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Cancer Letters, ISSN 0304-3835, 2012, Volume 328, Issue 2, pp. 307 - 317
Highlights ► Nilotinib compared to panel of tyrosine kinase inhibitors most potently reverse ABCB1, ABCG2 and ABCC10 transporters mediated drug resistance. ►... 
Hematology, Oncology and Palliative Medicine | Nilotinib | ABCB1/P-gp | ABC transporters | ABCG2/BCRP | Multidrug resistance | ABCC10/MRP7 | CANCER-CELLS | TRANSPORTERS | BCR-ABL | SUBFAMILY-B MEMBER-1 | TYROSINE KINASE INHIBITORS | IN-VITRO | PROTEIN BCRP/ABCG2 | ONCOLOGY | IMATINIB | REVERSES MULTIDRUG-RESISTANCE | BINDING | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Male | Antineoplastic Agents - administration & dosage | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | HEK293 Cells | Multidrug Resistance-Associated Proteins - genetics | Tumor Burden - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Pyrimidines - administration & dosage | Multidrug Resistance-Associated Proteins - chemistry | Neoplasm Proteins - chemistry | Pyrimidines - pharmacology | Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Mice, Nude | Cell Line, Tumor | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Mice | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Tyrosine | Drug resistance in microorganisms | Anthracyclines | Care and treatment | Epidermal growth factor | Analysis | Universities and colleges | Cancer | Laboratories | Cytotoxicity | Bioavailability | Kinases | Metabolism | Drug resistance | DNA repair | Proteins | Studies | Chemotherapy | Metabolites | Tumors | Index Medicus | BCRP | multidrug resistance | ABCB1 | P-gp | MRP7 | ABCC10 | ABCG2
Journal Article
Chinese Journal of Cancer, ISSN 1000-467X, 2012, Volume 31, Issue 2, pp. 58 - 72
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2013, Volume 72, Issue 1, pp. 189 - 199
Specific tyrosine kinase inhibitors were recently reported to modulate the activity of ABC transporters, leading to an increase in the intracellular... 
ABCB1 | Medicine & Public Health | Tyrosine kinase inhibitor | PD173074 | Multidrug resistance | Oncology | Cancer Research | Pharmacology/Toxicology | ABC transporter | Fibroblast growth factor receptor | MEDIATED MULTIDRUG-RESISTANCE | POTENT MODULATOR | SUBFAMILY-B MEMBER-1 | P-GLYCOPROTEIN | TYROSINE KINASE INHIBITORS | IN-VITRO | ONCOLOGY | PHARMACOLOGY & PHARMACY | ANTICANCER DRUGS | ABC TRANSPORTERS | BINDING | MOLECULAR-MECHANISMS | Neoplasms - metabolism | Paclitaxel - metabolism | Colchicine - pharmacology | Vincristine - pharmacology | Paclitaxel - pharmacology | Hydrolysis - drug effects | Paclitaxel - agonists | Tubulin Modulators - pharmacology | Allosteric Regulation | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Antineoplastic Agents - metabolism | Antineoplastic Agents - agonists | Vincristine - agonists | Colchicine - agonists | Adenosine Triphosphate - metabolism | HEK293 Cells | Tubulin Modulators - metabolism | Antineoplastic Agents - pharmacology | Biological Transport - drug effects | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Neoplasms - enzymology | Recombinant Proteins - agonists | Pyrimidines - pharmacology | Neoplasms - drug therapy | Affinity Labels - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - agonists | Neoplasm Proteins - agonists | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Protein Kinase Inhibitors - pharmacology | Tubulin Modulators - agonists | Drug Resistance, Neoplasm - drug effects | Care and treatment | Analysis | Photographic industry | Fibroblast growth factors | Colchicine | Drug therapy | Drug resistance | Cells | Adenosine triphosphatase | Cancer
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2013, Volume 132, Issue 1, pp. 224 - 235
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 153 - 161
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e74573
Natural products are frequently used for adjuvant chemotherapy in cancer treatment. 23-O-(1,4'-bipiperidine-1-carbonyl) betulinic acid (BBA) is a synthetic... 
CELL LUNG-CANCER | VITRO | PROTEIN-7 ABCC10 | ABCB1 | MULTIDISCIPLINARY SCIENCES | IN-VIVO | CHINENSIS BUNGE REGEL | 23-HYDROXYBETULINIC ACID | CASSETTE DRUG TRANSPORTERS | EXPRESSION | CHEMOTHERAPY | Paclitaxel - metabolism | Triterpenes - toxicity | Gene Expression | Drug Resistance, Multiple - genetics | Paclitaxel - pharmacology | Triterpenes - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Drug Resistance, Neoplasm | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Protein Transport - drug effects | Antineoplastic Agents - metabolism | Triterpenes - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Adenosine Triphosphate - metabolism | HEK293 Cells | Cell Line, Tumor | Inhibitory Concentration 50 | Multidrug Resistance-Associated Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family B | Antineoplastic Agents - pharmacology | Multidrug Resistance-Associated Proteins - metabolism | Drug resistance in microorganisms | Research | Adjuvant treatment | Cancer | Health sciences | Membranes | Laboratories | Clinical trials | Immunoblotting | Genomes | Kinases | Epidemiology | Cancer therapies | Accumulation | Proteins | Acid resistance | Paclitaxel | ABC transporters | Localization | P-Glycoprotein | Pharmaceutical sciences | Public health | Adenosine triphosphate | Carbonyls | Efflux | Vinblastine | Multidrug resistance | Glycoprotein | Chromatography | Studies | Chemotherapy | Acids | Natural products | Pharmacy | Plasma membranes | Betulinic acid | Sensitivity enhancement | Intracellular | Immunofluorescence
Journal Article
生物医学研究杂志:英文版, ISSN 1674-8301, 2016, Volume 30, Issue 2, pp. 120 - 133
ATP-binding cassette(ABC) transporters ABCC1(MRP1),ABCB1(P-gp),and ABCG2(BCRP) contribute to chemotherapy failure.The primary goals of this study were to... 
阿霉素 | 谷胱甘肽 | 药物敏感性 | 非甾体类抗炎药 | 硫化 | 化疗药物 | 肿瘤细胞株 | 灵敏度 | MRP1 | Multi-drug resistance | Doxorubicin | Sulindac | Glutathione | multi-drug resistance | sulindac | doxorubicin | Original | glutathione
Journal Article