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1. Full Text Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection
by Zhou, Wei-Jie and Geng, Zhen H and Spence, Jason R and Geng, Jian-Guo
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7465, pp. 107 - 111
Cancer research has been rightly and successfully focused on prevention, early detection, and identification of specific molecular targets that distinguish the... 
IN-VITRO | COLON | MICE | R-SPONDIN1 | MULTIDISCIPLINARY SCIENCES | GROWTH | Intestines - drug effects | Intestines - radiation effects | Nerve Tissue Proteins - deficiency | Thrombospondins - administration & dosage | Male | Stem Cells - cytology | Stem Cells - metabolism | Wnt Proteins - metabolism | Regeneration - radiation effects | Thrombospondins - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasm Metastasis - drug therapy | Nerve Tissue Proteins - pharmacology | Female | Neoplasms - radiotherapy | Homeostasis - drug effects | Intestines - pathology | Neoplasm Metastasis - radiotherapy | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Immunologic - deficiency | Stem Cells - radiation effects | Survival Rate | Nerve Tissue Proteins - genetics | Neoplasms - drug therapy | Nerve Tissue Proteins - metabolism | Cell Lineage | Regeneration - drug effects | Animals | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Stem Cells - drug effects | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Receptors, Immunologic - genetics | Thrombospondins - metabolism | Receptors, Immunologic - metabolism | Intestines - cytology | Index Medicus
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2. Full Text Carotid plaque measurement is superior to IMT: Invited editorial comment on: Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: A meta-analysis—Yoichi Inaba, M.D., Jennifer A. Chen M.D., Steven R. Bergmann M.D., Ph.D
by Spence, J. David
Atherosclerosis, ISSN 0021-9150, 01/2012, Volume 220, Issue 1, pp. 34 - 35
ATHEROSCLEROSIS | PERIPHERAL VASCULAR DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | Plaque, Atherosclerotic - diagnostic imaging | Carotid Arteries - diagnostic imaging | Carotid Artery Diseases - diagnostic imaging | Coronary Artery Disease - etiology | Carotid Intima-Media Thickness | Humans | Index Medicus
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3. Full Text TCT-773 Initial Experience of the Medtronic 34mm Evolut R Valve: The UK & Ireland Implanters’ Registry
by Dowling, Cameron and Firoozi, Sami and Doyle, Niamh and Spence, Mark and Manoharan, Ganesh and Owens, Colum and Kashyap, Mavin and Kabir, Tito and Panoulas, Vasileios and Dalby, Miles and Mylotte, Darren and Neylon, Antoinette and Martin, Niamh and Roberts, David and More, Ranjit and Wiper, Andrew and Abdelaziz, Hesham and Grech, Ever and Hall, Ian and Neville, Melanie and Rampat, Rajiv and Hildick-Smith, David and Mullen, Michael and Simon Kennon and Chandrala, Pavan and Anderson, Richard Anthony and Rajathurai, Thirumaran and Tapp, Luke and Deegan, Lauren and Doshi, Sagar and Kovac, Jan and Kontoprias, Kosmas and Brecker, Stephen
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2017, Volume 70, Issue 18, pp. B263 - B263
The Medtronic 34mm Evolut R valve is a self-expanding, repositionable and fully-recapturable second-generation transcatheter heart valve, designed to treat... 
Heart | Catheters
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4. Full Text Guideliner (R) catheteruFriend or foe?
by Murphy, JC and Spence, MS
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, ISSN 1522-1946, 09/2012, Volume 80, Issue 3, pp. 447 - 450
Performing percutaneous coronary intervention (PCI) in arteries with complex anatomy remains a clinical problem. In particular tortuosity within a coronary... 
