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science & technology (78) 78
animals (73) 73
mice (65) 65
life sciences & biomedicine (60) 60
biochemistry & molecular biology (31) 31
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stem cells (23) 23
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phenotype (15) 15
biochemistry (14) 14
chemistry (14) 14
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genetics & heredity (14) 14
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biochemical research methods (13) 13
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fundamental and applied biological sciences. psychology (10) 10
gene expression (10) 10
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gene targeting (8) 8
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proteins (8) 8
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1. Full Text Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice
by Migliorini, Domenico and Bogaerts, Sven and Defever, Dieter and Vyas, Rajesh and Denecker, Geertrui and Radaelli, Enrico and Zwolinska, Aleksandra and Depaepe, Vanessa and Hochepied, Tino and Skarnes, William C and Marine, Jean-Christophe
The Journal of clinical investigation, ISSN 0021-9738, 04/2011, Volume 121, Issue 4, pp. 1329 - 1343
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neoplasms - metabolism | RNA, Small Interfering - genetics | Cell Proliferation | Neoplasms - etiology | Transcription Factor AP-1 - genetics | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Mice, 129 Strain | Transcription Factor AP-1 - metabolism | MAP Kinase Signaling System | Neoplasms - genetics | Mice, Mutant Strains | Tumor Suppressor Proteins - deficiency | Base Sequence | Nuclear Proteins - deficiency | Tumor Suppressor Proteins - genetics | Female | JNK Mitogen-Activated Protein Kinases - genetics | Protein Stability | Nuclear Proteins - genetics | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Mice, Transgenic | Nuclear Proteins - metabolism | Pregnancy | Animals | Ubiquitin-Protein Ligases - deficiency | Heterozygote | Mice | Ubiquitin-Protein Ligases - genetics | Index Medicus | Abridged Index Medicus
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2. Full Text Is mouse embryonic stem cell technology obsolete?
by Skarnes, William C
Genome Biology, ISSN 1474-7596, 05/2015, Volume 16, Issue 1, pp. 109 - 109
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Animals | Humans | Cloning, Molecular | Female | Male | CRISPR-Cas Systems - genetics | Gene Knock-In Techniques | CRISPR | Zygotes | Gene disruption | Embryo cells | Stem cells | Stem cell transplantation | Zebrafish | Genetic engineering | Embryos | Index Medicus | Research Highlight
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3. Full Text Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
by Shen, Bin and Zhang, Wensheng and Zhang, Jun and Zhou, Jiankui and Wang, Jianying and Chen, Li and Wang, Lu and Hodgkins, Alex and Iyer, Vivek and Huang, Xingxu and Skarnes, William C
Nature methods, ISSN 1548-7091, 2014, Volume 11, Issue 4, pp. 399 - 402
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Genome, Bacterial | Embryo, Mammalian | Deoxyribonuclease I - genetics | Humans | Endonucleases - metabolism | Gene Expression Regulation, Enzymologic | Deoxyribonuclease I - metabolism | Animals | Base Sequence | CRISPR-Cas Systems | Mice | RNA, Bacterial | HeLa Cells | Mutation | Genomes | Research | Genetic transcription | Gene mutations | Ribonucleic acid--RNA | Index Medicus
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4. Full Text Off-target mutations are rare in Cas9-modified mice
by Iyer, Vivek and Shen, Bin and Zhang, Wensheng and Hodgkins, Alex and Keane, Thomas and Huang, Xingxu and Skarnes, William C
Nature methods, ISSN 1548-7091, 06/2015, Volume 12, Issue 6, pp. 479 - 479
