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Clinical Cancer Research, ISSN 1078-0432, 06/2017, Volume 23, Issue 12, pp. 3097 - 3108
Purpose: PARP inhibition (PARPi) has modest clinical activity in recurrent BRCA-mutant (BRCA(MUT)) high-grade serous ovarian cancers (HGSOC). We hypothesized... 
OLAPARIB | THERAPY | RANDOMIZED PHASE-2 | CHK1 | ONCOLOGY | PHOSPHORYLATION | SYNTHETIC LETHALITY | CELL-CYCLE | CHECKPOINT | REPLICATION FORK COLLAPSE | ATR | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Phthalazines - administration & dosage | Pyrimidines - administration & dosage | Humans | Checkpoint Kinase 1 - antagonists & inhibitors | Ovarian Neoplasms - pathology | Molecular Targeted Therapy | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Drug Synergism | Ovarian Neoplasms - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Sulfoxides - administration & dosage | Pyrazoles - administration & dosage | Animals | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cell Line, Tumor | Genomic Instability - drug effects | Female | Cell Proliferation - drug effects | Mice | Ovarian Neoplasms - drug therapy | Ovarian carcinoma | G2 phase | Genomes | Ovarian cancer | Genomic instability | Quality | Cell cycle | Xenografts | Remission | Inhibition | Cell survival | Stability | BRCA1 protein | Colonies | CHK1 protein | Regression | Poly(ADP-ribose) polymerase | Breast cancer | Stability analysis | Regression analysis | Survival | Experimental design | Cell death | Aberration | Chromosome aberrations | Cancer | Apoptosis
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 6/2015, Volume 75, Issue 6, pp. 1217 - 1227
This study was performed to determine whether or not in cervical, ovarian and lung cancer cell lines, free radicals (ROS) play a role in cisplatin cytotoxicity... 
Reactive oxygen species | Medicine & Public Health | Oncology | Cancer Research | Dihydrodiol dehydrogenase | JNK/p38 pathways | Cisplatin resistance | Pharmacology/Toxicology | Human cervical, ovarian and lung carcinoma cells | Human cervical ovarian and lung carcinoma cells | DRUG-SENSITIVITY | CARCINOMA CELLS | POLYCYCLIC AROMATIC-HYDROCARBONS | ADENOCARCINOMA CELLS | INDUCTION | ALDO-KETO REDUCTASE | CHEMOTHERAPY | IN-VITRO | ONCOLOGY | PHARMACOLOGY & PHARMACY | EXPRESSION | Lung Neoplasms - drug therapy | Reactive Oxygen Species - metabolism | Oxidoreductases - metabolism | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Uterine Cervical Neoplasms - drug therapy | Antineoplastic Agents - therapeutic use | Mitochondria - metabolism | Mitochondria - drug effects | Membrane Potential, Mitochondrial - drug effects | MAP Kinase Signaling System - drug effects | Cisplatin - therapeutic use | Uterine Cervical Neoplasms - metabolism | Cell Line, Tumor | Female | Thioredoxins - metabolism | Ovarian Neoplasms - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Oxidative Stress - drug effects | Phosphorylation - drug effects | Ovarian Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Enzymes | Cysteine | RNA | Analysis | Lung cancer | Cancer cells | Cisplatin | Cervical cancer
Journal Article
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2016, Volume 75, Issue 5, pp. 940 - 949
Background Pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment. Objective We sought to estimate the effectiveness of... 
Dermatology | corticosteroid | cohort | side effects | pyoderma gangrenosum | topical therapy | tacrolimus | UNITED-KINGDOM | DISEASE | DERMATOLOGY | Medicine, Experimental | Medical research | Care and treatment | Pyoderma | Patient outcomes | Corticosteroids
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2013, Volume 19, Issue 19 Supplement, pp. B50 - B50
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2017, Volume 9, Issue 3, pp. 304 - 318
Journal Article
Journal Article
Civilisations - revue internationale d'Antropologie et de sciences humaines, ISSN 2032-0442, 2011, Issue 11, pp. 207 - 228
Journal Article
PLoS Medicine, ISSN 1549-1277, 2017, Volume 14, Issue 4, p. e1002280
Journal Article