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The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10104, pp. 1758 - 1768
Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration. In preclinical testing,... 
MIGLUSTAT THERAPY | STORAGE | MEDICINE, GENERAL & INTERNAL | HEPATOCELLULAR-CARCINOMA | CHOLESTEROL | BIOMARKER | CYCLODEXTRIN | CALBINDIN-D | PATIENT | BRAIN | CHILDREN | Injections, Spinal | Niemann-Pick Disease, Type C - drug therapy | 2-Hydroxypropyl-beta-cyclodextrin - adverse effects | Humans | Rare Diseases - drug therapy | Hearing Loss, High-Frequency - chemically induced | Child, Preschool | Niemann-Pick Disease, Type C - cerebrospinal fluid | Fatty Acid Binding Protein 3 - cerebrospinal fluid | Male | Biomarkers - blood | Hydroxycholesterols - cerebrospinal fluid | 2-Hydroxypropyl-beta-cyclodextrin - administration & dosage | Disease Progression | Dose-Response Relationship, Drug | Young Adult | Adolescent | Calbindins - cerebrospinal fluid | Female | Hydroxycholesterols - blood | Biomarkers - cerebrospinal fluid | Niemann-Pick Disease, Type C - blood | Child | Niemann-Pick disease | Medical research | Genetic disorders | Research & development--R&D | Clinical trials | Patients | Cholesterol | Studies | Cyclodextrin | Neurodegeneration | Biomarkers | Drug therapy | Drug dosages | Cerebellum | Slopes | Regulatory agencies | Animal models | Medical services | Childrens health | Hepatocellular carcinoma | Cognition | Cyclodextrins | Cerebrospinal fluid | Dosage | Proteins | Randomization | Npc1 protein | Bioindicators | Safety | Age | Health | FDA approval | Hearing loss | Domains | Medical centres | Life span | Hearing aids | Mastoiditis | Ototoxicity
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 13, pp. 1423 - 1423
  Methods Patients admitted with acute decompensated HF performed a 10-second Valsalva maneuver standardized at 20 mmHg while photoplethysmography waveforms... 
Cardiovascular | Internal Medicine | Heart failure | Cardiac arrhythmia
Journal Article
Journal of surgical education, ISSN 1931-7204, 12/2019
As the competitiveness of matching to an orthopedic residency continues to increase, applicants attempt to bolster their application by participating in... 
Journal Article
Journal Article
Journal for Research in Mathematics Education, ISSN 0021-8251, 2016, Volume 47, Issue 2, p. 199
Journal Article
The American Journal of Medicine, ISSN 0002-9343, 01/2014, Volume 127, Issue 1, p. S1
  An abstract of a study by Bakris et al examining gout and hyperuricemia management is presented. Patients with gout often have multiple comorbidities, and... 
Comorbidity | Medical treatment | Rheumatism | Disease management
Journal Article
American Journal of Human Genetics, ISSN 0002-9297, 11/2012, Volume 91, Issue 5, p. 890
  Deletions involving the Y chromosome's AZFc region are the most common known genetic cause of severe spermatogenic failure (SSF). Six recurrent interstitial... 
Men | Chromosomes | Population genetics | Risk factors
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 02/2014, Volume 14, Issue 3, pp. 330 - 339
In 2010, the National Institutes of Health (NIH) established the Therapeutics for Rare and Neglected Diseases (TRND) program within the National Center for... 
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2007, Volume 47, Issue 12, pp. 1476 - 1488
This was a double‐blind, placebo‐controlled, randomized, 5‐period crossover study in 49 healthy subjects with a history of light (occasional) recreational... 
abuse | pharmacodynamics | amphetamine | pharmacokinetics | osmotic | extended release | Methylphenidate | Extended release | Pharmacodynamics | Amphetamine | Abuse | Osmotic | Pharmacokinetics | methylphenidate | METHAMPHETAMINE | BINGE COCAINE | LIABILITY ASSESSMENT | INTRAVENOUS COCAINE | INVESTIGATING DRUG REINFORCEMENT | DOPAMINE | PHARMACOLOGY & PHARMACY | ACUTE TOLERANCE | D-AMPHETAMINE | MULTIPLE-CHOICE PROCEDURE | BRAIN | Area Under Curve | Humans | Middle Aged | Amphetamine - administration & dosage | Half-Life | Male | Osmosis | Chromatography, High Pressure Liquid | Syncope, Vasovagal - chemically induced | Delayed-Action Preparations - administration & dosage | Dose-Response Relationship, Drug | Central Nervous System Stimulants - adverse effects | Delayed-Action Preparations - pharmacokinetics | Adult | Female | Methylphenidate - administration & dosage | Substance-Related Disorders - metabolism | Double-Blind Method | Administration, Oral | Substance-Related Disorders - physiopathology | Cross-Over Studies | Central Nervous System Stimulants - pharmacokinetics | Delayed-Action Preparations - adverse effects | Methylphenidate - pharmacokinetics | Adolescent | Methylphenidate - blood | Central Nervous System Stimulants - administration & dosage | Drugs | Drug delivery systems | Dosage and administration | Research | Methylphenidate hydrochloride | Health aspects | Vehicles
Journal Article
Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2007, Volume 47, Issue 12, pp. 1476 - 1488
This was a double-blind, placebo-controlled, randomized, 5-period crossover study in 49 healthy subjects with a history of light (occasional) recreational... 
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 2004, Volume 97, Issue 6, pp. 2395 - 2397
Journal Article
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