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Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 364 - 370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of g-secretase inhibitors (GSIs) that... 
NOTCH1 | INHIBITION | CHROMATIN | PATHWAY | GENES | GENETICS & HEREDITY | C-MYC | ACUTE MYELOID-LEUKEMIA | CANCER | LENTIVIRAL RNAI LIBRARY | GENOME | Chromatin - metabolism | Humans | Flow Cytometry | Chromatin Immunoprecipitation | Gene Expression Regulation, Neoplastic - drug effects | Indoles | Nuclear Proteins - genetics | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Enzyme-Linked Immunosorbent Assay | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | Enzyme Inhibitors - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Epigenesis, Genetic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Histones - metabolism | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Chromatin - genetics | Care and treatment | Pharmacology, Experimental | Acute lymphocytic leukemia | Research | Drug resistance | Proteins | Genotype & phenotype | Leukemia | Epigenetics | Genomes | Kinases | Gene expression | Cancer therapies | Index Medicus
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Nature Genetics, ISSN 1061-4036, 08/2010, Volume 42, Issue 8, pp. 715 - 721
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Nature, ISSN 0028-0836, 11/2009, Volume 462, Issue 7269, pp. 108 - 112
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2009, Volume 106, Issue 6, pp. 1826 - 1831
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by McDonald, E. Robert and de Weck, Antoine and Schlabach, Michael R and Billy, Eric and Mavrakis, Konstantinos J and Hoffman, Gregory R and Belur, Dhiren and Castelletti, Deborah and Frias, Elizabeth and Gampa, Kalyani and Golji, Javad and Kao, Iris and Li, Li and Megel, Philippe and Perkins, Thomas A and Ramadan, Nadire and Ruddy, David A and Silver, Serena J and Sovath, Sosathya and Stump, Mark and Weber, Odile and Widmer, Roland and Yu, Jianjun and Yu, Kristine and Yue, Yingzi and Abramowski, Dorothee and Ackley, Elizabeth and Barrett, Rosemary and Berger, Joel and Bernard, Julie L and Billig, Rebecca and Brachmann, Saskia M and Buxton, Frank and Caothien, Roger and Caushi, Justina X and Chung, Franklin S and Cortés-Cros, Marta and deBeaumont, Rosalie S and Delaunay, Clara and Desplat, Aurore and Duong, William and Dwoske, Donald A and Eldridge, Richard S and Farsidjani, Ali and Feng, JiaJia and Feng, Fei and Flemming, Daisy and Forrester, William and Galli, Giorgio G and Gao, Zhenhai and Gauter, François and Gibaja, Veronica and Haas, Kristy and Hattenberger, Marc and Hood, Tami and Hurov, Kristen E and Jagani, Zainab and Jenal, Mathias and Johnson, Jennifer A and Jones, Michael D and Kapoor, Avnish and Korn, Joshua and Liu, Jilin and Liu, Shumei and Liu, Qiumei and Liu, Yue and Loo, Alice T and Macchi, Kaitlin J and Martin, Typhaine and McAllister, Gregory and Meyer, Amandine and Mollé, Sandra and Pagliarini, Raymond A and Phadke, Tanushree and Repko, Brian and Schouwey, Tanja and Shanahan, Frances and Shen, Qiong and Stamm, Christelle and Stephan, Christine and Stucke, Volker M and Tiedt, Ralph and Varadarajan, Malini and Venkatesan, Kavitha and Vitari, Alberto C and Wallroth, Marco and Weiler, Jan and Zhang, Jing and Mickanin, Craig and Myer, Vic E and Porter, Jeffery A and Lai, Albert and Bitter, Hans and Lees, Emma and Keen, Nicholas and Kauffmann, Audrey and Stegmeier, Frank and Hofmann, Francesco and Schmelzle, Tobias and Sellers, William R
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 3, pp. 577 - 592.e10
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Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2723 - 2735
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Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9727, pp. 1695 - 1703
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