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Breeding | CRISPR-Associated Proteins - genetics | Deoxyribonuclease I - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Male | RNA, Messenger - metabolism | Mice, Knockout | Gene Expression Regulation, Enzymologic | Deoxyribonuclease I - metabolism | Sequence Alignment | Animals | CRISPR-Associated Proteins - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Female | Mice | Mutation | Genome | Physiological aspects | Nucleases | Genetic aspects | Research | Gene mutations | Index Medicus
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5. Full Text One-step generation of conditional and reversible gene knockouts
by Andersson-Rolf, Amanda and Mustata, Roxana C and Merenda, Alessandra and Kim, Jihoon and Perera, Sajith and Grego, Tiago and Andrews, Katie and Tremble, Katie and Silva, José C.R and Fink, Juergen and Skarnes, William C and Koo, Bon-Kyoung
Nature methods, ISSN 1548-7091, 02/2017, Volume 14, Issue 3, pp. 287 - 289
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Cell Line | Animals | Embryonic Stem Cells - cytology | Humans | Genome - genetics | HEK293 Cells | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Mice | CRISPR-Cas Systems - genetics | Gene Knockout Techniques - methods | beta Catenin - genetics | Genetic engineering | Genetic aspects | Gene mutations | Identification and classification | Methods | Cellular control mechanisms | Genomes | Cellular biology | Technology | Genes | Index Medicus
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6. Full Text Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
by Leleu, Marion and Klose, Robert J and Pereira, C. Filipe and Poot, Raymond and Jørgensen, Helle F and Fisher, Cynthia and Merkenschlager, Matthias and Piccolo, Francesco M and Spivakov, Mikhail and Brookes, Emily and Snoek, Tim and Landeira, David and Dvorkina, Maria and Sauer, Stephan and Casanova, Miguel and Skarnes, William C and Tavares, Ligia and Mazzarella, Luca and Bezstarosti, Karel and Fisher, Amanda G and Brockdorff, Neil and Pombo, Ana and Demmers, Jeroen
Nature cell biology, ISSN 1465-7392, 06/2010, Volume 12, Issue 6, pp. 618 - 624
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Pluripotent Stem Cells - metabolism | Proteins - genetics | Cell Differentiation - genetics | Chromatin - metabolism | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Histones - genetics | Proteins - metabolism | Humans | RNA Polymerase II - genetics | Histones - metabolism | RNA Polymerase II - metabolism | Physiological aspects | Genetic aspects | Research | Embryonic stem cells | Genetic regulation | RNA polymerases | Index Medicus
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7. Full Text Agouti C57BL/6N embryonic stem cells for mouse genetic resources
by Prosser, Haydn M and Skarnes, William C and Liang, Qi and Bradley, Allan and Lloyd, Kent C and Rairdan, Xin Y and Moran, Jennifer L and Pettitt, Stephen J and Beier, David R
Nature methods, ISSN 1548-7091, 07/2009, Volume 6, Issue 7, pp. 493 - 495
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Cell Line | Embryonic Stem Cells - metabolism | Gene Targeting | Embryonic Stem Cells - cytology | Hair Color - genetics | Male | Mice, Transgenic | DNA Primers - genetics | Genetic Techniques | Mice, Knockout | Transplantation Chimera - genetics | Pregnancy | Animals | Mice, Inbred C57BL - classification | Mice, Mutant Strains | Agouti Signaling Protein - genetics | Base Sequence | Germ-Line Mutation | Mice, Inbred C57BL - genetics | Female | Mice | Polymorphism, Single Nucleotide | Crosses, Genetic | Genomic libraries | Genetic engineering | Genetic aspects | Research | Embryonic stem cells | Properties | Methods | Scientific method | Embryos | Rodents | Stem cells | Index Medicus
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8. Full Text A conditional knockout resource for the genome-wide study of mouse gene function
by Skarnes, William C and Rosen, Barry and West, Anthony P and Koutsourakis, Manousos and Bushell, Wendy and Iyer, Vivek and Mujica, Alejandro O and Thomas, Mark and Harrow, Jennifer and Cox, Tony and Jackson, David and Severin, Jessica and Biggs, Patrick and Fu, Jun and Nefedov, Michael and De Jong, Pieter J and Stewart, A. Francis and Bradley, Allan
