Gut, ISSN 0017-5749, 10/2017, Volume 66, Issue 10, pp. 1748 - 1760
ObjectiveEpidemiological and clinical data indicate that patients suffering from IBD with long-standing colitis display a higher risk to develop colorectal...
COLORECTAL CANCER | IBD | CELL MATRIX INTERACTION | INTEGRINS | INTESTINAL BARRIER FUNCTION | CELLS | ALPHA-6-BETA-4 INTEGRIN | INFLAMMATION | ABSENCE | EPIDERMOLYSIS-BULLOSA | INTESTINAL BARRIER | GASTROENTEROLOGY & HEPATOLOGY | TUMOR-GROWTH | EXPRESSION | PROMOTES | BETA | Intestinal Mucosa - metabolism | Intestinal Mucosa - physiopathology | Epithelial Cells - metabolism | Colitis - genetics | Colorectal Neoplasms - genetics | B-Lymphocytes | Hemidesmosomes - physiology | Caspase 1 - metabolism | Colitis - pathology | Hemidesmosomes - genetics | Adenocarcinoma - metabolism | Adenocarcinoma - physiopathology | Mucus - metabolism | Adenocarcinoma - genetics | Integrin alpha6beta4 - metabolism | Cytokines - genetics | Colorectal Neoplasms - metabolism | Adaptive Immunity | Severity of Illness Index | Cytokines - metabolism | Signal Transduction | T-Lymphocytes | Lymphocyte Activation | Myeloid Differentiation Factor 88 - genetics | Integrin alpha6 - genetics | Permeability | Colorectal Neoplasms - physiopathology | Basement Membrane - physiopathology | Animals | Colitis - physiopathology | Keratin-8 - metabolism | Keratin-18 - metabolism | Colitis - metabolism | Mice | Homeostasis - genetics | Intestinal Mucosa - pathology | Complications and side effects | Inflammatory bowel diseases | Antibiotics | Colorectal cancer | Dosage and administration | Research | Epidemiology | Risk factors | Adenocarcinoma | Transformation | Animal models | Epithelial cells | Hyperplasia | Colorectal carcinoma | Helper cells | Homeostasis | Genomes | Lymphocytes T | Small intestine | Defects | Metastases | Keratin | Cell activation | Laminin | Intestine | Hemidesmosomes | Tumorigenesis | Colon | Immune system | Dysplasia | Cytokines | Secretion | Inflammation | Patients | Interleukin 18 | Inflammatory bowel disease | Studies | Lymphocytes B | Colitis | Tumors | Life Sciences | Development Biology | Inflammatory Bowel Disease | 1506
COLORECTAL CANCER | IBD | CELL MATRIX INTERACTION | INTEGRINS | INTESTINAL BARRIER FUNCTION | CELLS | ALPHA-6-BETA-4 INTEGRIN | INFLAMMATION | ABSENCE | EPIDERMOLYSIS-BULLOSA | INTESTINAL BARRIER | GASTROENTEROLOGY & HEPATOLOGY | TUMOR-GROWTH | EXPRESSION | PROMOTES | BETA | Intestinal Mucosa - metabolism | Intestinal Mucosa - physiopathology | Epithelial Cells - metabolism | Colitis - genetics | Colorectal Neoplasms - genetics | B-Lymphocytes | Hemidesmosomes - physiology | Caspase 1 - metabolism | Colitis - pathology | Hemidesmosomes - genetics | Adenocarcinoma - metabolism | Adenocarcinoma - physiopathology | Mucus - metabolism | Adenocarcinoma - genetics | Integrin alpha6beta4 - metabolism | Cytokines - genetics | Colorectal Neoplasms - metabolism | Adaptive Immunity | Severity of Illness Index | Cytokines - metabolism | Signal Transduction | T-Lymphocytes | Lymphocyte Activation | Myeloid Differentiation Factor 88 - genetics | Integrin alpha6 - genetics | Permeability | Colorectal Neoplasms - physiopathology | Basement Membrane - physiopathology | Animals | Colitis - physiopathology | Keratin-8 - metabolism | Keratin-18 - metabolism | Colitis - metabolism | Mice | Homeostasis - genetics | Intestinal Mucosa - pathology | Complications and side effects | Inflammatory bowel diseases | Antibiotics | Colorectal cancer | Dosage and administration | Research | Epidemiology | Risk factors | Adenocarcinoma | Transformation | Animal models | Epithelial cells | Hyperplasia | Colorectal carcinoma | Helper cells | Homeostasis | Genomes | Lymphocytes T | Small intestine | Defects | Metastases | Keratin | Cell activation | Laminin | Intestine | Hemidesmosomes | Tumorigenesis | Colon | Immune system | Dysplasia | Cytokines | Secretion | Inflammation | Patients | Interleukin 18 | Inflammatory bowel disease | Studies | Lymphocytes B | Colitis | Tumors | Life Sciences | Development Biology | Inflammatory Bowel Disease | 1506
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2233
To ensure genome stability, pericentromeric regions are compacted in a dense heterochromatic structure through a combination of specific 'epigenetic' factors...
