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leishmaniasis (10) 10
mutation (10) 10
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[sdv.mp]life sciences [q-bio]/microbiology and parasitology (9) 9
amastigotes (9) 9
amino acid sequence (9) 9
cells (9) 9
leishmania donovani - growth & development (9) 9
lipophosphoglycan (9) 9
mexicana (9) 9
physiological aspects (9) 9
proteins (9) 9
axenic amastigotes (8) 8
biology (8) 8
gene expression (8) 8
health aspects (8) 8
infectious diseases (8) 8
leishmania major - immunology (8) 8
mesh : animals (8) 8
multidisciplinary sciences (8) 8
visceral leishmaniasis (8) 8
biochemical research methods (7) 7
cell cycle (7) 7
cutaneous leishmaniasis (7) 7
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phosphoproteins (7) 7
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protozoan parasite leishmania (7) 7
article (6) 6
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phosphotransferases (6) 6
protein kinases (6) 6
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stage (6) 6
testing (6) 6
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antiprotozoal agents (5) 5
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arrangements for measuring two or more variables not coveredin a single other subclass (5) 5
biochemistry, molecular biology (5) 5
biological sciences (5) 5
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cricetinae (5) 5
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1. Full Text The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery
by Lamotte, Suzanne and Späth, Gerald F and Rachidi, Najma and Prina, Eric
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 06/2017, Volume 11, Issue 6, p. e0005480
The state of antileishmanial chemotherapy is strongly compromised by the emergence of drug-resistant Leishmania. The evolution of drug-resistant phenotypes has... 
PROGRAMMED CELL-DEATH | GENE-EXPRESSION | RESISTANT LEISHMANIA | ANTIGEN PRESENTATION | DIRECTED THERAPIES | LEISHMANIA-DONOVANI | INFECTED MACROPHAGES | CASEIN KINASE 1 | VISCERAL LEISHMANIASIS | PARASITOLOGY | TROPICAL MEDICINE | LIPOSOMAL AMPHOTERICIN-B | Epigenesis, Genetic | Humans | Drug Discovery - trends | Leishmaniasis - drug therapy | Macrophages - parasitology | Host-Parasite Interactions - drug effects | Animals | Leishmania - drug effects | Mice | Leishmania - pathogenicity | Antiprotozoal Agents - therapeutic use | Drug Resistance | Leishmania - genetics | Host-parasite relationships | Drug resistance in microorganisms | Care and treatment | Forecasts and trends | Leishmaniasis | Drug discovery | Drugs | Intervention | Regulations | Transcription | Virulence | Gene regulation | Intracellular signalling | Genomes | Biology | Parasites | Drug resistance | Genomic instability | Virulence factors | Parasitic diseases | Phenotypes | Bacterial infections | Stability | Environmental factors | Survival | Amplification | Chemotherapy | Instability | Viability | Fitness | Macrophages | Drug Discovery | Life Sciences | Microbiology and Parasitology | Antiprotozoal Agents | Leishmania | Host-Parasite Interactions
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2. Full Text Protein Phosphorylation in Parasites : Novel Targets for Antiparasitic Intervention
by Doerig, Christian and Spaeth, Gerald and Wiese, Martin and Selzer, Paul M
01/2014, ISBN 3527332359, 452
This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections.... 
Antiparasitic agents | Parasitology | Synthesis | Parasites | Phosphoproteins
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3. Full Text Joining forces: first application of a rapamycin‐induced dimerizable Cre system for conditional null mutant analysis in Leishmania
by Späth, Gerald F and Clos, Joachim
Molecular Microbiology, ISSN 0950-382X, 06/2016, Volume 100, Issue 6, pp. 923 - 927
Summary Reverse genetics in Leishmania spp has gained importance beyond basic research as efforts increase to discover and validate new drug targets. Often,... 
THYMIDINE KINASE | CHROMOSOME | INVASION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | GENE AMPLIFICATION | MICROBIOLOGY | INTERFERENCE | INHIBITORS | PROTEINS | EXPRESSION | DNA RECOMBINATION | Leishmania - enzymology | Reverse Genetics - methods | Leishmania - drug effects | Integrases - metabolism | Molecular Targeted Therapy | Antiprotozoal Agents - pharmacology | Integrases - genetics | Proto-Oncogene Proteins c-crk - genetics | Sirolimus - pharmacology | Leishmania - genetics | Bacteria | Pharmacology | Mutation | Microbiology | Kinases | Genes | Life Sciences | Microbiology and Parasitology | Parasitology
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4. Full Text Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation
by Pescher, Pascale and Blisnick, Thierry and Bastin, Philippe and Späth, Gerald F
Cellular Microbiology, ISSN 1462-5814, 07/2011, Volume 13, Issue 7, pp. 978 - 991
Summary Protozoan parasites of the genus Leishmania are important human pathogens that differentiate inside host macrophages into an amastigote life cycle... 
