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The New England journal of medicine, ISSN 1533-4406, 2017, Volume 377, Issue 18, pp. 1723 - 1732
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2018, Volume 378, Issue 7, pp. 625 - 635
Journal Article
by Tomlinson, Ian PM and Webb, Emily and Carvajal-Carmona, Luis and Broderick, Peter and Howarth, Kimberley and Pittman, Alan M and Spain, Sarah and Lubbe, Steven and Walther, Axel and Sullivan, Kate and Jaeger, Emma and Fielding, Sarah and Rowan, Andrew and Vijayakrishnan, Jayaram and Domingo, Enric and Chandler, Ian and Kemp, Zoe and Qureshi, Mobshra and Farrington, Susan M and Tenesa, Albert and Prendergast, James GD and Barnetson, Rebecca A and Penegar, Steven and Barclay, Ella and Wood, Wendy and Martin, Lynn and Gorman, Maggie and Thomas, Huw and Peto, Julian and Bishop, D Timothy and Gray, Richard and Maher, Eamonn R and Lucassen, Anneke and Kerr, David and Evans, D Gareth R and Schafmayer, Clemens and Buch, Stephan and Völzke, Henry and Hampe, Jochen and Schreiber, Stefan and John, Ulrich and Koessler, Thibaud and Pharoah, Paul and van Wezel, Tom and Morreau, Hans and Wijnen, Juul T and Hopper, John L and Southey, Melissa C and Giles, Graham G and Severi, Gianluca and Castellví-Bel, Sergi and Ruiz-Ponte, Clara and Carracedo, Angel and Castells, Antoni and Försti, Asta and Hemminki, Kari and Vodicka, Pavel and Naccarati, Alessio and Lipton, Lara and Ho, Judy WC and Cheng, K K and Sham, Pak C and Luk, J and Agúndez, Jose AG and Ladero, Jose M and de la Hoya, Miguel and Caldés, Trinidad and Niittymäki, Iina and Tuupanen, Sari and Karhu, Auli and Aaltonen, Lauri and Cazier, Jean-Baptiste and Campbell, Harry and Dunlop, Malcolm G and Houlston, Richard S and The EPICOLON Consortium and The CORGI Consortium and EPICOLON Consortium and CORGI Consortium
Nature genetics, ISSN 1546-1718, 2008, Volume 40, Issue 5, pp. 623 - 630
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 547, Issue 7662, pp. 173 - 178
Journal Article
by Dunlop, Malcolm G and Dobbins, Sara E and Farrington, Susan Mary and Jones, Angela M and Palles, Claire and Whiffin, Nicola and Tenesa, Albert and Spain, Sarah and Broderick, Peter and Ooi, Li-Yin and Domingo, Enric and Smillie, Claire and Henrion, Marc and Frampton, Matthew and Martin, Lynn and Grimes, Graeme and Gorman, Maggie and Semple, Colin and Ma, Yusanne P and Barclay, Ella and Prendergast, James and Cazier, Jean-Baptiste and Olver, Bianca and Penegar, Steven and Lubbe, Steven and Chander, Ian and Carvajal-Carmona, Luis G and Ballereau, Stephane and Lloyd, Amy and Vijayakrishnan, Jayaram and Zgaga, Lina and Rudan, Igor and Theodoratou, Evropi and Starr, John M and Deary, Ian and Kirac, Iva and Kovacević, Dujo and Aaltonen, Lauri A and Renkonen-Sinisalo, Laura and Mecklin, Jukka-Pekka and Matsuda, Koichi and Nakamura, Yusuke and Okada, Yukinori and Gallinger, Steven and Duggan, David J and Conti, David and Newcomb, Polly and Hopper, John and Jenkins, Mark A and Schumacher, Fredrick and Casey, Graham and Easton, Douglas and Shah, Mitul and Pharoah, Paul and Lindblom, Annika and Liu, Tao and Smith, Christopher G and West, Hannah and Cheadle, Jeremy P and Midgley, Rachel and Kerr, David J and Campbell, Harry and Tomlinson, Ian P and Houlston, Richard S and The Swedish Low-Risk Colorectal Cancer Study Group and The COIN Collaborative Group and The Colorectal Tumour Gene Identification (CORGI) Consortium and Colorectal Tumour Gene Identificat and Coin Collaborative Grp and Swedish Low-Risk Colorectal Canc and COIN Collaborative Group and Swedish Low-Risk Colorectal Cancer Study Group and Colorectal Tumour Gene Identification (CORGI) Consortium and Inst för molekylär medicin och kirurgi and Karolinska Institutet and Dept of Molecular Medicine and Surgery
