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1. Full Text PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
by Toska, Eneda and Castel, Pau and Chhangawala, Sagar and Arruabarrena-Aristorena, Amaia and Chan, Carmen and Hristidis, Vasilis C and Cocco, Emiliano and Sallaku, Mirna and Xu, Guotai and Park, Jane and Minuesa, Gerard and Shifman, Sophie G and Socci, Nicholas D and Koche, Richard and Leslie, Christina S and Scaltriti, Maurizio and Baselga, José
Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 1, pp. 294 - 306.e5
The PI3K pathway integrates extracellular stimuli to phosphorylate effectors such as AKT and serum-and-glucocorticoid-regulated kinase (SGK1). We have... 
KMT2D | estrogen receptor | chromatin regulation | PI3K pathway | breast cancer | AKT | SGK1 | PI3K inhibitors | READ ALIGNMENT | MTORC1 | AKT/PKB | PHOSPHORYLATION | 3-KINASE | PROTEIN-KINASE | TRANSCRIPTION | COMPASS FAMILY | SERUM | CANCER | CELL BIOLOGY
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2. Full Text DNA methylation of the first exon is tightly linked to transcriptional silencing
by Brenet, Fabienne and Moh, Michelle and Funk, Patricia and Feierstein, Erika and Viale, Agnes J and Socci, Nicholas D and Scandura, Joseph M
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 1, pp. e14524 - e14524
Tissue specific patterns of methylated cytosine residues vary with age, can be altered by environmental factors, and are often abnormal in human disease yet... 
METHYLOME | X-CHROMOSOME | REPRESSION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RESOLUTION | GENOME-WIDE ANALYSIS | CYTOSINE-METHYLATION | GENE-EXPRESSION | CPG ISLANDS | CANCER | Promoter Regions, Genetic | Animals | Exons | Humans | Transcription Initiation Site | Gene Silencing | Cell Line, Tumor | Transcription, Genetic | DNA Methylation - genetics | Gene Expression Profiling | Genome | Analysis | Genes | Genomics | DNA | Genetic aspects | Genomes | Genetic transcription | Methylation | Cells | Laboratories | Introns | Leukemia | Breast cancer | Environmental factors | Mammals | Gene expression | Mammalian cells | Gene sequencing | Medicine | Polymerase | Gene silencing | DNA microarrays | DNA methylation | Epigenetics | Cytosine | Deoxyribonucleic acid--DNA | DNA sequencing | Index Medicus | Deoxyribonucleic acid
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3. Full Text Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
by Philip A. Watson and Yinan F. Chen and Minna D. Balbas and John Wongvipat and Nicholas D. Socci and Agnes Viale and Kwanghee Kim and Charles L. Sawyers
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2010, Volume 107, Issue 39, pp. 16759 - 16765
Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally isolated from prostate cancer cell lines derived from a single... 
Messenger RNA | Castration | Exons | Androgen receptors | Genes | Cell lines | Small interfering RNA | Prostate cancer | Heterologous transplantation | Tumors | MESSENGER-RIBONUCLEIC-ACID | THERAPY | SEQUENCES | CWR22 | MULTIDISCIPLINARY SCIENCES | BINDING DOMAIN | XENOGRAFT | CELL-LINE | PROGRESSION | Amino Acid Sequence | Prostatic Neoplasms - metabolism | Androgen Receptor Antagonists | Alternative Splicing | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Exons - genetics | Male | Protein Structure, Tertiary - genetics | RNA, Messenger - biosynthesis | Sequence Analysis, Protein | Animals | Prostatic Neoplasms - genetics | Receptors, Androgen - genetics | Androgens - pharmacology | Cell Line, Tumor | Mice | Disease Models, Animal | Androgens | Genetic aspects | Chemical properties | Research | Gene expression | Health aspects | Rodents | Models | Ribonucleic acid--RNA | Binding sites | Index Medicus | Biological Sciences
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4. Full Text Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage
by Malchow, Sven and Leventhal, Daniel S and Lee, Victoria and Nishi, Saki and Socci, Nicholas D and Savage, Peter A
Immunity, ISSN 1074-7613, 05/2016, Volume 44, Issue 5, pp. 1102 - 1113
The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), is critical for the protection of... 
