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1. Full Text Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial
by Gross, Robert E, Dr and Watts, Raymond L, MD and Hauser, Robert A, MD and Bakay, Roy AE, MD and Reichmann, Heinz, MD and von Kummer, Rüdiger, MD and Ondo, William G, MD and Reissig, Elke, MD and Eisner, Wilhelm, MD and Steiner-Schulze, Heike, MS and Siedentop, Harald, PhD and Fichte, Klaus, PhD and Hong, Walter, MD and Cornfeldt, Michael, PhD and Beebe, Katherine, PhD and Sandbrink, Rupert, MD and Spheramine Invest Grp and Spheramine Investigational Group
Lancet Neurology, The, ISSN 1474-4422, 2011, Volume 10, Issue 6, pp. 509 - 519
Summary Background Human retinal pigment epithelial (RPE) cells produce levodopa and their transplantation into the striatum might improve continuity of... 
Neurology | FETAL NIGRAL TRANSPLANTATION | TYROSINASE BIOSYNTHESIS | PHASE-I TRIAL | IMPLANTATION | NEUROTROPHIC FACTOR | TOLERABILITY | IMPROVEMENT | GENE-THERAPY | OPEN-LABEL | PROGRESSION | CLINICAL NEUROLOGY | Epithelial Cells - transplantation | Parkinson Disease - pathology | Epithelial Cells - metabolism | Double-Blind Method | Levodopa - therapeutic use | Humans | Middle Aged | Male | Treatment Outcome | Parkinson Disease - drug therapy | Parkinson Disease - physiopathology | Drug Carriers | Parkinson Disease - surgery | Placebos - therapeutic use | Adult | Female | Aged | Corpus Striatum - surgery | Epithelial Cells - cytology | Levodopa - metabolism | Retinal Pigment Epithelium - cytology
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2. Full Text Inhaled Iloprost for Severe Pulmonary Hypertension
by Olschewski, Horst and Simonneau, Gerald and Galiè, Nazzareno and Higenbottam, Timothy and Naeije, Robert and Rubin, Lewis J and Nikkho, Sylvia and Speich, Rudolf and Hoeper, Marius M and Behr, Jürgen and Winkler, Jörg and Sitbon, Olivier and Popov, Wladimir and Ghofrani, H. Ardeschir and Manes, Alessandra and Kiely, David G and Ewert, Ralph and Meyer, Andreas and Corris, Paul A and Delcroix, Marion and Gomez-Sanchez, Miguel and Siedentop, Harald and Seeger, Werner and Aerosolized Iloprost Randomized Study Group
The New England Journal of Medicine, ISSN 0028-4793, 08/2002, Volume 347, Issue 5, pp. 322 - 329
The number of effective, long-term treatments for pulmonary hypertension is limited. In this double-blind, randomized trial, an aerosolized form of iloprost, a... 
MEDICINE, GENERAL & INTERNAL | THERAPY | ANALOG | ARTERIAL-HYPERTENSION | AEROSOLIZED PROSTACYCLIN | NITRIC-OXIDE | DOUBLE-BLIND | EXERCISE CAPACITY | CONTINUOUS INTRAVENOUS EPOPROSTENOL | Hypertension, Pulmonary - classification | Iloprost - administration & dosage | Iloprost - adverse effects | Humans | Middle Aged | Administration, Inhalation | Hypertension, Pulmonary - physiopathology | Male | Dyspnea - etiology | Exercise Tolerance - drug effects | Walking | Dyspnea - drug therapy | Female | Hemodynamics - drug effects | Hypertension, Pulmonary - drug therapy | Vasodilator Agents - adverse effects | Vasodilator Agents - administration & dosage | Drug therapy | Pulmonary hypertension | Hypertension | Pulmonary arteries | Nitric oxide | Mortality | Hemophilia
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3. Full Text Correction
by Gerke, Oke and Siedentop, Harald
Statistics in Medicine, ISSN 0277-6715, 11/2008, Volume 27, Issue 26, pp. 5564 - 5564
‘Optimal phase I dose‐escalation trial designs in oncology—A simulation study’, by Oke Gerke and Harald Siedentop (Statistics in Medicine 2007, published... 
