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British Journal of Pharmacology, ISSN 0007-1188, 06/2018, Volume 175, Issue 11, pp. 1789 - 1804
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2017, Volume 292, Issue 7, pp. 2729 - 2740
Journal Article
Neuropharmacology, ISSN 0028-3908, 06/2019, pp. 107660 - 107660
The ten types of nicotinic acetylcholine receptor α-subunits show substantial sequence homology, yet some types confer high affinity for α-bungarotoxin,... 
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2014, Volume 106, Issue 2, pp. 340a - 340a
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 02/2017, Volume 292, Issue 7, pp. 2729 - 2740
Journal Article
BIOPHYSICAL JOURNAL, ISSN 0006-3495, 10/2007, Volume 93, Issue 8, pp. 2622 - 2634
We explore the conformational dynamics of a homology model of the human alpha 7 nicotinic acetylcholine receptor using molecular dynamics simulation and... 
MOLECULAR-DYNAMICS | GABA(A) RECEPTOR | BIOPHYSICS | CYS-LOOP RECEPTOR | GATING MECHANISM | NICOTINIC ACETYLCHOLINE-RECEPTOR | ION-CHANNEL | TRANSMEMBRANE DOMAIN | LIGAND-BINDING DOMAIN | NORMAL-MODE ANALYSIS | CYSTEINE-ACCESSIBILITY METHOD
Journal Article
Journal of General Physiology, ISSN 0022-1295, 05/2018, Volume 150, Issue 5, pp. 713 - 729
The muscle acetylcholine (ACh) receptor transducer a chemical into an electrical signal, but the efficiency of transduction, or efficacy, depends on the... 
PHYSIOLOGY | PROTEIN | MECHANISM | CRYSTAL-STRUCTURE | KINETICS | X-RAY-STRUCTURE | RESOLUTION | DIFFERENT ORIENTATIONS | LIGAND-BINDING DOMAIN | NICOTINIC RECEPTOR | CURARIFORM ANTAGONISTS BIND | Signal transduction | Cysteine | Channel opening | Crosslinking polymerization | Choline | Oxidation | Acetylcholine | Binding sites | 511 | 501 | s
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, p. 2613
  Congenital myasthenic syndromes (CMSs) are neuromuscular disorders that can be caused by defects in acetylcholine receptor (AChR) function.... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, p. 2613
Congenital myasthenic syndromes (CMSs) are neuromuscular disorders that can be caused by defects in acetylcholine receptor (AChR) function. Disease-associated... 
Receptors | Myasthenia gravis | Gene mutations | Physiological aspects | Genetic aspects | Acetylcholine | Research | Health aspects | Risk factors
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 303 - 310
To identify high-affinity interactions between long-chain α-neurotoxins and nicotinic receptors, we determined the crystal structure of the complex between... 
Molecular recognition | Neurotoxin | Nicotinic acetylcholine receptor | Crystal structure | Reptilian Proteins - chemistry | Nicotinic Agonists - metabolism | Cobra Neurotoxin Proteins - metabolism | Pyridines - chemistry | Humans | Recombinant Fusion Proteins - metabolism | Nicotinic Agonists - chemistry | Receptors, Nicotinic - chemistry | Carrier Proteins - chemistry | Protein Interaction Domains and Motifs | Binding Sites | Peptide Fragments - genetics | Bridged Bicyclo Compounds, Heterocyclic - metabolism | Bungarotoxins - metabolism | Neurotoxins - chemistry | Peptide Fragments - metabolism | Receptors, Nicotinic - metabolism | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Bungarotoxins - chemistry | Lymnaea | Models, Molecular | Mutant Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Cobra Neurotoxin Proteins - chemistry | Bungarus | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Carrier Proteins - metabolism | Pyridines - metabolism | Mutant Proteins - chemistry | Ligands | Neurotoxins - metabolism | Protein Conformation | Receptors, Nicotinic - genetics | Amino Acid Substitution | Reptilian Proteins - metabolism | alpha7 Nicotinic Acetylcholine Receptor | Index Medicus | BASIC BIOLOGICAL SCIENCES | crystal structure | neurotoxin | molecular recognition | nicotinic acetylcholine receptor
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2013, Volume 110, Issue 51, pp. 20819 - 20824
Neuronal alpha 7 nicotinic receptors elicit rapid cation influx in response to acetylcholine (ACh) or its hydrolysis product choline. They contribute to... 
SINGLE-CHANNEL | AGONIST BINDING-SITES | GATED ION-CHANNEL | patch-clamp | DESENSITIZATION | MULTIDISCIPLINARY SCIENCES | alpha 7 nicotinic receptor | SCHIZOPHRENIA | Cys-loop receptors | ACETYLCHOLINE-RECEPTOR | PHARMACOLOGY | CHANNEL KINETIC-ANALYSIS | DISEASE | channel gating | agonist binding site
Journal Article
Nature Neuroscience, ISSN 1097-6256, 10/2011, Volume 14, Issue 10, p. 1253
  The α(7) acetylcholine receptor (AChR) mediates pre- and postsynaptic neurotransmission in the central nervous system and is a potential therapeutic target... 
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 11/2005, Volume 68, Issue 5, pp. 1475 - 1483
Journal Article
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