American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2008, Volume 177, Issue 4, pp. 426 - 432
Rationale: Little is known about clearance of ultrafine carbon particles from the different regions of the human lung. These particles may accumulate and...
Translocation | Air pollution | Ultrafine particles | Clearance | translocation | CIRCULATION | INHALATION | SIZE | HEALTHY | LONG-TERM CLEARANCE | REGIONAL DEPOSITION | NANOPARTICLES | RESPIRATORY SYSTEM | ultrafine particles | clearance | air pollution | MUCUS | CRITICAL CARE MEDICINE | Air Pollutants - analysis | Humans | Middle Aged | Air Pollutants - pharmacokinetics | Male | Reference Values | Case-Control Studies | Tissue Distribution | Biological Transport | Female | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Radiopharmaceuticals | Aerosols - pharmacology | Carbon - urine | Mucociliary Clearance | Administration, Inhalation | Probability | Carbon - administration & dosage | Carbon - pharmacokinetics | Particle Size | Smoking - metabolism | Aged | Respiratory Function Tests | Respiratory Mechanics
Translocation | Air pollution | Ultrafine particles | Clearance | translocation | CIRCULATION | INHALATION | SIZE | HEALTHY | LONG-TERM CLEARANCE | REGIONAL DEPOSITION | NANOPARTICLES | RESPIRATORY SYSTEM | ultrafine particles | clearance | air pollution | MUCUS | CRITICAL CARE MEDICINE | Air Pollutants - analysis | Humans | Middle Aged | Air Pollutants - pharmacokinetics | Male | Reference Values | Case-Control Studies | Tissue Distribution | Biological Transport | Female | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Radiopharmaceuticals | Aerosols - pharmacology | Carbon - urine | Mucociliary Clearance | Administration, Inhalation | Probability | Carbon - administration & dosage | Carbon - pharmacokinetics | Particle Size | Smoking - metabolism | Aged | Respiratory Function Tests | Respiratory Mechanics
Journal Article
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, ISSN 1941-2711, 06/2019, Volume 32, Issue 3, pp. 156 - 163
Background: As non-cystic fibrosis bronchiectasis (NCFB) progresses, patients suffer irreversible lung damage and deterioration in lung function. This study...
inhaled antibiotics | dry powder for inhalation | RESPIRATORY SYSTEM | peak inspiratory flow | non-CF bronchiectasis | Respiratory therapy | Drug delivery systems | Respiratory function | Cystic fibrosis | Flow rates | Drug delivery | Bronchiectasis | Powder | Inhalation | Air flow | Lungs | Fibrosis | Flow velocity | Respiration | Ciprofloxacin
inhaled antibiotics | dry powder for inhalation | RESPIRATORY SYSTEM | peak inspiratory flow | non-CF bronchiectasis | Respiratory therapy | Drug delivery systems | Respiratory function | Cystic fibrosis | Flow rates | Drug delivery | Bronchiectasis | Powder | Inhalation | Air flow | Lungs | Fibrosis | Flow velocity | Respiration | Ciprofloxacin
Journal Article
Journal of Aerosol Medicine and Pulmonary Drug Delivery, ISSN 1941-2711, 02/2017, Volume 30, Issue 1, pp. 53 - 63
Background: Ciprofloxacin dry powder for inhalation (Ciprofloxacin DPI) is in development as long-term intermittent therapy to reduce the frequency of acute...
