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1. Full Text Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy
by James, Nicholas D and de Bono, Johann S and Spears, Melissa R and Clarke, Noel W and Mason, Malcolm D and Dearnaley, David P and Ritchie, Alastair W.S and Amos, Claire L and Gilson, Clare and Jones, Rob J and Matheson, David and Millman, Robin and Attard, Gerhardt and Chowdhury, Simon and Cross, William R and Gillessen, Silke and Parker, Christopher C and Russell, J. Martin and Berthold, Dominik R and Brawley, Chris and Adab, Fawzi and Aung, San and Birtle, Alison J and Bowen, Jo and Brock, Susannah and Chakraborti, Prabir and Ferguson, Catherine and Gale, Joanna and Gray, Emma and Hingorani, Mohan and Hoskin, Peter J and Lester, Jason F and Malik, Zafar I and McKinna, Fiona and McPhail, Neil and Money-Kyrle, Julian and O’Sullivan, Joe and Parikh, Omi and Protheroe, Andrew and Robinson, Angus and Srihari, Narayanan N and Thomas, Carys and Wagstaff, John and Wylie, James and Zarkar, Anjali and Parmar, Mahesh K.B and Sydes, Matthew R and STAMPEDE Investigators
The New England journal of medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 4, pp. 338 - 351
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Prednisolone - adverse effects | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prostatic Neoplasms - radiotherapy | Prednisolone - administration & dosage | Prostatic Neoplasms - surgery | Humans | Middle Aged | Abiraterone Acetate - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Abiraterone Acetate - administration & dosage | Neoplasm Metastasis - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Prostatic Neoplasms - drug therapy | Androgen suppression therapy | Usage | Care and treatment | Prostate cancer | Prednisolone | Medical research | Prostate-specific antigen | Clinical trials | Endocrine therapy | Oncology | Metastasis | Radiation therapy | Cancer therapies | Metastases | Mens health | Androgens | Medical prognosis | Death | Prostate | Index Medicus | Abridged Index Medicus
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2. Full Text Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial
by James, Nicholas D, Prof and Sydes, Matthew R, MSc and Clarke, Noel W, Prof and Mason, Malcolm D, Prof and Dearnaley, David P, Prof and Spears, Melissa R, MSc and Ritchie, Alastair W S, MD and Parker, Christopher C, MD and Russell, J Martin, FRCR and Attard, Gerhardt, MD PhD and de Bono, Johann, Prof and Cross, William, PhD and Jones, Rob J, Prof and Thalmann, George, Prof and Amos, Claire, PhD and Matheson, David, PhD and Millman, Robin and Alzouebi, Mymoona, FRCR and Beesley, Sharon, FRCR and Birtle, Alison J, MD and Brock, Susannah, FRCR and Cathomas, Richard, MD and Chakraborti, Prabir, FRCR and Chowdhury, Simon, MD and Cook, Audrey, FRCR and Elliott, Tony, PhD and Gale, Joanna, DM and Gibbs, Stephanie, FRCR and Graham, John D, FRCP and Hetherington, John, FRCS[Eng] and Hughes, Robert, FRCR and Laing, Robert, FRCR and McKinna, Fiona, FRCR and McLaren, Duncan B, FRCR, FRCP[Ed] and O'Sullivan, Joe M, Prof and Parikh, Omi, FRCR and Peedell, Clive, FRCR and Protheroe, Andrew, PhD and Robinson, Angus J, FRCR and Srihari, Narayanan, MD and Srinivasan, Rajaguru, FRCR and Staffurth, John, MD and Sundar, Santhanam, FRCR and Tolan, Shaun, MD and Tsang, David, MCRP and Wagstaff, John, Prof and Parmar, Mahesh K B, Prof and STAMPEDE investigators and STAMPEDE Investigators
The Lancet (British edition), ISSN 0140-6736, 2015, Volume 387, Issue 10024, pp. 1163 - 1177
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Male | Antineoplastic Agents, Hormonal - adverse effects | Neoplasm Metastasis | Aged, 80 and over | Adult | Diphosphonates - adverse effects | Prostatic Neoplasms - drug therapy | Taxoids - adverse effects | Drug Administration Schedule | Antineoplastic Agents, Hormonal - administration & dosage | Imidazoles - adverse effects | Docetaxel | Kaplan-Meier Estimate | Treatment Outcome | Diphosphonates - administration & dosage | Zoledronic Acid | Disease Progression | Taxoids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Survival analysis | Medical prognosis | Clinical trials | Hormone replacement therapy | Metastasis | Prostate cancer | Cancer therapies | Index Medicus | Abridged Index Medicus
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3. Full Text Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis
by Rydzewska, Larysa H.M and Burdett, Sarah and Vale, Claire L and Clarke, Noel W and Fizazi, Karim and Kheoh, Thian and Mason, Malcolm D and Miladinovic, Branko and James, Nicholas D and Parmar, Mahesh K.B and Spears, Melissa R and Sweeney, Christopher J and Sydes, Matthew R and Tran, NamPhuong and Tierney, Jayne F and the STOPCaP Abiraterone Collaborators and STOPCaP Abiraterone Collaborators
