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International Journal of Molecular Medicine, ISSN 1107-3756, 2/2015, Volume 35, Issue 2, pp. 519 - 524
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 02/2015, Volume 35, Issue 2, p. 519
The tree shrew (Tupaia belangeri) diverges from the primate order (Primates) and is classified as a separate taxonomic group of mammals--Scandentia. It has... 
Actin | Physiological aspects | Genetic aspects | Research | Gene expression
Journal Article
Journal Article
CNS & neurological disorders drug targets, ISSN 1871-5273, 2006, Volume 5, Issue 3, pp. 355 - 361
The accumulation of amyloid beta peptide (Abeta) is believed to be an early and critical event leading to synapse and neuronal cell loss in Alzheimer's Disease... 
Animals | Signal Transduction - drug effects | Amyloid beta-Peptides - toxicity | Humans | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Alzheimer Disease - drug therapy | Signal Transduction - physiology | Drug Delivery Systems - methods
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 7, pp. 2693 - 2698
Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously,... 
Brain | Eclosion | Phenotypes | Disease models | Neurons | Drosophila | Mortality | Parkinson disease | Genetic mutation | Genotypes | Dopaminergic neuron | Parkinson's disease | KINASE-ACTIVITY | MULTIDISCIPLINARY SCIENCES | MECHANISMS | dopaminergic neuron | NEURODEGENERATIVE DISEASES | DEGENERATION | arkinson's disease | FLY | COMMON LRRK2 MUTATION | TARGETED GENE-EXPRESSION | NEURONS | NEUROPATHOLOGY | MELANOGASTER | Retina - metabolism | Dopamine - genetics | Nerve Degeneration - genetics | Gait Disorders, Neurologic - genetics | Drosophila melanogaster - genetics | Nerve Degeneration - metabolism | Drosophila melanogaster - metabolism | Parkinsonian Disorders - metabolism | Gait Disorders, Neurologic - pathology | Parkinsonian Disorders - genetics | Dopamine - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Animals, Genetically Modified | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Drosophila melanogaster - ultrastructure | Microscopy, Electron | Nerve Degeneration - pathology | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Dopa Decarboxylase - metabolism | Gait Disorders, Neurologic - metabolism | Animals | Parkinsonian Disorders - pathology | Dopa Decarboxylase - genetics | Parkinsonism | Usage | Genetic aspects | Models | Biological Sciences
Journal Article
PLOS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0122461
Leucine-rich repeat kinase-2 (LRRK2), a cytoplasmic protein containing both GTP binding and kinase activities, has emerged as a highly promising drug target... 
Brain | Phosphorylation | GTP | Animal models | Parkinson's disease | Toxicity | Pathogenesis | Leucine | Kinases | Lipopolysaccharides | Proteins | Neurodegeneration | Rodents | Biocompatibility | Inhibition | Toxic diseases | LRRK2 protein | Movement disorders | Binding | Effectiveness | Neurodegenerative diseases | Pharmacology | Inflammation | Microglia | Inhibitors | Mutation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2009, Volume 106, Issue 8, pp. 2897 - 2902
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142314 - e0142314
Journal Article
Journal Article
PLoS ONE, 01/2015, Volume 10, Issue 11
Previously, we have identified a novel role for the cytoplasmic protein, synphilin-1(SP1), in the controls of food intake and body weight in both mice and... 
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 10/2011, Volume 20, Issue 20, pp. 3933 - 3942
Journal Article
Journal Article