charcoal block | lung deposition | NCFB | scintigraphy | non-cystic fibrosis bronchiectasis | Ciprofloxacin DPI (dry powder for inhalation) | chronic obstructive pulmonary disease | COPD | LONG-TERM | DOSE-ESCALATION | TOBRAMYCIN | PHARMACOKINETICS | RESPIRATORY SYSTEM | PHASE-I | Dry Powder Inhalers | Bronchiectasis - drug therapy | Humans | Middle Aged | Administration, Inhalation | Biological Availability | Male | Lung - physiopathology | Ciprofloxacin - pharmacokinetics | Case-Control Studies | Cross-Over Studies | Tissue Distribution | Young Adult | Ciprofloxacin - administration & dosage | Anti-Bacterial Agents - pharmacokinetics | Adult | Female | Aged | Lung - metabolism | Anti-Bacterial Agents - administration & dosage | Pulmonary Disease, Chronic Obstructive - drug therapy
charcoal block | lung deposition | NCFB | scintigraphy | non-cystic fibrosis bronchiectasis | Ciprofloxacin DPI (dry powder for inhalation) | chronic obstructive pulmonary disease | COPD | LONG-TERM | DOSE-ESCALATION | TOBRAMYCIN | PHARMACOKINETICS | RESPIRATORY SYSTEM | PHASE-I | Dry Powder Inhalers | Bronchiectasis - drug therapy | Humans | Middle Aged | Administration, Inhalation | Biological Availability | Male | Lung - physiopathology | Ciprofloxacin - pharmacokinetics | Case-Control Studies | Cross-Over Studies | Tissue Distribution | Young Adult | Ciprofloxacin - administration & dosage | Anti-Bacterial Agents - pharmacokinetics | Adult | Female | Aged | Lung - metabolism | Anti-Bacterial Agents - administration & dosage | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
Journal of Aerosol Medicine and Pulmonary Drug Delivery, ISSN 1941-2711, 06/2010, Volume 23, Issue 3, pp. 137 - 148
Background: When inhaling medication, it is essential that drug particles are delivered to all sites of lung inflammation, including the peripheral airways....
Hydrofluoroalkane | Lung deposition | Beclomethasone dipropionate | Small airways | Formoterol | Chronic obstructive pulmonary disease | Extra fine | Asthma | MODERATE | SALBUTAMOL | hydrofluoroalkane | lung deposition | COMBINATION THERAPY | FIXED COMBINATION | INHALATION | asthma | formoterol | METERED-DOSE INHALER | RESPIRATORY SYSTEM | INFLAMMATION | beclomethasone dipropionate | PARTICLE-SIZE | small airways | chronic obstructive pulmonary disease | extra fine | Formoterol Fumarate | Bronchodilator Agents - administration & dosage | Beclomethasone - pharmacokinetics | Humans | Middle Aged | Male | Ethanolamines - administration & dosage | Case-Control Studies | Forced Expiratory Volume | Tissue Distribution | Ethanolamines - pharmacokinetics | Metered Dose Inhalers | Adult | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Female | Lung - metabolism | Beclomethasone - administration & dosage | Administration, Inhalation | Asthma - drug therapy | Particle Size | Bronchodilator Agents - pharmacokinetics | Aged | Respiratory Function Tests | Drug Combinations | Pulmonary Disease, Chronic Obstructive - drug therapy | Lung diseases, Obstructive | Usage | Corticosteroids | Research | Drug therapy | Health aspects | Risk factors | Original Research
Hydrofluoroalkane | Lung deposition | Beclomethasone dipropionate | Small airways | Formoterol | Chronic obstructive pulmonary disease | Extra fine | Asthma | MODERATE | SALBUTAMOL | hydrofluoroalkane | lung deposition | COMBINATION THERAPY | FIXED COMBINATION | INHALATION | asthma | formoterol | METERED-DOSE INHALER | RESPIRATORY SYSTEM | INFLAMMATION | beclomethasone dipropionate | PARTICLE-SIZE | small airways | chronic obstructive pulmonary disease | extra fine | Formoterol Fumarate | Bronchodilator Agents - administration & dosage | Beclomethasone - pharmacokinetics | Humans | Middle Aged | Male | Ethanolamines - administration & dosage | Case-Control Studies | Forced Expiratory Volume | Tissue Distribution | Ethanolamines - pharmacokinetics | Metered Dose Inhalers | Adult | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Female | Lung - metabolism | Beclomethasone - administration & dosage | Administration, Inhalation | Asthma - drug therapy | Particle Size | Bronchodilator Agents - pharmacokinetics | Aged | Respiratory Function Tests | Drug Combinations | Pulmonary Disease, Chronic Obstructive - drug therapy | Lung diseases, Obstructive | Usage | Corticosteroids | Research | Drug therapy | Health aspects | Risk factors | Original Research
Journal Article
Respiratory Medicine, ISSN 0954-6111, 05/2018, Volume 138, pp. 107 - 114
A combination of fluticasone propionate/formoterol fumarate (FP/FORM) has been incorporated within a novel, breath-triggered device, named K-haler . This low...