Nature genetics, ISSN 1546-1718, 2012, Volume 44, Issue 7, pp. 770 - 776
Journal Article
by Arce Vargas, Frederick and Furness, Andrew J.S and Solomon, Isabelle and Joshi, Kroopa and Mekkaoui, Leila and Lesko, Marta H and Miranda Rota, Enrique and Dahan, Rony and Georgiou, Andrew and Sledzinska, Anna and Ben Aissa, Assma and Franz, Dafne and Werner Sunderland, Mariana and Wong, Yien Ning Sophia and Henry, Jake Y and O’Brien, Tim and Nicol, David and Challacombe, Ben and Beers, Stephen A and Turajlic, Samra and Gore, Martin and Larkin, James and Swanton, Charles and Chester, Kerry A and Pule, Martin and Ravetch, Jeffrey V and Marafioti, Teresa and Peggs, Karl S and Quezada, Sergio A and Spain, Lavinia and Wotherspoon, Andrew and Francis, Nicholas and Smith, Myles and Strauss, Dirk and Hayes, Andrew and Soultati, Aspasia and Stares, Mark and Lynch, Joanna and Fotiadis, Nicos and Fernando, Archana and Hazell, Steve and Chandra, Ashish and Pickering, Lisa and Rudman, Sarah and Chowdhury, Simon and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Shafi, Seema and Czyzewska-Khan, Justyna and Johnson, Diana and Laycock, Joanne and Bosshard-Carter, Leticia and Goh, Gerald and Rosenthal, Rachel and Gorman, Pat and Murugaesu, Nirupa and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B.K and McGranahan, Nicholas and Horswell, Stuart and Mitter, Richard and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Xu, Hang and Hiley, Crispin and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Matthews, Nik and Elgar, Greg and Ward, Sophia and Biggs, Jennifer and Costa, Marta and Begum, Sharmin and Phillimore, Ben and Chambers, Tim and Nye, Emma and Graca, Sofia and Al Bakir, Maise and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Kolvekar, Shyam and Falzon, Mary and Borg, Elaine and Simeon, Celia and Hector, Gemma and Smith, Amy and Aranda, Marie and Novelli, Marco and Oukrif, Dahmane and Janes, Sam M and ... and Melanoma TRACERx Consortium and Renal TRACERx Consortium and Lung TRACERx Consortium
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 46, Issue 4, pp. 577 - 586
CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies... 
regulatory T cells | tumor immunotherapy | anti-CD25 | Treg depletion | inhibitory Fc receptor | CD25 | tumor microenvironment | Fc gamma receptors | anti-PD-1 | EFFECTOR | RESPONSES | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | CANCER-PATIENTS | MELANOMA | MONOCLONAL-ANTIBODY | ANTI-CTLA-4 ANTIBODIES | IMMUNOLOGY | ANTITUMOR-ACTIVITY | COMBINATION | GAMMA-RS | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Lymphocyte Depletion | Receptors, IgG - metabolism | T-Lymphocytes, Regulatory - immunology | Neoplasms - therapy | Flow Cytometry | Immunoglobulin Fc Fragments - immunology | Antibodies, Monoclonal - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Kaplan-Meier Estimate | Programmed Cell Death 1 Receptor - metabolism | Receptors, IgG - immunology | Protein Binding - immunology | Animals | Neoplasms - immunology | K562 Cells | Cell Line, Tumor | Mice | Antibodies, Monoclonal - metabolism | Programmed Cell Death 1 Receptor - immunology | Neoplasms - pathology | Viral antibodies | Cell death | Analysis | Immunotherapy | Antibodies | T cells | Cancer | Fc receptors | Beer | Immunoglobulins | Lymphatic system | Immune response | Cytokines | Melanoma | Light emitting diodes | Lymphocytes T | Anticancer properties | Depletion | Lymphocytes | Tumors | Immune system | Report