SATELLITE REPEATS | HP1 PROTEINS | PATERNAL GENOME | DNA METHYLATION | CHROMATIN-STRUCTURE | BINDING PROTEIN MECP2 | HISTONE H3 | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | EPIGENETIC REGULATION | MAMMALIAN-CELLS | NIH 3T3 Cells | Chromosomal Proteins, Non-Histone - metabolism | Humans | Zygote - metabolism | DNA Methylation - genetics | Centromere - metabolism | Animals | Heterochromatin - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Fluorescent Antibody Technique | Lysine - metabolism | Mice | Histones - metabolism
SATELLITE REPEATS | HP1 PROTEINS | PATERNAL GENOME | DNA METHYLATION | CHROMATIN-STRUCTURE | BINDING PROTEIN MECP2 | HISTONE H3 | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | EPIGENETIC REGULATION | MAMMALIAN-CELLS | NIH 3T3 Cells | Chromosomal Proteins, Non-Histone - metabolism | Humans | Zygote - metabolism | DNA Methylation - genetics | Centromere - metabolism | Animals | Heterochromatin - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Fluorescent Antibody Technique | Lysine - metabolism | Mice | Histones - metabolism
Journal Article
Haematologica, ISSN 0390-6078, 10/2016, Volume 101, Issue 11, pp. 1380 - 1389
MicroRNA are well-established players in post-transcriptional gene regulation. However, information on the effects of microRNA deregulation mainly relies on...
PATHOGENESIS | BURKITT-LYMPHOMA | SIGNATURES | GENE | PAR-CLIP | MYC | DISTINCT | MALIGNANCIES | MIRNAS | HEMATOLOGY | TRANSCRIPTOME-WIDE IDENTIFICATION | RNA Editing | Humans | Child, Preschool | Infant | Male | MicroRNAs - metabolism | Gene Expression Profiling | Lymphoma, B-Cell - genetics | RNA, Messenger - metabolism | Sequence Analysis, RNA - methods | Germinal Center | Lymphoma, Follicular - genetics | Adolescent | Burkitt Lymphoma - genetics | Female | MicroRNAs - genetics | Mutation | Child | Lymphoma, Large B-Cell, Diffuse - genetics | Infant, Newborn
PATHOGENESIS | BURKITT-LYMPHOMA | SIGNATURES | GENE | PAR-CLIP | MYC | DISTINCT | MALIGNANCIES | MIRNAS | HEMATOLOGY | TRANSCRIPTOME-WIDE IDENTIFICATION | RNA Editing | Humans | Child, Preschool | Infant | Male | MicroRNAs - metabolism | Gene Expression Profiling | Lymphoma, B-Cell - genetics | RNA, Messenger - metabolism | Sequence Analysis, RNA - methods | Germinal Center | Lymphoma, Follicular - genetics | Adolescent | Burkitt Lymphoma - genetics | Female | MicroRNAs - genetics | Mutation | Child | Lymphoma, Large B-Cell, Diffuse - genetics | Infant, Newborn
Journal Article
Blood, ISSN 0006-4971, 04/2007, Volume 109, Issue 8, pp. 3451 - 3461
CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid...