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4. Full Text Correction
by Gerke, Oke and Siedentop, Harald
Statistics in Medicine, ISSN 0277-6715, 11/2008, Volume 27, Issue 26, pp. 5564 - 5564
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5. Full Text Correction
by Gerke, Oke and Siedentop, Harald
Statistics in Medicine, ISSN 0277-6715, 11/2008, Volume 27, Issue 26, p. 5564
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6. Full Text Betaferon in chronic viral cardiomyopathy trial: Effects of interferon-[beta] treatment in patients with chronic viral cardiomyopathy
by Schultheiss, Heinz-Peter and Piper, Cornelia and Sowade, Olaf and Waagstein, Finn and Kapp, Joachim-Friedrich and Wegscheider, Karl and Groetzbach, Georg and Pauschinger, Matthias and Escher, Felicitas and Arbustini, Eloisa and Siedentop, Harald and Kuehl, Uwe
Clinical Research in Cardiology, ISSN 1861-0684, 09/2016, Volume 105, Issue 9, p. 763
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00392-016-0986-9 Chronic... 
Heart failure | Care and treatment | Cardiomyopathy | Analysis | Cardiac patients | Interferon beta | Clinical trials | Biological response modifiers | Cardiology | Health aspects | Heart diseases
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7. Full Text Optimal phase I dose‐escalation trial designs in oncology—A simulation study
by Gerke, Oke and Siedentop, Harald
Statistics in Medicine, ISSN 0277-6715, 11/2008, Volume 27, Issue 26, pp. 5329 - 5344
In phase I oncology trials conducted over the past few decades, the maximum tolerated dose (MTD) has usually been estimated by the traditional escalation rule... 
clinical trial | dose finding | phase I | maximum tolerated dose | Bayesian ADEPT | oncology | Clinical trial | Oncology | Maximum tolerated dose | Phase I | Dose finding | MEDICINE, RESEARCH & EXPERIMENTAL | MEDICAL INFORMATICS | CONTINUAL REASSESSMENT METHOD | STATISTICS & PROBABILITY | CANCER | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CLINICAL-TRIALS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Dose-Response Relationship, Drug | Medical Oncology - methods | Maximum Tolerated Dose | Antineoplastic Agents - adverse effects | Computer Simulation | Humans | Bayes Theorem | Clinical Trials, Phase I as Topic - methods | Antineoplastic Agents - administration & dosage | Models, Statistical | Research Design
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8. Full Text Betaferon in chronic viral cardiomyopathy (BICC) trial: Effects of interferon-β treatment in patients with chronic viral cardiomyopathy
by Schultheiss, Heinz-Peter and Piper, Cornelia and Sowade, Olaf and Waagstein, Finn and Kapp, Joachim-Friedrich and Wegscheider, Karl and Groetzbach, Georg and Pauschinger, Matthias and Escher, Felicitas and Arbustini, Eloisa and Siedentop, Harald and Kuehl, Uwe
Clinical Research in Cardiology, ISSN 1861-0684, 9/2016, Volume 105, Issue 9, pp. 763 - 773
Chronic viral infections of the heart are considered one antecedent event leading to progressive dysfunction of the myocardium, often with an impaired... 
