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Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | BASIC BIOLOGICAL SCIENCES
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 09/2010, Volume 190, Issue 6, pp. i13 - i13
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2010, Volume 207, Issue 10, pp. 2195 - 2206
The inhibitor of apoptosis proteins (IAPs) have recently been shown to modulate nuclear factor B (NF-B) signaling downstream of tumor necrosis factor (TNF)... 
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. 138 - 138
Journal Article
Cancer Research, ISSN 0008-5472, 12/2007, Volume 67, Issue 24, pp. 11493 - 11498
Journal Article
Journal Article
Journal Article
Xenotransplantation, ISSN 0908-665X, 05/2001, Volume 8, Issue 2, pp. 90 - 93
Journal Article
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