DISTAL STENT DELIVERY | percutaneous coronary intervention | complication | CARDIAC & CARDIOVASCULAR SYSTEMS | tortuosity | EXPERIENCE
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5. Full Text Femtosecond X-ray protein nanocrystallography
by Chapman, Henry N and Fromme, Petra and Barty, Anton and White, Thomas A and Kirian, Richard A and Aquila, Andrew and Hunter, Mark S and Schulz, Joachim and Deponte, Daniel P and Weierstall, Uwe and Doak, R. Bruce and Maia, Filipe R. N. C and Martin, Andrew V and Schlichting, Ilme and Lomb, Lukas and Coppola, Nicola and Shoeman, Robert L and Epp, Sascha W and Hartmann, Robert and Rolles, Daniel and Rudenko, Artem and Foucar, Lutz and Kimmel, Nils and Weidenspointner, Georg and Holl, Peter and Liang, Mengning and Barthelmess, Miriam and Caleman, Carl and Boutet, Sébastien and Bogan, Michael J and Krzywinski, Jacek and Bostedt, Christoph and Bajt, Sǎa and Gumprecht, Lars and Rudek, Benedikt and Erk, Benjamin and Schmidt, Carlo and Hömke, André and Reich, Christian and Pietschner, Daniel and Ströder, Lothar and Hauser, Günter and Gorke, Hubert and Ullrich, Joachim and Herrmann, Sven and Schaller, Gerhard and Schopper, Florian and Soltau, Heike and Kühnel, Kai-Uwe and Messerschmidt, Marc and Bozek, John D and Hau-Riege, Stefan P and Frank, Matthias and Hampton, Christina Y and Sierra, Raymond G and Starodub, Dmitri and Williams, Garth J and Hajdu, Janos and Timneanu, Nicusor and Seibert, M. Marvin and Andreasson, Jakob and Rocker, Andrea and Jönsson, Olof and Svenda, Martin and Stern, Stephan and Nass, Karol and Andritschke, Robert and Schröter, Claus-Dieter and Krasniqi, Faton and Bott, Mario and Schmidt, Kevin E and Wang, Xiaoyu and Grotjohann, Ingo and Holton, James M and Barends, Thomas R. M and Neutze, Richard and Marchesini, Stefano and Fromme, Raimund and Schorb, Sebastian and Rupp, Daniela and Adolph, Marcus and Gorkhover, Tais and Andersson, Inger and Hirsemann, Helmut and Potdevin, Guillaume and Graafsma, Heinz and Nilsson, Björn and Spence, John C. H and Energy Frontier Research Centers (EFRC) and Center for Bio-Inspired Solar Fuel Production (BISfuel) and Teknisk-naturvetenskapliga vetenskapsområdet and Biologiska sektionen and Uppsala universitet and Institutionen för cell- och molekylärbiologi and Molekylär biofysik
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7332, pp. 73 - 78
X-ray crystallography provides the vast majority of macromolecular structures, but the success of the method relies on growing crystals of sufficient size. In... 
