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by Flannick, Jason and Thorleifsson, Gudmar and Beer, Nicola L and Jacobs, Suzanne B.R and Grarup, Niels and Burtt, Noël P and Mahajan, Anubha and Fuchsberger, Christian and Atzmon, Gil and Benediktsson, Rafn and Blangero, John and Bowden, Don W and Brandslund, Ivan and Brosnan, Julia and Burslem, Frank and Chambers, John and Cho, Yoon Shin and Christensen, Cramer and Douglas, Desirée A and Duggirala, Ravindranath and Dymek, Zachary and Farjoun, Yossi and Fennell, Timothy and Fontanillas, Pierre and Forsén, Tom and Gabriel, Stacey and Glaser, Benjamin and Gudbjartsson, Daniel F and Hanis, Craig and Hansen, Torben and Hreidarsson, Astradur B and Hveem, Kristian and Ingelsson, Erik and Isomaa, Bo and Johansson, Stefan and Jørgensen, Torben and Jørgensen, Marit Eika and Kathiresan, Sekar and Kong, Augustine and Kooner, Jaspal and Kravic, Jasmina and Laakso, Markku and Lee, Jong-Young and Lind, Lars and Lindgren, Cecilia M and Linneberg, Allan and Masson, Gisli and Meitinger, Thomas and Mohlke, Karen L and Molven, Anders and Morris, Andrew P and Potluri, Shobha and Rauramaa, Rainer and Ribel-Madsen, Rasmus and Richard, Ann-Marie and Rolph, Tim and Salomaa, Veikko and Segrè, Ayellet V and Skärstrand, Hanna and Steinthorsdottir, Valgerdur and Stringham, Heather M and Sulem, Patrick and Tai, E Shyong and Teo, Yik Ying and Teslovich, Tanya and Thorsteinsdottir, Unnur and Trimmer, Jeff K and Tuomi, Tiinamaija and Tuomilehto, Jaakko and Vaziri-Sani, Fariba and Voight, Benjamin F and Wilson, James G and Boehnke, Michael and McCarthy, Mark I and Njølstad, Pål R and Pedersen, Oluf and Groop, Leif and Cox, David R and Stefansson, Kari and Altshuler, David and Go-T2D Consortium and T2D-Genes Consortium and T2D-GENES Consortium
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 357 - 363
Journal Article
Diabetes, ISSN 0012-1797, 03/2017, Volume 66, Issue 3, pp. 735 - 740
Journal Article
Journal of Diabetes and Its Complications, ISSN 1056-8727, 2013, Volume 27, Issue 6, pp. 609 - 617
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 40, pp. 29013 - 29023
Insulin is a major autoantigen in islet autoimmunity and progression to type 1 diabetes. It has been suggested that the insulin B-chain may be critical to... 
DEPENDENT DIABETES-MELLITUS | GLUTAMIC-ACID DECARBOXYLASE | Beta Cell | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELLS | Antibodies | Insulin | RADIOBINDING ASSAY | ANTIBODY STANDARDIZATION PROGRAM | Antigen | INSULIN AUTOANTIBODIES | INTERNATIONAL WORKSHOP | Radioimmune Assays | Pancreatic Islets | SWEDISH PATIENTS | Diabetes | TYPE-1 | Insulin-like Growth Factor (IGF) | T-CELLS | Protein Biosynthesis | Oligonucleotide Array Sequence Analysis | Protein Precursors - blood | Autoantibodies - blood | Humans | Insulin - immunology | Middle Aged | DNA, Complementary - genetics | Male | Insulin - blood | Insulin-Like Growth Factor II - genetics | Autoimmunity - immunology | Islets of Langerhans - metabolism | Mutant Chimeric Proteins - blood | Female | Transcription, Genetic | Diabetes Mellitus, Type 1 - immunology | Insulin - genetics | Islets of Langerhans - pathology | Electrophoresis, Polyacrylamide Gel | Gene Expression Regulation | Diabetes Mellitus, Type 1 - genetics | Islets of Langerhans - immunology | Protein Precursors - immunology | Chromosomes, Human, Pair 11 - genetics | Genome, Human - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 8 - metabolism | Diabetes Mellitus, Type 1 - blood | Adolescent | Fluorescent Antibody Technique | Mutant Chimeric Proteins - immunology | Index Medicus | Immunology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Immunologi inom det medicinska området | Cell- och molekylärbiologi | Immunology in the medical area
Journal Article
Diabetes Care, ISSN 0149-5992, 03/2014, Volume 37, Issue 3, pp. e49 - e50
Journal Article
Scandinavian Journal of Immunology, ISSN 1365-3083, 11/2012
The SNP rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein.... 
Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Immunologi inom det medicinska området | Immunology in the medical area
Journal Article
Pediatric Diabetes, ISSN 1399-543X, 2015, Volume 16, Issue 8, p. 621
Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at... 
Clinical Medicine | Pediatrics | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Pediatrik | Klinisk medicin | Endocrinology and Diabetes
Journal Article
Journal of Diabetes and its Complications1992-01-01+01:00, ISSN 1873-460X, 2013, Volume 27, Issue 6, p. 609
Aims: The neurotransmitter Neuropeptide Y (NPY) was previously reported as a minor autoantigen in newly diagnosed type 1 diabetes (T1D) patients. The single... 
Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Endocrinology and Diabetes
Journal Article
Arquivos Brasileiros de Endocrinologia & Metabologia, ISSN 1677-9487, 10/2014, Volume 58, Issue 7, pp. 737 - 743
Objective Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8... 
ENDOCRINOLOGY & METABOLISM
Journal Article
Arquivos Brasileiros de Endocrinologia e Metabologia, ISSN 1677-9487, 2014, Volume 58, Issue 7, p. 737
Objective Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8... 
Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Endocrinology and Diabetes
Journal Article
Journal Article
by Flannick, Jason and Thorleifsson, Gudmar and Beer, Nicola L and Jacobs, Suzanne B R and Grarup, Niels and Burtt, Noël P and Mahajan, Anubha and Fuchsberger, Christian and Atzmon, Gil and Benediktsson, Rafn and Blangero, John and Bowden, Don W and Brandslund, Ivan and Brosnan, Julia and Burslem, Frank and Chambers, John and Cho, Yoon Shin and Christensen, Cramer and Douglas, Desiree and Duggirala, Ravindranath and Dymek, Zachary and Farjoun, Yossi and Fennell, Timothy and Fontanillas, Pierre and Forsén, Tom and Gabriel, Stacey and Glaser, Benjamin and Gudbjartsson, Daniel F and Hanis, Craig and Hansen, Torben and Hreidarsson, Astradur B and Hveem, Kristian and Ingelsson, Erik and Isomaa, Bo and Johansson, Stefan and Jørgensen, Torben and Jørgensen, Marit Eika and Kathiresan, Sekar and Kong, Augustine and Kooner, Jaspal and Kravic, Jasmina and Laakso, Markku and Lee, Jong-Young and Lind, Lars and Lindgren, Cecilia M and Linneberg, Allan and Masson, Gisli and Meitinger, Thomas and Mohlke, Karen L and Molven, Anders and Morris, Andrew P and Potluri, Shobha and Rauramaa, Rainer and Ribel-Madsen, Rasmus and Richard, Ann-Marie and Rolph, Tim and Salomaa, Veikko and Segrè, Ayellet V and Skärstrand, Hanna and Steinthorsdottir, Valgerdur and Stringham, Heather M and Sulem, Patrick and Tai, E Shyong and Teo, Yik Ying and Teslovich, Tanya and Thorsteinsdottir, Unnur and Trimmer, Jeff K and Tuomi, Tiinamaija and Tuomilehto, Jaakko and Vaziri Sani, Fariba and Voight, Benjamin F and Wilson, James G and Boehnke, Michael and McCarthy, Mark I and Njølstad, Pål R and Pedersen, Oluf and Groop, Leif and Cox, David R and Stefansson, Kari and Altshuler, David and Lund University and Diabetes and Celiac Unit and Genomics, Diabetes and Endocrinology and Cell Pathology, Malmö and Cellpatologi, Malmö and Genomik, diabetes och endokrinologi and Diabetes och celiaki and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Nature Genetics, ISSN 1546-1718, 2014, Volume 46, Issue 4, p. 357
Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2... 
Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Endocrinology and Diabetes
Journal Article