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1. Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: A randomised study
by Stolz, D and Smyrnios, N and Eggimann, P and Pargger, H and Thakkar, N and Siegemund, M and Marsch, S and Azzola, A and Rakic, J and Mueller, B and Tamm, M
European Respiratory Journal, ISSN 0903-1936, 12/2009, Volume 34, Issue 6, pp. 1364 - 1375
In patients with ventilator-associated pneumonia (VAP), guidelines recommend antibiotic therapy adjustment according to microbiology results after 72 h.... 
Biomarker | Ventilator-associated pneumonia | Procalcitonin | Antibiotic therapy | C-REACTIVE PROTEIN | DIAGNOSIS | ANTIMICROBIAL THERAPY | ACQUIRED PNEUMONIA | procalcitonin | ventilator-associated pneumonia | SEPSIS | biomarker | DE-ESCALATION | TRIAL | INTENSIVE-CARE-UNIT | RESPIRATORY SYSTEM | INFECTION | CRITICALLY-ILL PATIENTS | Calcitonin Gene-Related Peptide | Calcitonin - blood | Guidelines as Topic | Protein Precursors - blood | Humans | Middle Aged | Proportional Hazards Models | Male | Treatment Outcome | Pneumonia, Ventilator-Associated - microbiology | Time Factors | Adolescent | Aged, 80 and over | Adult | Female | Aged | Anti-Bacterial Agents - administration & dosage | Pneumonia, Ventilator-Associated - drug therapy
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2. Full Text Comparison of a Self-Inflating Bulb Syringe and a Colorimetric CO2 Indicator With Capnography and Radiography to Detect the Misdirection of Naso/Orogastric Tubes Into the Airway of Critically Ill Adult Patients
by Smyrnios, Nicholas A., MD, FCCP and Lenard, Richard, RRT-NPS, RPFT and Rajan, Sunil, MD, FCCP and Newman, Michael S., DO and Baker, Stephen P., MScPH and Thakkar, Nehal, MD, FCCP and Wassef, Wahid, MD and Ajmere, Niraj K., MD and Irwin, Richard S., MD, Master FCCP
Chest, ISSN 0012-3692, 2015, Volume 147, Issue 6, pp. 1523 - 1529
OBJECTIVE The objective of this study was to develop a mechanism of discovering misdirection into the airway of naso/orogastric (NG) tubes before they reach... 
Pulmonary/Respiratory | INSERTION | PLACEMENT | FEEDING TUBES | INTENSIVE-CARE-UNIT | RESPIRATORY SYSTEM | DEVICE | PREVENTION | ESOPHAGEAL INTUBATION | COMPLICATIONS | NASOGASTRIC TUBE | CRITICAL CARE MEDICINE | Prospective Studies | Humans | Middle Aged | Capnography - economics | Colorimetry - economics | Critical Illness | Colorimetry - instrumentation | Male | Carbon Dioxide - analysis | Swine | Sensitivity and Specificity | Female | Models, Animal | Colorimetry - methods | Intensive Care Units | Carbon Dioxide - metabolism | Respiratory System - diagnostic imaging | Radiography, Thoracic - economics | Intubation, Gastrointestinal - adverse effects | Capnography - methods | Animals | Syringes | Exhalation - physiology | Respiratory System - metabolism | Cost-Benefit Analysis | Radiography, Thoracic - methods | Respiratory System - physiopathology | Capnography - instrumentation | Radiography | Respiratory therapy | Usage | Capnography | Critically ill | Equipment and supplies | Health aspects
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3. Full Text The Sequential Organ Failure Assessment score and copeptin for predicting survival in ventilator-associated pneumonia
by Boeck, Lucas, MD and Eggimann, Philippe, MD and Smyrnios, Nicholas, MD and Pargger, Hans, MD and Thakkar, Nehal, MD and Siegemund, Martin, MD and Morgenthaler, Nils G., MD and Rakic, Janko, MD and Tamm, Michael, MD and Stolz, Daiana, MD
Journal of Critical Care, ISSN 0883-9441, 2012, Volume 27, Issue 5, pp. 523.e1 - 523.e9
Abstract Introduction Ventilator-associated pneumonia remains the most common nosocomial infection in the critically ill and contributes to significant... 
