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Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1741, pp. 31 - 51
In this chapter, we describe the use of Illumina Infinium HD Assay in conjunction with Illumina's EPIC Methylation 8-sample array platform to obtain... 
Array | GBM | Profiling | FFPE | DNA | Multiplex | DNA methylation | Tumor | Illumina | Subgroup classification | DNA Methylation | Glioblastoma - genetics | Oligonucleotide Array Sequence Analysis | Humans | Gene Dosage | High-Throughput Nucleotide Sequencing | Genome, Human | Genomics - methods | Nucleic Acid Amplification Techniques | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4476 - 4481
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously... 
Anti-angiogenic therapy | Macrophage polarization | Tumor microenvironment | Microglia reprogramming | Anti-tumor immunity | anti-angiogenic therapy | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | macrophage polarization | RANDOMIZED-TRIAL | ANGIOPOIETIN-2 | CANCER | THERAPY | microglia reprogramming | TIE2-EXPRESSING MONOCYTES | BLOOD-VESSELS | TUMOR-ASSOCIATED MACROPHAGES | tumor microenvironment | NORMALIZATION | anti-tumor immunity | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Antibodies, Bispecific - pharmacology | Vesicular Transport Proteins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Macrophages - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Animals | Antibodies, Neoplasm - pharmacology | Ribonuclease, Pancreatic - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Mice | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Models | Macrophages | Vascular endothelial growth factor | Health aspects | Glioblastoma multiforme | Genotype & phenotype | Survival analysis | Protein expression | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2018, Volume 24, Issue 10, pp. 1559 - 1567
Visual inspection of histopathology slides is one of the main methods used by pathologists to assess the stage, type and subtype of lung tumors. Adenocarcinoma... 
TARGETED THERAPY | INACTIVATION | MEDICINE, RESEARCH & EXPERIMENTAL | NEURAL-NETWORKS | PROMISE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOCARCINOMAS | EGFR MUTATION | KRAS | LKB1 | SOCIETY | CELL BIOLOGY | Carcinoma, Non-Small-Cell Lung - pathology | Adenocarcinoma - pathology | Neoplasm Proteins - classification | Carcinoma, Non-Small-Cell Lung - genetics | Adenocarcinoma - classification | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Non-Small-Cell Lung - diagnosis | Mutation - genetics | Deep Learning | Carcinoma, Squamous Cell - diagnosis | Adenocarcinoma - diagnosis | Carcinoma, Non-Small-Cell Lung - classification | Carcinoma, Squamous Cell - classification | Adenocarcinoma - genetics | Neoplasm Proteins - genetics | Neural Networks (Computer) | Usage | Gene mutations | Machine learning | Development and progression | Genetic aspects | Lung cancer, Non-small cell | Histology, Pathological | Identification and classification | Methods | Adenocarcinoma | Paraffins | Visual discrimination learning | Squamous cell carcinoma | Medical imaging | Epidermal growth factor receptors | p53 Protein | Lung | Lung cancer | Artificial neural networks | Inspection | Genomes | Paraffin | Tissues | Histopathology | Neural networks | Predictions | Mathematical models | Mutation | Cancer | Tumors | Image classification | Index Medicus
Journal Article
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Adriana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Rodriguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, Jürgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Andreas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and Driever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and Von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Gudrun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7697, pp. 469 - 474
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 520, Issue 7547, pp. 363 - 367
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 47, pp. 19059 - 19064
Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms... 
Oxygen | Perfusion | Glioblastoma | Biological markers | Radiotherapy | Blood | Tissue oxygenation | Tumors | Cancer | Blood plasma | VEGFR2 | VASCULAR NORMALIZATION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | brain tumor | RADIATION | personalized treatment | TEMOZOLOMIDE | GROWTH-FACTOR RECEPTOR | ANTIANGIOGENIC THERAPY | AMPLIFICATION | MICROENVIRONMENT | TYROSINE KINASE INHIBITOR | Prospective Studies | Humans | Brain Neoplasms - pathology | Quinazolines | Glioblastoma - radiotherapy | Brain Neoplasms - metabolism | Oxygen - metabolism | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Polymerase Chain Reaction | Statistics, Nonparametric | Glioblastoma - metabolism | Brain Neoplasms - radiotherapy | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Enzyme-Linked Immunosorbent Assay | Angiogenesis Inhibitors - pharmacology | Treatment Outcome | Brain Neoplasms - drug therapy | Receptor Protein-Tyrosine Kinases - metabolism | Biomarkers, Tumor - blood | Magnetic Resonance Imaging | Glioblastoma - pathology | Protein Kinase Inhibitors - pharmacology | Glioblastoma - drug therapy | Cancer patients | Chemotherapy | Patient outcomes | Physiological aspects | Dosage and administration | Drug therapy | Glioblastoma multiforme | Methods | Cediranib | Survival analysis | Cell growth | Biomarkers | Clinical trials | Kinases | Patients | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4470 - 4475
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2)... 
