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phagocytosis (44) 44
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 47, p. E11120
Journal Article
Journal Article
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 5/2018, Volume 55, Issue 5, pp. 4320 - 4332
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1590 - 9
Phosphatidylserine externalization is an early molecular signature for apoptosis. In many retinal degenerative diseases, photoreceptor neurons die by... 
DYSTROPHY | MULTIDISCIPLINARY SCIENCES | INFRARED ZINC(II)-DIPICOLYLAMINE PROBE | MICE | DEATH | CELL APOPTOSIS | PIGMENT-EPITHELIUM | DAMAGE | DEGENERATION | Retinal degeneration | Retina | Photoreceptors | Cell death | Phosphatidylserine | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/1997, Volume 94, Issue 24, pp. 12932 - 12937
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/1997, Volume 94, Issue 24, pp. 12932 - 12937
Phagocytosis of shed photoreceptor rod outer segments (ROS) by the retinal pigment epithelium (RPE) is essential for retinal function. Here, we demonstrate... 
Phagocytes | Receptors | Internalization | Cell lines | Antibodies | Fluorescence | Fluorescent antibody techniques | Photoreceptors | Phagocytosis | Integrins | APOPTOSIS | ATTACHMENT | PROTEIN | RAT | DYSTROPHY | INGESTION | MULTIDISCIPLINARY SCIENCES | INTEGRIN-ALPHA-V-BETA-5 | CD36 | EXPRESSION | VITRONECTIN RECEPTOR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2007, Volume 104, Issue 29, pp. 12005 - 12010
The integrin receptor αvβ5 controls two independent forms of interactions of the retinal pigment epithelium (RPE) with adjacent photoreceptor outer segments... 
Receptors | Retinal pigments | Phagosomes | Retina | Ligands | Photoreceptors | Immunoblotting | Adhesion | Phagocytosis | Integrins | Outer segment | Circadian rhythm | Retinal pigment epithelium | photoreceptors | outer segment | Biological Sciences | adhesion | retinal pigment epithelium | circadian rhythm
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2012, Volume 109, Issue 21, p. 8145
In the mammalian retina, life-long renewal of light-sensitive photoreceptor outer segments (POS) involves circadian shedding of distal rod POS tips and their... 
Plasma | Rodents | Fluorescence | Retina | Lipids
Journal Article
Stem Cell Reports, ISSN 2213-6711, 03/2018, Volume 10, Issue 3, pp. 1075 - 1087
With stem cell-derived retinal pigment epithelial (RPE) replacement therapies in clinical testing, establishing potency of RPE prior to transplantation is... 
phagocytosis | F-actin | adult RPE stem cells | cytoskeleton | RPE | retinal pigment epithelium | RhoA/ROCK | stress fibers | ROD OUTER SEGMENTS | MFG-E8 | RAT | ALPHA-V-BETA-5 INTEGRIN | PROLIFERATION | FOCAL ADHESION KINASE | LIGAND | BINDING | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
Nature Communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, p. 12832
Retinitis pigmentosa (RP) is a blinding disease often associated with mutations in rhodopsin, a light-sensing G protein-coupled receptor and phospholipid... 
TRANSDUCIN | FLIP-FLOP | ACTIVATION | BOVINE RHODOPSIN | FLUORESCENCE | GENE | PROTEIN-COUPLED RECEPTOR | MEMBRANE | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL RECONSTITUTION | MUTATIONS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24770 - 24780
Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are characteristic age-related changes of post-mitotic retinal pigment... 
LIPOFUSCIN FLUOROPHORE | RAT | DYSTROPHY | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | COMPONENT | RPE CELLS | N-RETINYLIDENE ETHANOLAMINE | BINDING | PHOTORECEPTORS | Retinoids - metabolism | Epithelial Cells - metabolism | Lipofuscin - pharmacology | Antioxidants - metabolism | Humans | Lysosomes - genetics | Rats, Long-Evans | Adenosine Triphosphate - genetics | Phagocytosis - genetics | Membrane Potential, Mitochondrial - drug effects | Mitosis - genetics | Oxidative Phosphorylation - drug effects | DNA, Mitochondrial - genetics | Lysosomes - metabolism | Aging - genetics | Cell Death - genetics | Mitochondria - genetics | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial - genetics | Pyruvic Acid - metabolism | Lysosomes - pathology | Cell Death - drug effects | Cell Line | Phagocytosis - drug effects | DNA, Mitochondrial - metabolism | Rats | Epithelial Cells - pathology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - pathology | Aging - pathology | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Point Mutation | Pyridinium Compounds - pharmacology | Animals | Mitosis - drug effects | Macular Degeneration - genetics | Glucose - metabolism | Pigment Epithelium of Eye - pathology | Pyridinium Compounds - metabolism | Lipofuscin - metabolism | Retinoids - pharmacology | Aging - metabolism | Macular Degeneration - pathology | Index Medicus | Molecular Basis of Cell and Developmental Biology
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0166348
Complement dysregulation plays a key role in the pathogenesis of age-related macular degeneration (AMD), but the specific mechanisms are incompletely... 
COMPLEMENT REGULATORY PROTEINS | FACTOR-H DEFICIENCY | CHELATOR DEFERIPRONE PROTECTS | OXIDATIVE STRESS | PIGMENT EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | DECAY-ACCELERATING FACTOR | MACULAR DEGENERATION | FUNCTIONAL-CHARACTERIZATION | PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA | CHOROIDAL NEOVASCULARIZATION | Retinaldehyde - analysis | Retina - metabolism | Up-Regulation - radiation effects | Ependymoglial Cells - metabolism | Male | Nerve Growth Factors - metabolism | RNA, Messenger - metabolism | Rhodopsin - metabolism | Retinal Degeneration - metabolism | Phagocytosis - radiation effects | Heat-Shock Proteins - genetics | Neuroglia - cytology | Photoreceptor Cells, Vertebrate - radiation effects | Light | Cytokines - genetics | Disease Models, Animal | Electroretinography | Cytokines - metabolism | Eye Enucleation | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | CD59 Antigens - genetics | Mice, Knockout | Endoplasmic Reticulum Stress - radiation effects | Neuroglia - radiation effects | Retina - diagnostic imaging | Animals | Rhodopsin - genetics | Nerve Growth Factors - genetics | Neuroglia - metabolism | Mice | Mice, Inbred BALB C | CD59 Antigens - metabolism | Photoreceptor Cells, Vertebrate - metabolism | Retinal Degeneration - pathology | Retinal Degeneration - veterinary | Microscopy, Fluorescence | Animal experimentation | Rhodopsin | RNA | Research | Gene expression | Macular degeneration | Prevention | Analysis | Physiological aspects | Photoreceptors | Diagnosis | Comparative analysis | Health aspects | Oxidative stress | Model testing | Complement inhibitors | Laboratories | Pathogenesis | Retina | Complement | Proteins | Cell activation | Rodents | Damage | Growth factors | Age | Euthanasia | Damage assessment | Genetic disorders | Glial fibrillary acidic protein | Neurotrophic factors | Electroretinograms | Medicine | Retinal degeneration | Endoplasmic reticulum | Preconditioning | Structure-function relationships
Journal Article
Journal Article
Experimental Eye Research, ISSN 0014-4835, 09/2014, Volume 126, pp. 51 - 60
RPE cells are the most actively phagocytic cells in the human body. In the eye, RPE cells face rod and cone photoreceptor outer segments at all times but... 
engulfment | phagocytosis |