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1. Full Text Making melanoma therapy personal: an interview with Dr Keiran Smalley for
by Smalley, Keiran SM
Melanoma management, ISSN 2045-0885, 05/2017, Volume 4, Issue 2, pp. 95 - 97
targeted therapy | immunotherapy | melanoma | BRAF
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2. Full Text Making melanoma therapy personal: an interview with Dr Keiran Smalley for Melanoma Management
by Smalley, Keiran Sm
Melanoma management, ISSN 2045-0885, 05/2017, Volume 4, Issue 2, pp. 95 - 97
Medical research | Immunotherapy | Melanoma | Clinical trials | Internships | Pharmacology | Scientists | Metastasis | FDA approval | Patients | Cancer therapies | Drug dosages | targeted therapy | melanoma | BRAF | immunotherapy | Interview
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3. Full Text Understanding Melanoma Signaling Networks as the Basis for Molecular Targeted Therapy
by Smalley, Keiran S.M
Journal of investigative dermatology, ISSN 0022-202X, 01/2010, Volume 130, Issue 1, pp. 28 - 37
Life Sciences & Biomedicine | Dermatology | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Biological and medical sciences | Medical sciences | Melanoma - metabolism | Skin Neoplasms - drug therapy | Signal Transduction - drug effects | Humans | Melanoma - drug therapy | Signal Transduction - physiology | Enzyme Inhibitors - therapeutic use | Skin Neoplasms - metabolism | Index Medicus
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4. Full Text Paradoxical oncogenesis-the long-term effects of BRAF inhibition in melanoma
by Gibney, Geoffrey T and Messina, Jane L and Fedorenko, Inna V and Sondak, Vernon K and Smalley, Keiran S. M
Nature reviews. Clinical oncology, ISSN 1759-4774, 07/2013, Volume 10, Issue 7, pp. 390 - 399
Life Sciences & Biomedicine | Oncology | Science & Technology | Melanoma - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Prognosis | Antineoplastic Agents - adverse effects | Humans | Melanoma - drug therapy | Cell Transformation, Neoplastic - chemically induced | Melanoma - pathology | Care and treatment | Gene mutations | Melanoma | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus
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5. Full Text K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
by Yin, Qing and Han, Tao and Fang, Bin and Zhang, Guolin and Zhang, Chao and Roberts, Evan R and Izumi, Victoria and Zheng, Mengmeng and Jiang, Shulong and Yin, Xiu and Kim, Minjung and Cai, Jianfeng and Haura, Eric B and Koomen, John M and Smalley, Keiran S. M and Wan, Lixin
Nature communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1870 - 1870
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Skin Neoplasms - pathology | Phosphorylation | Cytokines - metabolism | Cell Survival | Humans | Ubiquitin-Protein Ligases - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Melanoma - pathology | MAP Kinase Signaling System | 14-3-3 Proteins - metabolism | Xenograft Model Antitumor Assays | Ubiquitination | Animals | Cell Transformation, Neoplastic | Mice, Nude | HEK293 Cells | Inflammation Mediators - metabolism | Cell Line, Tumor | Lysine - metabolism | Mice | Proto-Oncogene Proteins B-raf - metabolism | Repressor Proteins - metabolism | Cell proliferation | Ubiquitin | Tyrosine | Cytokines | Melanoma | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Tumorigenicity | Kinases | Signaling | Signal transduction | Cell activation | Lysine | Proteolysis | Protein-tyrosine kinase receptors | Tumorigenesis | Growth factors | Protein-tyrosine kinase | Ubiquitin-protein ligase | Index Medicus
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6. Full Text BRAF Inhibition Generates a Host–Tumor Niche that Mediates Therapeutic Escape
by Fedorenko, Inna V and Wargo, Jennifer A and Flaherty, Keith T and Messina, Jane L and Smalley, Keiran S.M
Journal of investigative dermatology, ISSN 0022-202X, 12/2015, Volume 135, Issue 12, pp. 3115 - 3124
Life Sciences & Biomedicine | Dermatology | Science & Technology | Phosphoinositide-3 Kinase Inhibitors | Fibronectins - analysis | Humans | Proto-Oncogene Proteins c-akt - physiology | Melanoma - pathology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Transforming Growth Factor beta - pharmacology | Vemurafenib | Sulfonamides - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Index Medicus | melanoma | fibroblasts | BRAF | resistance
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7. Full Text Ipilimumab
by Kudchadkar, Ragini and Sondak, Vernon K and Smalley, Keiran S. M and Grippon, Seden and Kirkpatrick, Peter
Nature reviews. Drug discovery, ISSN 1474-1776, 06/2011, Volume 10, Issue 6, pp. 411 - 412
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | CTLA-4 Antigen | Antigens, CD - immunology | Animals | Antibodies, Monoclonal - administration & dosage | Melanoma - immunology | Humans | Ipilimumab | Melanoma - drug therapy | Antibodies, Monoclonal - therapeutic use | Melanoma - secondary | Product development | Pharmaceutical industry | Licensing, certification and accreditation
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8. Full Text Why do women with melanoma do better than men?
