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PLoS ONE, ISSN 1932-6203, 11/2009, Volume 4, Issue 11, p. e7897
Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD(+) synthesis that show promise for the treatment of... 
BIOSYNTHESIS INHIBITOR | APOPTOSIS | ENZYME | PATHWAY | BIOLOGY | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | CYCLING ASSAY | CD38 | DEATH | CELL-SURVIVAL | FK866 | Tumor Necrosis Factor-alpha - metabolism | Cell Proliferation | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Jurkat Cells | Lymphocyte Activation | Humans | Mice, Inbred C57BL | Interferon-gamma - metabolism | Autophagy | NAD - chemistry | Poly(ADP-ribose) Polymerases - metabolism | Animals | Membrane Potentials | Nicotinamide Phosphoribosyltransferase - metabolism | Piperidines - pharmacology | T-Lymphocytes - metabolism | Female | Mice | Myelin Sheath - chemistry | Adenosine Triphosphate - chemistry | Acrylamides - pharmacology | NAD - metabolism | NADPH | Neurosciences | Encephalomyelitis | Laboratories | Leukemia | Cytotoxicity | Lymphocytes T | Nucleotides | Kinases | ADP | Mitochondria | Cell growth | Demyelination | Lymphocytes | Ribose | Pyridine nucleotides | Phosphoribosyltransferase | Mathematical models | Inhibition | Adenosine triphosphate | Enzymes | Pyridines | Cell survival | Internal medicine | Dendritic cells | Secretion | Immune response (cell-mediated) | Poly(ADP-ribose) polymerase | Tumor necrosis factor-α | Experimental allergic encephalomyelitis | Medicine | Polymerase | NAD | Depletion | Inhibitors | Lymphopenia | Nicotinamide phosphoribosyltransferase | γ-Interferon | Stem cells | Interferon | Nicotinamide | Viability | Cancer | Apoptosis
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Suppl_1, pp. 3221 - 3221
Abstract Background: Human tumours rely on Glutamine (Gln) metabolism to sustain wide range of metabolic processes and macromolecules synthesis. Such... 
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22739
Aberrant histone deacetylase (HDAC) activity is frequent in human leukemias. However, while classical, NAD(+)-independent HDACs are an established therapeutic... 
BIOSYNTHESIS INHIBITOR | APOPTOSIS | HISTONE DEACETYLASE INHIBITOR | BIOLOGY | CHRONIC LYMPHOCYTIC-LEUKEMIA | ACUTE MYELOID-LEUKEMIA | MELANOMA-CELLS | ANTITUMOR-ACTIVITY | HEMATOLOGIC MALIGNANCIES | MYELODYSPLASTIC SYNDROMES | P53 | Antigens, CD34 - metabolism | Gene Silencing - drug effects | Leukemia - pathology | Humans | Leukemia - enzymology | bcl-2-Associated X Protein - metabolism | Drug Synergism | Up-Regulation - drug effects | Piperidines - pharmacology | NAD - biosynthesis | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Cell Death - drug effects | Sirtuins - antagonists & inhibitors | Acrylamides - pharmacology | Sirtuins - metabolism | Drug Screening Assays, Antitumor | Divalproex | Care and treatment | Cell death | Leukemia | Valproic acid | Drug therapy | Health aspects | Cancer | Sirtuins | Histone deacetylase | Biomedical research | Bax protein | Laboratories | Multiple myeloma | Staining | Clinical trials | Oncology | Propidium iodide | Biosynthesis | Biochemistry | Leukocytes | Western blotting | Anticancer properties | Mitochondria | Stress response | Translocation | Hematology | Iodides | Internal medicine | RNA-mediated interference | Melanoma | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | SIRT1 protein | Hemopoiesis | Medicine | White blood cells | NAD | Sodium butyrate | Cytometry | Hospitals | Inhibitors | Sodium | Cell lines | Aberration | Prostate cancer | Apoptosis | RNA | Ribonucleic acid
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 25938 - 25949
NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The... 