MAMMALIAN HOSTS | ATTENUATED VIRULENCE | TRYPAREDOXIN PEROXIDASE | TRYPANOSOMA-CRUZI | PROTEINASE-DEFICIENT MUTANTS | AMASTIGOTE-STAGE | GENE-EXPRESSION | VIRULENCE FACTOR | CYTOSOLIC TRYPAREDOXIN | MICROBIOLOGY | VISCERAL LEISHMANIASIS | CELL BIOLOGY | Cricetinae | Mice, Inbred C57BL | Virulence | Cells, Cultured | Gene Expression Regulation | Electrophoresis, Gel, Two-Dimensional | Proteome - analysis | Leishmania donovani - growth & development | Macrophages, Peritoneal - parasitology | Spleen - parasitology | Animals | Mass Spectrometry | Female | Mice | Protozoan Proteins - analysis | Leishmania donovani - chemistry | Physiological aspects | Enzymes | Hamsters | Analysis | Spleen | tryparedoxin peroxidase | Pathogens | Statistical analysis | Phagolysosomes | proteomics | Amino acids | Cytotoxicity | survival factor | Leishmaniasis | Parasites | Amastigotes | Macrophages | Survival | Protein turnover | Infection | Life cycle | Infectivity | Nutrients | Pure culture | Life Sciences | Microbiology and Parasitology
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5. Full Text CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation
by Müller, Andreas J and Filipe-Santos, Orchidée and Eberl, Gerard and Aebischer, Toni and Späth, Gerald F and Bousso, Philippe
Immunity, ISSN 1074-7613, 07/2012, Volume 37, Issue 1, pp. 147 - 157
Effector T cells are critical for clearance of pathogens from sites of infection. Like cytotoxic CD8 T cells, CD4 helper T cells have been shown to deliver... 
IMMUNE-RESPONSE | LEISHMANIA-MAJOR INFECTION | INTERFERON-GAMMA | DENDRITIC CELLS | IN-VIVO | EFFECTOR FUNCTION | LYMPH-NODE | INNATE | MICE | IMMUNOLOGY | EXPRESSION | Leishmania major - immunology | Mice, Inbred C57BL | Antigen Presentation - immunology | Leishmaniasis, Cutaneous - immunology | Dermis - immunology | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Animals | Interferon-gamma - immunology | Mice | Bystander Effect - immunology | Dermis - parasitology | Cytokines - immunology | Nitric Oxide Synthase Type II - metabolism | Cytokines | Microscopy | Lymphocytes | Cloning | Skin & tissue grafts | Cytotoxicity | Infections | Defense mechanisms | Parasites | Experiments | Immune system | Life Sciences | Immunology
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6. Full Text PhosTryp: A phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae
by Palmeri, Antonio and Gherardini, Pier Federico and Tsigankov, Polina and Ausiello, Gabriele and Späth, Gerald F and Zilberstein, Dan and Helmer-Citterich, Manuela
BMC Genomics, ISSN 1471-2164, 12/2011, Volume 12, Issue 1, pp. 614 - 614
Background: Protein phosphorylation modulates protein function in organisms at all levels of complexity. Parasites of the Leishmania genus undergo various... 
MOTIFS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STAGE | SEQUENCE | PHOSPHOPROTEOME | GENETICS & HEREDITY | DISORDER | BRUCEI | DIFFERENTIATION | PROTEIN-PHOSPHORYLATION | LEISHMANIA-DONOVANI | IDENTIFICATION | Trypanosoma - metabolism | Phosphorylation | Animals | Physiological aspects | Genetic aspects | Research | Peptides | Leishmania | Proteins | Neural networks | Cell cycle | Organisms | Kinases | Life Sciences | Biochemistry, Molecular Biology | Genomics
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7. Full Text A touch of Zen: post‐translational regulation of the Leishmania stress response
by Späth, Gerald F and Drini, Sima and Rachidi, Najma
Cellular Microbiology, ISSN 1462-5814, 05/2015, Volume 17, Issue 5, pp. 632 - 638
Summary Across bacterial, archaeal and eukaryotic kingdoms, heat shock proteins (HSPs) are defined as a class of highly conserved chaperone proteins that are... 
