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Journal Article
Cancer Cell, ISSN 1535-6108, 06/2019, Volume 35, Issue 6, pp. 825 - 826
Only a subset of cancer patients currently benefit from personalized treatment approaches. Detection of actionable drug targets in cell-free DNA, more... 
Analysis | Genetic transcription
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 09/2018, Volume 18, Issue 9, pp. 527 - 528
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2002, Volume 8, Issue 5, pp. 986 - 993
Journal Article
by Weinstein, John N and Akbani, Rehan and Broom, Bradley M and Wang, Wenyi and Verhaak, Roeland G. W and McConkey, David and Lerner, Seth and Morgan, Margaret and Creighton, Chad J and Smith, Carolyn and Cherniack, Andrew D and Kim, Jaegil and Pedamallu, Chandra Sekhar and Noble, Michael S and Al-Ahmadie, Hikmat A and Reuter, Victor E and Rosenberg, Jonathan E and F.Bajorin, Dean and Bochner, Bernard H and Solit, David B and Koppie, Theresa and Robinson, Brian and Gordenin, Dmitry A and Fargo, David and Klimczak, Leszek J and Roberts, Steven A and Au, Jessie and Laird, Peter W and Hinoue, Toshinori and Schultz, Nikolaus and Ramirez, Ricardo and Hansel, Donna and Hoadley, Katherine A and Kim, William Y and Damrauer, Jeffrey S and Baylin, Stephen B and Mungall, Andrew J and Robertson, A. Gordon and Chu, Andy and Kwiatkowski, David J and Sougnez, Carrie and Cibulskis, Kristian and Lichtenstein, Lee and Sivachenko, Andrey and Stewart, Chip and Lawrence, Michael S and Getz, Gad and Lander, Eric and Gabrie, Stacey B and Donehower, Lawrence and Carter, Scott L and Saksena, Gordon and Schumacher, Steven E and Freeman, Samuel S and Jung, Joonil and Bhatt, Ami S and Pugh, Trevor and Beroukhim, Rameen and Meyerson, Matthew and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Dhalla, Noreen and Hirst, Carrie and Holt, Robert A and Jones, Steven J. M and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Thiessen, Nina and Wong, Tina and Wye, Natasja and Bowlby, Reanne and Chuah, Eric and Guin, Ranabir and Shen, Hui and Bootwalla, Moiz S and Triche Jr, Timothy and Lai, Phillip H and Van Den Berg, David J and Weisenberger, Daniel J and Balu, Saianand and Bodenheimer, Tom and Hoyle, Alan P and Jefferys, Stuart R and Meng, Shaowu and Mose, Lisle E and Simons, Janae V and Soloway, Mathew G and Wu, Junyuan and Parker, Joel S and Hayes, D. Neil and Roach, Jeffrey and Buda, Elizabeth and Jones, Corbin D and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7492, pp. 315 - 322
Journal Article
by Zehir, Ahmet and Benayed, Ryma and Shah, Ronak H and Syed, Aijazuddin and Middha, Sumit and Kim, Hyunjae R and Srinivasan, Preethi and Gao, Jianjiong and Chakravarty, Debyani and Devlin, Sean M and Hellmann, Matthew D and Barron, David A and Schram, Alison M and Hameed, Meera and Dogan, Snjezana and Ross, Dara S and Hechtman, Jaclyn F and DeLair, Deborah F and Yao, JinJuan and Mandelker, Diana L and Cheng, Donavan T and Chandramohan, Raghu and Mohanty, Abhinita S and Ptashkin, Ryan N and Jayakumaran, Gowtham and Prasad, Meera and Syed, Mustafa H and Rema, Anoop Balakrishnan and Liu, Zhen Y and Nafa, Khedoudja and Borsu, Laetitia and Sadowska, Justyna and Casanova, Jacklyn and Bacares, Ruben and Kiecka, Iwona J and Razumova, Anna and Son, Julie B and Stewart, Lisa and Baldi, Tessara and Mullaney, Kerry A and Al-Ahmadie, Hikmat and Vakiani, Efsevia and Abeshouse, Adam A and Penson, Alexander V and Jonsson, Philip and Camacho, Niedzica and Chang, Matthew T and Won, Helen H and Gross, Benjamin E and Kundra, Ritika and Heins, Zachary