Formoterol fumarate | Radiolabelled | Scintigraphy | Deposition | Fluticasone propionate | CARDIAC & CARDIOVASCULAR SYSTEMS | EFFICACY | SAFETY | COMBINATION THERAPY | PLUME CHARACTERISTICS | FLOW | TRIAL | METERED-DOSE INHALER | LUNG DEPOSITION | HYDROFLUOROALKANE-134A BECLOMETHASONE | RESPIRATORY SYSTEM | EXACERBATIONS | Asthma - metabolism | Bronchodilator Agents - administration & dosage | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Healthy Volunteers | Equipment Design | Young Adult | Inhalation - physiology | Fluticasone - pharmacokinetics | Sodium Pertechnetate Tc 99m | Metered Dose Inhalers | Adult | Female | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Asthma - physiopathology | Forced Expiratory Volume - physiology | Administration, Inhalation | Particle Size | Diagnostic Imaging | Fluticasone - administration & dosage | Bronchodilator Agents - pharmacokinetics | Vital Capacity - physiology | Adolescent | Formoterol Fumarate - pharmacokinetics | Radionuclide Imaging - methods | Aged | Drug Combinations | Nebulizers and Vaporizers | Formoterol Fumarate - administration & dosage | Formoterol | Analysis | Asthmatics | Asthma | Steroids | Drug delivery systems | Image processing | Life assessment | Fluticasone | Mental depression | Low resistance | Dosage | Population | Chronic obstructive pulmonary disease | Drug dosages | Ethanol | Propionic acid | Lung diseases | Regional analysis | Flow rates | Patients | Inhalation | Image analysis | Obstructive lung disease | Flow velocity | Image transmission | Respiration
Formoterol fumarate | Radiolabelled | Scintigraphy | Deposition | Fluticasone propionate | CARDIAC & CARDIOVASCULAR SYSTEMS | EFFICACY | SAFETY | COMBINATION THERAPY | PLUME CHARACTERISTICS | FLOW | TRIAL | METERED-DOSE INHALER | LUNG DEPOSITION | HYDROFLUOROALKANE-134A BECLOMETHASONE | RESPIRATORY SYSTEM | EXACERBATIONS | Asthma - metabolism | Bronchodilator Agents - administration & dosage | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Healthy Volunteers | Equipment Design | Young Adult | Inhalation - physiology | Fluticasone - pharmacokinetics | Sodium Pertechnetate Tc 99m | Metered Dose Inhalers | Adult | Female | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Asthma - physiopathology | Forced Expiratory Volume - physiology | Administration, Inhalation | Particle Size | Diagnostic Imaging | Fluticasone - administration & dosage | Bronchodilator Agents - pharmacokinetics | Vital Capacity - physiology | Adolescent | Formoterol Fumarate - pharmacokinetics | Radionuclide Imaging - methods | Aged | Drug Combinations | Nebulizers and Vaporizers | Formoterol Fumarate - administration & dosage | Formoterol | Analysis | Asthmatics | Asthma | Steroids | Drug delivery systems | Image processing | Life assessment | Fluticasone | Mental depression | Low resistance | Dosage | Population | Chronic obstructive pulmonary disease | Drug dosages | Ethanol | Propionic acid | Lung diseases | Regional analysis | Flow rates | Patients | Inhalation | Image analysis | Obstructive lung disease | Flow velocity | Image transmission | Respiration
Journal Article
Journal of Aerosol Medicine and Pulmonary Drug Delivery, ISSN 1941-2711, 10/2018, Volume 31, Issue 5, pp. 269 - 280
This study evaluated the lung deposition and the distribution pattern in the airways of a fixed combination of beclometasone dipropionate (BDP) and formoterol...
