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PLoS biology, ISSN 1545-7885, 05/2019, Volume 17, Issue 5, pp. e3000285 - e3000285
Starvation is among the most ancient of selection pressures, driving evolution of a robust arsenal of starvation survival defenses. In order to survive... 
Journal Article
Autophagy, ISSN 1554-8627, 10/2019, Volume 15, Issue 10, pp. 1852 - 1853
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | Index Medicus | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2014, Volume 19, Issue 1, pp. 96 - 108
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and... 
SKELETAL-MUSCLE | PPAR-ALPHA | MITOCHONDRIAL UNCOUPLING PROTEIN | INSULIN-RESISTANCE | COACTIVATOR PGC-1 | IN-VIVO | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | LIVER-DISEASE | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | CELL BIOLOGY | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 02/2009, Volume 23, Issue 4, pp. 496 - 511
Rictor is a component of the target of rapamycin complex 2 (TORC2). While TORC2 has been implicated in insulin and other growth factor signaling pathways, the... 
AKT | Fat metabolism | C. Elegans | Life span | Insulin/IGF | NERVOUS-SYSTEM | C. elegans | AKT/PKB | life span | DEVELOPMENTAL BIOLOGY | AGE-1 PI3 KINASE | CELL BIOLOGY | INSULIN | RAPTOR | MTOR COMPLEX-2 | LONGEVITY | SIGNALING PATHWAY | insulin/IGF | GENETICS & HEREDITY | C-ELEGANS | fat metabolism | TRANSCRIPTION FACTOR | Caenorhabditis elegans Proteins - metabolism | Reproduction - physiology | Fixatives - metabolism | Intestines - metabolism | Adipose Tissue - metabolism | Caenorhabditis elegans - physiology | Immediate-Early Proteins - metabolism | Oxazines - metabolism | Oncogene Protein v-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Somatomedins - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Boron Compounds - metabolism | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | Signal Transduction | Caenorhabditis elegans - genetics | Mutation - genetics | Feeding Behavior - physiology | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Diet | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Lipid Metabolism - physiology | Life spans (Biology) | Caenorhabditis elegans | Immune response | Physiological aspects | Genetic aspects | Rapamycin | Research | Index Medicus | insulin | IGF | Research Paper
Journal Article
Cell, ISSN 0092-8674, 12/2016, Volume 167, Issue 7, pp. 1705 - 1718.e13
Metformin has utility in cancer prevention and treatment, though the mechanisms for these effects remain elusive. Through genetic screening in , we uncover two... 
NPC | RagC GTPase | lifespan | C. elegans | nuclear pore complex | mitochondrial respiratory capacity | nuclear transport | mechanistic target of rapamycin complex 1 | growth | cancer | Metformin | acyl-CoA dehydrogenase family member 10 | ACAD10 | mTORC1 | diabetes | C. elegans | MAMMALIAN TARGET | CELLS | CAENORHABDITIS-ELEGANS | RAG GTPASES | GLUCONEOGENESIS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-PORE COMPLEX | PANCREATIC-CANCER | SACCHAROMYCES-CEREVISIAE | MTOR | CELL BIOLOGY | Acyl-CoA Dehydrogenase - genetics | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | TOR Serine-Threonine Kinases - metabolism | Body Size | Humans | Metformin - pharmacology | Oxidative Phosphorylation | Caenorhabditis elegans Proteins - metabolism | Mitochondria - metabolism | Longevity | Nuclear Pore - metabolism | Mechanistic Target of Rapamycin Complex 1 | Neoplasms - drug therapy | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Monomeric GTP-Binding Proteins - metabolism | Signal Transduction - drug effects | Aging | Cell Line, Tumor | Caenorhabditis elegans Proteins - genetics | Prevention | Growth | Pancreatic cancer | Melanoma | Molecular biology | Gross domestic product | Cells | Cancer | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2013, Volume 9, Issue 10
  Lysosomes are membrane-bound organelles that contain acid hydrolases that degrade cellular proteins, lipids, nucleic acids, and oligosaccharides, and are... 
Dyes | Genes | Nematodes | Aging | Lipids | Mutation | Kinases
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 50, pp. 15378 - 15383
Animals in nature are continually challenged by periods of feast and famine as resources inevitably fluctuate, and must allocate somatic reserves for... 
Journal Article
Cell, ISSN 0092-8674, 04/2019, Volume 177, Issue 2, pp. 299 - 314.e16
Autophagy is required in diverse paradigms of lifespan extension, leading to the prevailing notion that autophagy is beneficial for longevity. However, why... 
mitochondrial permeability | autophagy | ischemia/reperfusion injury | SGK | longevity | aging | mTORC2 | mPTP | ACTIVATION | TRANSITION PORE | CAENORHABDITIS-ELEGANS | PHOSPHORYLATION | MONITORING AUTOPHAGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | GUIDELINES | SERUM | STRESS | IDENTIFICATION | CELL BIOLOGY | Medical colleges | Permeability | Liver | Stem cells
Journal Article