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EMBO Molecular Medicine, ISSN 1757-4676, 08/2009, Volume 1, Issue 5, pp. 280 - 287
Journal Article
Cell Reports, ISSN 2211-1247, 06/2019, Volume 27, Issue 11, pp. 3124 - 3138.e13
Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating... 
bone | poly(ADP-ribose) | vascular smooth muscle cell | DNA damage
Journal Article
Plant Physiology, ISSN 0032-0889, 2/2015, Volume 167, Issue 2, pp. 558 - 573
The accumulation of carbon storage compounds by many unicellular algae after nutrient deprivation occurs despite declines in their photosynthetic apparatus. To... 
Carotenoids | Genes | Fluorescence | Lipids | Thylakoids | Starches | Gene expression regulation | Plants | Photosynthesis | Nitrogen | SYSTEMS AND SYNTHETIC BIOLOGY
Journal Article
Gut, ISSN 0017-5749, 01/2013, Volume 62, Issue 1, pp. 112 - 120
Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This... 
INTERSTITIAL FLUID PRESSURE | CELLS | THERAPY | SOLID TUMORS | MICROENVIRONMENT | PERMEABILITY | DUCTAL ADENOCARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | GEMCITABINE | CHEMOTHERAPY | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Cell Adhesion Molecules - administration & dosage | Tissue Array Analysis | Pancreatic Neoplasms - blood supply | Antineoplastic Agents - administration & dosage | Hyaluronic Acid - physiology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Delivery Systems | Pancreatic Neoplasms - drug therapy | Hyaluronoglucosaminidase - administration & dosage | Carcinoma, Pancreatic Ductal - mortality | Cell Adhesion Molecules - pharmacology | Pancreatic Neoplasms - mortality | Doxorubicin - administration & dosage | Deoxycytidine - administration & dosage | Kaplan-Meier Estimate | Mice, Transgenic | Treatment Outcome | Biomarkers, Tumor - physiology | Recombinant Proteins - pharmacology | Recombinant Proteins - administration & dosage | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Pancreatic Ductal - physiopathology | Mice | Carcinoma, Pancreatic Ductal - blood supply | Pancreatic Neoplasms - physiopathology | Drug Resistance, Neoplasm - physiology | Deoxycytidine - analogs & derivatives | Drug Resistance, Neoplasm - drug effects | Care and treatment | Blood-vessels | Pancreatic cancer | Patient outcomes | Physiological aspects | Models | Research | Hyaluronic acid | Tumors | Studies | Angiogenesis | Medical research | Medical prognosis | Cytotoxicity | Extracellular matrix | Permeability | Kinases | Vascular endothelial growth factor | stem cells | cell death | cancer vaccines | hyaluronan | epithelial cell growth | cancer immunobiology | drug delivery | matrix | epithelial cell adhesion | cancer genetics | carcinogenesis | pancreatic fibrosis | pharmacology | pharmacokinetics | tumour microenvironment | cancer | fibrosis | pancreatic disease | Original | 1506 | pancreatic tumours | extracellular matrix | oxidative stress
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 11/2007, Volume 2, Issue 11, pp. 713 - 717
Journal Article
Biomaterials, ISSN 0142-9612, 01/2014, Volume 35, Issue 3, pp. 1074 - 1088
Agglomeration dramatically affects many aspects of nanoparticle-cell interactions. Here we show that hydroxyapatite nanoparticles formed large agglomerates in... 
Aggregation | Surface-connected compartment | Cytotoxicity | Hydroxyapatite nanoparticles | Agglomeration | Macrophages
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2014, Volume 111, Issue 14, pp. E1354 - E1363
We provide evidence that citrate anions bridge between mineral platelets in bone and hypothesize that their presence acts to maintain separate platelets with... 