REFINEMENT | CRYSTALS | DIFFRACTION | MICROSCOPY | MULTIDISCIPLINARY SCIENCES | RESOLUTION | Crystallography, X-Ray - methods | Crystallography, X-Ray - instrumentation | Nanoparticles - chemistry | Time Factors | Lasers | Nanotechnology - methods | X-Rays | Models, Molecular | Nanotechnology - instrumentation | Protein Conformation | Photosystem I Protein Complex - chemistry | Fourier transforms | X rays | Diffraction | Nanocrystals | Methods | Silicon nitride | Index Medicus | synthesis (novel materials) | synthesis (self-assembly) | materials and chemistry by design | catalysis (homogeneous) | catalysis (heterogeneous) | MATERIALS SCIENCE | solar (fuels) | charge transport | photosynthesis (natural and artificial) | NANOSCIENCE AND NANOTECHNOLOGY | electrodes - solar | hydrogen and fuel cells | bio-inspired | Biological Sciences | Biology | Biologi | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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6. Full Text Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser
by Lars Redecke and Karol Nass and Daniel P. Deponte and Thomas A. White and Dirk Rehders and Anton Barty and Francesco Stellato and Mengning Liang and Thomas R.M. Barends and Sébastien Boutet and Garth J. Williams and Marc Messerschmidt and M. Marvin Seibert and Andrew Aquila and David Arnlund and Sasa Bajt and Torsten Barth and Michael J. Bogan and Carl Caleman and Tzu-Chiao Chao and R. Bruce Doak and Holger Fleckenstein and Matthias Frank and Raimund Fromme and Lorenzo Galli and Ingo Grotjohann and Mark S. Hunter and Linda C. Johansson and Stephan Kassemeyer and Gergely Katona and Richard A. Kirian and Rudolf Koopmann and Chris Kupitz and Lukas Lomb and Andrew V. Martin and Stefan Mogk and Richard Neutze and Robert L. Shoeman and Jan Steinbrener and Nicusor Timneanu and Dingjie Wang and Uwe Weierstall and Nadia A. Zatsepin and John C. H. Spence and Petra Fromme and Ilme Schlichting and Michael Duszenko and Christian Betzel and Henry N. Chapman and Teknisk-naturvetenskapliga vetenskapsområdet and Biologiska sektionen and Uppsala universitet and Institutionen för cell- och molekylärbiologi and Molekylär biofysik
Science, ISSN 0036-8075, 1/2013, Volume 339, Issue 6116, pp. 227 - 230
The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host protein degradation, is a promising target to develop new treatments... 
Enzymes | Electronic structure | Active sites | Lasers | REPORTS | Crystals | Atoms | Biochemistry | Electron density | Molecular biology | Crystal structure | HUMAN AFRICAN TRYPANOSOMIASIS | ACTIVE-SITE | MULTIDISCIPLINARY SCIENCES | OCCLUDING LOOP | NANOCRYSTALLOGRAPHY | DISEASE | PROTEIN-STRUCTURE DETERMINATION | PAPAIN | CRYSTALLOGRAPHY | CYSTEINE PROTEASES | PROPEPTIDE | Amino Acid Sequence | Catalytic Domain | Enzyme Precursors - chemistry | Protozoan Proteins - antagonists & inhibitors | Crystallization | Cathepsin B - antagonists & inhibitors | Cathepsin B - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Glycosylation | Trypanosoma brucei brucei - enzymology | Spodoptera | Sf9 Cells | Animals | X-Rays | Protein Conformation | Protozoan Proteins - chemistry | Usage | Physiological aspects | Cathepsins | Microbiological chemistry | Research | Trypanosoma brucei | Health aspects | Lasers in medicine | Protozoa | Proteases | Parasitic diseases | Crystallography | Index Medicus | Inhibitors | Diffraction | X-ray lasers | Activation | Radiation damage | Biological Sciences | Naturvetenskap | Natural Sciences | Structural Biology | Biologiska vetenskaper | Strukturbiologi
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7. Full Text Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography
by Stagno, J.R and Liu, Y and Bhandari, Y.R and Conrad, C.E and Panja, S and Swain, M and Fan, L and Nelson, G and Li, C and Wendel, D.R and White, T.A and Coe, J.D and Wiedorn, M.O and Knoska, J and Oberthuer, D and Tuckey, R.A and Yu, P and Dyba, M and Tarasov, S.G and Weierstall, U and Grant, T.D and Schwieters, C.D and Zhang, J and Ferré-D'Amaré, A.R and Fromme, P and Draper, D.E and Liang, M and Hunter, M.S and Boutet, S and Tan, K and Zuo, X and Ji, X and Barty, A and Zatsepin, N.A and Chapman, H.N and Spence, J.C.H and Woodson, S.A and Wang, Y.-X and SLAC National Accelerator Lab., Menlo Park, CA (United States) and Argonne National Lab. (ANL), Argonne, IL (United States)
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7636, pp. 242 - 246
Riboswitches are structural RNA elements that are generally located in the 5' untranslated region of messenger RNA. During regulation of gene expression,... 