NEXThaler | inhaled drug | lung deposition | asthma | DPI | BDP/formoterol combination | COPD | NEXThaler((R)) DPI | HFA-BECLOMETHASONE | VOLUNTEERS | SMALL AIRWAYS | formoterol combination | BDP | METERED-DOSE INHALER | THERAPY | RESPIRATORY SYSTEM | OBSTRUCTION | PARTICLE-SIZE | Respiratory therapy | Particle size | Respiratory function | Chlorofluorocarbons | Lung diseases | Pharmacology | Scintigraphy | Dosage | Patients | Powder | Inhalation | Asthma | Airway management | Lungs | Formoterol | Chronic obstructive pulmonary disease | Respiration | Drug dosages | Deposition
NEXThaler | inhaled drug | lung deposition | asthma | DPI | BDP/formoterol combination | COPD | NEXThaler((R)) DPI | HFA-BECLOMETHASONE | VOLUNTEERS | SMALL AIRWAYS | formoterol combination | BDP | METERED-DOSE INHALER | THERAPY | RESPIRATORY SYSTEM | OBSTRUCTION | PARTICLE-SIZE | Respiratory therapy | Particle size | Respiratory function | Chlorofluorocarbons | Lung diseases | Pharmacology | Scintigraphy | Dosage | Patients | Powder | Inhalation | Asthma | Airway management | Lungs | Formoterol | Chronic obstructive pulmonary disease | Respiration | Drug dosages | Deposition
Journal Article
Journal of Aerosol Medicine and Pulmonary Drug Delivery, ISSN 1941-2711, 06/2016, Volume 29, Issue 3, pp. 242 - 250
In cystic fibrosis (CF) patients, inhalation of alpha1-proteinase inhibitor (A1-PI) can prevent or slow down persistent infections and reduce the massive...
lung imaging | inhaled drug | lung deposition | cystic fibrosis | scintigraphy | I-neb AAD System | nebulizer | alpha1-proteinase inhibitor | alpha-1-antitrypsin | pulmonary function testing | Drug Delivery Systems - instrumentation | Cystic Fibrosis - physiopathology | Humans | Male | Equipment Design | Tissue Distribution | Young Adult | Anti-Inflammatory Agents - adverse effects | Adult | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Female | Lung - metabolism | Anti-Infective Agents - adverse effects | Cystic Fibrosis - metabolism | Administration, Inhalation | Lung - physiopathology | Inhalation | Cross-Over Studies | alpha 1-Antitrypsin - administration & dosage | Algorithms | Anti-Infective Agents - administration & dosage | Models, Biological | Anti-Infective Agents - pharmacokinetics | Lung - drug effects | Aerosols | alpha 1-Antitrypsin - pharmacokinetics | Cystic Fibrosis - drug therapy | Germany | Nebulizers and Vaporizers | alpha 1-Antitrypsin - adverse effects
lung imaging | inhaled drug | lung deposition | cystic fibrosis | scintigraphy | I-neb AAD System | nebulizer | alpha1-proteinase inhibitor | alpha-1-antitrypsin | pulmonary function testing | Drug Delivery Systems - instrumentation | Cystic Fibrosis - physiopathology | Humans | Male | Equipment Design | Tissue Distribution | Young Adult | Anti-Inflammatory Agents - adverse effects | Adult | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Female | Lung - metabolism | Anti-Infective Agents - adverse effects | Cystic Fibrosis - metabolism | Administration, Inhalation | Lung - physiopathology | Inhalation | Cross-Over Studies | alpha 1-Antitrypsin - administration & dosage | Algorithms | Anti-Infective Agents - administration & dosage | Models, Biological | Anti-Infective Agents - pharmacokinetics | Lung - drug effects | Aerosols | alpha 1-Antitrypsin - pharmacokinetics | Cystic Fibrosis - drug therapy | Germany | Nebulizers and Vaporizers | alpha 1-Antitrypsin - adverse effects
Journal Article
Journal of Aerosol Medicine and Pulmonary Drug Delivery, ISSN 1941-2711, 12/2012, Volume 25, Issue S1, pp. S-1 - S-28
Two-dimensional (2D or planar) imaging with 99m Tc radiolabels enables quantification of whole-lung and regional lung depositions for orally inhaled drug...