Nature (London), ISSN 0028-0836, 06/2011, Volume 474, Issue 7351, pp. 337 - 344
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Classical genetics, quantitative genetics, hybrids | Biological and medical sciences | Vertebrata | Animals | Genetics of eukaryotes. Biological and molecular evolution | Mice, Knockout - genetics | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Mutagenesis, Insertional - methods | Genomics | Humans | Mice, Inbred C57BL | Computational Biology | Genome - genetics | Genes - genetics | Genetic Association Studies - methods | Rats | Genotype | Gene Knockout Techniques - methods | Genetic Vectors - genetics | Phenotype | Gene Deletion | Genes, Lethal - genetics | Alleles | Polymerase Chain Reaction | Mice | Proteins | Genetics | Mutation | Genes | Index Medicus
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9. Full Text Efficient CRISPR/cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells
by Bressan, Raul Bardini and Dewari, Pooran Singh and Kalantzaki, Maria and Gangoso, Ester and Matjusaitis, Mantas and Garcia-Diaz, Claudia and Blin, Carla and Grant, Vivien and Bulstrode, Harry and Gogolok, Sabine and Skarnes, William C and Pollard, Steven M
Development (Cambridge), ISSN 0950-1991, 02/2017, Volume 144, Issue 4, pp. 635 - 648
Gene targeting | CRISPR/Cas9 | Homologous recombination | Glioblastoma | Neural stem cell | Genome editing | Transcription factor | Epitope tagging | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Oligonucleotides - genetics | Epitope Mapping | Gene Targeting - methods | Humans | Homologous Recombination | Regenerative Medicine | Neural Stem Cells - cytology | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Recombination, Genetic | Transgenes | Green Fluorescent Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Brain Neoplasms - genetics | Oligodendrocyte Transcription Factor 2 | Epitopes | Nerve Tissue Proteins - genetics | Mice, Knockout | Point Mutation | Animals | Alleles | CRISPR-Cas Systems | Mice | Mutation | CRISPR | Developmental biology | Brain tumors | p53 Protein | Embryo cells | Stem cell transplantation | Insertion | Nervous system | Genomes | Regeneration | Glioma | Clonal deletion | Genetic analysis | Cell lines | Stem cells | Neural stem cells | Genetic engineering | Index Medicus | 203 | Stem Cells and Regeneration | Cas9
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10. Full Text Enhancing the genome editing toolbox: Genome wide CRISPR arrayed libraries
by Metzakopian, Emmanouil and Strong, Alex and Iyer, Vivek and Hodgkins, Alex and Tzelepis, Konstantinos and Antunes, Liliana and Friedrich, Mathias J and Kang, Qiaohua and Davidson, Teresa and Lamberth, Jacob and Hoffmann, Christina and Davis, Gregory D and Vassiliou, George S and Skarnes, William C and Bradley, Allan
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 2244 - 9
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gene Library | Signal Transduction | Humans | GPI-Linked Proteins - metabolism | Phenotype | Animals | CRISPR-Cas Systems | Lentivirus - genetics | Gene Editing - methods | Mice | RNA, Guide | Genetic Vectors | Genome-Wide Association Study - methods | CRISPR | Genes | Cloning | Cell lines | Labelling | Genomes | Transposase | Deoxyribonucleic acid--DNA | Index Medicus
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11. Full Text Response to "unexpected mutations after CRISPR-Cas9 editing in vivo"
by Nutter, Lauryl M.J and Heaney, Jason D and Kent Lloyd, K.C and Murray, Stephen A and Seavitt, John R and Skarnes, William C and Teboul, Lydia and Brown, Steve D.M and Moore, Mark
Nature methods, ISSN 1548-7091, 04/2018, Volume 15, Issue 4, pp. 235 - 236
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Mutation | Gene Editing | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Restriction enzymes, DNA | Gene mutations | Nucleotide sequence | Causes of | Physiological aspects | Genetic engineering | Genetic aspects | Health aspects | Methods | CRISPR | Index Medicus
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