Critical Care | Infection | Biomarker | Prognosis | APACHE-II | MANAGEMENT | SOFA SCORE | RISK | VASOPRESSIN PRECURSOR | SEPSIS | STABLE PEPTIDE | SEVERITY SCORES | CRITICALLY-ILL PATIENTS | CRITICAL CARE MEDICINE | Pneumonia, Ventilator-Associated - mortality | Prospective Studies | Humans | Middle Aged | Pneumonia, Ventilator-Associated - blood | Male | Pneumonia, Ventilator-Associated - diagnosis | Biomarkers | Adult | Female | Glycopeptides - blood | Organ Dysfunction Scores | ROC Curve | Aged | Pneumonia | Bacterial pneumonia | Patient outcomes
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4. Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP
by Boeck, L and Eggimann, P and Smyrnios, N and Pargger, H and Thakkar, N and Siegemund, M and Marsch, S and Rakic, J and Tamm, M and Stolz, D
European Respiratory Journal, ISSN 0903-1936, 03/2011, Volume 37, Issue 3, pp. 595 - 603
Ventilator-associated pneumonia (VAP) affects mortality, morbidity and cost of critical care. Reliable risk estimation might improve end-of-life decisions,... 
Midregional pro-atrial natriuretic peptide | Biomarker | Ventilator-associated pneumonia | Prognosis | Procalcitonin | Risk stratification | C-REACTIVE PROTEIN | COMMUNITY-ACQUIRED PNEUMONIA | risk stratification | PULMONARY-HYPERTENSION | HEART-FAILURE | INTENSIVE-CARE UNITS | procalcitonin | ventilator-associated pneumonia | RANDOMIZED CONTROLLED-TRIAL | prognosis | PROGNOSTIC VALUE | RESPIRATORY SYSTEM | CRITICALLY-ILL PATIENTS | midregional pro-atrial natriuretic peptide | RESPIRATORY-TRACT INFECTIONS | Biomarkers - metabolism | Calcitonin Gene-Related Peptide | Pneumonia, Ventilator-Associated - mortality | Calcitonin - blood | Prospective Studies | Protein Precursors - blood | Pneumonia, Ventilator-Associated - therapy | Humans | Middle Aged | Gene Expression Regulation | Male | Risk | Treatment Outcome | Atrial Natriuretic Factor - blood | Regression Analysis | Adult | Female | ROC Curve | Aged
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5. Full Text Pancreatic stone protein: A marker of organ failure and outcome in ventilator-associated pneumonia
by Boeck, Lucas and Graf, Rolf and Eggimann, Philippe and Pargger, Hans and Raptis, Dimitri A and Smyrnios, Nicholas and Thakkar, Nehal and Siegemund, Martin and Rakic, Janko and Tamm, Michael and Stolz, Daiana
Chest, ISSN 0012-3692, 2011, Volume 140, Issue 4, pp. 925 - 932
Background: Ventilator-associated pneumonia (VAP) is the most common hospital-acquired, life-threatening infection. Poor outcome and health-care costs of... 
PSP/REG | SECRETORY STRESS-PROTEINS | ICU MORTALITY | RAT | RESPIRATORY SYSTEM | PROCALCITONIN | GENE-EXPRESSION | COORDINATE REGULATION | REG PROTEIN | CELL-GROWTH | PAP | Pneumonia, Ventilator-Associated - mortality | Multiple Organ Failure - mortality | Prognosis | Humans | Middle Aged | Kaplan-Meier Estimate | Pneumonia, Ventilator-Associated - blood | Male | Survival Rate | Biomarkers - blood | Lithostathine - blood | Multiple Organ Failure - diagnosis | Pneumonia, Ventilator-Associated - diagnosis | Pilot Projects | Sensitivity and Specificity | Adult | Female | ROC Curve | Aged | Multiple Organ Failure - blood | Retrospective Studies | Complications and side effects | Pneumonia | Bacterial pneumonia | Patient outcomes | Cross infection | Research | Nosocomial infections | Binding proteins | Biological markers | Artificial respiration
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6. Full Text Chronic cough with a history of excessive sputum production: The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy
by Smyrnios, N.A and Irwin, R.S and Curley, F.J
Chest, ISSN 0012-3692, 1995, Volume 108, Issue 4, pp. 991 - 997
Study objective: To determine (1) the spectrum and frequency of causes of chronic cough with a history of excessive sputum production (CCS) and (2) the... 