Articles | orally inhaled products | gamma scintigraphy | lung deposition | planar imaging | COUGH CLEARANCE | PARTICLES | QUANTIFICATION | REGIONAL DEPOSITION | MUCOCILIARY CLEARANCE | DRY POWDER INHALER | RESPIRATORY SYSTEM | GAMMA-SCINTIGRAPHY | BREATHING PATTERN | CYSTIC-FIBROSIS | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Humans | Administration, Inhalation | Lung - diagnostic imaging | Drug Delivery Systems | Radiopharmaceuticals - administration & dosage | Tissue Distribution | Pharmaceutical Preparations - metabolism | Radionuclide Imaging - instrumentation | Radionuclide Imaging - standards | Pharmaceutical Preparations - chemistry | Radionuclide Imaging - methods | Aerosols | Pharmaceutical Preparations - administration & dosage | Technetium - chemistry
Articles | orally inhaled products | gamma scintigraphy | lung deposition | planar imaging | COUGH CLEARANCE | PARTICLES | QUANTIFICATION | REGIONAL DEPOSITION | MUCOCILIARY CLEARANCE | DRY POWDER INHALER | RESPIRATORY SYSTEM | GAMMA-SCINTIGRAPHY | BREATHING PATTERN | CYSTIC-FIBROSIS | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Humans | Administration, Inhalation | Lung - diagnostic imaging | Drug Delivery Systems | Radiopharmaceuticals - administration & dosage | Tissue Distribution | Pharmaceutical Preparations - metabolism | Radionuclide Imaging - instrumentation | Radionuclide Imaging - standards | Pharmaceutical Preparations - chemistry | Radionuclide Imaging - methods | Aerosols | Pharmaceutical Preparations - administration & dosage | Technetium - chemistry
Journal Article
Oncogene, ISSN 0950-9232, 01/2004, Volume 23, Issue 2, pp. 554 - 558
Activation of the Raf/MEK/ERK (MAPK) signal transduction cascade by RAS mutations has been found in a variety of human cancers. Mutations of BRAF provide an...
BRAF | Barrett | Neoplasia | KRAS2 | barrett | ACTIVATION | ESOPHAGUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | neoplasia | CELL BIOLOGY | MELANOMA | GENE | ONCOLOGY | PATHWAY | GENETICS & HEREDITY | B-RAF | PROTEINS | CARCINOMA | PROGRESSION | Immunohistochemistry | Proto-Oncogene Proteins p21(ras) | ras Proteins | Proto-Oncogene Proteins c-raf - genetics | Humans | Adenocarcinoma - enzymology | Proto-Oncogene Proteins - genetics | Mutation - genetics | DNA Mutational Analysis | Base Sequence | Barrett Esophagus - enzymology | Adenocarcinoma - genetics | Proto-Oncogene Proteins B-raf | Barrett Esophagus - genetics | Genes, ras - genetics | Mitogen-Activated Protein Kinases - metabolism | BRAF gene | Raf protein | mismatch repair | KRAS2 gene | MEK protein | Barrett's adenocarcinoma
BRAF | Barrett | Neoplasia | KRAS2 | barrett | ACTIVATION | ESOPHAGUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | neoplasia | CELL BIOLOGY | MELANOMA | GENE | ONCOLOGY | PATHWAY | GENETICS & HEREDITY | B-RAF | PROTEINS | CARCINOMA | PROGRESSION | Immunohistochemistry | Proto-Oncogene Proteins p21(ras) | ras Proteins | Proto-Oncogene Proteins c-raf - genetics | Humans | Adenocarcinoma - enzymology | Proto-Oncogene Proteins - genetics | Mutation - genetics | DNA Mutational Analysis | Base Sequence | Barrett Esophagus - enzymology | Adenocarcinoma - genetics | Proto-Oncogene Proteins B-raf | Barrett Esophagus - genetics | Genes, ras - genetics | Mitogen-Activated Protein Kinases - metabolism | BRAF gene | Raf protein | mismatch repair | KRAS2 gene | MEK protein | Barrett's adenocarcinoma
Journal Article
Journal of Aerosol Medicine and Pulmonary Drug Delivery, ISSN 1941-2711, 12/2012, Volume 25, Issue S1, pp. S-6 - S-9
Radiolabeling of inhaler formulations for imaging studies is an indirect method of determining lung deposition and regional distribution of drug in human...
Articles | aerosol deposition studies | radiolabeling methods | WORKSHOP | MEDICATIONS | MDIS | RESPIRATORY SYSTEM | INHALATION | DELIVERY | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Humans | Administration, Inhalation | Lung - diagnostic imaging | Drug Delivery Systems | Particle Size | Radiopharmaceuticals - administration & dosage | Tissue Distribution | Pharmaceutical Preparations - metabolism | Pharmaceutical Preparations - chemistry | Radionuclide Imaging - methods | Aerosols | Lung - metabolism | Pharmaceutical Preparations - administration & dosage
Articles | aerosol deposition studies | radiolabeling methods | WORKSHOP | MEDICATIONS | MDIS | RESPIRATORY SYSTEM | INHALATION | DELIVERY | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Humans | Administration, Inhalation | Lung - diagnostic imaging | Drug Delivery Systems | Particle Size | Radiopharmaceuticals - administration & dosage | Tissue Distribution | Pharmaceutical Preparations - metabolism | Pharmaceutical Preparations - chemistry | Radionuclide Imaging - methods | Aerosols | Lung - metabolism | Pharmaceutical Preparations - administration & dosage
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/2011, Volume 28, Issue 9, pp. 2157 - 2164
To determine distribution and deposition of Technosphere® Insulin (TI) inhalation powder and the rate of clearance of fumaryl diketopiperazine (FDKP; major...