Clonal Selection, Antigen-Mediated | Mice, Inbred C57BL | Autoimmunity - genetics | Male | T-Lymphocyte Subsets - physiology | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Mice, Knockout | Transcription Factors - metabolism | Cell Lineage | Clonal Deletion | Animals | Prostate - immunology | Forkhead Transcription Factors - metabolism | Autoantigens - immunology | Immune Tolerance - genetics | T-Cell Antigen Receptor Specificity | Thymus Gland - immunology | Cell Differentiation | Clone Cells | Mice | T-Lymphocytes, Regulatory - physiology | Autoimmunity | T cells | Antigens | Medical research | Flow cytometry | Data analysis | Statistical analysis | T cell receptors | Experiments | Proteins | Scholarships & fellowships | Lymphocytes | Software | Mutation | Cancer | Index Medicus
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5. Full Text Inducible in vivo genome editing with CRISPR-Cas9
by Dow, Lukas E and Fisher, Jonathan and O'Rourke, Kevin P and Muley, Ashlesha and Kastenhuber, Edward R and Livshits, Geulah and Tschaharganeh, Darjus F and Socci, Nicholas D and Lowe, Scott W
Nature Biotechnology, ISSN 1087-0156, 04/2015, Volume 33, Issue 4, pp. 390 - 394
CRISPR-Cas9-based genome editing enables the rapid genetic manipulation of any genomic locus without the need for gene targeting by homologous recombination.... 
SYSTEM | CELLS | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE | TRANSCRIPTION | MICE | CAS9 | DIFFERENTIATION | CANCER | ONE-STEP GENERATION | Animals | Genome - genetics | Recombination, Genetic - genetics | Mutagenesis, Site-Directed - methods | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Mice | CRISPR-Cas Systems - genetics | Genetic research | Research | Nucleotide sequencing | Genetic recombination | DNA sequencing | Genotype & phenotype | Genetics | Genomes | Cancer | Index Medicus | CRISPR | genome editing | Cas9 | APC | polyposis
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6. Full Text Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity
by Chang, Matthew T and Asthana, Saurabh and Gao, Sizhi Paul and Lee, Byron H and Chapman, Jocelyn S and Kandoth, Cyriac and Gao, JianJiong and Socci, Nicholas D and Solit, David B and Olshen, Adam B and Schultz, Nikolaus and Taylor, Barry S
Nature Biotechnology, ISSN 1087-0156, 02/2016, Volume 34, Issue 2, pp. 155 - 163
Mutational hotspots indicate selective pressure across a population of tumor samples, but their prevalence within and across cancer types is incompletely... 