cough | sputum | bronchorrhea | BRONCHORRHEA | RESPIRATORY MUCUS | SPUTUM | RESPIRATORY SYSTEM | CHRONIC PERSISTENT COUGH | COUGH | MUCUS HYPERSECRETION | CRITICAL CARE MEDICINE | Diagnosis, Differential | Cough - physiopathology | Prospective Studies | Cough - therapy | Humans | Middle Aged | Cough - diagnosis | Male | Treatment Outcome | Combined Modality Therapy | Chi-Square Distribution | Remission Induction | Sputum - metabolism | Cough - etiology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Respiratory Function Tests | Chronic Disease | Care and treatment | Respiratory mucosa | Analysis | Cough
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7. Full Text Effects of a multifaceted, multidisciplinary, hospital-wide quality improvement program on weaning from mechanical ventilation
by Smyrnios, Nicholas A and Connolly, Ann and Wilson, Mark M and Curley, Frederick J and French, Cynthia T and Heard, Stephen O and Irwin, Richard S
Critical Care Medicine, ISSN 0090-3493, 06/2002, Volume 30, Issue 6, pp. 1224 - 1230
OBJECTIVETo examine the effects of a mechanical ventilation weaning management protocol that was implemented as a hospital-wide, quality improvement program on... 
Quality improvement | Ventilator | Respiratory failure | Weaning | Mechanical ventilation | Cost containment | mechanical ventilation | FACILITIES | PROTOCOL | TIME | weaning | INTENSIVE-CARE | COST | ventilator | quality improvement | respiratory failure | cost containment | DURATION | CRITICAL CARE MEDICINE | Prospective Studies | Hospital Mortality | Length of Stay - economics | Humans | Middle Aged | Diagnosis-Related Groups | Male | Respiration, Artificial - economics | Quality of Health Care - trends | Cost Control | Female | Ventilator Weaning | APACHE
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8. Full Text Accuracy of 30-Minute Indirect Calorimetry Studies in Predicting 24-Hour Energy Expenditure in Mechanically Ventilated, Critically Ill Patients
by Smyrnios, Nicholas A and Curley, Frederick J and Shaker, K. Gem
Journal of Parenteral and Enteral Nutrition, ISSN 0148-6071, 05/1997, Volume 21, Issue 3, pp. 168 - 174
Background: There is no consensus regarding the optimal duration of measurement or time of day to perform indirect calorimetry (IC). Energy expenditure (EE)... 
TOTAL PARENTERAL-NUTRITION | SURGICAL PATIENTS | NUTRITION & DIETETICS | GLUCOSE | HUMANS | RESTING METABOLIC-RATE | GAS-EXCHANGE | Reproducibility of Results | Humans | Middle Aged | Oxygen Consumption | Critical Illness | Male | Calorimetry, Indirect | Respiration, Artificial | Monitoring, Physiologic | Energy Metabolism | Capnography | Aged, 80 and over | Adult | Female | Aged
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9. Full Text Reward-punishment sensitivity bias predicts narcissism subtypes: Implications for the etiology of narcissistic personalities
by Miles, Gabrielle J and Smyrnios, Kosmas X and Jackson, Mervyn and Francis, Andrew J.P
Personality and Individual Differences, ISSN 0191-8869, 04/2019, Volume 141, pp. 143 - 151
Etiology for narcissism is undetermined, although associations have been reported between subtypes of narcissism and Gray's (1970, revised 2000) biologically... 
Behavioral avoidance | Behavioral approach | Entrepreneurship | Reinforcement Sensitivity Theory | Genetics | Narcissism | Approach-avoidance bias | ACTIVATION SYSTEMS | PSYCHOLOGY, SOCIAL | BEHAVIORAL-INHIBITION | VALIDATION | HEALTHY | IMPULSIVITY | PATHOLOGICAL NARCISSISM | ASYMMETRY | INDIVIDUAL-DIFFERENCES | INVENTORY | BAS | Development and progression | Causes and theories of causation | Diseases
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10. Full Text The jury on femoral vein catheterization is still out
by Smyrnios, Nicholas A and Irwin, Richard S
Critical Care Medicine, ISSN 0090-3493, 12/1997, Volume 25, Issue 12, pp. 1943 - 1946
Deep vein thrombosis | Central venous catheters | Catheterization | Femoral vein | femoral vein | UPPER-EXTREMITY | THROMBOSIS | central venous catheters | PREVALENCE | SEPSIS | FAILURE | RANDOMIZED TRIAL | deep vein thrombosis | PLACEMENT | catheterization, femoral vein | K FF EMERGENCY MEDICINE & CRITICAL CARE | PULMONARY-EMBOLISM | EMERGENCY MEDICINE & CRITICAL CARE | Femoral Vein | Intensive Care Units | Thrombophlebitis - etiology | Humans | Catheterization, Central Venous - adverse effects
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11. Full Text The Influence of Liposome-Encapsulated Prostaglandin E1 on Hydrogen Peroxide Concentrations in the Exhaled Breath of Patients with the Acute Respiratory Distress Syndrome
by Heard, Stephen O and Longtine, Karen and Toth, Ildiko and Puyana, Juan Carlos and Potenza, Bruce and Smyrnios, Nicholas
Anesthesia & Analgesia, ISSN 0003-2999, 08/1999, Volume 89, Issue 2, pp. 353 - 357
Hydrogen peroxide (H2 O2) levels are increased in the exhaled breath of patients with the acute respiratory distress syndrome (ARDS).Because... 