Biomineralization | NMR crystallography | CORTICAL BONE | biomineralization | SOLID-STATE NMR | CHEMICAL-SHIFTS | MULTIDISCIPLINARY SCIENCES | NUCLEAR-MAGNETIC-RESONANCE | HYDROXYAPATITE | MECHANICAL-PROPERTIES | CALCIUM PHOSPHATES | OCTACALCIUM PHOSPHATE CARBOXYLATES | H-1 MAS NMR | CRYSTALS | Biological Sciences | PNAS Plus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e30753
Angiogenesis, the formation of new blood vessels, is an essential process for tumour progression and is an area of significant therapeutic interest. Different... 
BREAST-CANCER | SPHEROIDAL COCULTURE MODEL | MATRIX METALLOPROTEINASES | SOLID TUMORS | TIP CELLS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | MULTICELLULAR SPHEROIDS | FIBRIN GELS | ENDOTHELIAL GROWTH-FACTOR | MURAL CELLS | Gene Silencing - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Stromal Cells - pathology | Humans | Spheroids, Cellular - pathology | Extracellular Matrix - metabolism | Spheroids, Cellular - enzymology | Luminescent Measurements | Neovascularization, Pathologic - pathology | Stromal Cells - drug effects | Spheroids, Cellular - drug effects | Tumor Cells, Cultured | Microscopy, Fluorescence, Multiphoton | Fibroblasts - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Extracellular Matrix - drug effects | Angiogenesis Inhibitors - pharmacology | Neoplasms - enzymology | Neoplasms - blood supply | Fibroblasts - pathology | Matrix Metalloproteinase 14 - metabolism | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Fibroblasts - drug effects | Cell Communication - drug effects | Cell Proliferation - drug effects | Neoplasms - pathology | Viral antibodies | Collagen | Antibodies | Models | Neovascularization | Health aspects | Cancer | Endothelium | Cell culture | Surgical implants | Motility | Oncology | Metastasis | Cell interactions | Skin cancer | Complexity | Angiogenesis | Fibroblasts | Extracellular matrix | Metalloproteinase | Vascular endothelial growth factor | Dissection | Growth factors | Medical research | Free radicals | Cytokines | Gels | Melanoma | Stroma | Blood vessels | Implantation | Breast cancer | Spheroids | Endothelial cells | In vivo methods and tests | Genetic engineering | Three dimensional models | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e97565
Journal Article
Circulation, ISSN 0009-7322, 10/2008, Volume 118, Issue 17, pp. 1748 - 1757
Journal Article
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1312 - 1323
Rationale: Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form the first nidus for mineralization and fetuin-A, a potent circulating... 
exosomes | extracellular matrix | vascular calcification | CALCIPROTEIN PARTICLES | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | RETICULOCYTE MATURATION | EXTRACELLULAR CALCIUM | MATRIX VESICLES | HUMAN ATHEROSCLEROTIC PLAQUES | MULTIVESICULAR ENDOSOMES | ARTERIAL CALCIFICATION | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | FETUIN-A | Exosomes - metabolism | Sphingomyelin Phosphodiesterase - genetics | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Humans | Middle Aged | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Secretory Vesicles - metabolism | Exosomes - pathology | Male | Exocytosis | Case-Control Studies | Young Adult | Intercellular Signaling Peptides and Proteins - metabolism | Vascular Calcification - metabolism | Transfection | RNA Interference | Time Factors | Sphingomyelin Phosphodiesterase - metabolism | Vascular Calcification - physiopathology | Adult | Female | Proteomics - methods | Tetraspanins - metabolism | Myocytes, Smooth Muscle - metabolism | Exosomes - secretion | Cytokines - metabolism | Cells, Cultured | Vascular Calcification - pathology | Myocytes, Smooth Muscle - secretion | Protein Transport | Secretory Vesicles - secretion | Muscle, Smooth, Vascular - pathology | Adolescent | alpha-2-HS-Glycoprotein - metabolism | Secretory Vesicles - pathology | Muscle, Smooth, Vascular - secretion
Journal Article