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PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62333
Hematopoietic stem cell gene therapy requires the use of integrating retroviral vectors in order to stably transmit a therapeutic gene to mature blood cells.... 
SEVERE COMBINED IMMUNODEFICIENCY | DESIGN | INTEGRATION | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL LYMPHOID RECONSTITUTION | HEMATOPOIETIC STEM-CELL | INSERTIONAL MUTAGENESIS | DEFICIENT MICE | RETROVIRAL VECTORS | SCID-X1 GENE-THERAPY | GAMMA-CHAIN | Humans | Bone Marrow Cells - pathology | X-Linked Combined Immunodeficiency Diseases - genetics | Hematopoietic Stem Cell Transplantation | Genetic Vectors - adverse effects | Spleen Focus-Forming Viruses - genetics | Lymphoma, B-Cell - genetics | Genetic Vectors - genetics | T-Lymphocytes - virology | Mice, Knockout | Animals | T-Lymphocytes - metabolism | Cell Transformation, Neoplastic - genetics | Myeloid Cells - metabolism | Female | Lentivirus - genetics | Lymphoma, B-Cell - virology | Mice | Myeloid Cells - pathology | Peptide Elongation Factor 1 - genetics | T-Lymphocytes - pathology | Gene Order | Bone Marrow Cells - metabolism | Cell Transformation, Viral | Complications and side effects | Leukemia | Oncology, Experimental | Stem cells | Transplantation | Research | T cells | Gene therapy | Cancer | Transformation | Animal models | Severe combined immunodeficiency | Transplants & implants | Clinical trials | Lymphocytes T | Malignancy | Assaying | Hematopoietic stem cells | Cell adhesion & migration | Lymphocytes | Hematopoiesis | Rodents | Bone marrow | Safety | Expression vectors | Medical research | Antigens | Hematology | Blood cells | Vectors (Biology) | Hemopoiesis | Studies | Passengers | Lymphocytes B | Lymphomas | Proto-oncogenes
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2015, Volume 23, pp. S176 - S177
Journal Article
Molecular Therapy, ISSN 1525-0016, 08/2012, Volume 20, Issue 8, pp. 1485 - 1487
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2036 - 2036
Abstract Chronic granulomatous disease (CGD) is an inherited immune deficiency due to mutations in the genes for the NADPH subunits (the genes for p47phox,... 
Journal Article
Blood, ISSN 0006-4971, 01/2010, Volume 115, Issue 4, pp. 751 - 752
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1211 - 1218
Journal Article
Blood, ISSN 0006-4971, 08/2005, Volume 106, Issue 3, pp. 827 - 832
It has long been known that prolonged culture or serial transplantation leads to the loss of hematopoietic stem cells (HSCs); however, the mechanisms for this... 
Cell Proliferation | Cell Survival | Mice, Inbred C57BL | Tumor Suppressor Protein p14ARF - physiology | Cells, Cultured | Cyclin-Dependent Kinase Inhibitor p16 - physiology | Mice, Knockout | Animals | Bone Marrow Cells | Cellular Senescence | Hematopoietic Stem Cells - cytology | Bone Marrow Transplantation | Female | Mice | Hematopoiesis
Journal Article
American Journal of Physiology, ISSN 0363-6135, 06/2014, Volume 306, Issue 12, p. H1610
  Due to their specialized location, stem and progenitor cells are often exposed to oxidative stress. Although ATP-binding cassette transporter subfamily G... 
Cardiovascular system | Immunohistochemistry | Oxidative stress | Cells
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 1662 - 1662
Abstract We have previously reported that LAM-PCR libraries derived from non-vector transduced NSG repopulating cells, even those proven negative by... 
Journal Article
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 21, pp. 47 - 47
Abstract Abstract 47 Lmo2 overexpression and Arf loss induce myeloid differentiation in primitive thymocytes LMO2 is a hematopoietic transcription factor that... 
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