Biomedical Engineering | Biochemistry, general | Afrezza | fumaryl diketopiperazine | Biomedicine | Technosphere Insulin inhalation powder | insulin clearance | Pharmacy | inhalation powder | Medical Law | Pharmacology/Toxicology | insulin lung disposition | Insulin lung disposition | Insulin clearance | Fumaryl diketopiperazine | Inhalation powder | Technosphere insulin inhalation powder | INHALED INSULIN | PHARMACOLOGY & PHARMACY | Afrezza (R) | ABSORPTION | CHEMISTRY, MULTIDISCIPLINARY | Sodium Pertechnetate Tc 99m - chemistry | Drug Delivery Systems - instrumentation | Humans | Male | Metabolic Clearance Rate | Lung - diagnostic imaging | Drug Carriers - chemistry | Tissue Distribution | Hypoglycemic Agents - administration & dosage | Adult | Female | Lung - metabolism | Piperazines - pharmacokinetics | Hypoglycemic Agents - pharmacokinetics | Powders | Administration, Inhalation | Insulin - administration & dosage | Hypoglycemic Agents - chemistry | Particle Size | Fumarates - analysis | Piperazines - analysis | Fumarates - pharmacokinetics | Insulin - chemistry | Radionuclide Imaging | Drug Carriers - pharmacokinetics | Bronchoalveolar Lavage Fluid - chemistry | Drug Delivery Systems - methods | Insulin - pharmacokinetics | Nebulizers and Vaporizers
Biomedical Engineering | Biochemistry, general | Afrezza | fumaryl diketopiperazine | Biomedicine | Technosphere Insulin inhalation powder | insulin clearance | Pharmacy | inhalation powder | Medical Law | Pharmacology/Toxicology | insulin lung disposition | Insulin lung disposition | Insulin clearance | Fumaryl diketopiperazine | Inhalation powder | Technosphere insulin inhalation powder | INHALED INSULIN | PHARMACOLOGY & PHARMACY | Afrezza (R) | ABSORPTION | CHEMISTRY, MULTIDISCIPLINARY | Sodium Pertechnetate Tc 99m - chemistry | Drug Delivery Systems - instrumentation | Humans | Male | Metabolic Clearance Rate | Lung - diagnostic imaging | Drug Carriers - chemistry | Tissue Distribution | Hypoglycemic Agents - administration & dosage | Adult | Female | Lung - metabolism | Piperazines - pharmacokinetics | Hypoglycemic Agents - pharmacokinetics | Powders | Administration, Inhalation | Insulin - administration & dosage | Hypoglycemic Agents - chemistry | Particle Size | Fumarates - analysis | Piperazines - analysis | Fumarates - pharmacokinetics | Insulin - chemistry | Radionuclide Imaging | Drug Carriers - pharmacokinetics | Bronchoalveolar Lavage Fluid - chemistry | Drug Delivery Systems - methods | Insulin - pharmacokinetics | Nebulizers and Vaporizers
Journal Article
Respiratory Medicine, ISSN 0954-6111, 2011, Volume 105, Issue 6, pp. 900 - 906
Summary Background Lung mucociliary clearance is impaired in patients with chronic obstructive pulmonary disease (COPD). Treatment guidelines recommend that...
