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1. Full Text Resistance to BRAF Inhibition in Melanomas
by Solit, David B and Rosen, Neal
The New England journal of medicine, ISSN 0028-4793, 02/2011, Volume 364, Issue 8, pp. 772 - 774
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Gene Expression Regulation, Neoplastic | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - enzymology | Drug Resistance, Neoplasm | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Indoles - pharmacology | Indoles - therapeutic use | Mutation | Care and treatment | Gene mutations | Melanoma | Therapeutics | Physiological aspects | Diagnosis | Research | Homeopathy | Materia medica and therapeutics | Proteins | Kinases | Tumors | Index Medicus | Abridged Index Medicus
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2. Full Text Tumor adaptation and resistance to RAF inhibitors
by Lito, Piro and Rosen, Neal and Solit, David B
Nature medicine, ISSN 1078-8956, 11/2013, Volume 19, Issue 11, pp. 1401 - 1409
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Adaptation, Physiological | Melanoma - metabolism | Neoplasms - metabolism | raf Kinases - antagonists & inhibitors | Humans | Drug Resistance, Neoplasm | MAP Kinase Signaling System | Neoplasms - drug therapy | Neoplasms - genetics | Melanoma - genetics | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutation | Enzyme inhibitors | Oncology, Experimental | Development and progression | Research | Properties | Drug therapy | Drug resistance | Phosphotransferases | Cancer | Tumors | Inhibitor drugs | Kinases | Cancer therapies | Melanoma | Index Medicus
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3. Full Text KRAS and BRAF: drug targets and predictive biomarkers
by Vakiani, Efsevia and Solit, David B
The Journal of pathology, ISSN 0022-3417, 01/2011, Volume 223, Issue 2, pp. 220 - 230
mutations | BRAF inhibitors | MEK inhibitors | KRAS | BRAF | cancer | EGFR inhibitors | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Humans | ras Proteins - antagonists & inhibitors | ras Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | Neoplasms - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Mice | Mutation | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins B-raf - metabolism | Index Medicus
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4. Full Text BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
by Yao, Zhan and Torres, Neilawattie M and Tao, Anthony and Gao, Yijun and Luo, Lusong and Li, Qi and de Stanchina, Elisa and Abdel-Wahab, Omar and Solit, David B and Poulikakos, Poulikos I and Rosen, Neal
Cancer cell, ISSN 1535-6108, 09/2015, Volume 28, Issue 3, pp. 370 - 383
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | ras Proteins - genetics | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | MAP Kinase Signaling System - genetics | Proto-Oncogene Proteins B-raf - genetics | Humans | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Mutation - genetics | Dimerization | Drug Resistance, Neoplasm - drug effects | Index Medicus
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5. Full Text RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
by Poulikakos, Poulikos I and Persaud, Yogindra and Janakiraman, Manickam and Kong, Xiangju and Ng, Charles and Moriceau, Gatien and Shi, Hubing and Atefi, Mohammad and Titz, Bjoern and Gabay, May Tal and Salton, Maayan and Dahlman, Kimberly B and Tadi, Madhavi and Wargo, Jennifer A and Flaherty, Keith T and Kelley, Mark C and Misteli, Tom and Chapman, Paul B and Sosman, Jeffrey A and Graeber, Thomas G and Ribas, Antoni and Lo, Roger S and Rosen, Neal and Solit, David B
Nature (London), ISSN 0028-0836, 12/2011, Volume 480, Issue 7377, pp. 387 - 390
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | General aspects | Dermatology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Humans | Melanoma - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Protein Multimerization - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Alternative Splicing - genetics | Mutant Proteins - genetics | Exons - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Vemurafenib | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Mutant Proteins - chemistry | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Protein Multimerization - drug effects | Drug Resistance, Neoplasm - drug effects | Protein Isoforms - genetics | Cellular proteins | Melanoma | Physiological aspects | Genetic aspects | Research | Drug therapy | Health aspects | Index Medicus
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6. Full Text Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
by Straussman, Ravid and Morikawa, Teppei and Shee, Kevin and Barzily-Rokni, Michal and Qian, Zhi Rong and Du, Jinyan and Davis, Ashli and Mongare, Margaret M and Gould, Joshua and Frederick, Dennie T and Cooper, Zachary A and Chapman, Paul B and Solit, David B and Ribas, Antoni and Lo, Roger S and Flaherty, Keith T and Ogino, Shuji and Wargo, Jennifer A and Golub, Todd R