LUNG-CANCER | METASTATIC MELANOMA | SIGNALING PATHWAYS | PROTEIN TC21 | RAS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | SENSITIVITY | BREAST CANCERS | TUMOR TYPES | CELL-LINE | Algorithms | Neoplasms - genetics | DNA Mutational Analysis - methods | Mutation - genetics | Humans | Computational Biology | Genetic aspects | Gene mutations | Observations | Guanosine triphosphatase | Health aspects | Cancer | Mutation | Tumors | Index Medicus
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7. Full Text Correction: miR-182 Is Largely Dispensable for Adaptive Immunity: Lack of Correlation between Expression and Function
by Pucella, Joseph N and Yen, Wei-Feng and Kim, Myoungjoo V and van der Veeken, Joris and Socci, Nicholas D and Naito, Yukiko and Li, Ming O and Iwai, Naoharu and Chaudhuri, Jayanta
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 08/2015, Volume 195, Issue 4, pp. 1903 - 1903
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8. Full Text The Somatic Genomic Landscape of Glioblastoma
by Brennan, Cameron W and Verhaak, Roel G.W and McKenna, Aaron and Campos, Benito and Noushmehr, Houtan and Salama, Sofie R and Zheng, Siyuan and Chakravarty, Debyani and Sanborn, J. Zachary and Berman, Samuel H and Beroukhim, Rameen and Bernard, Brady and Wu, Junyuan and Wu, Chang-Jiun and Genovese, Giannicola and Shmulevich, Ilya and Barnholtz-Sloan, Jill and Zou, Lihua and Vegesna, Rahulsimham and Shukla, Sachet A and Ciriello, Giovanni and Yung, W.K and Yung, W.K. Alfred and Zhang, Zhaobin and Zhang, Wei and Zhang, Jianhua and Zhang, Hailei and Sougnez, Carrie and Mikkelsen, Tom and Aldape, Kenneth and Bigner, Darell D and Bigner, Darell and Van Meir, Erwin G and Prados, Michael and Sloan, Andrew and Sloan, Andrew E and Black, Keith L and Eschbacher, Jennifer and Finocchiaro, Gaetano and Friedman, William and Andrews, David W and Guha, Abhijit and Iacocca, Mary and O’Neill, Brian P and Foltz, Greg and Myers, Jerome and Weisenberger, Daniel J and Penny, Robert and Kucherlapati, Raju and Perou, Charles M and Hayes, D. Neil and Gibbs, Richard and Marra, Marco and Mills, Gordon and Mills, Gordon B and Lander, Eric S and Lander, Eric and Spellman, Paul and Wilson, Richard K and Wilson, Richard and Sander, Chris and Weinstein, John N and Weinstein, John and Meyerson, Matthew and Gabriel, Stacey B and Gabriel, Stacey and Laird, Peter W and Haussler, David and Getz, Gad and Chin, Lynda and Benz, Christopher and Barrett, Wendi and Ostrom, Quinn and Wolinsky, Yingli and Bose, Bikash and Boulos, Madgy and Boulos, Paul T and Brown, Jenn and Czerinski, Christine and Eppley, Matthew and Kempista, Thelma and Kitko, Teresa and Koyfman, Yakov and Rabeno, Brenda and Rastogi, Pawan and Sugarman, Michael and Swanson, Patricia and Yalamanchii, Kennedy and Otey, Ilana P and Liu, Yuexin and Liu, Yingchun Spring and Liu, Wenbin and Xiao, Yonghong and Auman, J.Todd and Chen, Qing-Rong and Chen, Peng-Chieh and Chen, Ken and Hadjipanayis, Angela and Lee, Eunjung and Lee, Semin and ... and TCGA Res Network and TCGA Research Network
Cell, ISSN 0092-8674, 10/2013, Volume 155, Issue 2, pp. 462 - 477
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors... 
PATHWAYS | SURVIVAL | GRADE GLIOMA | MELANOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN CANCERS | COPY-NUMBER ALTERATION | TUMORS | EXPRESSION | DRIVER MUTATIONS | EGFR | CELL BIOLOGY | Glioblastoma - genetics | Signal Transduction | Humans | Brain Neoplasms - genetics | Female | Glioblastoma - metabolism | Male | Gene Expression Profiling | Mutation | Proteome - analysis | Gene Regulatory Networks | Brain Neoplasms - metabolism | Platelet-derived growth factor | RNA | Gene mutations | Analysis | Methylation | Glioblastoma multiforme | Telomerase | Index Medicus
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9. Full Text Intestinal Domination and the Risk of Bacteremia in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
by Ying Taur and Joao B. Xavier and Lauren Lipuma and Carles Ubeda and Jenna Goldberg and Asia Gobourne and Yeon Joo Lee and Krista A. Dubin and Nicholas D. Socci and Agnes Viale and Miguel-Angel Perales and Robert R. Jenq and Marcel R. M. van den Brink and Eric G. Pamer
Clinical Infectious Diseases, ISSN 1058-4838, 10/2012, Volume 55, Issue 7, pp. 905 - 914
Background. Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It is unclear whether changes in the... 