Pulmonary/Respiratory | Formoterol | Mucus clearance | Tiotropium bromide | CHRONIC-BRONCHITIS | CARDIAC & CARDIOVASCULAR SYSTEMS | AEROSOLS | COUGH CLEARANCE | DEPOSITION | LUNG MUCOCILIARY CLEARANCE | OBSTRUCTIVE PULMONARY-DISEASE | THERAPY | RESPIRATORY SYSTEM | TERBUTALINE | AIRWAYS | IPRATROPIUM BROMIDE | Ethanolamines - pharmacology | Spirometry | Formoterol Fumarate | Bronchodilator Agents - administration & dosage | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Male | Mucus - drug effects | Ethanolamines - administration & dosage | Adult | Female | Quality of Life - psychology | Scopolamine Derivatives | Drug Therapy, Combination | Tiotropium Bromide | Dry Powder Inhalers | Forced Expiratory Volume - physiology | Administration, Inhalation | Bronchodilator Agents - pharmacology | Mucus - secretion | Pulmonary Disease, Chronic Obstructive - complications | Cross-Over Studies | Pulmonary Disease, Chronic Obstructive - psychology | Aged | Pulmonary Disease, Chronic Obstructive - drug therapy | Antiasthmatic agents | Lung diseases, Obstructive | Care and treatment | Parasympatholytic agents | Drug therapy | Retention | Drug dosages | Personal relationships | Manuscripts | Smoking
Pulmonary/Respiratory | Formoterol | Mucus clearance | Tiotropium bromide | CHRONIC-BRONCHITIS | CARDIAC & CARDIOVASCULAR SYSTEMS | AEROSOLS | COUGH CLEARANCE | DEPOSITION | LUNG MUCOCILIARY CLEARANCE | OBSTRUCTIVE PULMONARY-DISEASE | THERAPY | RESPIRATORY SYSTEM | TERBUTALINE | AIRWAYS | IPRATROPIUM BROMIDE | Ethanolamines - pharmacology | Spirometry | Formoterol Fumarate | Bronchodilator Agents - administration & dosage | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Male | Mucus - drug effects | Ethanolamines - administration & dosage | Adult | Female | Quality of Life - psychology | Scopolamine Derivatives | Drug Therapy, Combination | Tiotropium Bromide | Dry Powder Inhalers | Forced Expiratory Volume - physiology | Administration, Inhalation | Bronchodilator Agents - pharmacology | Mucus - secretion | Pulmonary Disease, Chronic Obstructive - complications | Cross-Over Studies | Pulmonary Disease, Chronic Obstructive - psychology | Aged | Pulmonary Disease, Chronic Obstructive - drug therapy | Antiasthmatic agents | Lung diseases, Obstructive | Care and treatment | Parasympatholytic agents | Drug therapy | Retention | Drug dosages | Personal relationships | Manuscripts | Smoking
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 09/2011, Volume 28, Issue 9, p. 2157
To determine distribution and deposition of Technosphere^sup ®^ Insulin (TI) inhalation powder and the rate of clearance of fumaryl diketopiperazine (FDKP;...
Drug delivery systems | Lungs | Insulin | Pharmaceutical sciences
Drug delivery systems | Lungs | Insulin | Pharmaceutical sciences
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 09/2011, Volume 28, Issue 9, p. 2157
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 2002, Volume 245, Issue 1, pp. 179 - 189
The purpose of this study was to evaluate the in vitro and in vivo dose delivery characteristics of two large porous particle placebo formulations with...
Large porous particles | Lung deposition | Inhalation | large porous particles | PULMONARY DRUG-DELIVERY | inhalation | IN-VITRO | HUMAN RESPIRATORY-TRACT | AEROSOL | MODELS | lung deposition | DEPOSITION | PHARMACOLOGY & PHARMACY | INHALER | Double-Blind Method | Humans | Middle Aged | Administration, Inhalation | Spectrometry, Fluorescence | Technetium | Cross-Over Studies | Particle Size | Powders - chemistry | Tissue Distribution | Powders - pharmacokinetics | Models, Biological | Adult | Female | Lung - metabolism | Porosity | Nebulizers and Vaporizers
Large porous particles | Lung deposition | Inhalation | large porous particles | PULMONARY DRUG-DELIVERY | inhalation | IN-VITRO | HUMAN RESPIRATORY-TRACT | AEROSOL | MODELS | lung deposition | DEPOSITION | PHARMACOLOGY & PHARMACY | INHALER | Double-Blind Method | Humans | Middle Aged | Administration, Inhalation | Spectrometry, Fluorescence | Technetium | Cross-Over Studies | Particle Size | Powders - chemistry | Tissue Distribution | Powders - pharmacokinetics | Models, Biological | Adult | Female | Lung - metabolism | Porosity | Nebulizers and Vaporizers
Journal Article
Chest, ISSN 0012-3692, 11/2005, Volume 128, Issue 5, pp. 3585 - 3589
Within a study on respiratory symptoms in rural areas, we used the European Community Respiratory Health Survey methacholine challenge protocol. For quicker...