TRYPANOSOMA-BRUCEI | DONOVANI | PHOSPHORYLATION | INTRACELLULAR INFECTION | MICROBIOLOGY | MAP KINASES | AMASTIGOTE STAGE | PARASITE | STAGE DIFFERENTIATION | HEAT-SHOCK-PROTEIN | REVEALS | CELL BIOLOGY | Molecular Chaperones - metabolism | Gene Expression Regulation | Leishmania - metabolism | Stress, Physiological | Leishmania - physiology | Protein Processing, Post-Translational | Leishmania - genetics | Proteins | Heat shock proteins | Analysis | Cells | Kinases | Parasitic diseases | Parasites | Index Medicus | Life Sciences | Microbiology and Parasitology
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8. Full Text Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage
by Miguel A. Morales and Reiko Watanabe and Mariko Dacher and Philippe Chafey and José Osorio y Fortéa and David A. Scott and Stephen M. Beverley and Gabi Ommen and Joachim Clos and Sonia Hem and Pascal Lenormand and Jean-Claude Rousselle and Abdelkader Namane and Gerald F. Späth and Elizabeth Anne Craig
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 18, pp. 8381 - 8386
Leishmania is exposed to a sudden increase in environmental temperature during the infectious cycle that triggers stage differentiation and adapts the parasite... 
Yeasts | Phosphorylation | Promastigotes | Gels | Phosphoproteins | Antibodies | Heat shock proteins | Parasitism | Parasites | Amastigotes | Stress response | Signaling | SYSTEM | PARASITES | HSP90 | FLY | signaling | stress response | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | DIFFERENTIATION | Amino Acid Sequence | Heat-Shock Proteins - metabolism | Humans | Molecular Sequence Data | Phosphoproteins - metabolism | Proteome - chemistry | Leishmania donovani - growth & development | Phosphoproteins - chemistry | Leishmania donovani - metabolism | Sequence Alignment | Animals | Protozoan Proteins - metabolism | Protein Binding | Protozoan Proteins - chemistry | Proteome - metabolism | Research | Properties | Phosphotransferases | Leishmania | Drugs | Pathogens | Gene regulation | Chaperones | Survival | Protein kinase | Temperature effects | Genetic analysis | Differentiation | phosphoproteomes | phosphoserine | Life Sciences | Microbiology and Parasitology | Parasitology | Biological Sciences
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9. Full Text Alba-domain proteins of trypanosoma brucei are cytoplasmic RNA-Binding proteins that interact with the translation machinery
by Mani, Jan and Güttinger, Andreas and Schimanski, Bernd and Heller, Manfred and Acosta-Serrano, Alvaro and Pescher, Pascale and Späth, Gerald and Roditi, Isabel
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22463
Trypanosoma brucei and related pathogens transcribe most genes as polycistronic arrays that are subsequently processed into monocistronic mRNAs. Expression is... 
METHIONYL-TRANSFER-RNA | MESSENGER-RNA | SURFACE PROTEIN | BLOOD-STREAM FORMS | MULTIDISCIPLINARY SCIENCES | 3 UNTRANSLATED REGION | RIBONUCLEASE-P | GENE-EXPRESSION | INSECT FORMS | ARCHAEBACTERIUM SULFOLOBUS-ACIDOCALDARIUS | PROCYCLIN EXPRESSION SITE | RNA-Binding Proteins - genetics | Protein Biosynthesis | Immunoprecipitation | Membrane Glycoproteins - metabolism | Trypanosoma brucei brucei - metabolism | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Cytoplasm - metabolism | Phylogeny | Protozoan Proteins - genetics | RNA, Messenger - metabolism | Membrane Glycoproteins - genetics | Protein Transport | Multiprotein Complexes - metabolism | Chromatography, Affinity | Protozoan Proteins - metabolism | Cytoplasmic Granules - metabolism | Protein Binding | Protozoan Proteins - chemistry | RNA-Binding Proteins - metabolism | Regulatory Sequences, Ribonucleic Acid - genetics | Glycerin | Messenger RNA | Genes | Glycerol | Binding proteins | Genetic translation | Cells | Protein binding | Post-transcription | Poly(A) | Yeast | Sucrose | Transcription | Midgut | Protein purification | Biological evolution | Material requirements planning | Ribosomal protein P0 | Biology | Regulatory sequences | Mammalian cells | Proteins | Plasticity (functional) | Ribonuclease P | Ribonuclease MRP | DNA-binding protein | User interface | Cell cycle | Cap-binding protein | Phylogenetics | Polyribosomes | Myelin P0 protein | Sugars | Deoxyribonucleic acid--DNA | Parasitology | Starvation | Translation | Nucleotide sequence | RNA-mediated interference | mRNA turnover | Archaea | Heat shock proteins | Gene expression | Ribonucleic acid--RNA | RNA-binding protein | Acids | Insects | 3' Untranslated regions | Phenols | Column chromatography | Life Sciences | Microbiology and Parasitology | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
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10. Full Text High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery
by Aulner, Nathalie and Danckaert, Anne and Rouault-Hardoin, Eline and Desrivot, Julie and Helynck, Olivier and Commere, Pierre-Henri and Munier-Lehmann, Hélène and Späth, Gerald F and Shorte, Spencer L and Milon, Geneviève and Prina, Eric
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 2013, Volume 7, Issue 4, p. e2154
Background/Objectives: Human leishmaniases are parasitic diseases causing severe morbidity and mortality. No vaccine is available and numerous factors limit... 