NAMPT INHIBITION | IN-VITRO | CYCLIC-ADP-RIBOSE | CHS 828 | ENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | CD38 | FK866 | LYMPHOCYTES | 5'-Nucleotidase - genetics | Gene Expression Regulation, Enzymologic - drug effects | Humans | Membrane Glycoproteins - biosynthesis | GPI-Linked Proteins - biosynthesis | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Neoplasms - genetics | Nicotinamide Phosphoribosyltransferase - metabolism | Piperidines - pharmacology | NAD - biosynthesis | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Acrylamides - pharmacology | Cytokines - genetics | Gene Expression Regulation, Neoplastic - genetics | 5'-Nucleotidase - biosynthesis | NAD - genetics | ADP-ribosyl Cyclase 1 - genetics | Cytokines - metabolism | Gene Silencing | Neoplasms - enzymology | Down-Regulation - drug effects | Down-Regulation - genetics | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Nicotinamide Phosphoribosyltransferase - genetics | Gene Expression Regulation, Enzymologic - genetics | ADP-ribosyl Cyclase 1 - biosynthesis | Cell Line, Tumor | Cytokines - antagonists & inhibitors | Nicotinamide Mononucleotide - biosynthesis | Nicotinamide Mononucleotide - genetics | GPI-Linked Proteins - genetics | NAD | Cancer Therapy | CD73 | Nicotinamide Riboside | NAD Biosynthesis | Signal Transduction | Cell Death | Nicotinamide Mononucleotide | Nicotinamide
Journal Article
BMC Cancer, ISSN 1471-2407, 11/2015, Volume 15, Issue 1, p. 855
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 5222 - 5222
Abstract Currently available therapeutics against Acute Myeloid Leukemia (AML) have improved patient outcome. However, resistance develops even to novel... 
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9024
The efficacy of anti-HER2 therapeutics, such as lapatinib and trastuzumab, is limited by primary and acquired resistance. Cellular adaptations that allow... 
SH2 DOMAIN | ADJUVANT CHEMOTHERAPY | GROWTH-FACTOR RECEPTOR | TRASTUZUMAB | CELL-MIGRATION | BIOLOGY | TYROSINE KINASES | FOCAL ADHESION KINASE | EXPRESSION | HER2-POSITIVE BREAST-CANCER | TRANSCRIPTION FACTOR FKHR | Receptor, ErbB-2 - genetics | Humans | Adaptation, Physiological - drug effects | Receptor, ErbB-2 - metabolism | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Mammary Neoplasms, Experimental - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mammary Neoplasms, Experimental - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | GRB7 Adaptor Protein - genetics | RNA Interference | Mammary Neoplasms, Experimental - pathology | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Signal Transduction | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | GRB7 Adaptor Protein - metabolism | Phosphatidylinositol 3-Kinases - genetics | Up-Regulation - drug effects | Cell Movement - drug effects | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Quinazolines - pharmacology | Tyrosine | Prognosis | RNA | Genes | Estrogen | Genetic aspects | Genetic engineering | Gene expression | Cancer | Adaptations | Drugs | Flow cytometry | Transcription factors | Biomedical research | Laboratories | Estrogens | Xenotransplantation | AKT protein | Drug delivery | Kinases | Drug resistance | Western blotting | Cell adhesion & migration | Metastases | Proteins | Transfection | Transgenic animals | Xenografts | Cell cycle | Protein-tyrosine kinase receptors | Inhibition | Protein-tyrosine kinase | FOXO3 protein | Cell survival | Internal medicine | RNA-mediated interference | Breast cancer | Ribonucleic acid--RNA | ErbB-2 protein | 1-Phosphatidylinositol 3-kinase | Medicine | Gene silencing | Signaling | Inhibitors | Medical prognosis | Morphology | Breast | Ligands | Receptor mechanisms | Viability | Cell migration | Trastuzumab | Tumors | Ribonucleic acid
Journal Article
Leukemia, ISSN 0887-6924, 08/2019
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) are still open questions. Herein, we investigated the... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2014, Volume 289, Issue 49, pp. 34189 - 34204
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