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Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 05/2013, Volume 23, Issue 10, pp. 2996 - 3000
This Letter describes the further chemical optimization of the M-5 PAM MLPCN probes ML129 and ML172. A multi-dimensional iterative parallel synthesis effort... 
CHEMISTRY, MEDICINAL | ALLOSTERIC MODULATORS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | KNOCKOUT MICE | MUSCARINIC ACETYLCHOLINE-RECEPTORS | M-5 | Positive allosteric modulator (PAM) | ISATINS | ML326 | RAT-BRAIN | Muscarinic acetylcholine receptors | INSIGHTS
Journal Article
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3029 - 3033
This Letter describes the chemical optimization of a novel series of M-4 positive allosteric modulators (PAMs) based on a 5,6-dimethyl-4-(piperidin-1-yl)... 
POSITIVE ALLOSTERIC MODULATOR | CHEMISTRY, MEDICINAL | Schizophrenia | CHEMISTRY, ORGANIC | DISORDERS | OPPORTUNITIES | Structure-Activity Relationship (SAR) | AGONISTS | Muscarinic acetylcholine receptor | MUSCARINIC ACETYLCHOLINE-RECEPTOR | M-4 | Positive allosteric modulator (PAM) | GPCRS | POTENTIATORS
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3029 - 3033
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2014, Volume 57, Issue 18, pp. 7804 - 7810
A functional high throughput screen identified a novel chemotype for the positive allosteric modulation (PAM) of the muscarinic acetylcholine receptor (mAChR)... 
CHEMISTRY, MEDICINAL | DISCOVERY | MUSCARINIC ACETYLCHOLINE-RECEPTOR
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 36, pp. 30063 - 30072
Journal Article
Canadian Journal of Fisheries and Aquatic Sciences, ISSN 0706-652X, 12/2014, Volume 71, Issue 12, p. 1840
  Variable fluorescence of chlorophyll a (Fv/Fm), as measured by pulse amplitude modulated (PAM) fluorometry, has been proposed as a metric of nutrient... 
Chlorophyll | Plankton | Correlation analysis | Fluorescence | Lakes
Journal Article
Canadian journal of fisheries and aquatic sciences/Journal canadien des sciences halieutiques et aquatiques, ISSN 0706-652X, 01/2014, Volume 71, Issue 12, pp. 12 - 12
Variable fluorescence of chlorophyll a (Fv/Fm), as measured by pulse amplitude modulated (PAM) fluorometry, has been proposed as a metric of nutrient... 
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 09/2016, Volume 26, Issue 17, pp. 4282 - 4286
This Letter describes the chemical optimization of a novel series of M-4 PAMs based on a non-enolizable ketone core, identified from an MLPCN functional... 
POSITIVE ALLOSTERIC MODULATOR | CHEMISTRY, MEDICINAL | M-4 | Positive allosteric modulator (PAM) | Schizophrenia | CHEMISTRY, ORGANIC | Structure-Activity Relationship (SAR) | AGONISTS | Muscarinic acetylcholine receptor | MUSCARINIC ACETYLCHOLINE-RECEPTOR
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 18, pp. 7804 - 7810
A functional high throughput screen identified a novel chemotype for the positive allosteric modulation (PAM) of the muscarinic acetylcholine receptor (mAChR)... 
Journal Article
Canadian Journal of Fisheries and Aquatic Sciences, ISSN 0706-652X, 2014, Volume 71, Issue 12, pp. 1840 - 1851
Variable fluorescence of chlorophyll a (F v /F m ), as measured by pulse amplitude modulated (PAM) fluorometry, has been proposed as a metric of nutrient... 
FISHERIES | FLUORESCENCE | QUANTUM YIELD | MARINE & FRESHWATER BIOLOGY | PHOSPHORUS LIMITATION | NITROGEN | MARINE | TRENDS | CHLOROPHYLL CONTENT | EUTROPHICATION | ALKALINE-PHOSPHATASE ACTIVITY | WATER | Environmental aspects | Phytoplankton | Fluorimetry | Methods
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2004, Volume 279, Issue 2, pp. 1351 - 1358
Journal Article
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