Enterococcus | Proteobacteria | Taxa | Microbiota | Streptococcus | Antibiotics | Infections | ARTICLES AND COMMENTARIES | Biodiversity | Bacteremia | Blood | MORTALITY | INFECTIOUS DISEASES | BLOOD-STREAM INFECTION | BONE-MARROW-TRANSPLANTATION | GASTROINTESTINAL-TRACT | VANCOMYCIN-RESISTANT ENTEROCOCCUS | MICROBIOLOGY | GUT MICROBIOTA | BACTERIAL | IMMUNOLOGY | RECIPIENTS | VERSUS-HOST-DISEASE | COLONIZATION RESISTANCE | Humans | Middle Aged | Risk Factors | Male | DNA, Bacterial - chemistry | Phylogeny | DNA, Ribosomal - chemistry | Sequence Analysis, DNA | Bacteremia - microbiology | Feces - microbiology | DNA, Bacterial - genetics | Hematopoietic Stem Cell Transplantation - adverse effects | RNA, Ribosomal, 16S - genetics | Adult | Bacteremia - epidemiology | Female | Aged | Longitudinal Studies | DNA, Ribosomal - genetics | Demographic aspects | Microbiota (Symbiotic organisms) | Transplantation | Research | Risk factors | Hematopoietic stem cells | Stomach | Bacterial infections | Infectious diseases | Transplants & implants | Ribonucleic acid--RNA | Stem cells | Index Medicus | and Commentaries
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10. Full Text Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
by Schvartzman, Juan-Manuel and Sotillo, Rocio and Socci, Nicholas D and Benezra, Robert
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 436 - 440
Inhibition of an initiating oncogene often leads to extensive tumour cell death, a phenomenon known as oncogene addiction. This has led to the search for... 
GENOMIC INSTABILITY | MULTIDISCIPLINARY SCIENCES | ADENOCARCINOMAS | MOUSE | RESISTANCE | CLONAL EVOLUTION | MICE | MECHANISMS | MITOTIC CHECKPOINT | TUMORIGENESIS | CANCER-THERAPY | Lung Neoplasms - genetics | Oncogenes - genetics | Neoplasm Recurrence, Local - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Lung Neoplasms - metabolism | Cell Cycle Proteins - metabolism | Aneuploidy | Lung Neoplasms - pathology | Mice, Transgenic | Oncogenes - physiology | Neoplasm Recurrence, Local - pathology | Chromosomal Instability - genetics | Animals | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - deficiency | Cell Cycle Proteins - genetics | Mad2 Proteins | Mice | Proto-Oncogene Proteins p21(ras) - metabolism | Care and treatment | Relapse | Lung cancer | Patient outcomes | Genetic aspects | Chromosomes | Health aspects | Oncogenes | Risk factors | Cancer | Proteins | Tissue | Artificial chromosomes | DNA repair | Apoptosis | Index Medicus
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11. Full Text Genome Sequencing Identifies a Basis for Everolimus Sensitivity
by Gopa Iyer and Aphrothiti J. Hanrahan and Matthew I. Milowsky and Hikmat Al-Ahmadie and Sasinya N. Scott and Manickam Janakiraman and Mono Pirun and Chris Sander and Nicholas D. Socci and Irina Ostrovnaya and Agnes Viale and Adriana Heguy and Luke Peng and Timothy A. Chan and Bernard Bochner and Dean F. Bajorin and Michael F. Berger and Barry S. Taylor and David B. Solit
Science, ISSN 0036-8075, 10/2012, Volume 338, Issue 6104, pp. 221 - 221
Cancer drugs often induce dramatic responses in a small minority of patients. We used whole-genome sequencing to investigate the genetic basis of a durable... 
Nervous system diseases | Urinary bladder | Genomes | Genetic mutation | Sequencing | BREVIA | Tumors | Cancer | MULTIDISCIPLINARY SCIENCES | Sequence Deletion | Genome-Wide Association Study |