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Journal of Nuclear Medicine, ISSN 0161-5505, 09/2018, Volume 59, Issue 9, pp. 1412 - 1414
The tumor microenvironment (TME) plays a crucial role in mediating drug resistance via impaired drug delivery and activity. TME has been recognized as driving... 
SIBROTUZUMAB | INHIBITORS | FAP | STROMAL CELLS | CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Proteins | Drug delivery systems | Transcription | Ecosystems | Fibroblasts | Drug delivery | Drug resistance | Tumors | Index Medicus
Journal Article
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10018, pp. 545 - 557
Summary Background Nanoliposomal irinotecan showed activity in a phase 2 study in patients with metastatic pancreatic ductal adenocarcinoma previously treated... 
Internal Medicine | PLUS GEMCITABINE | SURVIVAL | 5-FLUOROURACIL | MEDICINE, GENERAL & INTERNAL | ADENOCARCINOMA | 2ND-LINE CHEMOTHERAPY | OXALIPLATIN | PEP02 | DOCETAXEL | CARCINOMA | FOLFIRI | Leucovorin - administration & dosage | Humans | Middle Aged | Male | Fatigue - chemically induced | Diarrhea - chemically induced | Pancreatic Neoplasms - drug therapy | Neoplasm Metastasis | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Camptothecin - administration & dosage | Carcinoma, Pancreatic Ductal - mortality | Deoxycytidine - adverse effects | Female | Pancreatic Neoplasms - mortality | Neutropenia - chemically induced | Camptothecin - analogs & derivatives | Camptothecin - adverse effects | Deoxycytidine - administration & dosage | Kaplan-Meier Estimate | Treatment Outcome | Carcinoma, Pancreatic Ductal - drug therapy | Vomiting - chemically induced | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Liposomes | Deoxycytidine - analogs & derivatives | Antimitotic agents | Medical colleges | Pancreatic cancer | Leucovorin | Product development | Research institutes | Metastasis | Antineoplastic agents | Analysis | Antigens | Chemotherapy | Medical prognosis | Clinical trials | Drug dosages | Cancer therapies | Tumors | Adenocarcinoma | Slopes | Therapy | Gemcitabine | Toxicity | Metastases | Nanoparticles | Randomization | Motivation | Vomiting | Safety management | Toxic diseases | Neutropenia | Folinic acid | Lymphatic system | Medical treatment | Diarrhea | FDA approval | Survival | Patients | Irinotecan | Acids | Equivalence | Interactive systems | Index Medicus | Abridged Index Medicus
Journal Article
Pancreatology, ISSN 1424-3903, 2014, Volume 14, Issue 2, pp. e4 - e4
  Recent studies using GEMM have shed light on the complex tissue- and context-specific signaling cascades in human cancers. Besides targeting of genes and... 
Endocrinology & Metabolism | Gastroenterology and Hepatology | Medical research | Pancreas | Pancreatic cancer | Rodents
Journal Article
Oncotarget, ISSN 1949-2553, 2012, Volume 3, Issue 11, pp. 1262 - 1263
Journal Article
Gut, ISSN 0017-5749, 03/2016, Volume 65, Issue 3, pp. 367 - 369
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2015, Volume 21, Issue 10, pp. 1163 - 1171
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2012, Volume 22, Issue 3, pp. 304 - 317
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1267, pp. 185 - 211
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2007, Volume 12, Issue 3, pp. 266 - 279
Growth factors have been implicated in pancreatic carcinogenesis. In this study we analyzed the effect of Tgfa overexpression in addition to mutant Kras by... 
CELLCYCLE
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, pp. 1859 - 1860
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, p. 1859
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, pp. 1859 - 1860
Journal Article
Hepatology, ISSN 0270-9139, 11/2013, Volume 58, Issue 5, pp. 1859 - 1860
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 30, pp. 13438 - 13443
Pancreatic cancer is one of the most fatal malignancies lacking effective therapies. Notch signaling is a key regulator of cell fate specification and... 
Acinar cells | Developmental biology | Cell lines | Pancreatic cells | Mice | Lesions | Carcinogenesis | Pancreatic neoplasms | Tumors | Notch receptors | K-Ras | Genetically engineered mice | Myc | Pancreatic cancer | Notch | ACTIVATION | MULTIDISCIPLINARY SCIENCES | MOUSE | C-MYC | ADULT MICE | CANCER | EPITHELIAL-MESENCHYMAL TRANSITION | pancreatic cancer | SIGNALING PATHWAY | GROWTH | ACINAR-CELLS | EXPRESSION | genetically engineered mice | Immunohistochemistry | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Male | Receptor, Notch2 - genetics | Gene Expression Profiling | Carcinoma, Pancreatic Ductal - genetics | Adenocarcinoma - metabolism | Carcinoma in Situ - genetics | Female | Adenocarcinoma - genetics | Proto-Oncogene Proteins p21(ras) - metabolism | Signal Transduction | Carcinoma in Situ - pathology | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Receptor, Notch2 - metabolism | Pancreas - pathology | Pancreatic Neoplasms - genetics | Pancreas - metabolism | Receptor, Notch1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Proto-Oncogene Proteins c-myc - metabolism | Blotting, Western | Disease Progression | Mice, Knockout | Animals | Cell Line, Tumor | Proto-Oncogene Proteins c-myc - genetics | Carcinoma in Situ - metabolism | Receptor, Notch1 - genetics | Signal transduction | Pancreas | Rodents | Cells | Index Medicus | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2445 - 2457
Journal Article