ALPHA C/EBP-ALPHA | BINDING-PROTEIN-EPSILON | POLYMERASE-CHAIN-REACTION | GRANULE DEFICIENCY | GRANULOCYTIC DIFFERENTIATION | MOLECULAR-CLONING | FUSION GENE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | HEMATOLOGY | CHROMOSOMAL TRANSLOCATION | Multigene Family - genetics | Oncogenes - genetics | Translocation, Genetic | Centromere - genetics | Chromosomes, Human - genetics | Humans | Polymerase Chain Reaction | Burkitt Lymphoma - genetics | In Situ Hybridization, Fluorescence | CCAAT-Enhancer-Binding Proteins - genetics | Immunoglobulin Heavy Chains - genetics | Telomere - genetics
ALPHA C/EBP-ALPHA | BINDING-PROTEIN-EPSILON | POLYMERASE-CHAIN-REACTION | GRANULE DEFICIENCY | GRANULOCYTIC DIFFERENTIATION | MOLECULAR-CLONING | FUSION GENE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | HEMATOLOGY | CHROMOSOMAL TRANSLOCATION | Multigene Family - genetics | Oncogenes - genetics | Translocation, Genetic | Centromere - genetics | Chromosomes, Human - genetics | Humans | Polymerase Chain Reaction | Burkitt Lymphoma - genetics | In Situ Hybridization, Fluorescence | CCAAT-Enhancer-Binding Proteins - genetics | Immunoglobulin Heavy Chains - genetics | Telomere - genetics
Journal Article
Genome Medicine, ISSN 1756-994X, 05/2019, Volume 11, Issue 1, pp. 31 - 31
As epigenetic studies become more common and lead to new insights into health and disease, the return of individual epigenetic results to research...
Epigenetics | ELSI | Return of results | Incidental findings | Epigenetic inheritance | Genetic research | Nervous system | Degeneration | Genetic aspects | Research | Gene expression | Consortia | Validity | Ethics | Researchers | Genomics | Bioethics | Genetics | Genomes | Communication
Epigenetics | ELSI | Return of results | Incidental findings | Epigenetic inheritance | Genetic research | Nervous system | Degeneration | Genetic aspects | Research | Gene expression | Consortia | Validity | Ethics | Researchers | Genomics | Bioethics | Genetics | Genomes | Communication
Journal Article
Genome Biology, ISSN 1474-760X, 2015, Volume 16, Issue 1, pp. 1 - 12
Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces...
INDIVIDUALS | HAPMAP PROJECT | DISEASE-ASSOCIATED VARIANTS | DNA METHYLATION | 5-METHYLCYTOSINE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GENETIC DISCRIMINATION | SCIENCE | IDENTIFICATION | LIFE-INSURANCE | REIDENTIFICATION | Genetic Variation | DNA Methylation | Epigenomics | Genetic Privacy | Epigenesis, Genetic | Humans | Data Anonymization | High-Throughput Nucleotide Sequencing | Sequence Analysis, DNA | Genetic Information Nondiscrimination Act 2008-US | Genomes | Genetic diversity | Research | Gene expression | Datasets | Consortia | Privacy | Ethics | Researchers | DNA methylation | Epigenetics | Social insurance numbers | Gene mapping | Deoxyribonucleic acid--DNA | Cancer | Opinion | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Reumatologi och inflammation
INDIVIDUALS | HAPMAP PROJECT | DISEASE-ASSOCIATED VARIANTS | DNA METHYLATION | 5-METHYLCYTOSINE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GENETIC DISCRIMINATION | SCIENCE | IDENTIFICATION | LIFE-INSURANCE | REIDENTIFICATION | Genetic Variation | DNA Methylation | Epigenomics | Genetic Privacy | Epigenesis, Genetic | Humans | Data Anonymization | High-Throughput Nucleotide Sequencing | Sequence Analysis, DNA | Genetic Information Nondiscrimination Act 2008-US | Genomes | Genetic diversity | Research | Gene expression | Datasets | Consortia | Privacy | Ethics | Researchers | DNA methylation | Epigenetics | Social insurance numbers | Gene mapping | Deoxyribonucleic acid--DNA | Cancer | Opinion | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Reumatologi och inflammation
Journal Article
Nature Materials, ISSN 1476-1122, 06/2015, Volume 14, Issue 6, pp. 643 - 651
The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of...
