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IEEE Journal of Selected Topics in Signal Processing, ISSN 1932-4553, 10/2014, Volume 8, Issue 5, pp. 787 - 801
In this paper, the problem of pilot beam pattern design for channel estimation in massive multiple-input multiple-output systems with a large number of... 
Training | Correlation | Channel estimation | massive MIMO systems | spatio-temporal correlation | MIMO | Vectors | Kalman filters | Covariance matrices | training signal design | LIMITED FEEDBACK | CAPACITY | ARRAY | WIRELESS | DOWNLINK | IDENTIFICATION | SUBSPACE | ENGINEERING, ELECTRICAL & ELECTRONIC | Design engineering | Beams (radiation) | Algorithms | Pilots | Mathematical models | Statistics | Channels | Antennas
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2609 - 2619
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We investigated mechanisms of acquired... 
BREAST-CANCER | GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | GROWTH-FACTOR-RECEPTOR | T790M MUTATIONS | IN-VIVO | TUMOR-CELLS | ANTITUMOR-ACTIVITY | GEFITINIB SENSITIVITY | ERLOTINIB | Insulin-Like Growth Factor Binding Protein 3 - genetics | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Gene Expression - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Insulin Receptor Substrate Proteins | Insulin-Like Growth Factor Binding Protein 4 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Quinazolines - pharmacology | Insulin-Like Growth Factor I - metabolism | Tyrosine | Phenols | Binding proteins | Analysis | Cancer cells | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2008, Volume 14, Issue 12, pp. 1351 - 1356
Journal Article
Science, ISSN 0036-8075, 5/2007, Volume 316, Issue 5827, pp. 1039 - 1043
The epidermal growth factor receptor (EGFR) kinase inhibitors gefitinib and erlotinib are effective treatments for lung cancers with EGFR activating mutations,... 
Tumor cell line | Phosphorylation | Cell lines | Antibodies | Reports | CHO cells | Genetic mutation | Signal amplification | Cell extracts | Tumors | Lung neoplasms | THERAPY | GROWTH-FACTOR-RECEPTOR | GENE | TYROSINE KINASE | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | MUTATIONS | INHIBITOR | GASTROINTESTINAL STROMAL TUMORS | IMATINIB MESYLATE | Lung Neoplasms - drug therapy | Enzyme Inhibitors | Receptor, ErbB-3 - metabolism | Cricetulus | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Sulfones - pharmacology | Receptors, Growth Factor - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | CHO Cells | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Cricetinae | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met | Carcinoma, Non-Small-Cell Lung - metabolism | Proto-Oncogene Proteins - genetics | Animals | Gene Amplification | Quinazolines - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Quinazolines - pharmacology | Receptors, Growth Factor - metabolism | Gene amplification | Gene mutations | Lung cancer | Physiological aspects | Genetic aspects | Chemical properties | Drug resistance | Gefitinib | Drug therapy | Health aspects | Oncology | Inhibitor drugs | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2013, Volume 110, Issue 52, pp. 21124 - 21129
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2009, Volume 106, Issue 46, pp. 19503 - 19508
Non-small cell lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are highly responsive to EGFR tyrosine kinase inhibitors... 
B lymphocytes | Cell death | Cell lines | Breast cancer | Down regulation | Genetic mutation | Apoptosis | Lung neoplasms | Cancer | Tumors | Mcl-1 | MEK | AKT | Acquired resistance | BIM | GEFITINIB | GROWTH-FACTOR-RECEPTOR | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | ANTITUMOR-ACTIVITY | PHOSPHATIDYLINOSITOL 3-KINASE/MAMMALIAN TARGET | acquired resistance | CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | PATHWAY | T790M MUTATIONS | RAPAMYCIN INHIBITOR | Erlotinib Hydrochloride | Protein Kinases - metabolism | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | Female | MAP Kinase Kinase Kinases - antagonists & inhibitors | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Antineoplastic Combined Chemotherapy Protocols | Imidazoles - pharmacology | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | Carcinoma, Non-Small-Cell Lung - drug therapy | Quinazolines - pharmacology | Physiological aspects | Research | Lung cancer, Non-small cell | Phosphotransferases | Health aspects | Mutation | Kinases | Lung cancer | Index Medicus | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2011, Volume 121, Issue 11, pp. 4311 - 4321
Therapies inhibiting receptor tyrosine kinases (RTKs) are effective against some human cancers when they lead to simultaneous downregulation of PI3K/AKT and... 