ECRHS = European Community Respiratory Health Survey | residual method | MMAD = mass median aerodynamic diameter | Lower Saxony Lung Study | PD20= provocative dose of methacholine causing a 20% drop in FEV1 | bronchial hyperresponsiveness | methacholine | Bronchial hyperresponsiveness | Methacholine | Residual method | RESPONSIVENESS | RESPIRATORY SYSTEM | DOSIMETER | AEROSOL OUTPUT | CRITICAL CARE MEDICINE | Forced Expiratory Volume | Particle Size | Bronchoconstrictor Agents - administration & dosage | Methacholine Chloride - administration & dosage | Bronchial Hyperreactivity - drug therapy | Humans | Bronchial Provocation Tests | Adult | Female | Male | Nebulizers and Vaporizers | Pulmonary manifestations of general diseases | Complications and side effects | Lung diseases | Dosage and administration | Research | Drug therapy
ECRHS = European Community Respiratory Health Survey | residual method | MMAD = mass median aerodynamic diameter | Lower Saxony Lung Study | PD20= provocative dose of methacholine causing a 20% drop in FEV1 | bronchial hyperresponsiveness | methacholine | Bronchial hyperresponsiveness | Methacholine | Residual method | RESPONSIVENESS | RESPIRATORY SYSTEM | DOSIMETER | AEROSOL OUTPUT | CRITICAL CARE MEDICINE | Forced Expiratory Volume | Particle Size | Bronchoconstrictor Agents - administration & dosage | Methacholine Chloride - administration & dosage | Bronchial Hyperreactivity - drug therapy | Humans | Bronchial Provocation Tests | Adult | Female | Male | Nebulizers and Vaporizers | Pulmonary manifestations of general diseases | Complications and side effects | Lung diseases | Dosage and administration | Research | Drug therapy
Journal Article
Journal of Magnetism and Magnetic Materials, ISSN 0304-8853, 2001, Volume 225, Issue 1, pp. 8 - 16
The production of spherical monodisperse iron-oxide microparticles in the size range between 0.8 and 5μm is described. The particles can be ferrimagnetic (Fe O...
Indium-111 (In-111) | Radiolabeling | Alveolar clearance | Monodisperse | Nebulization | Ferrimagnetic | Lung imaging | Spherical | Cell motility | Magnetite | Iron-oxide particles | Spinning top aerosol generator | Preparation | Technetium-99 m (Tc-99 m) | Technetium-99m (Tc-99m)
Indium-111 (In-111) | Radiolabeling | Alveolar clearance | Monodisperse | Nebulization | Ferrimagnetic | Lung imaging | Spherical | Cell motility | Magnetite | Iron-oxide particles | Spinning top aerosol generator | Preparation | Technetium-99 m (Tc-99 m) | Technetium-99m (Tc-99m)
Journal Article
Journal of Aerosol Science, ISSN 0021-8502, 2006, Volume 37, Issue 5, pp. 631 - 644
A generator for the production of radiolabelled ultrafine carbonaceous particles for inhalation and clearance studies is described. A Technegas generator in...
Technegas generator | Carbonaceous | Ultrafine particles | Clearance | Technetium-99m | Indium-111 | Inhalation | indium-111 | LUNG | TRANSLOCATION | TECHNEGAS | SIZE | HEALTHY | carbonaceous | ENGINEERING, MECHANICAL | ENGINEERING, CHEMICAL | inhalation | ENVIRONMENTAL SCIENCES | PERTECHNEGAS | AEROSOL | ultrafine particles | technetium-99m | clearance | METEOROLOGY & ATMOSPHERIC SCIENCES | EXPOSURE | VENTILATION AGENT | Leaching
Technegas generator | Carbonaceous | Ultrafine particles | Clearance | Technetium-99m | Indium-111 | Inhalation | indium-111 | LUNG | TRANSLOCATION | TECHNEGAS | SIZE | HEALTHY | carbonaceous | ENGINEERING, MECHANICAL | ENGINEERING, CHEMICAL | inhalation | ENVIRONMENTAL SCIENCES | PERTECHNEGAS | AEROSOL | ultrafine particles | technetium-99m | clearance | METEOROLOGY & ATMOSPHERIC SCIENCES | EXPOSURE | VENTILATION AGENT | Leaching
Journal Article