Chronic viral cardiomyopathy | Medicine & Public Health | Antiviral therapy, myocardial biopsies | Cardiology | Interferon beta | CARDIAC & CARDIOVASCULAR SYSTEMS | ENTEROVIRAL RNA | PERSISTENCE | VENTRICULAR ENDOMYOCARDIAL BIOPSY | MYOCARDITIS | B19 | DILATED CARDIOMYOPATHY | PREVALENCE | PATHOGENESIS | INFECTION | DYSFUNCTION | Adenoviridae Infections - drug therapy | Adenoviridae Infections - virology | Humans | Middle Aged | Male | Enterovirus Infections - physiopathology | Recovery of Function | Viral Load | Cardiomyopathies - physiopathology | Adenoviridae Infections - physiopathology | Enterovirus Infections - virology | Erythema Infectiosum - physiopathology | Time Factors | Cardiomyopathies - diagnosis | Erythema Infectiosum - diagnosis | Adult | Female | Erythema Infectiosum - virology | Cardiomyopathies - drug therapy | Enterovirus Infections - drug therapy | Enterovirus Infections - diagnosis | Double-Blind Method | Antiviral Agents - therapeutic use | Europe | Treatment Outcome | Erythema Infectiosum - drug therapy | Adenoviridae Infections - diagnosis | Interferon beta-1b - adverse effects | Cardiomyopathies - virology | Biopsy | Antiviral Agents - adverse effects | Interferon beta-1b - therapeutic use | Quality of Life | Aged | Chronic Disease
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9. Full Text Authors' rejoinder to ‘Dose‐escalation designs in oncology: ADEPT and the CRM’
by Gerke, Oke and Siedentop, Harald
Statistics in Medicine, ISSN 0277-6715, 11/2008, Volume 27, Issue 26, pp. 5354 - 5355
MEDICINE, RESEARCH & EXPERIMENTAL | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MEDICAL INFORMATICS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | STATISTICS & PROBABILITY | I CLINICAL-TRIALS | CANCER
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10. Full Text Optimal dose de-escalation trial designs for novel contraceptives in women
by Gerlinger, Christoph and Siedentop, Harald and Gerke, Oke and Schellschmidt, Ilka and Endrikat, Jan
Computational Statistics and Data Analysis, ISSN 0167-9473, 05/2012, Volume 56, Issue 5, pp. 1061 - 1068
Dose finding for classical hormonal contraceptives for women is usually done by investigating the surrogate endpoint inhibition of ovulation. For novel... 
Pearl Index | Dose finding | Continual reassessment method | Contraception | Group-sequential design | 3+3 design | Dose de-escalation | DOWN DESIGNS | STATISTICS & PROBABILITY | I CLINICAL-TRIALS | LATE-ONSET TOXICITIES | CANCER | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | Group-sequential design Dose de-escalation Dose finding Contraception Pearl Index Continual reassessment method 3+3 design | Oral contraceptives | Contraceptives | Pregnancy | Design engineering | Ethics | Effectiveness | Light-emitting diodes | Statistics | Cancer
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11. Full Text Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial
by Brose, Marcia S and Nutting, Christopher and Jarzab, Barbara and Elisei, Rossella and Siena, Salvatore and Bastholt, Lars and de la Fouchardiere, Christelle and Pacini, Furio and Paschke, Ralf and Shong, Young Kee and Sherman, Steven I and Smit, Johannes WA and Chung, John Woojune and Siedentop, Harald and Molnar, Istvan and Schlumberger, Martin
Journal of Clinical Oncology, ISSN 0732-183X, 06/2013, Volume 31, Issue 18_suppl, pp. 4 - 4
4 Background: Sorafenib, an orally active inhibitor of VEGFR1-3 and Raf kinases, has shown promising clinical activity in single-arm phase II studies in... 
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12. Full Text Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/v1a receptor blockade in a preclinical heart failure model
by Mondritzki, Thomas and Kolkhof, Peter and Sabbah, Hani N and Gheorghiade, Mihai and Fürstner, Chantal and Schmeck, Carsten and Siedentop, Harald and Schaefer, Stefan and Truebel, Hubert
American Journal of Therapeutics, ISSN 1075-2765, 01/2011, Volume 18, Issue 1, pp. 31 - 37
Arginine vasopressin (AVP) is increased in patients with heart failure (HF). Its actions are linked to free water reabsorption (V2-) and arteriolar... 