CUTANEOUS LEISHMANIASIS | AMAZONENSIS AMASTIGOTES | IN-VITRO | RETINOIC ACID | HIGH-THROUGHPUT | TOPICAL TREATMENT | GENE-EXPRESSION | PARASITOPHOROUS VACUOLES | SODIUM STIBOGLUCONATE | VISCERAL LEISHMANIASIS | PARASITOLOGY | TROPICAL MEDICINE | Macrophages - parasitology | Drug Evaluation, Preclinical - methods | Animals | Cells, Cultured | Leishmania - drug effects | Drug Discovery - methods | Leishmaniasis - parasitology | Mice | Leishmania - pathogenicity | Antiprotozoal Agents - pharmacology | Host-parasite relationships | Development and progression | Research | Leishmaniasis | Macrophages | Leishmania | Life Sciences | Microbiology and Parasitology | Antiprotozoal Agents | Drug Evaluation, Preclinical | Drug Discovery | Health facilities | Parasitic diseases | Toxicity | Quality control | Statistical methods | Parasites | Vaccines | Mammals | Experiments
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11. Full Text Photoconvertible Pathogen Labeling Reveals Nitric Oxide Control of Leishmania major Infection In Vivo via Dampening of Parasite Metabolism
by Müller, Andreas J and Aeschlimann, Salome and Olekhnovitch, Romain and Dacher, Mariko and Späth, Gerald F and Bousso, Philippe
Cell Host & Microbe, ISSN 1931-3128, 10/2013, Volume 14, Issue 4, pp. 460 - 467
The immune system can control infectious diseases through different modes of action, including direct killing or spatial confinement. Addressing how the immune... 
Recombinant Proteins - metabolism | Staining and Labeling - methods | Nitric Oxide - immunology | Gene Expression | Leishmania major - immunology | Cell Survival | Leishmania major - drug effects | Recombinant Proteins - genetics | Nitric Oxide - toxicity | Leishmaniasis, Cutaneous - immunology | Animals | Leishmaniasis, Cutaneous - parasitology | Metabolism - drug effects | Leishmania major - metabolism | Luminescent Proteins - genetics | Mice | Genes, Reporter | Disease Models, Animal | Luminescent Proteins - metabolism | Nitric oxide | Physiological aspects | Fluorescence | Control systems | Labeling | Health aspects | Infection control | Life Sciences | Microbiology and Parasitology | Immunology
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12. Full Text Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity
by Hombach-Barrigah, Antje and Bartsch, Katharina and Smirlis, Despina and Rosenqvist, Heidi and MacDonald, Andrea and Dingli, Florent and Loew, Damarys and Späth, Gerald F and Rachidi, Najma and Wiese, Martin and Clos, Joachim
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 5074 - 16
Leishmania parasites are thought to control protein activity at the post-translational level, e.g. by protein phosphorylation. In the pathogenic amastigote,... 
INHIBITION | STRESS-PROTEINS | RADICICOL | STAGE | GELDANAMYCIN | MULTIDISCIPLINARY SCIENCES | COMPLEXES | DIFFERENTIATION | CHAPERONE MACHINE | HSP90 PHOSPHORYLATION | MEXICANA | Post-transcription | Hsp90 protein | Phosphorylation | Promastigotes | Gene regulation | Heat shock proteins | Casein kinase I | Mass spectroscopy | Parasites | Kinases | Macrophages | Mimicry | Signal transduction | Casein | Infectivity | Morphology | Post-translation | Transduction | Complementation | Mutation | Fitness
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