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Analytical Biochemistry, ISSN 0003-2697, 02/2019, Volume 567, pp. 21 - 26
Nucleic acids exist in biological systems as linear and cyclic forms and in most cases the biology of the cyclic form is different from the linear form of... 
CRISPR/Cas-related signaling molecule | Discriminating cyclic nucleotides from linear form | Cyclic hexaadenosine monophosphate detection | Fluorescence assay | CHEMISTRY, ANALYTICAL | ACTIVATION | COMPLEX | AMP | C-DI-GMP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | RECEPTOR | HELIX | DNA
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 19, pp. 3754 - 3757
Journal Article
Chemical Communications, ISSN 1359-7345, 7/2016, Volume 52, Issue 6, pp. 9327 - 9342
Bacteria utilize nucleotide-based second messengers to regulate a myriad of physiological processes. Cyclic dinucleotides have emerged as central regulators of... 
DIGUANYLATE CYCLASE | AFFECT BACTERIAL-GROWTH | PSEUDOMONAS-AERUGINOSA | STRUCTURAL-ANALYSIS | STING PATHWAY | FLUORESCENT BIOSENSORS | BIOCHEMICAL-CHARACTERIZATION | CHEMISTRY, MULTIDISCIPLINARY | DIADENYLATE CYCLASE CDAS | ACETOBACTER-XYLINUM | PILZ DOMAIN | Screening | Regulators | Inhibitors | Virulence | Homeostasis | Bacteria | Manuscripts | Walls
Journal Article
Journal of Microbiological Methods, ISSN 0167-7012, 11/2018, Volume 154, pp. 40 - 45
The continuing emergence and spread of antibiotic-resistant bacteria is worrisome and new strategies to curb bacterial infections are being sought. The... 
High throughput screening | Autoinducer-2 | Bioreporter strain | Assay miniaturization | Quorum sensing inhibitors
Journal Article
Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2018, Volume 54, Issue 36, pp. 4521 - 4524
Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the... 
Kinases | Cyclin-dependent kinases | Cancer
Journal Article
Organic letters, ISSN 1523-7060, 08/2018, Volume 20, Issue 17, pp. 5528 - 5528
Journal Article
ISSN 1359-7345, 2/2016, Volume 52, Issue 19, pp. 3754 - 3757
C-di-AMP synthases are essential in several bacteria, including human pathogens; hence these enzymes are potential antibiotic targets. However, there is a... 
Journal Article
Chemical Science, ISSN 2041-6520, 2016, Volume 7, Issue 9, pp. 6238 - 6244
Various important cellular processes in bacteria are controlled by c-di-GMP, such as motility, biofilm formation and virulence factors production. C-di-GMP is... 
EAL | CELLULOSE SYNTHESIS | VIRULENCE FACTORS | STRUCTURAL BASIS | CYCLIC DIGUANYLIC ACID | CELL-CYCLE | BINDING PROTEIN | CHEMISTRY, MULTIDISCIPLINARY | ACETOBACTER-XYLINUM | DOMAIN PROTEIN | BIOFILM FORMATION | Inhibitors | Biofilms | Virulence | Bacteria | Formations | Derivatives | Swarming | Dispersion
Journal Article
Journal of Proteomics, ISSN 1874-3919, 06/2019, Volume 202, p. 103368
Halogenated 4-hydroxybenzylidene indolinones have been shown to re-sensitize methicillin-resistant (MRSA) and vancomycin-resistant (VRE) to methicillin and... 
SceD | Purine biosynthesis inhibition | S. aureus global proteomics | Lytic transglycosylase | Quorum sensing inhibition
Journal Article
Molecular BioSystems, ISSN 1742-206X, 03/2016, Volume 12, Issue 3, pp. 773 - 777
A cyclic dinucleotide riboswitch has been fused with a G-quadruplex motif to produce a conditional riboswitch-peroxidase-mimicking sensor that oxidizes both... 
PEROXIDASE-ACTIVITY | DNAZYME | BACTERIA | RNA | AMP | C-DI-GMP | STABILITY | KINETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIGUANYLATE | APTAMER | Tyramine | Riboswitch | Cyclic GMP - analogs & derivatives | Oxidation-Reduction | Base Sequence | Cyclic GMP - analysis | Fluorescence | Molecular Sequence Data | G-Quadruplexes | Dimerization | Nucleic Acid Heteroduplexes - chemistry | Peroxidase - metabolism
Journal Article
ISSN 1359-7345, 5/2018, Volume 54, Issue 42, pp. 5354 - 5356
The presence of a bromide substituent, instead of a hydrogen or methyl group, on a carbon-carbon double bond, protects the alkene from addition reactions when... 
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 09/2019, Volume 90, p. 103052
RET rearrangement is a recently identified oncogenic mutation in lung adenocarcinoma (LADC) that accounts for approximately 2% of all NSCLCs. More than six... 
RET rearrangement | RET inhibitor | Non-small cell lung cancer | Antitumor | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | GENE FUSION | CCDC6-RET FUSION | CANCER | CELL-LINE
Journal Article
MedChemComm, ISSN 2040-2503, 2019
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 64, pp. 36840 - 36851
Global and quantitative analysis of the proteome help to reveal how host cells sense invading bacteria and respond to bacterial signaling molecules. Here, we... 
SP100 | VIRUS | REPLICATION | AMP | INFLAMMATION | RECEPTOR | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | CYCLIC DINUCLEOTIDES
Journal Article
Beilstein journal of organic chemistry, ISSN 1860-5397, 2019, Volume 15, Issue 1, pp. 1194 - 1202
( , )-Dimethyl tartrate acetonide in THF/HMPA undergoes deprotonation with LDA and reaction at -78 °C during 12-72 h with a range of alkyl halides, including... 
Studies | Chemistry | Acids | Asymmetric synthesis | Natural products | Oxidation | Tartaric acid | Alkylation | Carbonyls | alkylation | diazoester | cycloaddition | tartaric acid | epimerisation
Journal Article
OMICS A Journal of Integrative Biology, ISSN 1536-2310, 01/2016, Volume 20, Issue 1, pp. 3 - 11
Oral health and systems medicine are intimately related but have remained, sadly, as isolated knowledge communities for decades. Are there veritable connector... 
Biomarkers - metabolism | Biofilms | Biomass
Journal Article
Analytical biochemistry, 11/2018, Volume 567, p. 21
Nucleic acids exist in biological systems as linear and cyclic forms and in most cases the biology of the cyclic form is different from the linear form of... 
Journal Article
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