European journal of cancer (1990), ISSN 0959-8049, 10/2017, Volume 84, pp. 88 - 101
Systematic review | Androgen deprivation therapy | Abiraterone | Prostate cancer | Metastases | Meta-analysis | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms, Hormone-Dependent - mortality | Age Factors | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents, Hormonal - adverse effects | Neoplasm Grading | Time Factors | Antineoplastic Agents, Hormonal - therapeutic use | Prednisolone - therapeutic use | Odds Ratio | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Androstenes - adverse effects | Risk Factors | Androstenes - therapeutic use | Treatment Outcome | Clinical Trials as Topic | Lymphatic Metastasis | Chi-Square Distribution | Prostatic Neoplasms - mortality | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms, Hormone-Dependent - pathology | Androgen Antagonists - therapeutic use | Aged | Neoplasms, Hormone-Dependent - drug therapy | Androgen Antagonists - adverse effects | Prednisone - therapeutic use | Metastasis | Hormones | Analysis | Therapy | Deprivation | Toxicity | Endocrine therapy | Clinical trials | Prednisone | Survival | Subgroups | Confidence intervals | Reduction | Randomization | Men | Acetic acid | Heart diseases | Prostate | Endocrinology | Prednisolone | Cancer | Acute toxicity | Index Medicus
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4. Full Text Aortic pulse wave velocity improves cardiovascular event prediction: An individual participant meta-analysis of prospective observational data from 17,635 subjects
by Ben-Shlomo, Yoav and Spears, Melissa and Boustred, Chris and May, Margaret and Anderson, Simon G and Benjamin, Emelia J and Boutouyrie, Pierre and Cameron, James and Chen, Chen-Huan and Cruickshank, J. Kennedy and Hwang, Shih-Jen and Lakatta, Edward G and Laurent, Stephane and Maldonado, João and Mitchell, Gary F and Najjar, Samer S and Newman, Anne B and Ohishi, Mitsuru and Pannier, Bruno and Pereira, Telmo and Vasan, Ramachandran S and Shokawa, Tomoki and Sutton-Tyrell, Kim and Verbeke, Francis and Wang, Kang-Ling and Webb, David J and Willum Hansen, Tine and Zoungas, Sophia and McEniery, Carmel M and Cockcroft, John R and Wilkinson, Ian B
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2014, Volume 63, Issue 7, pp. 636 - 646
meta-analysis | cardiovascular disease | prognostic factor | pulse wave velocity | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Predictive Value of Tests | Cardiovascular Diseases - physiopathology | Prospective Studies | Humans | Cardiovascular Diseases - epidemiology | Observational Studies as Topic | Pulse Wave Analysis - methods | Aorta - physiology | Cardiovascular Diseases - diagnosis | Sex | Cardiovascular disease | Systematic review | Subgroups | Risk factors | Confidence intervals | Ethics | Population | Aorta | Heart diseases | Age | Hypertension | Stroke | Mortality | Diabetes mellitus | Health risks | Risk analysis | Estimates | Velocity | Reclassification | Coronary artery disease | Meta-analysis | Studies | Statistical models | Predictions | Models | Diabetes | Wave velocity | Cardiovascular diseases | Health risk assessment | Risk management | Index Medicus | Abridged Index Medicus
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5. Full Text Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols
by Parmar, Mahesh KB and Sydes, Matthew R and Cafferty, Fay H and Choodari-Oskooei, Babak and Langley, Ruth E and Brown, Louise and Phillips, Patrick PJ and Spears, Melissa R and Rowley, Sam and Kaplan, Richard and James, Nicholas D and Maughan, Timothy and Paton, Nicholas and Royston, Patrick J
Clinical trials (London, England), ISSN 1740-7745, 10/2017, Volume 14, Issue 5, pp. 451 - 461
randomised trials | basket | multi-stage | umbrella | platform | Multi-arm | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Clinical Trials, Phase III as Topic | Humans | London | Clinical Protocols - standards | Male | Treatment Outcome | Outcome Assessment, Health Care | Research Design | Patient Selection | Randomized Controlled Trials as Topic | Clinical trials | Medical research | Design improvements | Index Medicus
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6. Full Text Survival with Newly Diagnosed Metastatic Prostate Cancer in the “Docetaxel Era”: Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019)
by James, Nicholas David and Spears, Melissa R and Clarke, Noel W and Dearnaley, David P and De Bono, Johann S and Gale, Joanna and Hetherington, John and Hoskin, Peter J and Jones, Robert J and Laing, Robert and Lester, Jason F and McLaren, Duncan and Parker, Christopher C and Parmar, Mahesh K.B and Ritchie, Alastair W.S and Russell, J. Martin and Strebel, Räto T and Thalmann, George N and Mason, Malcolm D and Sydes, Matthew R