Anti-angiogenic therapy | Colony-stimulating factor 1 | Tumor immunity | Tumor microenvironment | Macrophage | anti-angiogenic therapy | ANGIOPOIETIN-2 FUNCTIONS | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | macrophage | BEVACIZUMAB PLUS IRINOTECAN | RANDOMIZED-TRIAL | ANTIBODY | tumor immunity | KINASE INHIBITOR | ANTIANGIOGENIC THERAPY | PHASE-II TRIAL | colony-stimulating factor 1 | tumor microenvironment | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Macrophages - metabolism | Animals | Antibodies, Neoplasm - pharmacology | Receptors, Vascular Endothelial Growth Factor - metabolism | Ribonuclease, Pancreatic - metabolism | Neovascularization, Pathologic - drug therapy | Glioblastoma - pathology | Cell Line, Tumor | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Glioblastoma - metabolism | Mice | Neovascularization, Pathologic - metabolism | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Quinazolines - pharmacology | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Survival analysis | Gene expression | Kinases | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
by Sturm, Dominik and Orr, Brent A and Toprak, Umut H and Hovestadt, Volker and Jones, David T.W and Jones, Chris and Capper, David and Sill, Martin and Buchhalter, Ivo and Northcott, Paul A and Leis, Irina and Ryzhova, Marina and Koelsche, Christian and Pfaff, Elke and Allen, Sariah J and Balasubramanian, Gnanaprakash and Worst, Barbara C and Pajtler, Kristian W and Brabetz, Sebastian and Johann, Pascal D and Sahm, Felix and Reimand, Jüri and Mackay, Alan and Carvalho, Diana M and Remke, Marc and Phillips, Joanna J and Perry, Arie and Cowdrey, Cynthia and Drissi, Rachid and Fouladi, Maryam and Giangaspero, Felice and Łastowska, Maria and Grajkowska, Wiesława and Scheurlen, Wolfram and Pietsch, Torsten and Hagel, Christian and Gojo, Johannes and Lötsch, Daniela and Berger, Walter and Slavc, Irene and Haberler, Christine and Jouvet, Anne and Holm, Stefan and Hofer, Silvia and Prinz, Marco and Keohane, Catherine and Fried, Iris and Mawrin, Christian and Scheie, David and Mobley, Bret C and Schniederjan, Matthew J and Santi, Mariarita and Buccoliero, Anna M and Dahiya, Sonika and Kramm, Christof M and von Bueren, André O and von Hoff, Katja and Rutkowski, Stefan and Herold-Mende, Christel and Frühwald, Michael C and Milde, Till and Hasselblatt, Martin and Wesseling, Pieter and Rößler, Jochen and Schüller, Ulrich and Ebinger, Martin and Schittenhelm, Jens and Frank, Stephan and Grobholz, Rainer and Vajtai, Istvan and Hans, Volkmar and Schneppenheim, Reinhard and Zitterbart, Karel and Collins, V. Peter and Aronica, Eleonora and Varlet, Pascale and Puget, Stephanie and Dufour, Christelle and Grill, Jacques and Figarella-Branger, Dominique and Wolter, Marietta and Schuhmann, Martin U and Shalaby, Tarek and Grotzer, Michael and van Meter, Timothy and Monoranu, Camelia-Maria and Felsberg, Jörg and Reifenberger, Guido and Snuderl, Matija and Forrester, Lynn Ann and Koster, Jan and Versteeg, Rogier and Volckmann, Richard and van Sluis, Peter and Wolf, Stephan and Mikkelsen, Tom and Gajjar, Amar and Aldape, Kenneth and Moore, Andrew S and Taylor, Michael D and ...
Cell, ISSN 0092-8674, 02/2016, Volume 164, Issue 5, pp. 1060 - 1072
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2018, Volume 20, Issue 7, pp. 775 - 781
As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell proliferation1-4. However, the limiting metabolites for proliferation... 
OXYGEN | AMINO-ACID TRANSPORTER | INHIBITION | MICROENVIRONMENT | GLUTAMATE | RESPIRATION | IN-VIVO | MITOCHONDRIA | SENSITIVITY | EXTRACELLULAR PROTEIN | CELL BIOLOGY | Neoplasms - metabolism | Humans | Middle Aged | Tumor Microenvironment | Excitatory Amino Acid Transporter 1 - genetics | Tumor Hypoxia | Young Adult | Biological Transport | Neoplasms - genetics | Time Factors | Aged, 80 and over | Adult | Antineoplastic Agents - pharmacology | Signal Transduction | Excitatory Amino Acid Transporter 1 - metabolism | Mitochondria - metabolism | Tumor Burden | Mice, SCID | Metabolomics - methods | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Electron Transport Chain Complex Proteins - metabolism | Cell Line, Tumor | Aspartic Acid - metabolism | Mice, Inbred NOD | Aged | Cell Proliferation - drug effects | Neoplasms - pathology | Energy Metabolism - drug effects | Physiological aspects | Hypoxia | Aspartate | Genetic aspects | Research | Cancer cells | Cell proliferation | Biotechnology | Oxygen | Sensitivity analysis | Xenotransplantation | Pharmacology | Metabolism | Molecular chains | Constraining | Electron transport chain | Sensitivity | Mitochondria | Metabolites | Cell lines | Xenografts | Metabolic pathways | Inhibition | Glutamic acid transporter | Electron transport | Transporter | Cancer | Tumors | Index Medicus
Journal Article