CELL LUNG-CANCER | ANAPLASTIC LYMPHOMA KINASE | BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | ONCOGENIC ACTIVATION | MUTATION STATUS | CYCLIN D1 | RAS | PHOSPHATIDYLINOSITOL 3-KINASE | ACQUIRED-RESISTANCE | Neoplasm Transplantation | RNA, Small Interfering - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Male | Transplantation, Heterologous | DNA Primers - genetics | Phosphatidylinositol 3-Kinases - metabolism | Gene Knockdown Techniques | MAP Kinase Signaling System | Base Sequence | Colorectal Neoplasms - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Colorectal Neoplasms - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | ras Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | Class I Phosphatidylinositol 3-Kinases | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Colorectal Neoplasms - pathology | Apoptosis | Tyrosine | Care and treatment | Gene mutations | Colorectal cancer | Cellular signal transduction | Genetic aspects | Research | Diagnosis | Properties | Genetic regulation | Identification and classification | Index Medicus | Abridged Index Medicus
Journal Article
IEEE Transactions on Wireless Communications, ISSN 1536-1276, 12/2014, Volume 13, Issue 12, pp. 7011 - 7024
A new precoder for precoding-based blind channel estimation for MIMO-OFDM systems is proposed. In the proposed scheme, only a small number of data symbols,... 
Blind equalizers | MIMO | OFDM | Covariance matrices | Channel estimation | Receiving antennas | Hadamard matrix | linear precoding | Blind channel estimation | SUBSPACE-BASED BLIND | TELECOMMUNICATIONS | ENGINEERING, ELECTRICAL & ELECTRONIC | Models
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2609 - 2619
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2015, Volume 112, Issue 11, pp. E1288 - E1296
BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in... 
Targeted therapies | Small-cell lung cancer | BH3 mimetics | BIM | Apoptosis | DRUG-SENSITIVITY | small-cell lung cancer | targeted therapies | ANTAGONIST ABT-737 | MCL-1 | MULTIDISCIPLINARY SCIENCES | apoptosis | KINASE INHIBITORS | OBATOCLAX GX15-070 | CAP-DEPENDENT TRANSLATION | BCL-2 FAMILY INHIBITOR | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHASE-I | Lung Neoplasms - drug therapy | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Lung Neoplasms - pathology | Mechanistic Target of Rapamycin Complex 2 | Small Cell Lung Carcinoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Bcl-2-Like Protein 11 | Inhibitory Concentration 50 | Membrane Proteins - metabolism | Morpholines - therapeutic use | Proto-Oncogene Proteins - metabolism | Aniline Compounds - pharmacology | Morpholines - pharmacology | Sulfonamides - pharmacology | Remission Induction | Apoptosis Regulatory Proteins - metabolism | Xenograft Model Antitumor Assays | Small Cell Lung Carcinoma - pathology | Animals | Genetic Engineering | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Mice | Aniline Compounds - therapeutic use | Antimitotic agents | Molecular targeted therapy | Care and treatment | Lung cancer, Small cell | Genetic aspects | Antineoplastic agents | Methods | Testing | Side effects | Gene expression | Cancer therapies | Lung cancer | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2012, Volume 109, Issue 45, pp. E3119 - E3127
Brain metastases are a serious obstacle in the treatment of patients with human epidermal growth factor receptor-2 ( HER2 )–amplified breast cancer. Although... 
targeted therapy | CELLS | TRASTUZUMAB | ANGIOGENESIS | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | PHASE-II | COMBINATION | CAPECITABINE | NERVOUS-SYSTEM METASTASES | tumor-stroma interaction | tumor microenvironment | antiangiogenesis | LAPATINIB GW572016 | treatment resistance | ENDOTHELIAL GROWTH-FACTOR | Receptor, ErbB-2 - genetics | Blood Vessels - pathology | Humans | Brain Neoplasms - pathology | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Brain Neoplasms - blood supply | Killer Cells, Natural - pathology | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Necrosis | Brain Neoplasms - secondary | Receptors, Vascular Endothelial Growth Factor - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | Receptor, ErbB-2 - antagonists & inhibitors | Cell Death - drug effects | Disease Models, Animal | Antibodies, Monoclonal, Humanized - therapeutic use | Antibodies, Monoclonal - pharmacology | Treatment Outcome | Brain Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Diagnostic Imaging | Animals | Gene Amplification | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neovascularization, Pathologic - drug therapy | Quinazolines - therapeutic use | Blood Vessels - drug effects | Survival Analysis | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Mice | Quinazolines - pharmacology | Trastuzumab | Brain | Breast cancer | Metastasis | Medical treatment | Tumors | Index Medicus | Biological Sciences | PNAS Plus | tumor–stroma interaction
Journal Article