European urology, ISSN 0302-2838, 2014, Volume 67, Issue 6, pp. 1028 - 1038
Urology | Control arm cohort | Hormone-naïve | Time to progression | Metastatic | Prospective data | Prostate cancer | Survival | Natural history | Prognostic factors | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Prognosis | Age Factors | Follow-Up Studies | Humans | Middle Aged | Male | Prostatic Neoplasms - diagnosis | Taxoids - therapeutic use | Neoplasm Grading | Aged, 80 and over | Adult | Physical Fitness | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Neoplasm Metastasis - therapy | Risk Factors | Docetaxel | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Early Detection of Cancer - mortality | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Disease-Free Survival | Neoplasm Metastasis - pathology | Neoplasm Metastasis - diagnosis | Androgen Antagonists - therapeutic use | Aged | Cohort Studies | Metastasis | Index Medicus
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7. Full Text Could a brief assessment of negative emotions and self-esteem identify adolescents at current and future risk of self-harm in the community? A prospective cohort analysis
by Phillips, Rhiannon and Spears, Melissa R and Montgomery, Alan A and Millings, Abigail and Sayal, Kapil and Stallard, Paul
BMC public health, ISSN 1471-2458, 2013, Volume 13, Issue 1, pp. 604 - 604
Screening | Self-esteem | Negative emotions | Adolescents | Self-harm | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Predictive Value of Tests | Prospective Studies | Humans | England | Male | Psychometrics | Adolescent Health Services | Self-Injurious Behavior - diagnosis | Affect | Self Concept | Adolescent | Female | Surveys and Questionnaires | Adolescent Behavior | Child | Cohort Studies | High schools | Self-destructive behavior | Depression, Mental | Child psychopathology | Studies | Medical research | Teenagers | Self esteem | Self destructive behavior | Suicides & suicide attempts | Index Medicus
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8. Full Text A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit
by Beal, M. Flint and Oakes, David and Shoulson, Ira and Henchcliffe, Claire and Galpern, Wendy R and Haas, Richard and Juncos, Jorge L and Nutt, John G and Voss, Tiffini Smith and Ravina, Bernard and Shults, Clifford M and Helles, Karen and Snively, Victoria and Lew, Mark F and Griebner, Brian and Watts, Arthur and Gao, Shan and Pourcher, Emmanuelle and Bond, Louisette and Kompoliti, Katie and Agarwal, Pinky and Sia, Cherissa and Jog, Mandar and Cole, Linda and Sultana, Munira and Kurlan, Roger and Richard, Irene and Deeley, Cheryl and Waters, Cheryl H and Figueroa, Angel and Arkun, Ani and Brodsky, Matthew and Ondo, William G and Hunter, Christine B and Jimenez-Shahed, Joohi and Palao, Alicia and Miyasaki, Janis M and So, Julie and Tetrud, James and Reys, Liza and Smith, Katharine and Singer, Carlos and Blenke, Anita and Russell, David S and Cotto, Candace and Friedman, Joseph H and Lannon, Margaret and Zhang, Lin and Drasby, Edward and Kumar, Rajeev and Subramanian, Thyagarajan and Ford, Donna Stuppy and Grimes, David A and Cote, Diane and Conway, Jennifer and Siderowf, Andrew D and Evatt, Marian Leslie and Sommerfeld, Barbara and Lieberman, Abraham N and Okun, Michael S and Rodriguez, Ramon L and Merritt, Stacy and Swartz, Camille Louise and Martin, W. R. Wayne and King, Pamela and Stover, Natividad and Guthrie, Stephanie and Watts, Ray L and Ahmed, Anwar and Fernandez, Hubert H and Winters, Adrienna and Mari, Zoltan and Dawson, Ted M and Dunlop, Becky and Feigin, Andrew S and Shannon, Barbara and Nirenberg, Melissa Jill and Ogg, Mattson and Ellias, Samuel A and Thomas, Cathi-Ann and Frei, Karen and Bodis-Wollner, Ivan and Glazman, Sofya and Mayer, Thomas and Hauser, Robert A and Pahwa, Rajesh and Langhammer, April and Ranawaya, Ranjit and Derwent, Lorelei and Sethi, Kapil D and Farrow, Buff and Prakash, Rajan and Litvan, Irene and Robinson, Annette and Sahay, Alok and Gartner, Maureen and Hinson, Vanessa K and Markind, Samuel and Pelikan, Melisa and Perlmutter, Joel S and ... and Parkinson Study Group QE3 Investigators and The Parkinson Study Group QE3 Investigators
JAMA neurology, ISSN 2168-6149, 03/2014, Volume 75, Issue 1, pp. 543 - 552
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Ubiquinone - administration & dosage | Prospective Studies | Double-Blind Method | Antioxidants - metabolism | Humans | Middle Aged | Ubiquinone - analogs & derivatives | Male | Treatment Outcome | Parkinson Disease - drug therapy | Dose-Response Relationship, Drug | Ubiquinone - blood | Parkinson Disease - enzymology | Antioxidants - administration & dosage | Parkinson Disease - diagnosis | Female | Aged | Early Diagnosis | Index Medicus | Abridged Index Medicus
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