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Clinical Therapeutics, ISSN 0149-2918, 2013, Volume 35, Issue 12, pp. 1876 - 1883
Abstract Background Opioid-induced constipation (OIC) is a common adverse effect associated with opioid use. Naloxegol is a PEGylated derivative of naloxone in... 
Internal Medicine | Medical Education | cardiac repolarization | opioid antagonist | peripheral µ-opioid receptor antagonist | naloxegol | opioid-induced constipation | electrocardiography | Naloxegol | Electrocardiography | Cardiac repolarization | Opioid-induced constipation | Peripheral μ-opioid receptor antagonist | Opioid antagonist | PALLIATIVE CARE | QT | MANAGEMENT | PRESCRIBED-OPIOIDS | PREVALENCE | PHYSICIANS | PATHOPHYSIOLOGY | CHRONIC NONMALIGNANT PAIN | INDUCED BOWEL DYSFUNCTION | peripheral mu-opioid receptor antagonist | PHARMACOLOGY & PHARMACY | CHRONIC NONCANCER PAIN | Fluoroquinolones | Aza Compounds - pharmacokinetics | Narcotic Antagonists - administration & dosage | Humans | Middle Aged | Polyethylene Glycols - adverse effects | Aza Compounds - adverse effects | Male | Healthy Volunteers | Quinolines - administration & dosage | Dose-Response Relationship, Drug | Quinolines - pharmacokinetics | Young Adult | Heart Rate - drug effects | Morphinans - administration & dosage | Morphinans - pharmacokinetics | Adult | Constipation - drug therapy | Narcotic Antagonists - pharmacokinetics | Morphinans - adverse effects | Naloxone - pharmacokinetics | Aza Compounds - administration & dosage | Cross-Sectional Studies | Drug Administration Schedule | Narcotic Antagonists - adverse effects | Polyethylene Glycols - pharmacokinetics | Electrocardiography - drug effects | Polyethylene Glycols - administration & dosage | Constipation - chemically induced | Naloxone - adverse effects | Heart - drug effects | Naloxone - administration & dosage | Quinolines - adverse effects | Cardiac arrhythmia | Substance abuse treatment | Narcotics | Antidepressants | Review boards | Laxatives | Drug therapy | Drug dosages
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 4, pp. S-314 - S-314
Journal Article
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S538 - S538
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 01/2016, Volume 81, Issue 1, pp. 89 - 100
Aims Naloxegol, a polyethylene glycol conjugated derivative of the opioid antagonist naloxone, is in clinical development for treatment of opioid‐induced... 
pharmacokinetics | nonmem | naloxegol | NKTR‐118 | Naloxegol | NKTR-118 | Nonmem | Pharmacokinetics | Area Under Curve | Models, Biological | Humans | Middle Aged | Morphinans - pharmacokinetics | Cytochrome P-450 CYP3A - physiology | Polyethylene Glycols - pharmacokinetics | Adult | Female | Male | Narcotic Antagonists - pharmacokinetics | Polyols | Analysis | Cytochrome P-450
Journal Article
The American Journal of Gastroenterology, ISSN 0002-9270, 2003, Volume 98, Issue 12, pp. 2616 - 2620
Objectives: Proton pump inhibitors owe their clinical efficacy to their ability to suppress gastric acid production. The objective of this study was to... 
GERD | EFFICACY | GASTROESOPHAGEAL-REFLUX DISEASE | EROSIVE ESOPHAGITIS | PH | SYMPTOMS | RANDOMIZED CONTROLLED-TRIAL | GASTROENTEROLOGY & HEPATOLOGY | 40 MG
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 5/2012, Volume 52, Issue 5, pp. 670 - 680
This randomized, 4-way crossover study assessed the single-dose pharmacokinetics and relative bioavailability of naproxen and esomeprazole after administration... 
gastrointestinal | analgesiology/pain management | clinical pharmacology | pharmacokinetics and drug metabolism | rheumatology/immunology | ULCERS | CLINICAL-TRIAL | NSAIDS | GUIDELINES | PREVENTION | PHARMACOLOGY & PHARMACY | Prospective Studies | Esomeprazole - administration & dosage | Area Under Curve | Humans | Middle Aged | Esomeprazole - adverse effects | Peptic Ulcer - prevention & control | Biological Availability | Male | Esomeprazole - blood | Anti-Inflammatory Agents, Non-Steroidal - blood | Young Adult | Capsules | Drug Interactions | Proton Pump Inhibitors - administration & dosage | Naproxen - pharmacokinetics | Naproxen - administration & dosage | Adult | Female | Proton Pump Inhibitors - blood | Drug Therapy, Combination | Naproxen - adverse effects | Proton Pump Inhibitors - adverse effects | Administration, Oral | Esomeprazole - pharmacokinetics | Naproxen - blood | Cross-Over Studies | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Proton Pump Inhibitors - pharmacokinetics | Analysis of Variance | Models, Biological | Adolescent | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Least-Squares Analysis | Peptic Ulcer - chemically induced | Tablets, Enteric-Coated | Drug Combinations | Usage | Research | Pharmacokinetics | Rheumatology | Bioavailability | Magnesium
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2016, Volume 39, Issue 1, pp. 75 - 88
Abstract Purpose Opioid-induced constipation (OIC) is a bothersome side effect of opioid use for the management of noncancer pain, affecting patients’... 
Internal Medicine | Medical Education | bowel movement changes | patient outcomes | opioid-induced constipation
Journal Article