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Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 596 - 599
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the... 
ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | MUTATION | KERATOACANTHOMAS | SENSITIVITY | SENESCENCE | SORAFENIB | HUMAN CANCER | PROGRESSION | BRAF(V600E) | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Macaca fascicularis | Melanoma - enzymology | Substrate Specificity | Positron-Emission Tomography | Extracellular Signal-Regulated MAP Kinases - metabolism | Indoles - administration & dosage | Neoplasm Metastasis | Melanoma - genetics | Phosphorylation - drug effects | Mutant Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Sulfonamides - chemistry | Mutant Proteins - genetics | Models, Molecular | Rats | Mutant Proteins - metabolism | Melanoma - pathology | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Indoles - adverse effects | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutant Proteins - chemistry | Alleles | Dogs | Sulfonamides - adverse effects | Indoles - therapeutic use | Indoles - chemistry | Sulfonamides - administration & dosage | Control | Gene mutations | Melanoma | Development and progression | Genetic aspects | Research | Health aspects | Protein kinases | Cancer | Proteins | Mutation | Kinases | Rodents | Index Medicus | targeted therapy | melanoma | BRAF | PLX4032 | biomarker | oncogene
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7574, pp. 583 - 586
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 14, pp. 5689 - 5694
Inflammation and cancer, two therapeutic areas historically addressed by separate drug discovery efforts, are now coupled in treatment approaches by a growing... 
Receptors | Kidneys | Bones | Osteoclasts | Mast cells | Arthritis | Macrophages | Inhibitory concentration 50 | Tumors | Cancer | CSF1R | Cancer bone metastasis | Rheumatoid arthritis | Scaffold-based drug design | CHRONIC MYELOGENOUS LEUKEMIA | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | scaffold-based drug design | COLONY-STIMULATING FACTOR | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | rheumatoid arthritis | PROTOONCOGENE C-KIT | cancer bone metastasis | GASTROINTESTINAL STROMAL TUMORS | OSTEOCLAST DIFFERENTIATION | IMATINIB MESYLATE | Human Umbilical Vein Endothelial Cells | Escherichia coli | Humans | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Mutation, Missense - genetics | Spodoptera | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Sf9 Cells | Neoplasm Metastasis - drug therapy | Inflammation - drug therapy | Proto-Oncogene Proteins c-kit - genetics | Molecular Structure | Indoles | Cell Survival - drug effects | Oncogene Protein gp140(v-fms) - genetics | Protein Kinase Inhibitors - chemical synthesis | Oncogene Protein gp140(v-fms) - antagonists & inhibitors | Crystallization | Models, Molecular | Mast Cells - drug effects | Aminopyridines - chemical synthesis | Pyrroles - pharmacology | Animals | Chromatography, Affinity | Pyrroles - chemical synthesis | Aminopyridines - pharmacology | Pyrroles - chemistry | Macrophages - drug effects | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Oncogene Protein gp140(v-fms) - chemistry | Proto-Oncogene Proteins c-kit - chemistry | Osteoclasts - drug effects | Cell receptors | Care and treatment | Pharmacology, Experimental | Cancer cells | Physiological aspects | Research | Properties | Oncogenes | Immune system | Inhibitor drugs | Research & development--R&D | Medical treatment | Pharmacology | Kinases | Inflammatory diseases | Index Medicus | Biological Sciences
Journal Article
BioMed Research International, ISSN 2314-6133, 2013, Volume 2013, pp. 295812 - 9
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4711 - 4711
Inhibitors against the bromodomain and extra terminal domain (BET) family of proteins have been pursued as promising oncology agents based on growing... 
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2015, Volume 5, Issue 6, pp. 668 - 679
Tyrosine kinase domain mutations are a common cause of acquired clinical resistance to tyrosine kinase inhibitors (TKIs) used to treat cancer, including the... 
Resistance | Gatekeeper Mutations | Quizartinib | FLT3
Journal Article
Science, ISSN 0036-8075, 7/1993, Volume 261, Issue 5121, pp. 585 - 588
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 06/2015, Volume 5, Issue 6, pp. 668 - 679
Journal Article
Journal Article
by Gulack, Brian C and Kirkwood, Katherine A and Shi, Wei and Smith, Peter K and Smith, Craig R and Alexander, John H and Burks, Sandra G and Gelijns, Annetine C and Thourani, Vinod H and Bell, Daniel and Greenberg, Ann and Goldfarb, Seth D and Mayer, Mary Lou and Bowdish, Michael E and Miller, Frank and Miller, Marissa A and Miller, Rachel and Taddei-Peters, Wendy C and Buxton, Dennis and Caulder, Ron and Geller, Nancy L and Gordon, David and Jeffries, Neal O and Lee, Albert and Moy, Claudia S and Gombos, Ilana Kogan and Ralph, Jennifer and Gardner, Timothy J and O'Gara, Patrick T and Parides, Michael K and Ascheim, Deborah D and Moskowitz, Alan J and Moquete, Ellen and Rose, Eric A and Chase, Melissa and Chen, Yingchun and Gagliardi, Rosemarie and Gupta, Lopa and Kumbarce, Edlira and Levitan, Ron and O'Sullivan, Karen and Santos, Milerva and Weinberg, Alan and Williams, Mathew and Williams, Judson B and Williams, David O and Williams, Paula and Wood, Carrie and Ye, Xia and Blackstone, Eugene H and Gillinov, A. Marc and Lackner, Pamela and Berroteran, Leoma and Dolney, Diana and Fleming, Suzanne and Palumbo, Roberta and Whitman, Christine and Sankovic, Kathy and Sweeney, Denise Kosty and Pattakos, Gregory and Clarke, Pamela A and Argenziano, Michael and Goldsmith, Lyn and Naka, Yoshifumi and Stewart, Allan and Schwartz, Allan and Van Patten, Danielle and Welsh, Stacey and Milano, Carmelo A and Glower, Donald D and Mathew, Joseph P and Harrison, J. Kevin and Berry, Mark F and Parsa, Cyrus J and Tong, Betty C and Ferguson, T. Bruce and Kypson, Alan P and Rodriguez, Evelio and Harris, Malissa and Akers, Brenda and O'Neal, Allison and Puskas, John D and Guyton, Robert and Baer, Jefferson and Baio, Kim and Neill, Alexis A and Michler, Robert E and D'Alessandro, David A and DeRose, Joseph J and Goldstein, Daniel J and Bello, Ricardo and Jakobleff, William and Garcia, Mario and Taub, Cynthia and Spevak, Daniel and Swayze, Roger and Perrault, Louis P and Basmadjian, Arsène-Joseph and Bouchard, Denis and Carrier, Michel and ... and Cardiothoracic Surgical Trials Net and Cardiothoracic Surgical Trials Network (CTSN)
The Journal of Thoracic and Cardiovascular Surgery, ISSN 0022-5223, 04/2018, Volume 155, Issue 4, pp. 1555 - 1562.e1
Journal Article
Rochester Democrat and Chronicle, 08/2012
  [...]he has yet to explore that last motivational technique. [...]when I quit smoking reefer. 