Journal Article
by Tsoi, Lam C and Spain, Sarah L and Knight, Jo and Ellinghaus, Eva and Stuart, Philip E and Capon, Francesca and Ding, Jun and Li, Yanming and Tejasvi, Trilokraj and Gudjonsson, Johann E and Kang, Hyun M and Allen, Michael H and McManus, Ross and Novelli, Giuseppe and Samuelsson, Lena and Schalkwijk, Joost and Ståhle, Mona and Burden, A David and Smith, Catherine H and Cork, Michael J and Estivill, Xavier and Bowcock, Anne M and Krueger, Gerald G and Weger, Wolfgang and Worthington, Jane and Tazi-Ahnini, Rachid and Nestle, Frank O and Hayday, Adrian and Hoffmann, Per and Winkelmann, Juliane and Wijmenga, Cisca and Langford, Cordelia and Edkins, Sarah and Andrews, Robert and Blackburn, Hannah and Strange, Amy and Band, Gavin and Pearson, Richard D and Vukcevic, Damjan and Spencer, Chris C A and Deloukas, Panos and Mrowietz, Ulrich and Schreiber, Stefan and Weidinger, Stephan and Koks, Sulev and Kingo, Külli and Esko, Tonu and Metspalu, Andres and Lim, Henry W and Voorhees, John J and Weichenthal, Michael and Wichmann, H Erich and Chandran, Vinod and Rosen, Cheryl F and Rahman, Proton and Gladman, Dafna D and Griffiths, Christopher E M and Reis, Andre and Kere, Juha and Nair, Rajan P and Franke, Andre and Barker, Jonathan N W N and Abecasis, Goncalo R and Elder, James T and Trembath, Richard C and Psoriasis Association Genetics Extension and Genetic Analysis of Psoriasis Consortium and Collaborative Association Study of Psoriasis (CASP) and Wellcome Trust Case Control Consortium 2 and Collaborative Assoc Study Psoriasi and Psoriasis Assoc Genetics Extension and Genetic Anal Psoriasis Consortium and Wellcome Trust Case Control Consor and Sahlgrenska akademin and Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik and Göteborgs universitet and Gothenburg University and Institute of Biomedicine, Department of Medical and Clinical Genetics and Sahlgrenska Academy
Nature genetics, ISSN 1546-1718, 2012, Volume 44, Issue 12, pp. 1341 - 1348
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent... 
COMMON VARIANTS | SIGNALING PATHWAYS | MULTIPLE COMMON | INTERFERON-GAMMA | TH17 DIFFERENTIATION | GENETICS & HEREDITY | GENE-EXPRESSION | T-CELL DEVELOPMENT | GENOME-WIDE ASSOCIATION | CELIAC-DISEASE | NEGATIVE REGULATOR | Oligonucleotide Array Sequence Analysis | Humans | Immunity, Innate - genetics | Genetic Loci | CARD Signaling Adaptor Proteins - genetics | Psoriasis - genetics | Core Binding Factor Alpha 3 Subunit - immunology | STAT3 Transcription Factor - genetics | Skin - immunology | Psoriasis - immunology | CARD Signaling Adaptor Proteins - immunology | DEAD Box Protein 58 | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Guanylate Cyclase - immunology | Membrane Proteins - genetics | Membrane Proteins - immunology | GTPase-Activating Proteins - immunology | DEAD-box RNA Helicases - genetics | Core Binding Factor Alpha 3 Subunit - genetics | DEAD-box RNA Helicases - immunology | Guanylate Cyclase - genetics | T-Lymphocytes - immunology | Polymorphism, Single Nucleotide | GTPase-Activating Proteins - genetics | STAT3 Transcription Factor - immunology | Psoriasis | Physiological aspects | Disease susceptibility | Genetic aspects | Research | Autoimmune diseases | Gene expression | Chromosomes | Risk factors | genetic analysis | innate immunity | Dermatologi och venereologi | Dermatology and Venereal Diseases | psoriasis
Journal Article