J and Chen, Hsiao-Wei and Phillips, Sarah and Zhang, Hongxin and Wang, Jiaojiao and Ochoa, Angelica and Wills, Jonathan and Eubank, Michael and Thomas, Stacy B and Gardos, Stuart M and Reales, Dalicia N and Galle, Jesse and Durany, Robert and Cambria, Roy and Abida, Wassim and Cercek, Andrea and Feldman, Darren R and Gounder, Mrinal M and Hakimi, A. Ari and Harding, James J and Iyer, Gopa and Janjigian, Yelena Y and Jordan, Emmet J and Kelly, Ciara M and Lowery, Maeve A and Morris, Luc G. T and Omuro, Antonio M and Raj, Nitya and Razavi, Pedram and Shoushtari, Alexander N and Shukla, Neerav and Soumerai, Tara E and Varghese, Anna M and Yaeger, Rona and Coleman, Jonathan and Bochner, Bernard and Riely, Gregory J and Saltz, Leonard B and Scher, Howard I and Sabbatini, Paul J and Robson, Mark E and Klimstra, David S and Taylor, Barry S and Baselga, Jose and Schultz, Nikolaus and Hyman, David M and Arcila, Maria E and Solit, David B and Ladanyi, Marc and Berger, Michael F
Nature Medicine, ISSN 1078-8956, 06/2017, Volume 23, Issue 6, pp. 703 - 713
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2018, Volume 34, Issue 5, pp. 852 - 862.e4
Driver mutations in oncogenes encode proteins with gain-of-function properties that enhance fitness. Heterozygous mutations are thus viewed as sufficient for... 
oncogenes | targeted therapy | cancer | exaptation | selection | competitive fitness | LUNG-CANCER | EXAPTATION | ONCOLOGY | GENETICS | GENES | MYELODYSPLASIA | TARGETS | KRAS | MUTATIONS | GENOME | DISCOVERY | CELL BIOLOGY | Proteins | Gene mutations | Epidemiology | Cancer
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2018, Volume 24, Issue 2, pp. 334 - 340
Purpose: KRAS mutations occur in approximately 25% of patients with non-small cell lung cancer (NSCLC). Despite the uniform presence of KRAS mutations,... 
ADJUVANT CHEMOTHERAPY | IMPACT | MUTATION STATUS | MECHANISM | NRF2 | ONCOLOGY | ADENOCARCINOMA | 4 TRIALS | POOLED ANALYSIS | EGFR MUTATION | DOCETAXEL | Adenocarcinoma | p53 Protein | Lung | Lung cancer | Multivariate analysis | Survival | Patients | Confidence intervals | Alterations | Chemotherapy | Immune checkpoint | Experimental design | Platinum | Mutation | Cancer
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2016, Volume 22, Issue 1 Supplement, pp. IA11 - IA11
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2018, Volume 378, Issue 20, p. 1945
In a patient with treatment-refractory follicular lymphoma, a biopsy showed a histiocytic sarcoma related to the lymphoma but with an activating mutation in... 
Medical imaging | Sarcoma | MEK inhibitors | Kinases | Patients | Lymphoma | Cancer therapies | Proteins | Lungs | Biopsy | Informed consent | Lymphomas | Mutation | Tumors
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 04/2019, Volume 25, Issue 7, pp. 2116 - 2126
Purpose: Prior molecular profiling of hepatocellular carcinoma (HCC) has identified actionable findings that may have a role in guiding therapeutic... 
ACTIVATION | SOLID TUMORS | ONCOLOGY | PATHWAY | PD-1 BLOCKADE | RECURRENT MUTATIONS | MUTATIONAL LANDSCAPE | PREDICTS RESPONSE | SORAFENIB | RENAL-CELL CARCINOMA | MTOR | Index Medicus
Journal Article
EUROPEAN UROLOGY, ISSN 0302-2838, 02/2019, Volume 75, Issue 2, pp. 231 - 239
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 33, pp. 14903 - 14908
Tumors with mutant BRAF and some with mutant RAS are dependent upon ERK signaling for proliferation, and their growth is suppressed by MAPK/ERK kinase (MEK)... 
Tumor cell line | Phosphorylation | Cell growth | Negative feedback | Genes