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Acta Pharmaceutica Sinica B, ISSN 2211-3835, 11/2015, Volume 5, Issue 6, pp. 506 - 519
Cysteine proteases continue to provide validated targets for treatment of human diseases. In neurodegenerative disorders, multiple cysteine proteases provide... 
Calpain | Cathepsin | Enzyme inhibitors | Cysteine protease | Neurodegeneration | Alzheimer's disease | BETA-SECRETASE | ALZHEIMERS-DISEASE | FOCAL CEREBRAL-ISCHEMIA | AMYLOID PRECURSOR PROTEIN | TRAUMATIC BRAIN-INJURY | PEPTIDE-BIPHENYL HYBRIDS | AFFINITY LABEL CONCEPT | IN-VIVO | PHARMACOLOGY & PHARMACY | SPINAL-CORD-INJURY | TRANSGENIC MOUSE MODEL | APP | AppLon, London familial amyloid precursor protein mutation, APP (V717I) | NFT, neurofibrilliary tangles | Ile, isoleucine | Arg, arginine | Lys, lysine | Gln, glutamine | Thr, threonine | AppSwe, Swedish amyloid precursor protein mutation, APP (K670N | Gly, glutamine | ERK1 | PD, Parkinson׳s disease | MMP-9, matrix metalloproteinase 9 | Tyr, tyrosine | WT, wildtype | WRX, Trp-Arg containing epoxysuccinate cysteine protease inhibitor | TNF, tumor necrosis factor | SP, senile plaques | Alzheimer׳s disease | PS1, Aβ overexpressing mice APP (K670N | EGFR, epidermal growth factor receptor | pGlu, pyroglutamate | p35, activator of cyclin-dependent kinase 5 | AD, Alzheimer׳s disease | CaMKII, Ca2 | KO, knockout | PK, pharmacokinetic | Phe, phenylalanine | Aβ, amyloid β | TBI, traumatic brain injury | calmodulin-dependent protein kinases II | DTT, dithioerythritol | APP, amyloid precursor protein | isoAsp, isoaspartate | Glu, glutamic acid | Leu, leucine | GSH, glutathione | PTP1B, protein-tyrosine phosphatase 1B | Review | ALS, amyotrophic lateral sclerosis | CREB, cyclic adenosine monophosphate response element binding protein | 2, extracellular signal-regulated kinase 1 | MAP-2, microtubule-associated protein 2 | M671L) and PS1 (M146L) mutants | Nle, norleucine | CANP, calcium-activated neutral protease | Hsp70.1, heat shock protein 70.1 | Met, methionine | BACE-1, β-amyloid cleaving enzyme | M671L | Aβ1-42, amyloid β, 42 amino acid protein | PKC, protein kinase C | BBB, blood–brain barrier | Pro, proline | CNS, central nervous system | Val, valine | Cdk5 | pyroGluAβ, pyroglutamate-amyloid β | Ala, alanine
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 4497 - 4497
Journal Article
Immunology Letters, ISSN 0165-2478, 2012, Volume 148, Issue 1, pp. 34 - 38
Journal Article
ChemMedChem, ISSN 1860-7179, 03/2014, Volume 9, Issue 3, pp. 413 - 413
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3639 - 3647
In breast tumors, activation of the nuclear factor κB (NFκB) pathway promotes survival, migration, invasion, angiogenesis, stem cell-like properties, and... 
Transcription Factor RelA - antagonists & inhibitors | Neoplastic Stem Cells - drug effects | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Neoplasm Proteins - metabolism | Transcription Factor RelA - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Breast Neoplasms - metabolism | Dimethyl Fumarate - pharmacology | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | NF-kappa B - antagonists & inhibitors | Dimethyl Fumarate - chemistry | Cysteine - chemistry | Random Allocation | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | NF-kappa B - genetics | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Tumor Burden - drug effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Breast Neoplasms - pathology | Dimethyl Fumarate - therapeutic use | Mice, Nude | Active Transport, Cell Nucleus - drug effects | Cell Line, Tumor | Genes, Reporter - drug effects | Cell Proliferation - drug effects | Molecular Bases of Disease | inhibitor | NFκB | covalent modification | inflammation | drug action | cysteine | breast cancer | dimethyl fumarate | mammosphere | chemical modification
Journal Article
ChemMedChem, ISSN 1860-7179, 03/2014, Volume 9, Issue 3, pp. 602 - 613
Breast cancer remains a significant cause of death in women, and few therapeutic options exist for estrogen receptor negative (ER (−)) cancers. Epigenetic... 
breast cancer | histone deacetylases | HDAC inhibitors | SERMs | estrogen receptors | CELLS | TRANSCRIPTIONAL ACTIVITY | CHEMISTRY, MEDICINAL | ANTIESTROGENS | MODULATORS | TAMOXIFEN | POTENT | ESTROGEN-RECEPTOR-ALPHA | GENE-EXPRESSION | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | Selective Estrogen Receptor Modulators - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Selective Estrogen Receptor Modulators - chemistry | Histone Deacetylases - metabolism | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | Breast Neoplasms - drug therapy | Dose-Response Relationship, Drug | Breast Neoplasms - enzymology | Histone Deacetylase Inhibitors - chemical synthesis | MCF-7 Cells | Breast Neoplasms - pathology | Isoenzymes - metabolism | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Death - drug effects | Selective Estrogen Receptor Modulators - pharmacology | Isoenzymes - antagonists & inhibitors | Drug Screening Assays, Antitumor | Antimitotic agents | Care and treatment | Estrogen | Drugstores | Breast cancer | Antineoplastic agents | Health aspects | Cancer | HDAC inhibitor | SERM | estrogen receptor | histone deacetylase
Journal Article
Journal of Polymer Science, Part A: Polymer Chemistry, ISSN 0887-624X, 09/2011, Volume 49, Issue 17, pp. 3688 - 3699
Journal Article
Hormones and Cancer, ISSN 1868-8497, 06/2017, Volume 8, Issue 3, p. 135
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12672-017-0294-5 Nearly... 
Usage | Care and treatment | Receptors | Hormone therapy | Estrogen | Breast cancer | Research | Drug therapy | Risk factors | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 619 - 619
Journal Article
Cancer Prevention Research, ISSN 1940-6207, 2014, Volume 7, Issue 5, pp. 505 - 515
Journal Article
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2015, Volume 49, Issue 3, pp. 707 - 721
Journal Article
BMC Pharmacology and Toxicology, ISSN 2050-6511, 08/2013, Volume 14, Issue S1, pp. P65 - P65
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 10/2015, Volume 49, Issue 3, pp. 707 - 721
Journal Article
01/2015, ISBN 1339594021
Epoxysuccinates have shown promising activity as irreversible inhibitors of calpain and cathepsin in indications from cancer to Alzheimer’s disease (AD). Their... 
Organic chemistry
Dissertation
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