SCATTERING DATA | BINDING RIBOSWITCHES | STANDARD ATOMIC VOLUMES | MOLECULAR-STRUCTURE | GENETIC-CONTROL | FEMTOSECOND CRYSTALLOGRAPHY | MULTIDISCIPLINARY SCIENCES | X-RAY-DIFFRACTION | PHOTOACTIVE YELLOW PROTEIN | LIGAND | ADENINE RIBOSWITCH | RNA Folding | Riboswitch | Vibrio vulnificus - genetics | Nanotechnology - methods | Crystallization | Aptamers, Nucleotide - chemistry | Models, Molecular | 5' Untranslated Regions - genetics | Crystallography, X-Ray - methods | Time Factors | Lasers | RNA, Bacterial - chemistry | RNA, Bacterial - genetics | Ligands | Kinetics | Diffusion | Nucleic Acid Conformation | Electrons | RNA sequencing | Crystallography | Methods | Studies | Nanocrystals | Gene expression | Index Medicus | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES
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8. Full Text Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
by Eikelboom, John W and Connolly, Stuart J and Bosch, Jackie and Dagenais, Gilles R and Hart, Robert G and Shestakovska, Olga and Diaz, Rafael and Alings, Marco and Lonn, Eva M and Anand, Sonia S and Widimsky, Petr and Hori, Masatsugu and Avezum, Alvaro and Piegas, Leopoldo S and Branch, Kelley R.H and Probstfield, Jeffrey and Bhatt, Deepak L and Zhu, Jun and Liang, Yan and Maggioni, Aldo P and Lopez-Jaramillo, Patricio and O’Donnell, Martin and Kakkar, Ajay K and Fox, Keith A.A and Parkhomenko, Alexander N and Ertl, Georg and Störk, Stefan and Keltai, Matyas and Ryden, Lars and Pogosova, Nana and Dans, Antonio L and Lanas, Fernando and Commerford, Patrick J and Torp-Pedersen, Christian and Guzik, Tomek J and Verhamme, Peter B and Vinereanu, Dragos and Kim, Jae-Hyung and Tonkin, Andrew M and Lewis, Basil S and Felix, Camilo and Yusoff, Khalid and Steg, P. Gabriel and Metsarinne, Kaj P and Cook Bruns, Nancy and Misselwitz, Frank and Chen, Edmond and Leong, Darryl and Yusuf, Salim and COMPASS Investigators
The New England Journal of Medicine, ISSN 0028-4793, 10/2017, Volume 377, Issue 14, pp. 1319 - 1330
In patients with stable cardiovascular disease, those receiving rivaroxaban plus aspirin had fewer major cardiovascular events but more major bleeding events... 
TRIAL | MEDICINE, GENERAL & INTERNAL | RISK | ORAL RIVAROXABAN | CLOPIDOGREL | SECONDARY PREVENTION | Atherosclerosis - drug therapy | Double-Blind Method | Cardiovascular Diseases - drug therapy | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Atherosclerosis - complications | Male | Secondary Prevention - methods | Factor Xa Inhibitors - therapeutic use | Rivaroxaban - adverse effects | Aspirin - adverse effects | Factor Xa Inhibitors - adverse effects | Cardiovascular Diseases - mortality | Female | Aged | Aspirin - therapeutic use | Hemorrhage - chemically induced | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Rivaroxaban - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Rivaroxaban | Aspirin | Patient outcomes | Outcome and process assessment (Health Care) | Reports | Dosage and administration | Research | Cardiovascular diseases | Drug therapy | Observations | Methods | Myocardial infarction | Cerebral infarction | Medical research | Cardiovascular disease | Bleeding | Studies | Disease prevention | Arteriosclerosis | Coronary vessels | Atherosclerosis | Drug dosages | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology
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