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The Lancet, ISSN 0140-6736, 06/2016, Volume 387, Issue 10038, pp. 2630 - 2640
Summary Background Systemic sclerosis is a rare disabling autoimmune disease with few treatment options. The efficacy and safety of tocilizumab, an interleukin... 
Internal Medicine | Medicine(all) | Multicenter Study | Clinical Trial, Phase II | Randomized Controlled Trial | Research Support, Non-U.S. Gov't | Journal Article | INTERSTITIAL LUNG-DISEASE | MORTALITY | SURVIVAL | MEDICINE, GENERAL & INTERNAL | PLACEBO | LYSOPHOSPHATIDIC ACID | DIFFUSE SCLERODERMA | SKIN FIBROSIS | INTERLEUKIN-6 | EXPRESSION | SSC SKIN | Biomarkers - metabolism | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Europe | Humans | Middle Aged | Scleroderma, Systemic - metabolism | Male | Treatment Outcome | United Kingdom | Canada | Vital Capacity | Antibodies, Monoclonal, Humanized - administration & dosage | Injections, Subcutaneous | Scleroderma, Systemic - complications | Interleukin-6 - physiology | Adult | Female | Aged | Scleroderma, Systemic - drug therapy | Medical colleges | Adults | Systemic scleroderma | Interleukins | Scleroderma (Disease) | Analysis | Tissue | Cytokines | Ulcers | Biomarkers | Fibroblasts | Clinical trials | Patient safety | Skin diseases | Skin | Health risk assessment | Scleroderma | Drug therapy | Pathogenesis | Interleukin | Medical services | Itching | Interleukin 6 | Cost-benefit analysis | Safety | Thickening | Effectiveness | Mortality | Lung diseases | Medical treatment | Rheumatology | Patients | Studies | Systemic sclerosis | Least squares | Autoimmune diseases
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