Humans | Middle Aged | Breath Tests | Male | Respiratory Distress Syndrome, Adult - metabolism | Alprostadil - administration & dosage | Drug Carriers | Respiratory Distress Syndrome, Adult - blood | Hydrogen Peroxide - analysis | Adult | Female | Leukocyte Count | Infusions, Intravenous | Liposomes | Respiratory Distress Syndrome, Adult - therapy
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12. Full Text The influence of liposome-encapsulated prostaglandin E-1 on hydrogen peroxide concentrations in the exhaled breath of patients with the acute respiratory distress syndrome
by Heard, SO and Longtine, K and Toth, I and Puyana, JC and Potenza, B and Smyrnios, N
ANESTHESIA AND ANALGESIA, ISSN 0003-2999, 08/1999, Volume 89, Issue 2, pp. 353 - 357
Hydrogen peroxide (H2O2) levels are increased in the exhaled breath of patients with the acute respiratory distress syndrome (ARDS). Because... 
CELLS | INTERLEUKIN-1 | TUMOR-NECROSIS-FACTOR | CLINICAL-TRIAL | EXPIRED BREATH | DOUBLE-BLIND | ACUTE LUNG INJURY | NEUTROPHILS | ANESTHESIOLOGY | PATHOPHYSIOLOGIC SIGNIFICANCE | FACTOR-ALPHA
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13. Full Text Pleural effusion in an asymptomatic patient. Spectrum and frequency of causes and management considerations
by N A Smyrnios and P J Jederlinic and R S Irwin
Chest, ISSN 0012-3692, 01/1990, Volume 97, Issue 1, pp. 192 - 196
We conducted retrospective chart and literature reviews to analyze the frequency and spectrum of causes of asymptomatic pleural effusion (APE). In our series,... 
RESPIRATORY SYSTEM | Pleural Effusion - therapy | Retrospective Studies | Pleural Effusion - etiology | Humans | Pleural Effusion - diagnosis | Pleural effusions | Chest | Diagnosis | Lungs | Biopsy | Paracentesis
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14. Full Text The effect of liposome-encapsulated PGE(1) on systemic oxygen delivery and consumption in patients with the acute respiratory distress syndrome
by Heard, SO and Longtine, K and Smyrnios, N and Puyana, JC
JOURNAL OF INTENSIVE CARE MEDICINE, ISSN 0885-0666, 05/2002, Volume 17, Issue 3, pp. 127 - 131
The goal of this study was to determine the effect of liposome-encapsulated prostaglandin E-1 (PGE(1)) on oxygen delivery and consumption and hemodynamics in... 
TRIAL | MULTICENTER | PULMONARY-HYPERTENSION | oxygen consumption | liposomes | DOUBLE-BLIND | oxygen delivery | prostaglandin E-1 cardiac index | PROSTAGLANDIN E-1 | acute respiratory distress syndrome (ARDS) | CRITICAL CARE MEDICINE
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15. Full Text Sailing or Sinking Ship? The Pulmonary Artery Catheter Treads Water
by Smyrnios, Nicholas A and Irwin, Richard S
Journal of Intensive Care Medicine, ISSN 0885-0666, 5/1997, Volume 12, Issue 3, pp. 113 - 115
TRIAL | EMERGENCY MEDICINE & CRITICAL CARE | CRITICALLY ILL PATIENTS | K FF EMERGENCY MEDICINE & CRITICAL CARE
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16. Full Text Interpretation of Positive Results of a Methacholine Inhalation Challenge and 1 Week of Inhaled Bronchodilator Use in Diagnosing and Treating Cough-Variant Asthma
by Irwin, Richard S and French, Cynthia T and Smyrnios, Nicholas A and Curley, Frederick J
Archives of Internal Medicine, ISSN 0003-9926, 09/1997, Volume 157, Issue 17, pp. 1981 - 1987
BACKGROUND: In diagnosing cough due to asthma, methacholine chloride inhalation challenge (MIC) interpreted in a traditional fashion has been shown to have... 