by Smalley, Keiran S. M
eLife, ISSN 2050-084X, 01/2018, Volume 7
Female | Male | Humans | Melanoma | Skin Neoplasms | Women | Prognosis | Ipilimumab | Hormones, Sex | Skin | Risk factors | Skin cancer | Transcription factors | Research | Hormones | Cancer therapies | Proteins | Sex hormones | Medical prognosis | Immunotherapy | Females | Hippocrates (460?-377? BC) | Immune system | Tumors | Index Medicus
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9. Full Text Pharmacological research and cancer: A call to arms
by Smalley, Keiran S.M
Pharmacological research, ISSN 1043-6618, 08/2019, Volume 146, pp. 104291 - 104291
Immunotherapy - methods | Neoplasms - therapy | Neoplasms - immunology | Pharmacology - methods | Humans | Antineoplastic Agents - therapeutic use | Research | Neoplasms - drug therapy | Index Medicus
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10. Full Text Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy
by Smalley, Keiran S.M and Fedorenko, Inna V and Kenchappa, Rajappa S and Sahebjam, Solmaz and Forsyth, Peter A
International journal of cancer, ISSN 0020-7136, 09/2016, Volume 139, Issue 6, pp. 1195 - 1201
leptomeninges | melanoma | BRAF | brain | immunotherapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Melanoma - metabolism | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Meningeal Neoplasms - diagnosis | Melanoma - pathology | Molecular Targeted Therapy | Disease Progression | Meningeal Neoplasms - mortality | Meningeal Neoplasms - therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | Protein Kinase Inhibitors - therapeutic use | Immunotherapy | Disease Management | Protein Kinase Inhibitors - pharmacology | Biomarkers, Tumor - antagonists & inhibitors | Meningeal Neoplasms - secondary | Proto-Oncogene Proteins B-raf - metabolism | Development and progression | Metastasis | Melanoma | Medical prognosis | Index Medicus
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11. Full Text Melanoma — An Unlikely Poster Child for Personalized Cancer Therapy
by Smalley, Keiran S.M and Sondak, Vernon K
The New England journal of medicine, ISSN 0028-4793, 08/2010, Volume 363, Issue 9, pp. 876 - 878
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Sulfonamides - therapeutic use | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Humans | Melanoma - drug therapy | Indoles - therapeutic use | Mutation | Drug Resistance | Proteins | Chemotherapy | Kinases | Tumors | Index Medicus | Abridged Index Medicus
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12. Full Text Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology
by Mancera, Norberto and Smalley, Keiran S.M and Margo, Curtis E
Survey of ophthalmology, ISSN 0039-6257, 05/2019, Volume 64, Issue 3, pp. 272 - 288
lentigo maligna | eyelid melanoma | lentigo maligna melanoma | periocular melanoma | nodular melanoma | molecular pathology | superficial spreading melanoma | Life Sciences & Biomedicine | Ophthalmology | Science & Technology | Skin Neoplasms - pathology | Eyelid Neoplasms - pathology | Melanoma - pathology | Humans | Medical colleges | Analysis | Melanoma | Skin | Molecular biology | Epidemiology | Cells | Index Medicus
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