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Journal of Chemical Information and Modeling, ISSN 1549-9596, 01/2019, Volume 59, Issue 1, pp. 373 - 385
We present a succession of structural changes involved in hormone peptide activation of a prototypical GPCR. Microsecond molecular dynamics simulation... 
Index Medicus
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 12/2013, Volume 34, Issue 12, pp. 1592 - 1606
Both endothelin ETA receptor antagonists and angiotensin AT1 receptor antagonists lower blood pressure in hypertensive patients. A dual AT1 and ETA receptor... 
quantum-polarized ligand docking (QPLD) | imidazole | ETA receptor | molecular dynamics simulation | 3D-QSAR | antihypertensive drug | Original | GBSA free-energy calculation | AT1 receptor
Journal Article
British journal of pharmacology, 12/2019, Volume 176 Suppl 1, p. S21
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key... 
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 01/2019, Volume 59, Issue 1, p. 373
We present a succession of structural changes involved in hormone peptide activation of a prototypical GPCR. Microsecond molecular dynamics simulation... 
Hypertension | Proteins | Binding | Peptides | Computer simulation | Pathogenesis | Breakage | Homeostasis | Molecular dynamics | Heart diseases | Cytoplasm | Strain
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 01/2018, Volume 58, Issue 1, p. 182
Crystal structures of the human angiotensin II type 1 receptor (AT1R) complex with the antihypertensive agent ZD7155 (PDB id: 4YAY) and the blood pressure... 
Binding | Molecules | Peptides | Computer simulation | Antagonist drugs | Chemical bonds | Docking | Blood pressure | Pharmacology | Hormones | Free energy | Crystal structure
Journal Article
by Alexander, Stephen PH and Christopoulos, Arthur and Davenport, Anthony P and Kelly, Eamonn and Mathie, Alistair and Peters, John A and Veale, Emma L and Armstrong, Jane F and Faccenda, Elena and Harding, Simon D and Pawson, Adam J and Sharman, Joanna L and Southan, Christopher and Davies, Jamie A and Abbracchio, Maria P and Alexander, Wayne and Al-hosaini, Khaled and Bäck, Magnus and Beaulieu, Jean‐Martin and Bernstein, Kenneth E and Bettler, Bernhard and Birdsall, Nigel JM and Blaho, Victoria and Bousquet, Corinne and Bräuner-Osborne, Hans and Burnstock, Geoffrey and Caló, Girolamo and Castaño, Justo P and Catt, Kevin J and Ceruti, Stefania and Chazot, Paul and Chiang, Nan and Chun, Jerold and Cianciulli, Antonia and Clapp, Lucie H and Couture, Réjean and Csaba, Zsolt and Dent, Gordon and Singh, Khuraijam Dhanachandra and Douglas, Steven D and Dournaud, Pascal and Eguchi, Satoru and Escher, Emanuel and Filardo, Edward and Fong, Tung M and Fumagalli, Marta and Gainetdinov, Raul R and Gasparo, Marc de and Gershengorn, Marvin and Gobeil, Fernand and Goodfriend, Theodore L and Goudet, Cyril and Gregory, Karen J and Gundlach, Andrew L and Hamann, Jörg and Hanson, Julien and Hauger, Richard L and Hay, Debbie and Heinemann, Akos and Hollenberg, Morley D and Holliday, Nicholas D and Horiuchi, Mastgugu and Hoyer, Daniel and Hunyady, László and Husain, Ahsan and Ijzerman, Adriaan P and Inagami, Tadashi and Jacobson, Kenneth A and Jensen, Robert T and Jockers, Ralf and Jonnalagadda, Deepa and Karnik, Sadashiva and Kaupmann, Klemens and Kemp, Jacqueline and Kennedy, Charles and Kihara, Yasuyuki and Kozielewicz, Paweł and Kreienkamp, Hans‐Jürgen and Kukkonen, Jyrki P and Langenhan, Tobias and Leach, Katie and Lecca, Davide and Lee, John D and Leeman, Susan E and Leprince, Jérôme and Lolait, Stephen J and Lupp, Amelie and Macrae, Robyn and Maguire, Janet and Mazella, Jean and McArdle, Craig A and Melmed, Shlomo and Michel, Martin C and Miller, Laurence and Mitolo, Vincenzo and Mouillac, Bernard and Murphy, Philip M and Nahon, Jean‐Louis and Norel, Xavier and Nyimanu, Duuamene and ... and CGTP Collaborators
British Journal of Pharmacology, ISSN 0007-1188, 12/2019, Volume 176, Issue S1, pp. S21 - S141
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key... 
PHARMACOLOGY & PHARMACY | POTENT | Proteins | Receptors | Websites | Nomenclature | Classification | Ligands | Pharmacology | Ion channels | Knowledge base | Nuclear receptors | Life Sciences | Neurons and Cognition
Journal Article
Methods in Cell Biology, ISSN 0091-679X, 01/2019, Volume 149, pp. 215 - 238
Maintenance of normal blood pressure under conditions of drug treatment is a measure of system-wide neuro-hormonal controls and electrolyte/fluid volume... 
Tail-cuff method | SUnSET | Angiotensin | EdU | Catecholamines | AT1R | Blood pressure | PATHWAYS | SUNSET | AT ANGIOTENSIN RECEPTOR | PROTEIN-COUPLED RECEPTORS | MECHANISMS | UPDATE | CELL BIOLOGY | Animals | Receptors, G-Protein-Coupled - metabolism | Humans | Receptor, Angiotensin, Type 1 - metabolism | Homeostasis | Ligands | Blood Pressure - physiology | Mice | Blood Vessels - physiology
Conference Proceeding
Journal of chemical information and modeling, 01/2019, Volume 59, Issue 1, p. 373
We present a succession of structural changes involved in hormone peptide activation of a prototypical GPCR. Microsecond molecular dynamics simulation... 
Angiotensin II - pharmacology | Humans | Receptor, Angiotensin, Type 1 - metabolism | Models, Molecular | Protein Conformation | Entropy | Receptor, Angiotensin, Type 1 - chemistry
Journal Article
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