MEDICINE, GENERAL & INTERNAL | RESPONSIVENESS | THERAPY | CLINICAL-TRIAL | KEY COMPONENTS | BRONCHOPROVOCATION | FREQUENCY | SYMPTOMS | SPECTRUM | BRONCHIAL-ASTHMA | AGONIST | Asthma - diagnosis | Bronchial Provocation Tests - methods | Prospective Studies | Bronchodilator Agents - administration & dosage | Double-Blind Method | Metaproterenol - administration & dosage | Cough - drug therapy | Humans | Middle Aged | Administration, Inhalation | Cough - diagnosis | Male | Asthma - drug therapy | Cross-Over Studies | Cough - etiology | Bronchoconstrictor Agents - administration & dosage | Time Factors | Asthma - complications | Bronchial Provocation Tests - statistics & numerical data | Methacholine Chloride - administration & dosage | Adrenergic beta-Agonists - administration & dosage | Adult | Female | Aged | Care and treatment | Methacholine | Diagnosis | Health aspects | Cough | Bronchodilator agents | Asthma
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17. Full Text Caring for Family Caregivers in Australia: A Model of Psychoeducational Support
by Schultz, Cynthia L and Smyrnios, Kosmas X and Grbich, Carolyn F and Schultz, Noel C
Ageing and Society, ISSN 0144-686X, 3/1993, Volume 13, Issue 1, pp. 1 - 25
The present paper describes and traces the emergence of an innovative psychoeducational model of support for family caregivers of dependent elderly persons,... 
HELP | DEMENTIA | CARE-GIVERS | EMOTIONAL DISTRESS | ADULTS | GERONTOLOGY | STRESS | BURDEN | GROUP INTERVENTION | STRATEGIES | Caregivers | Social policy | Care and treatment | Aged | Families & family life | Social research | Social services | Older people
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18. Full Text Pancreatic Stone Protein
by Boeck, Lucas, MD and Graf, Rolf, MD and Eggimann, Philippe, MD and Pargger, Hans, MD and Raptis, Dimitri A., MD and Smyrnios, Nicholas, MD and Thakkar, Nehal, MD and Siegemund, Martin, MD and Rakic, Janko, MD and Tamm, Michael, MD, FCCP and Stolz, Daiana, MD, MPH
Chest, ISSN 0012-3692, 2011, Volume 140, Issue 4, pp. 925 - 932
Background Ventilator-associated pneumonia (VAP) is the most common hospital-acquired, life-threatening infection. Poor outcome and health-care costs of... 
Pulmonary/Respiratory
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19. Full Text From a Prospective Study of Chronic Cough: Diagnostic and Therapeutic Aspects in Older Adults
by Smyrnios, Nicholas A and Irwin, Richard S and Curley, Frederick J and French, Cynthia L
Archives of Internal Medicine, ISSN 0003-9926, 06/1998, Volume 158, Issue 11, pp. 1222 - 1228
BACKGROUND Cough is the most common complaint for which adults see a physician in the ambulatory setting in the United States. An anatomical diagnostic... 
MEDICINE, GENERAL & INTERNAL | GASTROESOPHAGEAL REFLUX | KEY COMPONENTS | FREQUENCY | CHRONIC PERSISTENT COUGH | ASTHMA | SPECTRUM | Cough - etiology | Prospective Studies | Humans | Middle Aged | Sensitivity and Specificity | Aged, 80 and over | Female | Male | Aged | Chronic Disease | Gastroesophageal reflux | Causes of | Physiological aspects | Cough | Asthma
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20. Grieving related to development: A preliminary comparison of three age cohorts of parents of children with intellectual disability
by Bruce, Elizabeth J and Bruce, E.J and Schultz, Cynthia L and Schultz, C.L and Smyrnios, Kosmas X and Smyrnios, K.X and Schultz, N.C and Schultz, Noel C
British Journal of Medical Psychology, ISSN 0007-1129, 1994, Volume 67, Issue 1, pp. 37 - 52
It is argued that a child with intellectual disability represents an ongoing source of loss and grief for parents. A developmental framework was employed to... 
Severity of Illness Index | Developmental Disabilities | Grief | Humans | Middle Aged | Child, Preschool | Infant | Male | Parents - psychology | Adolescent | Sex Factors | Adult | Female | Child | Cohort Studies
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