heart failure | pharmacology | vasopressin | CONIVAPTAN | V-1A | TRIAL | ORAL TOLVAPTAN | DOGS | PHARMACOLOGY & PHARMACY | Arginine Vasopressin - antagonists & inhibitors | Cardiac Output - drug effects | Urodynamics - drug effects | Benzazepines - pharmacology | Cardiac Pacing, Artificial | Arginine Vasopressin - pharmacology | Pacemaker, Artificial | Heart Failure - drug therapy | Animals | Benzazepines - therapeutic use | Dogs | Vascular Resistance - drug effects | Blood Pressure - drug effects | Hemodynamics - drug effects | Antidiuretic Hormone Receptor Antagonists
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13. Full Text Computer-Assisted Quantitative Analysis of Bone Marrow Edema of the Knee: Initial Experience with a New Method
by Mayerhoefer, Marius E and Breitenseher, Martin and Hofmann, Siegfried and Aigner, Nicolas and Meizer, Roland and Siedentop, Harald and Kramer, Josef
American Journal of Roentgenology, ISSN 0361-803X, 06/2004, Volume 182, Issue 6, pp. 1399 - 1403
OBJECTIVE. The purpose of this study was to describe a largely observer-independent computer-assisted method for accurate quantitative analysis of bone marrow... 
MRI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Bone Marrow Diseases - diagnosis | Knee Joint | Humans | Magnetic Resonance Imaging - statistics & numerical data | Diagnosis, Computer-Assisted - statistics & numerical data | Observer Variation | Edema - diagnosis
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14. Full Text MRI-Demonstrated Outcome of Subchondral Stress Fractures of the Knee After Treatment with Iloprost or Tramadol: Observations in 14 Patients
by Mayerhoefer, Marius E and Kramer, Josef and Breitenseher, Martin J and Norden, Cornelia and Vakil-Adli, Anosheh and Hofmann, Siegfried and Meizer, Roland and Siedentop, Harald and Landsiedl, Franz and Aigner, Nicolas
Clinical Journal of Sport Medicine, ISSN 1050-642X, 07/2008, Volume 18, Issue 4, pp. 358 - 362
OBJECTIVE:To investigate the outcome of subchondral stress fractures (SSF) of the knee after treatment with the prostacyclin analogue Iloprost or the opioid... 
Knee | Bone marrow | Stress fractures | Iloprost | Magnetic resonance imaging | SPORT SCIENCES | magnetic resonance imaging | PHYSIOLOGY | ANALOG | stress fractures | SPONTANEOUS OSTEONECROSIS | bone marrow | knee | TIBIAL PLATEAU | BONE-MARROW EDEMA | FEMORAL CONDYLE | ORTHOPEDICS | Double-Blind Method | Vasodilator Agents - therapeutic use | Humans | Middle Aged | Knee Injuries - drug therapy | Analgesics, Opioid - therapeutic use | Male | Treatment Outcome | Tramadol - therapeutic use | Magnetic Resonance Imaging | Fracture Healing - drug effects | Knee Injuries - pathology | Fractures, Stress - pathology | Adult | Female | Iloprost - therapeutic use | Aged | Retrospective Studies | Drug Therapy, Combination | Fractures, Stress - drug therapy
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15. Full Text Medizinische und okonomische aspekte einer fruhzeitigen mikrobiologischen diagnose bei patienten mit schweren infektionen
by Siedentop, Harald and Rychlik, Reinhard
Medizinische Klinik, ISSN 0723-5003, 11/1999, Volume 94, Issue 11, pp. 603 - 608
Cost-effectiveness analysis | Sensitivity analysis | RAST | ONAST
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16. Einsatz statistischer Verfahren bei Benchmarkingprozessen in der Versorgungsforschung ein methodischer Beitrag zur Analyse von Registerdaten
by Siedentop, Harald
Berlin, Techn. Universiẗat, Diss., 2008. 
Dissertation
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17. Full Text Rezensionen
by Siedentop, Stefan and Döring, Ralf and Weiland, Ulrike and Oppermann, Betinna and Rosenfeld, Martin T. W
7/2008, Volume 66, Issue 4
Geography | Landscape/Regional and Urban Planning | Environmental Law/Policy/Ecojustice
Book Review
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