BIOCOMPATIBILITY | PHYSICS, CONDENSED MATTER | HYDROGELS | DESIGN | PHYSICS, APPLIED | ISLETS | ALGINATE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | DELIVERY | BIOMATERIALS | MICROCAPSULES | ALTERNATIVE ACTIVATION | THICKNESS | Primates | Mice | Animals | Foreign-Body Reaction - immunology | Mice, Inbred C57BL | Transplants & implants | Biomedical materials | Size | Encapsulation | Medical devices | Biocompatibility | Alginates | Devices | Foreign bodies
BIOCOMPATIBILITY | PHYSICS, CONDENSED MATTER | HYDROGELS | DESIGN | PHYSICS, APPLIED | ISLETS | ALGINATE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | DELIVERY | BIOMATERIALS | MICROCAPSULES | ALTERNATIVE ACTIVATION | THICKNESS | Primates | Mice | Animals | Foreign-Body Reaction - immunology | Mice, Inbred C57BL | Transplants & implants | Biomedical materials | Size | Encapsulation | Medical devices | Biocompatibility | Alginates | Devices | Foreign bodies
Journal Article
Nature Biotechnology, ISSN 1087-0156, 03/2016, Volume 34, Issue 3, pp. 345 - 352
The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient(1-6). There...
ACTIVATION | CONFOCAL RAMAN | ISLETS | EFFICACY | INFLAMMATORY RESPONSES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENCAPSULATION | PURIFICATION | MECHANISMS | ALGINATE-BASED MICROCAPSULES | Animals | Prostheses and Implants - adverse effects | Foreign-Body Reaction - immunology | Humans | Hydrogels - adverse effects | Primates - immunology | Foreign Bodies - immunology | Biocompatible Materials - therapeutic use | Biocompatible Materials - adverse effects | Hydrogels - therapeutic use | Macrophages - immunology | Medical equipment | Medical research | Biomedical materials | Immune response | Foreign bodies (Medical care) | Materials | Medicine, Experimental | Research | Design and construction | Identification and classification | Physiological apparatus | Hydrogels | Transplants & implants | Monkeys & apes | Immune system
ACTIVATION | CONFOCAL RAMAN | ISLETS | EFFICACY | INFLAMMATORY RESPONSES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENCAPSULATION | PURIFICATION | MECHANISMS | ALGINATE-BASED MICROCAPSULES | Animals | Prostheses and Implants - adverse effects | Foreign-Body Reaction - immunology | Humans | Hydrogels - adverse effects | Primates - immunology | Foreign Bodies - immunology | Biocompatible Materials - therapeutic use | Biocompatible Materials - adverse effects | Hydrogels - therapeutic use | Macrophages - immunology | Medical equipment | Medical research | Biomedical materials | Immune response | Foreign bodies (Medical care) | Materials | Medicine, Experimental | Research | Design and construction | Identification and classification | Physiological apparatus | Hydrogels | Transplants & implants | Monkeys & apes | Immune system
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 391 - 10
Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo...
DISEASES | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | DNA ELEMENTS | RISK | PREVALENCE | GENOME-WIDE ASSOCIATION | Haplotypes | Dendritic cells | Health risks | mRNA | Gene expression | Loci | Subgroups | Proteins | Monocytes | Vitiligo | Enhancers | Major histocompatibility complex | Histocompatibility antigen HLA | Variation | Autoimmune diseases | Age
DISEASES | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | DNA ELEMENTS | RISK | PREVALENCE | GENOME-WIDE ASSOCIATION | Haplotypes | Dendritic cells | Health risks | mRNA | Gene expression | Loci | Subgroups | Proteins | Monocytes | Vitiligo | Enhancers | Major histocompatibility complex | Histocompatibility antigen HLA | Variation | Autoimmune diseases | Age
Journal Article
Nature Materials, ISSN 1476-1122, 06/2017, Volume 16, Issue 6, pp. 671 - 680
Host recognition and immune-mediated foreign body response to biomaterials can compromise the performance of implanted medical devices. To identify key cell...