Musical recordings | Musicians & conductors | Self destructive behavior
Newspaper Article
Rochester Democrat and Chronicle, 11/2008
  According to Lil Wayne publicist Myiah Hughes, who is quoted on www.allhiphop.com, Wayne offered the promoter, Ed Strickland, another date without penalty.... 
Musical performances | Rap music
Newspaper Article
by Ferket, Bart S and Thourani, Vinod H and Voisine, Pierre and Hohmann, Samuel F and Chang, Helena L and Smith, Peter K and Michler, Robert E and Ailawadi, Gorav and Perrault, Louis P and Miller, Marissa A and O'Sullivan, Karen and Mick, Stephanie L and Bagiella, Emilia and Acker, Michael A and Moquete, Ellen and Hung, Judy W and Overbey, Jessica R and Lala, Anuradha and Iraola, Margaret and Gammie, James S and Gelijns, Annetine C and O'Gara, Patrick T and Moskowitz, Alan J and Taddei-Peters, Wendy C and Buxton, Dennis and Caulder, Ron and Geller, Nancy L and Gordon, David and Jeffries, Neal O and Lee, Albert and Moy, Claudia S and Gombos, Ilana Kogan and Ralph, Jennifer and Weisel, Richard and Gardner, Timothy J and Rose, Eric A and Parides, Michael K and Ascheim, Deborah D and Chang, Helena and Chase, Melissa and Chen, Yingchun and Goldfarb, Seth and Gupta, Lopa and Kirkwood, Katherine and Dobrev, Edlira and Levitan, Ron and Overbey, Jessica and Santos, Milerva and Weglinski, Michael and Williams, Paula and Wood, Carrie and Ye, Xia and Nielsen, Sten Lyager and Wiggers, Henrik and Malgaard, Henning and Mack, Michael and Adame, Tracine and Settele, Natalie and Adams, Jenny and Ryan, William and Smith, Robert L and Grayburn, Paul and Chen, Frederick Y and Nohria, Anju and Cohn, Lawrence and Shekar, Prem and Aranki, Sary and Couper, Gregory and Davidson, Michael and Bolman, R. Morton and Burgess, Anne and Conboy, Debra and Noiseux, Nicolas and Stevens, Louis-Mathieu and Prieto, Ignacio and Basile, Fadi and Dionne, Joannie and Fecteau, Julie and Blackstone, Eugene H and Gillinov, A. Marc and Lackner, Pamela and Berroteran, Leoma and Dolney, Diana and Fleming, Suzanne and Palumbo, Roberta and Whitman, Christine and Sankovic, Kathy and Sweeney, Denise Kosty and Pattakos, Gregory and Clarke, Pamela A and Argenziano, Michael and Williams, Mathew and Goldsmith, Lyn and Smith, Craig R and Naka, Yoshifumi and Stewart, Allan and Schwartz, Allan and Bell, Daniel and Van Patten, Danielle and Sreekanth, Sowmya and ...
The Journal of Thoracic and Cardiovascular Surgery, ISSN 0022-5223, 07/2019
OBJECTIVEThe Cardiothoracic Surgical Trials Network reported that left ventricular reverse remodeling at 2 years did not differ between patients with moderate... 
Index Medicus | Abridged Index Medicus
Journal Article
Rochester Democrat and Chronicle, 10/1999
  [...] Newton's murder spree was limited to an episode of the old '70s TV show Switch. [...] the characters Newton has played are hardly any more interesting... 
Musical performances
Newspaper Article
Rochester Democrat and Chronicle, 08/2009
  Critics noted that a guy with a hit like "Birthday Sex" was probably not an appropriate message for kids, but that's a promise that'll probably set some... 
Performing arts | Rap music
Newspaper Article
Rochester Democrat and Chronicle, 08/2009
  Critics noted that a guy with a hit like "Birthday Sex" was probably not an appropriate message for kids, but that's a promise that'll probably set some... 
Performing arts | Rap music
Newspaper Article
Journal Article