Nature (London), ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 500 - 504
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Proto-Oncogene Proteins c-met - metabolism | Prognosis | Coculture Techniques | Humans | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Tumor Microenvironment - physiology | Molecular Targeted Therapy | Melanoma - genetics | Stromal Cells - drug effects | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Melanoma - metabolism | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Stromal Cells - metabolism | Antineoplastic Combined Chemotherapy Protocols | Melanoma - pathology | Sulfonamides - pharmacology | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Vemurafenib | Signal Transduction - drug effects | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Mutation | Stromal Cells - cytology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Physiological aspects | Genetic aspects | Research | Gene expression | Drug resistance | Growth factors | Health aspects | Liver cells | Cancer | Cytotoxicity | Epidermal growth factor | FDA approval | Cancer therapies | Tumors | Index Medicus
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7. Full Text Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer
by Datta, Jashodeep and Smith, J. Joshua and Chatila, Walid K and McAuliffe, John C and Kandoth, Cyriac and Vakiani, Efsevia and Frankel, Timothy L and Ganesh, Karuna and Wasserman, Isaac and Lipsyc-Sharf, Marla and Guillem, Jose and Nash, Garrett M and Paty, Philip B and Weiser, Martin R and Saltz, Leonard B and Berger, Michael F and Jarnagin, William R and Balachandran, Vinod and Kingham, T. Peter and Kemeny, Nancy E and Cercek, Andrea and Garcia-Aguilar, Julio and Taylor, Barry S and Viale, Agnes and Yaeger, Rona and Solit, David B and Schultz, Nikolaus and D'Angelica, Michael
Clinical cancer research, ISSN 1078-0432, 03/2020, Volume 26, Issue 5, pp. 1077 - 1085
Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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8. Full Text BRAF Mutation is associated with early stage disease and improved outcome in patients with low‐grade serous ovarian cancer
by Grisham, Rachel N and Iyer, Gopa and Garg, Karuna and DeLair, Deborah and Hyman, David M and Zhou, Qin and Iasonos, Alexia and Berger, Michael F and Dao, Fanny and Spriggs, David R and Levine, Douglas A and Aghajanian, Carol and Solit, David B
Cancer, ISSN 0008-543X, 02/2013, Volume 119, Issue 3, pp. 548 - 554
BRAF | ovarian cancer | outcomes | early stage disease | low‐grade serous ovarian cancer | low-grade serous ovarian cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Biological and medical sciences | Medical sciences | Tumors | Female genital diseases | Prognosis | Early Detection of Cancer - methods | Proto-Oncogene Proteins B-raf - physiology | Glutamic Acid - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Ovarian Neoplasms - mortality | Ovarian Neoplasms - genetics | Neoplasm Grading | Female | Ovarian Neoplasms - diagnosis | Biomarkers, Tumor - physiology | Cystadenoma, Serous - diagnosis | Mutation, Missense - physiology | Cystadenoma, Serous - mortality | Amino Acid Substitution - physiology | Proto-Oncogene Proteins B-raf - genetics | Survival Analysis | Amino Acid Substitution - genetics | Valine - genetics | Aged | Biomarkers, Tumor - genetics | Neoplasm Staging | Cystadenoma, Serous - genetics | Cystadenoma, Serous - pathology | Care and treatment | Research | Diagnosis | Gene mutations | Oncogenes | Ovarian cancer | Index Medicus | Abridged Index Medicus
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9. Full Text Mechanisms of acquired resistance to BRAF V600E inhibition in colon cancers converge on RAF dimerization and are sensitive to its inhibition
by Yaeger, Rona and Yao, Zhan and Hyman, David M and Hechtman, Jaclyn F and Vakiani, Efsevia and Zhao, HuiYong and Su, Wenjing and Wang, Lu and Joelson, Andrew and Cercek, Andrea and Baselga, Jose and De Stanchina, Elisa and Saltz, Leonard and Berger, Michael F and Solit, David B and Rosen, Neal
Cancer research (Chicago, Ill.), ISSN 0008-5472, 12/2017, Volume 77, Issue 23, pp. 6513 - 6523
Life Sciences & Biomedicine | Oncology | Science & Technology | ras Proteins - genetics | Colonic Neoplasms - genetics | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | raf Kinases - antagonists & inhibitors | Humans | Melanoma - pathology | Mice, SCID | raf Kinases - metabolism | HT29 Cells | Monomeric GTP-Binding Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | Monomeric GTP-Binding Proteins - metabolism | Melanoma - genetics | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Dimerization | Tyrosine | Epidermal growth factor receptors | Colorectal carcinoma | Colorectal