FIBROSIS | CELLS | PHYSICS, CONDENSED MATTER | ACTIVATION | PHYSICS, APPLIED | MATERIALS SCIENCE, MULTIDISCIPLINARY | ENCAPSULATION | ARTHROPLASTY | CHEMISTRY, PHYSICAL | MECHANISMS | INHIBITION | ALGINATE-BASED MICROCAPSULES | INFLAMMATORY RESPONSE | MACROPHAGE POLARIZATION | Animals | Prostheses and Implants - adverse effects | Foreign-Body Reaction - immunology | Foreign-Body Reaction - chemically induced | Foreign-Body Reaction - metabolism | Primates | Mice | Biocompatible Materials - adverse effects | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Surgical implants | Adaptive systems | Medical devices | Wound healing | Transplants & implants | Neurons | Implantation | Systems analysis | Ceramics | Macrophages | Recruitment | Biomedical materials | Immunosuppression | Rodents | Fibrosis | Healing | Biocompatibility | Inhibition | Phagocytosis
FIBROSIS | CELLS | PHYSICS, CONDENSED MATTER | ACTIVATION | PHYSICS, APPLIED | MATERIALS SCIENCE, MULTIDISCIPLINARY | ENCAPSULATION | ARTHROPLASTY | CHEMISTRY, PHYSICAL | MECHANISMS | INHIBITION | ALGINATE-BASED MICROCAPSULES | INFLAMMATORY RESPONSE | MACROPHAGE POLARIZATION | Animals | Prostheses and Implants - adverse effects | Foreign-Body Reaction - immunology | Foreign-Body Reaction - chemically induced | Foreign-Body Reaction - metabolism | Primates | Mice | Biocompatible Materials - adverse effects | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Surgical implants | Adaptive systems | Medical devices | Wound healing | Transplants & implants | Neurons | Implantation | Systems analysis | Ceramics | Macrophages | Recruitment | Biomedical materials | Immunosuppression | Rodents | Fibrosis | Healing | Biocompatibility | Inhibition | Phagocytosis
Journal Article
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6062, pp. 1565 - 1569
The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several...
Larvae | Neuroscience | Neurotransmitters | Neurons | Drosophila | REPORTS | Alleles | Genetic loci | T tests | Synapses | P branes | MULTIDISCIPLINARY SCIENCES | CA2+ CHANNELS | CACOPHONY | BRUCHPILOT | MATURATION | DROSOPHILA | SYNAPTIC CALCIUM-CHANNEL | MOLECULES | FAMILY | Carrier Proteins - physiology | Calcium Channels - physiology | Drosophila Proteins - physiology | Animals | Neurotransmitter Agents - metabolism | Male | Presynaptic Terminals - physiology | Drosophila Proteins - genetics | Mutation | Physiological aspects | Research | Protein binding | Proteins | Brain | Insects | Binding sites | Neurobiology
Larvae | Neuroscience | Neurotransmitters | Neurons | Drosophila | REPORTS | Alleles | Genetic loci | T tests | Synapses | P branes | MULTIDISCIPLINARY SCIENCES | CA2+ CHANNELS | CACOPHONY | BRUCHPILOT | MATURATION | DROSOPHILA | SYNAPTIC CALCIUM-CHANNEL | MOLECULES | FAMILY | Carrier Proteins - physiology | Calcium Channels - physiology | Drosophila Proteins - physiology | Animals | Neurotransmitter Agents - metabolism | Male | Presynaptic Terminals - physiology | Drosophila Proteins - genetics | Mutation | Physiological aspects | Research | Protein binding | Proteins | Brain | Insects | Binding sites | Neurobiology
Journal Article
Journal of Sea Research, ISSN 1385-1101, 06/2019, Volume 148-149, pp. 12 - 16
First reports on cases of grey seal predation on other marine mammals from different parts of Europe have been published in recent years, but few cases provide...
Laceration | North Sea | Cannibalism | Predation | Grey seal | Marine mammals | Wildlife conservation | Seals | Case reports | Knowledge base | Grey seals | Lesions |
Laceration | North Sea | Cannibalism | Predation | Grey seal | Marine mammals | Wildlife conservation | Seals | Case reports | Knowledge base | Grey seals | Lesions |