premotor...
specificity | Parkinson's disease | early detection | sensitivity | Sensitivity | Specificity | Early detection | OLFACTORY DYSFUNCTION | POSITRON-EMISSION TOMOGRAPHY | DOPAMINERGIC FUNCTION | LEWY BODY DISEASE | SUBSTANTIA-NIGRA | HUNTINGTON DISEASE | CLINICAL NEUROLOGY | SLEEP BEHAVIOR DISORDER | CIGARETTE-SMOKING | ALPHA-SYNUCLEINOPATHY | CARDIAC UPTAKE | Parkinson Disease - therapy | Humans | Parkinson Disease - diagnosis | Parkinson Disease - classification | Parkinson Disease - genetics | Early Diagnosis | Motor Neurons - pathology | Parkinson Disease - etiology
specificity | Parkinson's disease | early detection | sensitivity | Sensitivity | Specificity | Early detection | OLFACTORY DYSFUNCTION | POSITRON-EMISSION TOMOGRAPHY | DOPAMINERGIC FUNCTION | LEWY BODY DISEASE | SUBSTANTIA-NIGRA | HUNTINGTON DISEASE | CLINICAL NEUROLOGY | SLEEP BEHAVIOR DISORDER | CIGARETTE-SMOKING | ALPHA-SYNUCLEINOPATHY | CARDIAC UPTAKE | Parkinson Disease - therapy | Humans | Parkinson Disease - diagnosis | Parkinson Disease - classification | Parkinson Disease - genetics | Early Diagnosis | Motor Neurons - pathology | Parkinson Disease - etiology
Journal Article