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CANCER RESEARCH, ISSN 0008-5472, 05/2017, Volume 77, Issue 10, pp. 2607 - 2619
Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One... 
HEAD | RESPONSES | ONCOLOGY | IMMUNE SUPPRESSION | REGULATORY T-CELLS | PI3K-GAMMA | BLOCKADE | EXPRESSION | CARCINOMA | NECK-CANCER | TUMOR MICROENVIRONMENT | Neoplasms - metabolism | Immunomodulation - drug effects | Myeloid-Derived Suppressor Cells - drug effects | Lymphocyte Activation - immunology | Isoquinolines - pharmacology | Lymphocytes, Tumor-Infiltrating - metabolism | Antineoplastic Agents - pharmacology | Epitopes, T-Lymphocyte - immunology | Myeloid-Derived Suppressor Cells - metabolism | Disease Models, Animal | Myeloid-Derived Suppressor Cells - immunology | Purines - pharmacology | Antibodies, Monoclonal - pharmacology | Lymphocytes, Tumor-Infiltrating - drug effects | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Neoplasms - drug therapy | Tumor Microenvironment - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Lymphocyte Activation - drug effects | Neoplasms - immunology | Survival Analysis | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Lymphocytes, Tumor-Infiltrating - immunology | Cell culture | Myeloid cells | Effectiveness | Cell survival | CD8 antigen | Effector cells | Lymphocytes T | Inflammation | Suppressor cells | Recruitment | Immunosuppression | Inhibitors | Immune checkpoint | Lymphocytes | PD-L1 protein | Isoforms | Head and neck | Neck | Head & neck cancer | Inhibition | Cancer | Immune system | immunosuppression | MDSC | IPI-145 | PI3K | head and neck cancer
Journal Article
Cancer Research, ISSN 0008-5472, 05/2017, Volume 77, Issue 10, pp. 2607 - 2619
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14_Supplement, pp. 1477 - 1477
BACKGROUND: IPI-145 (duvelisib) is an oral inhibitor of the p110 isoforms of phosphinositide 3-kinase (PI3K) that are differentially expressed in leukocytes.... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 1477 - 1477
Journal Article
by Zurnic, Irena and Hütter, Sylvia and Lehmann, Ute and Stanke, Nicole and Reh, Juliane and Kern, Tobias and Lindel, Fabian and Gerresheim, Gesche and Hamann, Martin and Müllers, Erik and Lesbats, Paul and Cherepanov, Peter and Serrao, Erik and Engelman, Alan and Lindemann, Dirk and Da Silva Santos, Claire and Tartour, Kevin and Cimarelli, Andrea and Burdick, Rya and Chen, Jianbo and Sastri, Jaya and Hu, Wei-Shau and Pathak, Vinay and Keppler, Oliver T and Pradeau, Karine and Eiler, Sylvia and Levy, Nicolas and Lennon, Sarah and Cianferani, Sarah and Emiliani, Stéphane and Ruff, Marc and Parissi, Vincent and Rato, Sylvie and Rausell, Antonio and Munoz, Miguel and Telenti, Amalio and Ciuffi, Angela and Zhyvoloup, Alexander and Melamed, Anat and Anderson, Ian and Planas, Delphine and Kriston-Vizi, Janos and Ketteler, Robin and Lee, Chen- Hsuin and Merritt, Andy and Ancuta, Petronela and Bangham, Charles and Fassati, Ariberto and Rodari, Anthony and Van Driessche, Benoit and Galais, Mathilde and Delacourt, Nadége and Fauquenoy, Sylvain and Vanhulle, Caroline and Kula, Anna and Burny, Arsène and Rohr, Olivier and Van Lint, Carine and van Montfort, Thijs and van der Sluis, Renee and Speijer, Dave and Berkhout, Ben and Meng, Bo and Rutkowski, Andrzej and Berry, Neil and Dölken, Lars and Lever, Andrew and Schuster, Thomas and Asbach, Benedikt and Wagner, Ralf and Gross, Christine and Wiesmann, Veit and Kalmer, Martina and Wittenberg, Thomas and Gettemans, Jan and Thoma-Kress, Andrea K and Li, Minghua and Freed, Eric O and Liu, Shan-Lu and Müller, Janis and Münch, Jan and Sewald, Xaver and Uchil, Pradeep and Ladinsky, Mark and Beloor, Jagadish and Pi, Ruoxi and Herrmann, Christin and Motamedi, Nasim and Murooka, Thomas and Brehm, Michael and Greiner, Dale and Mempel, Thorsten and Bjorkman, Pamela and Kumar, Priti and Mothes, Walther and Joas, Simone and Parrish, Erica and Gnanadurai, Clement Wesley and Lump, Edina and Stürzel, Christina M and ...
Retrovirology, ISSN 1742-4690, 09/2016, Volume 13, Issue S1
Journal Article
JCI INSIGHT, ISSN 2379-3708, 04/2019, Volume 4, Issue 7
Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally... 
CHEMOKINE RECEPTORS CXCR1 | IMMUNE | MEDICINE, RESEARCH & EXPERIMENTAL | RECRUITMENT | HEAD | ANGIOGENESIS | MICROENVIRONMENT | GROWTH | TUMOR-ASSOCIATED MACROPHAGES | CANCER | CARCINOMA
Journal Article
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